Current opinion in pediatrics最新文献

The era of advanced therapeutics for pediatric atopic dermatitis - can early systemic intervention reduce the type 2 inflammatory response and modify the atopic march? 儿童特应性皮炎的先进治疗时代——早期全身干预能否减少2型炎症反应并改变特应性进展？

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2026-05-07 DOI: 10.1097/MOP.0000000000001576

Florence Vroman, Marlies de Graaf

{"title":"The era of advanced therapeutics for pediatric atopic dermatitis - can early systemic intervention reduce the type 2 inflammatory response and modify the atopic march?","authors":"Florence Vroman, Marlies de Graaf","doi":"10.1097/MOP.0000000000001576","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001576","url":null,"abstract":"Purpose of review: The recent development of advanced systemic treatment options for pediatric atopic dermatitis (AD) means that achieving long-term, off-therapy remission, so-called disease modification, has become a subject of discussion. Emerging evidence suggests that early intervention during a potential 'window of opportunity' could alter the natural course of AD. If such a window could be identified, early and targeted treatment might induce long-term disease remission and might reduce the risk of the development of highly burdensome atopic comorbidities.Recent findings: Among currently available therapies, dupilumab, targeting interleukin (IL)-4 and IL-13 signaling, provides the most compelling evidence for potential disease modification. Studies indicate that a subset of patients treated with dupilumab may achieve prolonged remission after treatment discontinuation, and that treatment may reduce the risk of subsequent allergic disease development.Summary: Disease modification and long-term remission are no longer an idle hope for AD patients. However, translating this into clinical practice remains challenging due to the heterogeneity of AD and the lack of consensus of definitions. Future research should therefore focus on establishing these definitions, and on determining whether early systemic intervention can truly modify the disease itself and the atopic march.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward a new paradigm of adolescent sexual and reproductive health: Reproductive justice, equity, and wellbeing. 迈向青少年性健康和生殖健康的新范式：生殖正义、公平和福祉。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2026-05-05 DOI: 10.1097/MOP.0000000000001577

Alana K Otto, Bianca A Allison, Marissa Raymond-Flesch, Christine Dehlendorf, April J Bell, Amanda E Bryson

{"title":"Toward a new paradigm of adolescent sexual and reproductive health: Reproductive justice, equity, and wellbeing.","authors":"Alana K Otto, Bianca A Allison, Marissa Raymond-Flesch, Christine Dehlendorf, April J Bell, Amanda E Bryson","doi":"10.1097/MOP.0000000000001577","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001577","url":null,"abstract":"Purpose of review: Despite longstanding consensus that \"sexual and reproductive health\" are defined as more than merely the absence of disease, clinical care and research in adolescent sexual and reproductive health are generally framed in negative terms, with a focus on disease and risk rather than wellbeing, satisfaction, or other desired outcomes. Emphases on risk and risk mitigation have led to the promotion of practices and policies that undermine adolescent autonomy and the principles of reproductive justice.Recent findings: Sexual and reproductive health care and research are evolving toward more holistic, asset-based frameworks. Clinical practice guidelines, particularly around contraceptive care, increasingly call for person-centered care. Sexual and reproductive wellbeing has been proposed as a positive outcome intended to assess fulfillment related to sexuality and reproduction. The sexual and reproductive health equity framework considers structural factors that influence health and wellbeing and calls for upending practices, policies, and systems that perpetuate injustice.Summary: Adolescent sexual and reproductive health care and research must evolve to incorporate principles of reproductive justice. The concepts of sexual and reproductive health equity and sexual and reproductive wellbeing can inform our understanding of what to change and how to measure success. Pediatric clinicians should consider the unique developmental needs of adolescents as they strive to incorporate principles of justice, wellbeing, and equity into clinical care and research.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of extracorporeal cardiopulmonary resuscitation in pediatric cardiac arrest: lifesaving rescue. 体外心肺复苏在小儿心脏骤停中的应用：挽救生命的抢救。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2026-04-15 DOI: 10.1097/MOP.0000000000001574

Sonia Labarinas, Jon Meliones

{"title":"Use of extracorporeal cardiopulmonary resuscitation in pediatric cardiac arrest: lifesaving rescue.","authors":"Sonia Labarinas, Jon Meliones","doi":"10.1097/MOP.0000000000001574","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001574","url":null,"abstract":"Purpose of review: Extracorporeal cardiopulmonary resuscitation (ECPR) is an advanced form of resuscitation where an extracorporeal circuit is used to temporarily support circulation in patients with refractory cardiac arrest. It represents a highly complex and resource-intensive therapy, with outcomes shaped by institutional experience, patient selection, arrest-related factors, and post ECPR care. This review aims to show the clinical advantages of such a complex therapy.Recent findings: More than 15 000 children undergo cardiopulmonary resuscitation annually for in-hospital cardiac arrest in the United States. ECPR utilization has been increasing over the last 20 years. There has been ongoing uncertainty throughout the years about its efficacy in the pediatric population, especially in the noncardiac population. Recent studies have shown an optimization in outcomes, also in the general pediatric population with increased survival rates and positive neurological outcomes.Summary: ECPR remains a valuable intervention for rescuing children after refractory cardiac arrest. Current resuscitation guidelines endorse ECPR for pediatric cardiac patients. Although outcomes are encouraging, ECPR remains a complex intervention associated with considerable morbidity, mortality, and resource requirements, including significant financial and personnel investment. Future research should focus on identifying patient-specific predictors of benefit, refining selection criteria, and optimizing peri-arrest and post-ECPR management strategies.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary complications in pediatric hematopoietic stem cell transplantation: an overview for pediatricians. 儿科造血干细胞移植的肺部并发症：儿科医生综述。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2026-04-15 DOI: 10.1097/MOP.0000000000001571

Meera A Srikanthan, Pi Chun Cheng, Samuel B Goldfarb

{"title":"Pulmonary complications in pediatric hematopoietic stem cell transplantation: an overview for pediatricians.","authors":"Meera A Srikanthan, Pi Chun Cheng, Samuel B Goldfarb","doi":"10.1097/MOP.0000000000001571","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001571","url":null,"abstract":"Purpose of review: This review will describe pulmonary complications of hematopoietic stem cell transplantation (HCT) are a significant source of short- and long-term morbidity and mortality. In recent years the amount of HCT being performed in pediatric continues to increase with new disease included as a form of treatment. Complications which include infection, inflammation, immune mediated damage, and regimen associated toxicity is critically import for early recognition to avoid end organ damage.Recent findings: This review encompasses current literature related to pediatric pulmonary complications of HCT. Types of HCT and conditioning treatments have changed over the past 15-20 years with the goal of reducing complications of HCT such as graft versus host disease. Updated guidelines will be referenced that address post HCT follow up recommendations in pediatrics.Summary: Timely diagnosis of post HCT complications will improve overall care. Ongoing research in this field is needed to continue to improve outcomes and identify biomarkers of disease. Large cohort prospective studies are needed and underway to improve our knowledge with the goal of narrowing the knowledge gap in this field.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A special education primer for the pediatrician: supporting families through educational evaluations and services. 儿科医生的特殊教育入门：通过教育评估和服务支持家庭。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2026-04-15 DOI: 10.1097/MOP.0000000000001575

Lillian Maidman Ravikoff, Joseph Mekhail, Caroline Howard, Ruth L Milanaik

引用次数: 0

Current opinion in pediatrics: pediatric lung transplantation in the 21st century. 当前儿科观点：21世纪儿科肺移植。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2026-04-09 DOI: 10.1097/MOP.0000000000001572

Spoorthi Davala, Xin Si

{"title":"Current opinion in pediatrics: pediatric lung transplantation in the 21st century.","authors":"Spoorthi Davala, Xin Si","doi":"10.1097/MOP.0000000000001572","DOIUrl":"10.1097/MOP.0000000000001572","url":null,"abstract":"Purpose of review: This review provides a summary of the evolving landscape of pediatric lung transplantation highlighting current trends, short and long-term outcomes, ongoing challenges in posttransplant survival, and unique considerations in pediatric populations.Recent findings: The annual volume of pediatric lung transplantation has declined over the past decade due to a decreased need among children with cystic fibrosis. Improvement in survival has paralleled advancements in bridge to transplant strategies, expanding what were once considered contraindications. Despite the ongoing shortage of donor organs, innovations in policy changes, surgical and immunologic strategies, and organ preservation technologies have expanded the donor lung pool. Chronic lung allograft dysfunction (CLAD) remains the primary limitation to long-term survival, with limited management strategies and emerging immunomodulatory therapies offering promise.Summary: As survival in pediatric lung transplantation improves, emphasis should shift to long-term outcomes including quality of life and equitable care, development of effective CLAD prevention strategies and pediatric-specific guidelines to optimize long-term survival.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the scan: quick MRI's emergence in pediatric emergency care. 扫描之外：快速核磁共振成像在儿科急诊护理中的出现。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2026-04-09 DOI: 10.1097/MOP.0000000000001570

Brenda Varriano, Kristina Brumme, Wee-Jhong Chua

{"title":"Beyond the scan: quick MRI's emergence in pediatric emergency care.","authors":"Brenda Varriano, Kristina Brumme, Wee-Jhong Chua","doi":"10.1097/MOP.0000000000001570","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001570","url":null,"abstract":"Purpose of review: Computed tomography (CT) remains the dominant neuroimaging modality in the pediatric emergency department despite growing awareness of the risks associated with cumulative ionizing radiation exposure. Advances in rapid MRI have renewed interest in quick brain MRI (qbMRI) as a feasible, radiation-free alternative. This manuscript explores emerging strategies to reduce unnecessary CT utilization, expand MRI accessibility, and synthesize growing evidence supporting the use of qbMRI across a range of pediatric emergency indications.Recent findings: Recent literature demonstrates that qbMRI offers significant reductions in radiation exposure with comparable diagnostic performance to CT for the evaluation of hydrocephalus and cerebrospinal fluid shunt malfunction. Studies also highlight its value in selected traumatic brain injuries, abusive head trauma screening, and nontraumatic neurologic emergencies; notably for pediatric stroke, where diffusion-weighted qbMRI shows superior sensitivity to CT. Quality improvement data highlight the successful integration of qbMRI protocols that produce substantial decreases in CT utilization while sustaining diagnostic accuracy.Summary: QbMRI increasingly represents a safer neuroimaging strategy compared to CT. While CT remains essential for detecting acute intracranial hemorrhage and skull fractures, qbMRI can meaningfully reduce radiation exposure in appropriately selected patients. Ongoing technological advances, such as improved fracture detection; along with targeted implementation efforts, are likely to further expand its role in pediatric emergency neuroimaging.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric tracheostomy-associated respiratory infections: an evolving paradigm. 儿童气管切开术相关的呼吸道感染：一个不断发展的范例。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2026-04-03 DOI: 10.1097/MOP.0000000000001559

John M Morrison, Rebecca Steuart, Christopher J Russell

{"title":"Pediatric tracheostomy-associated respiratory infections: an evolving paradigm.","authors":"John M Morrison, Rebecca Steuart, Christopher J Russell","doi":"10.1097/MOP.0000000000001559","DOIUrl":"10.1097/MOP.0000000000001559","url":null,"abstract":"Purpose of review: Children with tracheostomy frequently experience tracheostomy-associated infections (TRAINs) such as pneumonia and tracheitis. This review will summarize current evidence regarding the diagnosis, treatment, and prevention of TRAINs.Recent findings: Recent evidence highlights limitations of respiratory culture testing in the face of a diverse, dynamic bacterial community within the airways of children with tracheostomy, challenging the notion that a positive bacterial culture is sufficient for diagnosing bacterial TRAIN. For this reason, recent consensus guidelines recommend against the routine obtainment of respiratory cultures for TRAIN diagnosis in the absence of specific clinical symptoms. Additional evidence for microbiome shifts and host inflammation as diagnostic tools may help identify those who will benefit from antibiotic treatment. Recent findings support selective anaerobic coverage when aspiration is suspected and suggest shorter antibiotic courses may be effective. Cycled inhaled tobramycin shows potential for reducing TRAIN frequency and related hospitalizations.Summary: With recent advances in TRAIN pathobiology, diagnosis, treatment, and prevention of TRAINs is undergoing a paradigm shift. Future translational research will define the airway microbiome during TRAINs and during wellness and its impact on host inflammation. Antibiotic clinical trials are needed to optimize treatment and prevention of TRAINs.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal trials and informed consent in the NICU: a literature review. 新生儿试验和知情同意在新生儿重症监护室：文献综述。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2026-04-01 Epub Date: 2026-01-28 DOI: 10.1097/MOP.0000000000001542

Tiffany Dial, Toby Yanowitz, Burhan Mahmood, John Ibrahim

{"title":"Neonatal trials and informed consent in the NICU: a literature review.","authors":"Tiffany Dial, Toby Yanowitz, Burhan Mahmood, John Ibrahim","doi":"10.1097/MOP.0000000000001542","DOIUrl":"10.1097/MOP.0000000000001542","url":null,"abstract":"Purpose of review: With the recent advances in neonatal care, resuscitation of periviable neonates and challenges to conducting clinical research and funding, efficient clinical trials with relevant outcomes are pivotal to direct the future of neonatology.Recent findings: Parents of neonates in the Neonatal ICU are supportive and hold positive views of clinical research. Timing and who approaches the parents plays a great role in parents' perception of a clinical trial. Parents prefer a bigger role for the clinical team at least when introducing the idea of research. The consent process has evolved, and newer technology should be incorporated to make it simple and more clear. Consenting mothers in labor remains a point of contention as timing of consent and ability to retain information matters. Different types of consent can be used based on timing of intervention of a research trial, to allow for efficient and diverse enrollment.Summary: The challenges inherent to conducting research in neonatology have not received the attention it deserves, especially when it comes to interventional trials, raising questions about equity of research in this patient cohort. Parents view research positively and are supportive provided that the timing is appropriate and language is clear.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"169-176"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growing bromance between infectious diseases and artificial intelligence: for better or for worse. 传染病和人工智能之间日益紧密的兄弟关系：是好是坏。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2026-04-01 Epub Date: 2026-03-05 DOI: 10.1097/MOP.0000000000001548

Elijah Paintsil

引用次数: 0