危重儿童个性化ICU解放:塑造ABCDEF捆绑的未来。

IF 2.2 3区 医学 Q2 PEDIATRICS
Current opinion in pediatrics Pub Date : 2025-06-01 Epub Date: 2025-04-02 DOI:10.1097/MOP.0000000000001465
Jessica M LaRosa, Sapna R Kudchadkar
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引用次数: 0

摘要

综述目的:重症监护病房(ICU)解放包旨在降低日益增长的儿科ICU幸存者的获得性发病率。本综述将探讨新兴的精准医学策略,以个性化实施ICU解放捆绑。ICU解放束,也称为ABCDEF束,由六个相互关联的部分组成:A:评估、预防和管理疼痛;B:自主呼吸试验;C:镇痛、镇静的选择;D:谵妄的评估、预防和管理;E:早期活动和锻炼;F:家庭参与和赋权。新兴的研究和技术正在推进每个组件的个性化方法,使研究人员和临床医生能够根据患者特定因素优化实施。关键的创新包括使用计算模型的自动筛选和风险分层,检测束元素的可穿戴技术,以及评估疾病风险和药物反应的基因评估。摘要:本综述概述了重症儿童的ICU解放包,并强调了个性化每个包元素以提高生存率的机会。通过整合精准医学的进步,临床医生和研究人员可以提高PICU幸存者的护理质量,最终实现更好的长期预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Personalizing ICU liberation for critically Ill children: shaping the future of the ABCDEF bundle.

Purpose of review: Intensive care unit (ICU) liberation bundles aim to reduce acquired morbidities in the growing population of pediatric ICU survivors. This review will explore emerging precision medicine strategies to personalize the implementation of the ICU liberation bundle.

Recent findings: The ICU liberation bundle, also known as the ABCDEF bundle, consists of six interrelated components: A: assess, prevent, and manage pain; B: spontaneous breathing trials; C: choice of analgesia and sedation; D: delirium assessment, prevention, and management; E: early mobility and exercise; F: family engagement and empowerment. Emerging research and technology are advancing personalized approaches to each component, enabling researchers and clinicians to optimize implementation based on patient-specific factors. Key innovations include automated screening and risk stratification using computational models, wearable technologies that detect bundle elements, and genetic assessments to evaluate disease risk and medication responses.

Summary: This review provides an overview of the ICU liberation bundle for critically ill children and highlights opportunities to personalize each bundle element to enhance survivorship. By integrating advancements in precision medicine, clinicians and researchers can improve the quality of care for the growing population of PICU survivors, ultimately leading to better long-term outcomes.

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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
184
审稿时长
6-12 weeks
期刊介绍: ​​​​​Current Opinion in Pediatrics is a reader-friendly resource which allows the reader to keep up-to-date with the most important advances in the pediatric field. Each issue of Current Opinion in Pediatrics contains three main sections delivering a diverse and comprehensive cover of all key issues related to pediatrics; including genetics, therapeutics and toxicology, adolescent medicine, neonatology and perinatology, and orthopedics. Unique to Current Opinion in Pediatrics is the office pediatrics section which appears in every issue and covers popular topics such as fever, immunization and ADHD. Current Opinion in Pediatrics is an indispensable journal for the busy clinician, researcher or student.
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