Current opinion in pediatrics最新文献_第2页

Precision medicine in the pediatric and neonatal intensive care units through genomics. 通过基因组学实现儿科和新生儿重症监护病房的精准医疗。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-06-01 Epub Date: 2025-04-11 DOI: 10.1097/MOP.0000000000001471

Phan Q Duy, Benjamin Dylik, Engin Deniz

{"title":"Precision medicine in the pediatric and neonatal intensive care units through genomics.","authors":"Phan Q Duy, Benjamin Dylik, Engin Deniz","doi":"10.1097/MOP.0000000000001471","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001471","url":null,"abstract":"Purpose of review: Genome-wide sequencing technologies have revolutionized the understanding of human disorders and advanced precision medicine, especially for pediatric disorders. Here, we discuss the utility of genomic technologies in advancing the care of children admitted to the pediatric and neonatal intensive care units.Recent findings: Rapid molecular diagnosis permitted by genomic medicine has yielded clinically actionable findings that influence decision-making and facilitate timely therapeutic interventions. Identifying a genetic association provides a causal anchor to understanding disease biology at the single nucleotide resolution, revealing hidden biological heterogeneity that may be obscured by traditional imaging, laboratory, and pathological workup. The importance of a genetic diagnosis is further highlighted by the promise of gene therapy to correct the underlying genetic perturbation, as evidenced by the recent emergence of FDA-approved gene therapies for childhood genetic conditions.Summary: We predict that whole-genome sequencing, in conjunction with other omic technologies, will become critical diagnostic adjuncts in the clinical workup of critically ill children.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 3","pages":"211-215"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence impacts in education and pediatric mental health. 人工智能对教育和儿童心理健康的影响。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-06-01 Epub Date: 2025-03-19 DOI: 10.1097/MOP.0000000000001453

Grace Liberatore, Alyssa Kim, Jack Brenner, Ruth Milanaik

{"title":"Artificial intelligence impacts in education and pediatric mental health.","authors":"Grace Liberatore, Alyssa Kim, Jack Brenner, Ruth Milanaik","doi":"10.1097/MOP.0000000000001453","DOIUrl":"10.1097/MOP.0000000000001453","url":null,"abstract":"Purpose of review: Increased accessibility of artificial intelligence to children has raised concerns regarding its effects on education and student mental health. Pediatricians should continue to be informed about the effects of artificial intelligence in their patients' daily lives, as artificial intelligence is becoming increasingly present.Recent findings: The use of artificial intelligence to create personalized study material illustrates a benefit of incorporating this technology into education. However, an overreliance on artificial intelligence could decrease students' problem-solving skills and increase plagiarism. Novel uses of artificial intelligence have also raised concerns regarding mental health. Deepfake technology, which utilizes artificial intelligence to create images, videos, and/or audio that appears real but is fabricated, can be viewed online by children, which could have negative mental health implications.Summary: Although artificial intelligence has the potential to revolutionize education at all levels, its use as an enhancement, not replacement, to current educational strategies is imperative. Both parents and students need to understand the limitations of artificial intelligence in education, and simultaneously prioritize developing the necessary cognitive skills strengthened throughout education. Pediatricians and parents should also be aware of the potentially dangerous material generated by artificial intelligence that can negatively impact children's mental health.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"296-302"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why some and not others? Understanding vascular phenotypes in genetic developmental lung diseases. 为什么是一些而不是另一些？了解遗传性发育性肺病的血管表型。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-06-01 Epub Date: 2025-03-28 DOI: 10.1097/MOP.0000000000001459

Lea C Steffes, Maya E Kumar, Nidhy P Varghese

{"title":"Why some and not others? Understanding vascular phenotypes in genetic developmental lung diseases.","authors":"Lea C Steffes, Maya E Kumar, Nidhy P Varghese","doi":"10.1097/MOP.0000000000001459","DOIUrl":"10.1097/MOP.0000000000001459","url":null,"abstract":"Purpose of review: Pulmonary vascular disease is more common in certain genetic developmental lung disorders. This review synthesizes clinical descriptions, molecular analyses, and single-cell transcriptional data to build a conceptual framework to help understand why some variants affect the vasculature while others primarily manifest with parenchymal disease.Recent findings: Genes predominantly expressed in endothelial and mesenchymal compartments ( TBX4 , FGF10 , FOXF1 , KDR ) commonly present with both parenchymal and pulmonary vascular disease, while epithelial-restricted genes ( SFTPC , ABCA3 , NKX2.1 ) typically manifest as parenchymal disease. Single-cell analyses reveal that compartment-specific expression patterns correlate with clinical phenotypes. Phenotypic variability, even among individuals sharing identical variants, suggests complex interactions between genetic modifiers, epigenetic factors, and developmental processes that remain poorly understood.Summary: Compartment-specific gene expression patterns fundamentally underlie the differential presence of vascular phenotypes in DEVLDs. Genetic advances and single cell technologies have revolutionized our understanding of these disorders, but we are in the early stages of translating this knowledge into meaningful clinical advances. Future efforts must bridge this gap to transform clinical care from supportive to targeted, disease-modifying treatment based on cell-specific molecular mechanisms.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"278-288"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric pulmonology: medical frontiers advanced, borders blurred. 儿科肺科：医学前沿先进，边界模糊。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-06-01 Epub Date: 2025-04-30 DOI: 10.1097/MOP.0000000000001467

David N Cornfield

引用次数: 0

Interventional pulmonology across the globe. 介入肺脏学。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-06-01 Epub Date: 2025-04-10 DOI: 10.1097/MOP.0000000000001470

Kubra Melike Bozkanat, Dirk Schramm

{"title":"Interventional pulmonology across the globe.","authors":"Kubra Melike Bozkanat, Dirk Schramm","doi":"10.1097/MOP.0000000000001470","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001470","url":null,"abstract":"Purpose of review: Pediatric interventional pulmonology (PIP) is an evolving subspecialty aiming at respiratory diseases in children through procedural interventions. This review discusses recent developments and challenges in global adoption of these advancements.Recent findings: Innovations such as ultra-thin cryoprobes and bronchoscopes allow for diagnostic and interventional procedures in pediatric airways. Cryotherapy demonstrates advantages in obtaining biopsies, treating airway stenosis, and extracting foreign bodies. Endobronchial ultrasound has improved the accuracy of diagnosing lymphadenopathy and pulmonary lesions, but its large size and high cost limit its use in resource-poor areas. Other newer techniques, such as tracheoesophageal fistula repair and endobronchial valves for air leaks, are promising but lack strong evidence for widespread adoption. Geographical and economic disparities impede progress, with high-income countries pioneering innovation, and low- and middle-income areas facing access and training challenges.Summary: While PIP does have the potential to be transformational, global disparities in its adoption are significant. International collaborations, standardized training, and resources are paramount. This can be achieved through virtual training platforms and global conferences that will help narrow the gaps, ensuring equitable PIP growth to benefit pediatric respiratory care globally.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 3","pages":"272-277"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision decisions in pediatric airway management: addressing physiologic difficulty. 儿科气道管理中的精确决策：解决生理困难。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-06-01 Epub Date: 2025-03-07 DOI: 10.1097/MOP.0000000000001450

Laura Wylie, Kelsey A Miller, Joshua Nagler

{"title":"Precision decisions in pediatric airway management: addressing physiologic difficulty.","authors":"Laura Wylie, Kelsey A Miller, Joshua Nagler","doi":"10.1097/MOP.0000000000001450","DOIUrl":"10.1097/MOP.0000000000001450","url":null,"abstract":"Purpose of review: Precision medicine is based on the idea that treatment can be individualized for each patient in a given clinical environment. This review summarizes factors that should be considered when clinicians are creating individualized plans for intubation, specifically focusing on physiologically difficult airways. Recent literature identifying physiologic risk factors is summarized, and individual and system-level interventions that can potentially mitigate risk are reviewed.Recent findings: Physiologic derangements, most notably hypoxia and hypotension, have been associated with increased incidence of severe adverse events during intubation attempts. Individualized peri-procedural efforts to improve physiologic parameters through optimal oxygen delivery, fluid resuscitation, vasopressor administration, and thoughtful choice in rapid sequence intubation (RSI) medications may improve patient outcomes. Systems of care are being built around airway bundles, cognitive aids, and collaborations with airway teams to optimize outcomes.Summary: Providers should develop individualized care plans for their patients to optimize physiologic and anatomic parameters peri-intubation. The physiologically difficult airway affects the rate of first pass success and adverse events, therefore patients should be optimized prior to undergoing the procedure based on their clinical presentation and data.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"233-239"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucocorticoid-induced osteoporosis in children: emerging vascular and molecular targets. 糖皮质激素诱导的儿童骨质疏松症：新出现的血管和分子靶点。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-05-22 DOI: 10.1097/MOP.0000000000001476

Sisir Kumar Barik, Janet L Crane

{"title":"Glucocorticoid-induced osteoporosis in children: emerging vascular and molecular targets.","authors":"Sisir Kumar Barik, Janet L Crane","doi":"10.1097/MOP.0000000000001476","DOIUrl":"10.1097/MOP.0000000000001476","url":null,"abstract":"Purpose of review: Glucocorticoid-induced osteoporosis (GIO) poses a significant risk to pediatric patients undergoing chronic glucocorticoid therapy for inflammatory, autoimmune, and genetic conditions. This review highlights the pathophysiology of GIO in children and emerging insights into the role of bone vasculature in skeletal health during growth.Recent findings: GIO arises from a dual mechanism of increased bone resorption and decreased bone formation, leading to rapid declines in bone mineral density. Recent studies emphasize the importance of angiogenic-osteogenic coupling, particularly in the growing skeleton. Endothelial cells are now recognized as active participants in bone health and regeneration. Advances in the understanding of signaling pathways regulating skeletal angiogenesis could predict skeletal side effects during drug development. Therapies enhancing endothelial cell function or promoting skeletal angiogenesis could mitigate glucocorticoid-induced damage. Key signaling pathways, such as platelet-derived growth factor type BB and nuclear factor (NF)-κB play critical roles in recruiting osteoprogenitors and establishing a vascular niche for skeletal angiogenesis.Summary: GIO is uniquely concerning in children due to its impact on peak bone mass and lifelong fracture risk. Understanding how glucocorticoids impair bone vasculature and skeletal remodeling may reveal new therapeutic targets to preserve bone health and mitigate the osteotoxic effects of long-term glucocorticoid use in the growing skeleton.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aisles of health? A pediatrician's guide to vitamins and dietary supplements in pharmacies and supermarkets. 健康通道？儿科医生的维生素和膳食补充剂指南在药店和超市。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-05-21 DOI: 10.1097/MOP.0000000000001475

Mary Lowance, Eric Wang, Mia Graybow, Ruth L Milanaik

{"title":"Aisles of health? A pediatrician's guide to vitamins and dietary supplements in pharmacies and supermarkets.","authors":"Mary Lowance, Eric Wang, Mia Graybow, Ruth L Milanaik","doi":"10.1097/MOP.0000000000001475","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001475","url":null,"abstract":"Purpose of review: In recent years, there have been increased discussions among parents about the use of Complementary and Alternative Medicine for kids, specifically dietary supplements and vitamins. While these were originally marketed to supplement nutrient needs, many families have begun to raise questions about the efficacy of vitamins and minerals to treat developmental conditions such as attention-hyperactivity deficit disorder, mood disorders, or sleep disturbances.Recent findings: Research investigating the use of vitamin supplements generally concludes that supplementation may be necessary in cases of deficiency; additional benefits are minimal. Some hormonal and mineral supplements like melatonin, fish oil, and magnesium have been found to reduce symptoms of hyperactivity, sleep disturbance, and conduct disorders in combination with other interventions. However, none of these therapies rival the efficacy of first-line treatment plans for these conditions. Additionally, overuse may lead to toxicity and adverse effects.Summary: While many parents may have concerns about their child's nutrient intake, much is still unknown about the dosing, safety, and efficacy of dietary supplements. For deficient children or patients resistant to eating certain food groups, mineral and vitamin supplements may be an effective way to meet nutritional needs. It is important to note that there is little evidence supporting the efficacy of dietary supplement use to treat other conditions nor any benefit for healthy children with a balanced diet.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomy and development of the pediatric knee: what do we know so far? 儿童膝关节的解剖和发育：到目前为止我们知道些什么？

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-05-02 DOI: 10.1097/MOP.0000000000001473

Tomás Fernández-Comparini, María Emilia Riquelme, María Jesús Tuca

{"title":"Anatomy and development of the pediatric knee: what do we know so far?","authors":"Tomás Fernández-Comparini, María Emilia Riquelme, María Jesús Tuca","doi":"10.1097/MOP.0000000000001473","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001473","url":null,"abstract":"Purpose of review: Understanding the normal anatomy and development of the pediatric knee is crucial due to its structural complexity and significant changes over time. This review covers current knowledge of various anatomical structures of the knee and provides insights into differentiating normal development from their variations.Recent findings: Recent literature highlights advancements in imaging techniques for assessing bone age and skeletal maturity. Knee magnetic resonance imaging (MRI) has emerged as a promising alternative to traditional X-rays, based on key features visible on standard MRI that demonstrate a predictable ossification pattern. However, further validation may be required. Studies have explored the morphologic development of the knee, including the different components, physis and vascularity. Several studies have aimed to elucidate the physiology of normal variants of development, though the etiology of many conditions remains unknown.Summary: The findings emphasize the importance of accurate interpretation and detailed knowledge of developmental changes in the pediatric knee. Improved imaging techniques and understanding of normal variants are essential for distinguishing between benign developmental changes and pathological conditions.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric orthostatic intolerance - a review with focus on recent research. 儿童立位不耐受-近期研究综述。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-04-11 DOI: 10.1097/MOP.0000000000001469

Camden Hebson, Matthew Harberg, Polly Borasino

{"title":"Pediatric orthostatic intolerance - a review with focus on recent research.","authors":"Camden Hebson, Matthew Harberg, Polly Borasino","doi":"10.1097/MOP.0000000000001469","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001469","url":null,"abstract":"Purpose of review: To provide pediatric providers with the most up to date information on evaluation, diagnosis, and treatment of orthostatic intolerance and postural orthostatic tachycardia syndrome (POTS).Recent findings: In this review, new research is summarized on the importance of exercise, the role of anxiety and depressed mood in exacerbating symptoms, and medication utilization.Summary: Orthostatic intolerance and POTS are increasingly common causes of significant infirmity during adolescence. Pediatricians are front line in implementing treatment, which is centered on patient education and nonpharmacologic strategies. Precise history taking identifies the conditions, and accurately explaining the pathophysiology to families encourages patient buy-in to follow a rigorous treatment program. While anxiety and depressed mood are not central causes of symptomatology, they do exacerbate a patient's presentation and thus must be treated aptly. Prognosis is excellent in patients who adhere to a treatment plan, and encouragement from providers as to this expectation is key to building a strong therapeutic alliance.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0