Current opinion in pediatrics最新文献_第2页

Detection and treatment of developmental dysplasia of the hip in infants: updates and recommendations. 婴儿髋关节发育不良的检测和治疗：最新进展和建议。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-28 DOI: 10.1097/MOP.0000000000001420

Aidan P Cosgrove, Claudia Maizen

{"title":"Detection and treatment of developmental dysplasia of the hip in infants: updates and recommendations.","authors":"Aidan P Cosgrove, Claudia Maizen","doi":"10.1097/MOP.0000000000001420","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001420","url":null,"abstract":"Purpose of review: Developmental dysplasia of the hip (DDH) is common and is a source of potentially avoidable morbidity through childhood and adult life. Despite progress over the past century, there is a wide variation in policy, practice and outcomes between countries. This review considers information from a geographically wide range of locations to evaluate the impact of these variations and understand how these variations arise. The aim is to help clinicians and policymakers adopt the best practices for their population.Recent findings: There is a lack of randomized controlled trials to guide decisions on screening. Given the large numbers to treat and preexisting practices, it is unlikely that such trials of sufficient statistical power will be performed. However, many whole population studies are becoming available from different countries that allow an assessment and comparison of the impact of their strategies.Summary: Standardizing metrics in studies and defining late diagnosis would improve comparisons across studies. The general trend appears to favour universal screening to reduce the risk of late diagnosis, the need for surgery and the subsequent poorer outcomes. Notably, resource-constrained countries like Mongolia have successfully implemented universal screening, showing that effective strategies can be adopted regardless of resources.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 1","pages":"88-93"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The childhood cancer data initiative: enabling data sharing to drive research advances and transform pediatric cancer diagnosis and treatment. 儿童癌症数据倡议：使数据共享能够推动研究进展并改变儿童癌症的诊断和治疗。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-27 DOI: 10.1097/MOP.0000000000001422

Subhashini Jagu, Jaime M Guidry Auvil, Gregory Reaman

{"title":"The childhood cancer data initiative: enabling data sharing to drive research advances and transform pediatric cancer diagnosis and treatment.","authors":"Subhashini Jagu, Jaime M Guidry Auvil, Gregory Reaman","doi":"10.1097/MOP.0000000000001422","DOIUrl":"10.1097/MOP.0000000000001422","url":null,"abstract":"Purpose of review: With growing emphasis on data-driven research in pediatric oncology, particularly in the context of advances in molecular characterization and precision medicine, there is an urgent need for comprehensive data-sharing initiatives. This review explores how the Childhood Cancer Data Initiative (CCDI) addresses this critical need.Recent findings: CCDI plays a key role in enhancing pediatric cancer research by improving data integration, sharing, and collaboration. Its Molecular Characterization Initiative advances the field by leveraging detailed molecular data to inform clinical trials and therapeutic strategies. For small patient populations, such as those with rhabdomyosarcoma, CCDI's efforts in integrating data across institutions are vital for advancing risk-based treatment strategies to achieve meaningful clinical outcomes.Summary: CCDI's advancements in data sharing have profound implications for both clinical practice and research. By enabling precise diagnoses, tailoring treatments based on individual genetic profiles, and addressing the challenges associated with small patient populations, CCDI is driving transformative changes in pediatric oncology. Continued support and expansion of such initiatives are crucial to fully realizing their potential in improving outcomes for children with cancer.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 1","pages":"42-47"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking household members and defining relational networks using routine health data. 利用常规健康数据将家庭成员联系起来并定义关系网络。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-04 DOI: 10.1097/MOP.0000000000001415

Jeffrey I Campbell, Ana Poblacion, Richard Sheward

{"title":"Linking household members and defining relational networks using routine health data.","authors":"Jeffrey I Campbell, Ana Poblacion, Richard Sheward","doi":"10.1097/MOP.0000000000001415","DOIUrl":"10.1097/MOP.0000000000001415","url":null,"abstract":"Purpose of review: The growth of rich electronic health record (EHR) data and large health databases has introduced new opportunities to link individuals together into households and relational networks. These 'linked relational networks' hold promise for providing family-level care and studying intergenerational epidemiology and clinical outcomes. However, as linked relational networks become more commonly available in EHRs and research databases, it is critical to understand their challenges and limitations.Recent findings: Matching algorithms are being used to create linked relational networks in EHR and health databases. Clinically, these algorithms have been most useful to provide dyadic maternal-newborn care. In research, studies using these algorithms investigate topics ranging from the pharmacoepidemiology of parental drug exposure on childhood health outcomes, to heritability of chronic conditions, to associations between parental and child healthcare access and service delivery. However, ethical and technical challenges continue to limit use of these algorithms. There is also a critical research gap in the external validity of these matching algorithms.Summary: Linked relational networks are in widespread use in pediatric clinical care and research. More research is needed to understand the scope, limitations, and biases inherent in existing matching strategies.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"27-33"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the potential role of financial interventions to improve the health of families impacted by incarceration. 探索金融干预措施在改善受监禁影响家庭的健康状况方面的潜在作用。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-02 DOI: 10.1097/MOP.0000000000001413

Destiny G Tolliver, Benjamin Howell, Sarah Blanton, Emily A Wang

{"title":"Exploring the potential role of financial interventions to improve the health of families impacted by incarceration.","authors":"Destiny G Tolliver, Benjamin Howell, Sarah Blanton, Emily A Wang","doi":"10.1097/MOP.0000000000001413","DOIUrl":"10.1097/MOP.0000000000001413","url":null,"abstract":"Purpose of review: To summarize the impact of financial hardship on children whose parents have been incarcerated, describe both existing cash transfer and guaranteed income programs, and highlight their impact on child and family well being.Recent findings: Emerging data on guaranteed income programs for formerly incarcerated adults indicates that the funds improve recipient health and legal system outcomes and allow participants to spend funds on stabilizing themselves and their families. Guaranteed income programs in the broader population similarly highlight the use of funds to support families' basic needs and improved parent-child relationships, but more data are needed to understand the impact on child health and well being among families impacted by the criminal legal system.Summary: Over 5 million children experience parental incarceration, which directly contributes to financial hardship and subsequent negative health outcomes. Cash transfers may assist these families, but policies and administrative burdens limit the ability of existing programs to fully address financial hardship. Guaranteed income programs may therefore serve a unique role in supporting the financial needs of families impacted by incarceration. More longitudinal data focusing on child health outcomes are necessary to fully understand the impact of guaranteed income of children and families impacted by parental incarceration.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"34-39"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What's up with patella alta? 上髌骨怎么了？

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-29 DOI: 10.1097/MOP.0000000000001428

Ruth H Jones, Emilie Lijesen, Daniel W Green

{"title":"What's up with patella alta?","authors":"Ruth H Jones, Emilie Lijesen, Daniel W Green","doi":"10.1097/MOP.0000000000001428","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001428","url":null,"abstract":"Purpose of review: Patella alta, which describes an abnormally proximally positioned patella, has become of particular interest as it has been identified as a potential factor in patellofemoral instability (PFI) and other common pediatric orthopedic conditions. The purpose of this review is to describe the condition, measuring techniques, and its association with pediatric orthopedic conditions, and to evaluate methods of correction of patella alta.Recent findings: Recent literature has explored the etiology of patella alta by investigating patellar height as age increases, with inconclusive findings as to whether the condition is congenital or acquired over time. Additionally, patella alta has been identified to be associated with several pediatric orthopedic conditions, including PFI, anterior knee pain, and cerebral palsy. As such, methods of correction for patella alta, including medial patellofemoral ligament reconstruction (MPFLR), tibial tubercle distalization, and patella tendon imbrication, have been studied.Summary: Patella alta, defined by an abnormally high patellar height, is associated with patellofemoral instability, anterior knee pain, and cerebral palsy. Various indices have been developed to measure and define patellar height, including the Caton-Deschamps Index and Koshino-Sugimoto Index which are applicable to a pediatric population. Treatments include isolated or concomitant MPFLR, distalizing tibial tubercle osteotomy, and patella tendon imbrication, which have shown success in reducing patellar height and improving patella alta, though risks for complications do exist.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 1","pages":"82-87"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cozen's phenomenon. 欺骗的现象。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-25 DOI: 10.1097/MOP.0000000000001425

Matias Sepúlveda, Macarena Ulloa, Estefanía Birrer

引用次数: 0

Overview of the etiology of childhood cancer and future directions. 儿童癌症的病因及未来发展方向。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-12-02 DOI: 10.1097/MOP.0000000000001419

Thanh T Hoang, Michael E Scheurer, Philip J Lupo

{"title":"Overview of the etiology of childhood cancer and future directions.","authors":"Thanh T Hoang, Michael E Scheurer, Philip J Lupo","doi":"10.1097/MOP.0000000000001419","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001419","url":null,"abstract":"Purpose of review: We provide an overview of the etiology of childhood cancer, the state of the literature, and highlight some opportunities for future research, including technological advancements that could be applied to etiologic studies of childhood cancer to accelerate our understanding.Recent findings: Risk factors of childhood cancer were summarized based on demographics and perinatal factors, environmental risk factors, and genetic risk factors. Overall, demographics and perinatal factors are the most well studied in relation to childhood cancer. While environmental risk factors have been implicated, more work is needed to pinpoint specific exposures, identify window(s) of susceptibility, and understand mechanisms. With genome-wide association studies (GWAS), genetic risk factors of eight childhood cancers have emerged, and opportunities remain to conduct GWAS for other cancer types and determine whether risk variants are inherited or de novo. Technological advancements that can shed light into the susceptibility of childhood cancer include metabolomics, using primary teeth as an exposure matrix, and long-read sequencing.Summary: The development of childhood cancer remains largely not well understood. Collaboration to increase sample size to conduct analyses by histology and/or molecular subtype and application of novel technologies will accelerate our understanding of childhood cancer.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 1","pages":"59-66"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates on neurologic manifestations of mitochondrial disease. 线粒体疾病神经系统表现的最新进展。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-12-06 DOI: 10.1097/MOP.0000000000001418

Britta Kuusik, Divakar S Mithal

引用次数: 0

Advances in pediatric oncology through collaborations. 通过合作在儿科肿瘤学方面取得进展。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-12-20 DOI: 10.1097/MOP.0000000000001429

Brigitte C Widemann

引用次数: 0

Do new quality measures for social risk screening 'measure up'? 社会风险筛查的新质量标准是否 "达标"？

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-02-01 Epub Date: 2024-11-02 DOI: 10.1097/MOP.0000000000001414

Kameswari Potharaju, Laura M Gottlieb, Matthew Pantell, Danielle Hessler Jones

{"title":"Do new quality measures for social risk screening 'measure up'?","authors":"Kameswari Potharaju, Laura M Gottlieb, Matthew Pantell, Danielle Hessler Jones","doi":"10.1097/MOP.0000000000001414","DOIUrl":"10.1097/MOP.0000000000001414","url":null,"abstract":"Purpose of review: New social risk screening standards and quality metrics reward or penalize healthcare delivery organizations for social risk screening. After summarizing the recent literature on social risk screening in pediatric healthcare settings we consider how this evidence - and persistent evidence gaps - might inform future standards development.Recent findings: Reported social risk screening rates, measures, and modality differ greatly across recent work. Although many caregivers report acceptability of screening, experiences and expectations around effective follow-up vary. Likewise, although most frontline clinical providers find screening acceptable, they report significant implementation challenges related to time constraints, insufficient workforce, and availability of social services. Qualitative findings suggest opportunities to improve screening implementation. Literature examining the impacts of screening continues to focus on immediate posited impacts of assistance programs; few studies assess health outcomes.Summary: The existing literature does not clearly indicate whether, when, how, or for whom social risk screening standards focused on screening quantity will contribute to child health or health equity. Informed by studies on patient experience, quality measures focused on screening quantity (e.g. how many individuals are screened) should be paired with efforts to improve screening quality (i.e. patient/caregiver screening experience) as well as social and health outcomes.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"7-12"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0