Current opinion in pediatrics最新文献_第2页

Synchronicity of climate change and outbreaks of infectious diseases in children.

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-04-01 Epub Date: 2025-03-06 DOI: 10.1097/MOP.0000000000001443

Elijah Paintsil

引用次数: 0

Long-term impact of early identification of cerebral palsy. 早期识别脑瘫的长期影响。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-04-01 Epub Date: 2025-01-10 DOI: 10.1097/MOP.0000000000001439

Ana-Marie Rojas

{"title":"Long-term impact of early identification of cerebral palsy.","authors":"Ana-Marie Rojas","doi":"10.1097/MOP.0000000000001439","DOIUrl":"10.1097/MOP.0000000000001439","url":null,"abstract":"Purpose of review: Early identification of cerebral palsy (CP), as in all neurologic conditions, has a profound impact on the ability to initiate interventions, support the education and empowerment of parents, ameliorate the effect of the conditions, and importantly identifies cohorts for neuroprotection or repair to address the primary injury. CP is a life span condition. Rapid initiation of services, support and anticipatory guidance is essential to maximize functional outcomes, prevent or manage complications and improve quality of life.Recent findings: CP diagnosis should not be delayed. Early imaging as well as motor and neurologic evaluation can aid in early detection of CP before age 5 months. Early therapeutic intervention can influence function and assist in prevention of complications that can impact abilities. There is important ongoing research with efforts to prevent CP or alter the phenotype of the condition.Summary: Literature review provides evidence to change in standard of care in diagnosing CP. There are published guidelines on how to pursue the diagnosis during early infancy. Early identification results in early intervention with the purpose of enhancing functional skill development, prevention of complications, and establishing parental support. Early identification provides an optimistic view and opportunity to intervene immediately in hopes to have an impact in the functional outcome and improving quality of life.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"205-210"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transgression of planetary boundaries and the effects on child health through an infectious diseases lens.

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-04-01 Epub Date: 2025-01-29 DOI: 10.1097/MOP.0000000000001442

Mikaela Coleman, Palwasha Y Khan, Lauren Linde, Phoebe C M Williams, Ben J Marais

{"title":"Transgression of planetary boundaries and the effects on child health through an infectious diseases lens.","authors":"Mikaela Coleman, Palwasha Y Khan, Lauren Linde, Phoebe C M Williams, Ben J Marais","doi":"10.1097/MOP.0000000000001442","DOIUrl":"10.1097/MOP.0000000000001442","url":null,"abstract":"Purpose of review: Life on earth, as we know it, is changing. The likelihood of more frequent pandemics and disease outbreaks is something that current global healthcare infrastructure is ill equipped to navigate. Human activity is forcing our planet into a new geologic epoch, the Anthropocene, which is typified by increased uncertainty resulting from human disruption of earth's life-giving ecosystems. Plagues and pandemics have always been unfortunate partners to periods of disruption, as they will be again if the frequency and severity of climate and conflict-mediated disasters increase in coming years. If we continue to exceed and degrade the planetary boundaries that protect human health, our children and their children will reap the consequences.Recent findings: Scientists have defined nine 'safe operating' planetary boundaries for life in all its glorious diversity to thrive on planet earth. Recent evidence suggests that six of these nine boundaries have already been transgressed, but the potential implications for these transgressions upon child health is not well articulated. We highlight how contravention of these boundaries will impact infectious disease risk and humans' ability to survive and thrive. We reflect specifically on how paediatricians are called upon to speak up for the most vulnerable members of our species, young children and as yet unborn future generations.Summary: Post COVID-19 initiatives to improve pandemic preparedness and response are certainly warranted, but pandemic prevention should include committed efforts not to exceed safe planetary boundaries. Willingly exceeding these boundaries has deep moral consequences that are poorly articulated by current ethical frameworks. Paediatricians are best placed to develop and champion the neglected 'third dimension' of medical ethics, recognizing the moral imperative to protect the long-term best interests of children and future generations.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"124-136"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The challenge of antimicrobial resistance in the Asia-Pacific: a pediatric perspective.

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1097/MOP.0000000000001437

Nguyen Xuan Huong, Michelle Harrison, Erena Kasahara, Ben Marais, Nina Dwi Putri, Phoebe Cm Williams

{"title":"The challenge of antimicrobial resistance in the Asia-Pacific: a pediatric perspective.","authors":"Nguyen Xuan Huong, Michelle Harrison, Erena Kasahara, Ben Marais, Nina Dwi Putri, Phoebe Cm Williams","doi":"10.1097/MOP.0000000000001437","DOIUrl":"10.1097/MOP.0000000000001437","url":null,"abstract":"Purpose of review: The densely populated Asia Pacific region is home to 600 million children, and suffers from a significant burden of morbidity and mortality due to infections associated with antimicrobial resistance (AMR). We aimed to identify the drivers, challenges and potential opportunities to alter the burden of AMR within the region.Recent findings: Despite the high AMR burden borne by the Asia Pacific region, there are limited (and geographically imbalanced) published data to delineate the contemporary epidemiology of serious multidrug-resistant bacterial infections in children. Furthermore, the region is impacted by overcrowded and poorly resourced healthcare facilities, insufficient microbiological resources, and widespread community and environmental antibiotic use leading to limited efficacy for frequently prescribed antibiotics. Vaccine coverage is also inadequate and inequitable, further driving the burden of infectious disease (and antibiotic overuse) in children.Summary of implications: There are many challenges in implementing antimicrobial stewardship and infection prevention and control programs to reduce the excessive AMR disease burden in children across the Asia Pacific region, yet locally-driven strategies have successfully reduced antibiotic overuse in some settings, and should be replicated. Reducing the AMR disease burden will require improved healthcare resourcing, including better access to microbiological diagnosis, and multidisciplinary approaches to enhance infection prevention and antibiotic prescribing.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"116-123"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of mucosal immunity and respiratory infections in children: a focus on Africa. 儿童粘膜免疫和呼吸道感染概述：聚焦非洲。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-04-01 Epub Date: 2025-02-05 DOI: 10.1097/MOP.0000000000001438

Richard K Mwape, Mish-Al Barday, Marieke M van der Zalm, Lilly M Verhagen

{"title":"Overview of mucosal immunity and respiratory infections in children: a focus on Africa.","authors":"Richard K Mwape, Mish-Al Barday, Marieke M van der Zalm, Lilly M Verhagen","doi":"10.1097/MOP.0000000000001438","DOIUrl":"10.1097/MOP.0000000000001438","url":null,"abstract":"Purpose of review: Given the substantial burden of respiratory tract infections (RTIs) on global paediatric health, enhancing our understanding of mucosal immunity can help us advance mucosal biomarkers for diagnosis, prognosis and possible interventions in order to improve health outcomes. This review highlights the critical role of mucosal immunity in paediatric RTIs and recent advances in mucosal interventions, which offer promising strategies to improve outcomes.Recent findings: The significant burden of paediatric RTIs and growing interest in mucosal immunity advanced our understanding of the role of the respiratory mucosal immune system in protective immunity against RTIs. Studies show that sub-Saharan Africa is disproportionately affected by paediatric RTIs with poverty-associated factors such as human immunodeficiency virus (HIV) and malnutrition as risk factors. Emerging evidence highlights the important role of the respiratory microbiome and mucosal innate and adaptive immune responses in protective immunity against RTIs.Summary: The growing interest in mucosal immunity in RTIs has not only advanced our understanding of the overall immune responses in RTIs but also created opportunities to improve RTI care through translation of knowledge from these studies into diagnostics, therapeutics, and vaccines.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"137-144"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11888837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of antimicrobial resistance on infections in children in Africa.

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-04-01 Epub Date: 2025-01-22 DOI: 10.1097/MOP.0000000000001440

Joycelyn Assimeng Dame, Yemah Mariama Bockarie, Anthony Kwame Enimil

{"title":"Impact of antimicrobial resistance on infections in children in Africa.","authors":"Joycelyn Assimeng Dame, Yemah Mariama Bockarie, Anthony Kwame Enimil","doi":"10.1097/MOP.0000000000001440","DOIUrl":"10.1097/MOP.0000000000001440","url":null,"abstract":"Purpose of review: Antimicrobial resistance is an escalating public health threat in Africa, and an awareness of the devastating impact on children is growing. This review highlights the prevalence and patterns of antimicrobial resistance among children in Africa, focusing on pathogens responsible for bloodstream infections, community-acquired pneumonia, bacterial meningitis, neonatal infections, diarrhea and malaria. Current strategies to tackle antimicrobial resistance in pediatric populations are discussed.Recent findings: Bloodstream infections significantly contribute to child mortality, with high resistance observed in pathogens like Salmonella spp., Klebsiella spp., Escherichia coli , and Staphylococcus aureus . Additionally, rising resistance in pathogens causing community-acquired pneumonia, meningitis and bacterial diarrhea challenges the effectiveness of WHO-recommended therapies. Antibiotics used to treat neonatal infections, such as ampicillin, gentamicin and cefotaxime, are threatened by high resistance in Escherichia coli and Klebsiella spp , contributing to adverse neonatal outcomes. PfKelch 13 mutations linked to artemisinin resistance in parts of Africa raise public health concerns, as malaria remains a major cause of illness and death.Summary: Stronger collaborative efforts are needed to enhance surveillance, improve diagnostic capabilities and update treatment protocols based on local pathogen sensitivities. More research is required on pediatric antimicrobial resistance in Africa.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"145-152"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The promise of cerebral organoids for neonatology. 脑器质性组织在新生儿学领域的前景。

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-04-01 Epub Date: 2025-02-12 DOI: 10.1097/MOP.0000000000001446

Clare E Howard, Manju Cheenath, Elizabeth E Crouch

{"title":"The promise of cerebral organoids for neonatology.","authors":"Clare E Howard, Manju Cheenath, Elizabeth E Crouch","doi":"10.1097/MOP.0000000000001446","DOIUrl":"10.1097/MOP.0000000000001446","url":null,"abstract":"Purpose of review: Applying discoveries from basic research to patients in the neonatal intensive care unit (NICU) is challenging given the difficulty of modeling this population in animal models, lack of translational relevance from animal models to humans, and scarcity of primary human tissue. Human cell-derived cerebral organoid models are an appealing way to address some of these gaps. In this review, we will touch on previous work to model neonatal conditions in cerebral organoids, some limitations of this approach, and recent strategies that have attempted to address these limitations.Recent findings: While modeling of neurodevelopmental disorders has been an application of cerebral organoids since their initial description, recent studies have dramatically expanded the types of brain regions and disease models available. Additionally, work to increase the complexity of organoid models by including immune and vascular cells, as well as modeling human heterogeneity with mixed donor organoids will provide new opportunities to model neonatal pathologies.Summary: Organoids are an attractive model to study human neurodevelopmental pathologies relevant to patients in the neonatal ICU. New technologies will broaden the applicability of these models to neonatal research and their usefulness as a drug screening platform.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"182-190"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11902893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of environmental changes on infectious diseases among children in North America.

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-04-01 Epub Date: 2025-02-07 DOI: 10.1097/MOP.0000000000001436

Kristen A Bastug, Elizabeth L Schwartz, Nadia A Sam-Agudu

{"title":"The impact of environmental changes on infectious diseases among children in North America.","authors":"Kristen A Bastug, Elizabeth L Schwartz, Nadia A Sam-Agudu","doi":"10.1097/MOP.0000000000001436","DOIUrl":"10.1097/MOP.0000000000001436","url":null,"abstract":"Purpose of review: Climate change is no longer a distant threat but a present and accelerating force reshaping the epidemiology of infectious diseases in North America and elsewhere. Rising temperatures, shifting precipitation patterns, and extreme weather events are impacting the geographic distribution of pathogens and their vectors. Understanding these environmental influences on infectious diseases in children is essential for equipping healthcare providers to deliver competent care in the era of climate change.Recent findings: The northward spread of vector-borne diseases, warming waters and soils, and disease outbreaks following extreme weather events highlight the complex and multifactorial ways through which the environment influences the spread of infectious diseases.Summary: Continuing medical education and training on the evolving epidemiology of climate-sensitive diseases is critical for clinicians to address emerging health threats effectively. We advocate for more equitable funding and resource allocation to support innovative pediatric research on climate change and infectious diseases in the United States and other countries in North America.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"153-164"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why some and not others? Understanding vascular phenotypes in genetic developmental lung diseases.

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-03-31 DOI: 10.1097/MOP.0000000000001459

Lea C Steffes, Maya E Kumar, Nidhy P Varghese

{"title":"Why some and not others? Understanding vascular phenotypes in genetic developmental lung diseases.","authors":"Lea C Steffes, Maya E Kumar, Nidhy P Varghese","doi":"10.1097/MOP.0000000000001459","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001459","url":null,"abstract":"Purpose of review: Pulmonary vascular disease is more common in certain genetic developmental lung disorders. This review synthesizes clinical descriptions, molecular analyses, and single-cell transcriptional data to build a conceptual framework to help understand why some variants affect the vasculature while others primarily manifest with parenchymal disease.Recent findings: Genes predominantly expressed in endothelial and mesenchymal compartments (TBX4, FGF10, FOXF1, KDR) commonly present with both parenchymal and pulmonary vascular disease, while epithelial-restricted genes (SFTPC, ABCA3, NKX2.1) typically manifest as parenchymal disease. Single-cell analyses reveal that compartment-specific expression patterns correlate with clinical phenotypes. Phenotypic variability, even among individuals sharing identical variants, suggests complex interactions between genetic modifiers, epigenetic factors, and developmental processes that remain poorly understood.Summary: Compartment-specific gene expression patterns fundamentally underlie the differential presence of vascular phenotypes in DEVLDs. Genetic advances and single cell technologies have revolutionized our understanding of these disorders, but we are in the early stages of translating this knowledge into meaningful clinical advances. Future efforts must bridge this gap to transform clinical care from supportive to targeted, disease-modifying treatment based on cell-specific molecular mechanisms.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral interventions for adolescents and young adults with type 2 diabetes or prediabetes.

IF 2.2 3区医学

Current opinion in pediatrics Pub Date : 2025-03-27 DOI: 10.1097/MOP.0000000000001461

Ashley S Ko, Ashley A Michel, Lauren E Wisk

{"title":"Behavioral interventions for adolescents and young adults with type 2 diabetes or prediabetes.","authors":"Ashley S Ko, Ashley A Michel, Lauren E Wisk","doi":"10.1097/MOP.0000000000001461","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001461","url":null,"abstract":"Purpose of review: Recent trends show an increase in the prevalence and incidence of type 2 diabetes and prediabetes among youth, adolescents, and young adults (AYA) in the United States, especially among minoritized groups, including American Indians and African Americans. Despite the growing urgency of addressing rising incidence, there is a notable lack of comprehensive intervention programs tailored to address the unique needs of AYA living with or at risk of diabetes, with current efforts largely focused on adult/older populations.Recent findings: This review highlights the large gap in research regarding the implementation and efficacy of behavioral and lifestyle interventions targeting AYA with type 2 diabetes or prediabetes. Although we identified some studies that were relevant to this largely under-researched area, these studies are often limited by lack of long-term follow-up and highly selected samples lacking diversity.Summary: The findings of this review underscore the need for more extensive studies on AYA-focused behavioral interventions to address diabetes prevention and management.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0