Mary Lowance, Julian Franco, Eric Wang, Ruth Milanaik
{"title":"Navigating nature's remedies: herbal and botanically derived complementary alternative medicine for children.","authors":"Mary Lowance, Julian Franco, Eric Wang, Ruth Milanaik","doi":"10.1097/MOP.0000000000001493","DOIUrl":"10.1097/MOP.0000000000001493","url":null,"abstract":"<p><strong>Purpose of review: </strong>The growing interest in complementary and alternative medicine (CAM) has sparked discussions about its role in modern pediatric healthcare. While some parents may turn to herbal supplements, essential oils, and other remedies for symptom management, questions remain regarding their safety, efficacy, and regulation for pediatric use. Pediatricians should understand the benefits and limitations of CAM to effectively inform families.</p><p><strong>Recent findings: </strong>Recent studies suggest that certain CAM therapies may offer relief for pediatric conditions like anxiety and digestive disorders. However, a lack of research and standardized regulation raises concerns about their clinical value, appropriate dosing, and misinformation. While parental interest has led to integration of CAM into some mainstream settings, further studies are needed to establish better evidence-based guidelines for use in pediatric patients.</p><p><strong>Summary: </strong>CAM continues to garner attention as families seek holistic alternatives to traditional healthcare. While CAM therapies may offer benefit when used alongside conventional medicine, they do not rival first-line treatments for pediatric disorders. Providers must be wary of unverified claims and risks. Incorporating evidence-based research and regulatory oversight can help maximize the well tolerated and effective use of CAM.</p>","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"495-507"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josephine S van de Maat, Andrew Redfern, Tigist Bacha, Jeroen Schouten, Esmée Ruizendaal
{"title":"Diagnostic testing and antibiotic stewardship for pneumonia in children worldwide: current developments and next steps.","authors":"Josephine S van de Maat, Andrew Redfern, Tigist Bacha, Jeroen Schouten, Esmée Ruizendaal","doi":"10.1097/MOP.0000000000001484","DOIUrl":"10.1097/MOP.0000000000001484","url":null,"abstract":"<p><strong>Purpose of review: </strong>Routine diagnostic tests for childhood pneumonia lack the accuracy to identify bacterial pneumonia, leading to inappropriate antibiotic prescription. Novel tests are being developed. Optimizing diagnostic strategies using available diagnostic tools and exploring the role of new tests is essential to improve antimicrobial stewardship (AMS) in children. This review provides an overview of advances in diagnostic testing for pediatric pneumonia and discusses how strategies can be optimized in different settings in order to improve AMS.</p><p><strong>Recent findings: </strong>All currently available tests for bacterial pneumonia are limited in their diagnostic accuracy. However, in settings with high baseline antibiotic prescription, routine diagnostics such as CRP or PCT-guided prescription can improve antibiotic use. Among the innovative tests, lung ultrasound with computer-aided detection and prediction models combining multiple tests holds most promise for low-resource settings. For high-resource settings, RNA signatures and next-generation sequencing are promising developments. The impact of innovative tests on AMS remains to be evaluated.</p><p><strong>Summary: </strong>Robust diagnostic and contextual research is needed to develop new diagnostic tests and to optimize current strategies for bacterial pneumonia in children. In order to tailor diagnostic approaches to specific settings, broad impact studies and stratification of risk groups are crucial.</p>","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"517-526"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transposition of the great arteries: anatomy, physiology and surgical outcomes today.","authors":"Elizabeth Carter, Lindsay S Rogers","doi":"10.1097/MOP.0000000000001495","DOIUrl":"10.1097/MOP.0000000000001495","url":null,"abstract":"<p><strong>Purpose of review: </strong>Dextro-transposition of the great arteries (d-TGA) is a relatively common form of cyanotic congenital heart disease that is not typically associated with chromosomal abnormalities or extracardiac abnormalities. Most cases of d-TGA are prenatally diagnosed, but there are cases of postnatal diagnosis that may present with cyanosis, acidosis and circulatory collapse. It is important for the general practitioner to be familiar with this patient population, as they require continued monitoring for postsurgical complications following surgical repair.</p><p><strong>Recent findings: </strong>The arterial switch operation was introduced in 1975 and is the current surgical treatment for d-TGA. As patients with arterial switch operation reach mid to late adulthood, we continue to explore the best ways to screen for, and treat, coronary insufficiency. Additionally, we are working to understand more about neurodevelopmental outcomes in this population.</p><p><strong>Summary: </strong>Advancements in prenatal diagnosis and surgical management of d-TGA have led to excellent outcomes in pre and postoperative mortality. Patients should be screened after surgical repair for complications related to coronary insufficiency with routine cardiology follow up.</p>","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"419-424"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Catheter-based therapies in congenital heart disease: a focus on neonatal innovations.","authors":"Bryan H Goldstein, Lauren N Carlozzi","doi":"10.1097/MOP.0000000000001500","DOIUrl":"10.1097/MOP.0000000000001500","url":null,"abstract":"<p><strong>Purpose of review: </strong>Technological advancements and therapeutic innovations have facilitated revolutionary changes in transcatheter management of patients with congenital heart disease (CHD). In this review, we highlight the evolution of existing and newer transcatheter therapies for management of neonates with CHD.</p><p><strong>Recent findings: </strong>Ductus arteriosus stenting (DAS) for patients with ductal-dependent pulmonary blood flow has broadly emerged as an alternative to surgical aortopulmonary shunt placement as evidence of therapeutic equivalency, if not superiority, has been demonstrated. The development of pulmonary flow restrictors (PFR) by modification of a commercial device has facilitated percutaneous limitation of pulmonary blood flow in an important subset of higher-risk single- and two-ventricle patients. Lastly, there are challenges to the deployment of stent angioplasty in young children, given the competing demands for a low-profile stent that is later dilatable to adult size. Given limitations to the current repurposing of existing commercial devices designed for other uses, purpose-built device development is underway in an effort to maximize safety, efficacy, and usability.</p><p><strong>Summary: </strong>Over the past decade, there has been substantial growth in the transcatheter management of infants with CHD. With continued technological advancements and multicenter collaborative efforts, it is anticipated that reparative and palliative transcatheter therapies will be increasingly applicable to young patients with CHD.</p>","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"425-432"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utility of the Coleman block test.","authors":"Caroline Cristofaro, Maryse Bouchard","doi":"10.1097/MOP.0000000000001509","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001509","url":null,"abstract":"<p><strong>Purpose of review: </strong>The Coleman block test is a key component of the foot and ankle physical examination in children and adults. This review describes the Coleman block test and summarizes its implications in surgical decision making as well as its limitations.</p><p><strong>Recent findings: </strong>The Coleman block test is a classic technique for evaluating whether the hindfoot deformity in a cavovarus foot is flexible or rigid. It involves placing a wooden block underneath the lateral column of the foot to remove the effect of the plantarflexed first ray of the cavus deformity and assessing whether the hindfoot varus subsequently corrects into valgus. When the hindfoot is flexible, only the cavus requires surgical correction. However, if the hindfoot varus is rigid, additional correction is needed, typically a lateral displacement osteotomy of the posterior calcaneus. More recent modifications to the test include radiographic evaluation of the foot while on the block, and a modification for block placement that is particularly useful in children.</p><p><strong>Summary: </strong>The Coleman block test is a simple clinical test should be performed routinely when assessing cavovarus deformities to help devise the most appropriate surgical plan.</p>","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atlantoaxial rotatory fixation.","authors":"Peter M Cirrincione, Jessica H Heyer","doi":"10.1097/MOP.0000000000001510","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001510","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review provides the most up to date information on diagnosing and treating atlantoaxial rotatory fixation (AARF). The condition can be confused with torticollis, but primary care physicians should have a high index of suspicion for AARF as timely noninvasive treatment facilitates excellent outcomes.</p><p><strong>Recent findings: </strong>A variety of etiologies have been described to cause AARF, but is most commonly seen following a viral infection of the upper respiratory system. When diagnosed early, nonoperative measures including rest, cervical collars, and antiinflammatories/muscle relaxants can allow for full resolution, avoidance of surgery and excellent outcomes.</p><p><strong>Summary: </strong>Atlantoaxial rotatory fixation is a treatable condition without need for surgery in most cases. Dynamic computed tomography scan is the imaging modality of choice to diagnose and confirm resolution of the condition, as diagnosis requires documented pathologic subluxation between the first and second cervical vertebrae.</p>","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fetal neurology: evolving roles for pediatricians and neurologists in prenatal and postnatal care.","authors":"Laura E Vernon, Andrea C Pardo","doi":"10.1097/MOP.0000000000001511","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001511","url":null,"abstract":"<p><strong>Purpose of review: </strong>Fetal neurology is a distinct subspecialty within pediatric neurology, and a core element of neonatal neurocritical care. Increased fidelity and availability of fetal imaging and increasing yields of advanced genetic testing help the fetal neurologist provide an assessment of potential neurodevelopmental outcomes when a suspected or confirmed fetal brain malformation is present. The postnatal care of infants with a previously diagnosed brain abnormality may include pediatricians in a general primary care setting. It is imperative that pediatricians have a basic understanding of common fetal neurologic conditions and comorbidities to provide the best care to new families facing these challenges.</p><p><strong>Recent findings: </strong>Growing literature of fetal brain abnormalities has allowed for increasing prenatal neurologic diagnoses. The recent recognition of neonatal neurocritical care as a distinct subspecialty seeks to optimize the management and care of this patient population.</p><p><strong>Summary: </strong>This review provides a broad overview of the evolution of fetal neurology as a distinct field within neurology and neonatal neurocritical care. This article highlights nuances of fetal consultations and reviews some of the more common fetal neurologic diagnoses and comorbidities. Finally, it provides a call to action for collaborative management in pediatric care.</p>","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemophagocytic lymphohistiocytosis: an update in diagnostics, criteria, and treatment considerations.","authors":"Kara Coffey, Samantha Minnicozzi","doi":"10.1097/MOP.0000000000001508","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001508","url":null,"abstract":"<p><strong>Purpose of review: </strong>Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory state in adult and pediatric patients, with associated severe morbidity and mortality. Here, we provide an updated overview of HLH, associated triggers, diagnostic tools and criteria, as well as treatment considerations.</p><p><strong>Recent findings: </strong>Hemophagocytosis lymphohistiocytosis, a state of severe inflammation and immune overactivation, can be life threatening with significant risk of morbidity and mortality. Diagnostic criteria initially used remain valid to this day, while newer laboratory measurements can be informative and helpful in identifying patients with this diagnosis, such as CXCL9, IL-18, and other serum cytokines. Initially thought to occur only in patients with inborn errors of immunity or malignancy, HLH is recognized as a spectrum of inflammation, occurring in healthy individuals in response to common infections. With this realization comes a pressing need for earlier consideration, identification, and treatment initiation to prevent severe or fatal outcomes.</p><p><strong>Summary: </strong>Recent insights into the diagnosis of HLH have led to earlier identification, associated triggers and laboratory criteria, with the goal of decreasing delays in time to treatment and improved outcomes.</p>","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ann L Robbins, Kathryn Yang, Darius Ebrahimi-Fakhari, Jennifer A O'Malley
{"title":"Early recognition of status dystonicus in children: a case-based approach for the general pediatrician.","authors":"Ann L Robbins, Kathryn Yang, Darius Ebrahimi-Fakhari, Jennifer A O'Malley","doi":"10.1097/MOP.0000000000001507","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001507","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review highlights the importance of promptly recognizing and correctly naming status dystonicus as a neurologic emergency in the outpatient and inpatient settings, and aims to equip general pediatricians with practical guidance to trigger rapid escalation of care through the recently published status dystonicus pathways.</p><p><strong>Recent findings: </strong>In 2024, Vogt et al. introduced two consensus algorithms - the acute dystonia pathway and the refractory status dystonicus pathway - aimed to unify diagnostic criteria, triage steps, and staged pharmacological and supportive interventions for status dystonicus across healthcare environments.</p><p><strong>Summary: </strong>Effective application of these pathways empowers frontline clinicians to identify status dystonicus early, initiate first-line treatments without delay, and expedite transfer to specialized teams, thereby reducing the morbidity and mortality associated with this life-threatening movement disorder emergency.</p>","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danielle Clifford, Brian H Walsh, Deirdre M Murray
{"title":"The role of social determinants of health in the developing injured brain.","authors":"Danielle Clifford, Brian H Walsh, Deirdre M Murray","doi":"10.1097/MOP.0000000000001505","DOIUrl":"10.1097/MOP.0000000000001505","url":null,"abstract":"<p><strong>Purpose of review: </strong>We provide a comprehensive review of the evidence on the influence social determinants of health play in the most common causes of perinatal brain injury. This area remains under-investigated, and the evidence can be difficult to navigate.</p><p><strong>Recent findings: </strong>There is strong emerging evidence on factors such as the influence of maternal education, and in particular a cognitively stimulating home environment, on the language development of preterm infants. The role of the home environment on children following hypoxic brain injury and congenital heart disease is less well studied.</p><p><strong>Summary: </strong>The social determinants of the child's home environment have a significant additive effect on the perinatal risk of a child on later development, particularly their language development.</p>","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}