Current opinion in pediatrics最新文献_第3页

Update in new-onset refractory status epilepticus and febrile infection-related epilepsy syndrome. 新发难治性癫痫持续状态和发热性感染相关癫痫综合征的最新进展。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-20 DOI: 10.1097/MOP.0000000000001501

Pooja D Shah, Heather A Voss-Hoynes, Rachel A Pauley

{"title":"Update in new-onset refractory status epilepticus and febrile infection-related epilepsy syndrome.","authors":"Pooja D Shah, Heather A Voss-Hoynes, Rachel A Pauley","doi":"10.1097/MOP.0000000000001501","DOIUrl":"10.1097/MOP.0000000000001501","url":null,"abstract":"Purpose of review: New-onset refractory status epileptics (NORSE) and a subset, febrile infection-related epilepsy syndrome (FIRES), are rare clinical presentations with rapid onset, cryptogenic etiology, unpredictable course, and long-standing neurologic sequalae. International consensus recommendations were published in 2022 to aid in diagnosis, treatment, and research of NORSE/FIRES. Subsequently, there have been advances in understanding both the pathophysiology and the efficacy of immunotherapies.Recent findings: There is growing evidence of immune dysregulation in NORSE/FIRES. Cytokine/chemokine profiles may serve as biomarkers to guide diagnosis and management. The treatment landscape for NORSE/FIRES is evolving, with increasing use of second-line immunotherapies such as anakinra and tocilizumab. Intrathecal dexamethasone is an emerging treatment. Additionally, studies are investigating more targeted immunotherapies based on immunologic profiles. Despite treatment, outcomes remain poor, with high morbidity and mortality. Neurologic sequalae includes intractable epilepsy, functional impairment, mood disorders, and behavioral disturbances. Many patients report poor quality of life.Summary: NORSE/FIRES is a severe neurologic entity. Research is underway to determine pathogenesis, develop biomarkers, and provide more targeted immunotherapies with hopes of improving patient outcomes.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From tradition to transformation: evolving models of care in clinical genetics. 从传统到转变：临床遗传学护理的演变模式。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-20 DOI: 10.1097/MOP.0000000000001502

Helen Curd, Anita Gorrie, Andrew Paul Fennell

{"title":"From tradition to transformation: evolving models of care in clinical genetics.","authors":"Helen Curd, Anita Gorrie, Andrew Paul Fennell","doi":"10.1097/MOP.0000000000001502","DOIUrl":"10.1097/MOP.0000000000001502","url":null,"abstract":"Purpose of review: The integration of genomics into mainstream healthcare is transforming clinical genetics into a foundational component of modern medicine. This review explores the evolution of clinical genetics service delivery, highlighting evolving models of care designed to meet rising demand, improve access, and ensure equitable, patient-centered genomic care.Recent findings: Key models of care discussed include multidisciplinary team approaches, embedded genetic counselors, advanced practice providers, upskilled non-genetics specialists, laboratory-based genetics clinicians, primary care providers of genetic healthcare and automated/patient-directed models. Educational needs, funding and adjuncts such as genetic assistants, collaborative telegenetics, and digital tools are also discussed for their role in supporting sustainable implementation.Summary: We recommend health organizations develop a roadmap for genomic medicine through creation of a genomic medicine governance framework, assessment of workforce capacity, definition of patient cohorts, and reviewing their infrastructure readiness. No single model of care is suitable for every context. By clearly defining needs, acknowledging limitations, and identifying potential risks, organizations can select the most appropriate models to address both current and future requirements. As genomics becomes increasingly embedded in routine care, we believe a coordinated, evidence-based approach is essential to ensure well tolerated, effective, accessible, equitable, and sustainable delivery of genomic medicine across diverse healthcare settings.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental impacts of perinatal infections. 围产期感染对发育的影响。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-08 DOI: 10.1097/MOP.0000000000001494

Sarah B Mulkey

{"title":"Developmental impacts of perinatal infections.","authors":"Sarah B Mulkey","doi":"10.1097/MOP.0000000000001494","DOIUrl":"https://doi.org/10.1097/MOP.0000000000001494","url":null,"abstract":"Purpose of review: Perinatal infections and their potential consequences on child neurodevelopment have become a topic of greater interest over the past decade. The purpose of this review is to describe the current knowledge of neurodevelopmental impacts from some of these infections including congenital cytomegalovirus, Zika virus, Chikungunya, and severe acute respiratory syndrome coronavirus 2. These infections have had recent publications about neurodevelopmental impacts.Recent findings: Children with congenital cytomegalovirus infection, especially those with symptomatic infection, are at a high risk for developmental delays. They also seem to be at an increased risk for autism spectrum disorder. Studies indicate that prenatal exposure to severe acute respiratory syndrome coronavirus 2 may also be a risk factor for developmental delay and that all children exposed prenatally should be followed more closely for early neurodevelopment. Children with congenital Zika syndrome and birth defects are at risk for a range of neurodevelopmental sequalae and at high risk for early mortality. However, normocephalic children with antenatal Zika virus exposure are also at risk for a range of neurodevelopmental effects including lower cognitive performance at school age.Summary: Congenital and perinatal infectious exposures increase the risk for impaired child neurodevelopment. All children with perinatal infections should have close neurodevelopmental follow-up during childhood.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evolving frontiers of pediatric dermatology - from steroid stewardship to targeted therapies. 不断发展的儿科皮肤科前沿-从类固醇管理到靶向治疗。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-07-03 DOI: 10.1097/MOP.0000000000001483

Nicole Harter

引用次数: 0

The changing landscape of adolescent health. 青少年健康状况的变化。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-07-03 DOI: 10.1097/MOP.0000000000001478

Areej Hassan, Carly E Guss

引用次数: 0

What we know about screen time and social media in early adolescence: a review of findings from the Adolescent Brain Cognitive Development Study. 我们对青少年早期屏幕时间和社交媒体的了解：对青少年大脑认知发展研究结果的回顾。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-04-01 DOI: 10.1097/MOP.0000000000001462

Jason M Nagata, Christopher M Lee, Jacqueline O Hur, Fiona C Baker

{"title":"What we know about screen time and social media in early adolescence: a review of findings from the Adolescent Brain Cognitive Development Study.","authors":"Jason M Nagata, Christopher M Lee, Jacqueline O Hur, Fiona C Baker","doi":"10.1097/MOP.0000000000001462","DOIUrl":"10.1097/MOP.0000000000001462","url":null,"abstract":"Purpose of review: To review recent literature based on Adolescent Brain and Cognitive Development (ABCD) Study data of over 11 000 participants about screen time and social media use in early adolescence, including epidemiology, trends, and associations with mental and physical health outcomes.Recent findings: Time spent on screens and social media has risen among early adolescents (aged 9-15 years), and these increasing trends have been more pronounced since the COVID-19 pandemic. Both cross-sectional and 1-2-year follow-up data show that higher screen use, particularly social media, video games, video chat, videos, and texting, is associated with a range of mental health symptoms, including depression, anxiety, eating disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity, and disruptive behavior disorders, although effect sizes vary. Screen time is also associated with sleep problems and various cardiometabolic risk factors. Parents' own screen use and restriction of bedroom and mealtime screen use are associated with lower early adolescent screen time and problematic use.Summary: Analyses of current ABCD Study data reveal increasing use of screens and social media across early adolescence, with sociodemographic disparities in screen use as well as numerous associations between screens and adverse mental and physical health effects.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"357-364"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Who may compete in the female category in sport? Chromosomes, genes, hormones, and psychosocial/cultural aspects. 谁可以参加女子体育比赛？染色体，基因，激素和社会心理/文化方面。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-03-20 DOI: 10.1097/MOP.0000000000001456

Natalie J Nokoff, Alan D Rogol

{"title":"Who may compete in the female category in sport? Chromosomes, genes, hormones, and psychosocial/cultural aspects.","authors":"Natalie J Nokoff, Alan D Rogol","doi":"10.1097/MOP.0000000000001456","DOIUrl":"10.1097/MOP.0000000000001456","url":null,"abstract":"Purpose of review: Throughout history, competitive sport has been categorized by sex. Since the 1930s, sporting organizations have implemented various methods of confirming sex for competition in the female category. These policies primarily impact individuals with differences of sex development (DSD), whose biology falls outside the binary of male/female, and individuals who identify as transgender, whose identity differs from their sex at birth. This review will cover the dimensions of biologic sex, the history of sex verification in sport, the role of testosterone, and review data for athletes who have DSD or are transgender.Recent findings: Several recent studies, reviews, and policy statements demonstrate that testosterone and its rise during masculinizing puberty are key determinants of differences in athletic performance between men and women. Recent studies in adult transgender women who went through a masculinizing puberty show that after 2 years of estradiol and antiandrogen therapy, run times are similar to cisgender women, but they still retrain strength advantages. Data are sparse for individuals who had masculinizing puberty blocked and also for individuals who have a DSD.Summary: Sex is complex and multidimensional, and there are shortcomings with any method of sex verification in sport. Testosterone remains a key determinant of differences in athletic performance by sex.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"398-407"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral interventions for adolescents and young adults with type 2 diabetes or prediabetes. 2型糖尿病或前驱糖尿病青少年和年轻人的行为干预。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-03-27 DOI: 10.1097/MOP.0000000000001461

Ashley S Ko, Ashley A Michel, Lauren E Wisk

{"title":"Behavioral interventions for adolescents and young adults with type 2 diabetes or prediabetes.","authors":"Ashley S Ko, Ashley A Michel, Lauren E Wisk","doi":"10.1097/MOP.0000000000001461","DOIUrl":"10.1097/MOP.0000000000001461","url":null,"abstract":"Purpose of review: Recent trends show an increase in the prevalence and incidence of type 2 diabetes and prediabetes among youth, adolescents, and young adults (AYA) in the United States, especially among minoritized groups, including American Indians and African Americans. Despite the growing urgency of addressing rising incidence, there is a notable lack of comprehensive intervention programs tailored to address the unique needs of AYA living with or at risk of diabetes, with current efforts largely focused on adult/older populations.Recent findings: This review highlights the large gap in research regarding the implementation and efficacy of behavioral and lifestyle interventions targeting AYA with type 2 diabetes or prediabetes. Although we identified some studies that were relevant to this largely under-researched area, these studies are often limited by lack of long-term follow-up and highly selected samples lacking diversity.Summary: The findings of this review underscore the need for more extensive studies on AYA-focused behavioral interventions to address diabetes prevention and management.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"350-356"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetics of short stature. 矮小的基因。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-20 DOI: 10.1097/MOP.0000000000001481

Ruxandra Nicolae, Ruta Navardauskaite, Youn Hee Jee

{"title":"Genetics of short stature.","authors":"Ruxandra Nicolae, Ruta Navardauskaite, Youn Hee Jee","doi":"10.1097/MOP.0000000000001481","DOIUrl":"10.1097/MOP.0000000000001481","url":null,"abstract":"Purpose of review: This review highlights recent genetic discoveries and therapeutic advancements in evaluating and managing children with short stature. With an increasing diagnostic yield from genetic testing and the emergence of genotype-specific treatments, a comprehensive update is necessary for timely application in clinical practice.Recent findings: New pathogenic variants have been identified in genes, including FBN1, IHH, NPR2, ACAN, FGFR3, COMP, MATN3, EXT2, and LZTR1, associated with syndromic and nonsyndromic short stature. Their clinical significance is underscored by sequencing studies showing a diagnostic yield of up to 33% in idiopathic short stature. Concurrently, targeted pharmacologic agents, such as vosoritide or infigratinib, are advanced treatment options for genetically defined achondroplasia. In addition, more data is available on growth hormone responses in children with various genetic short statures.Summary: Incorporating genetic testing into the routine investigation of short stature improves diagnostic accuracy, enables early discussion of prognostic outcomes, and facilitates precision therapy. Timely identification of specific gene variants helps avoid ineffective treatments - such as growth hormone in resistant genotypes - and supports the adoption of personalized medicine interventions.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":"37 4","pages":"380-385"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aisles of health? A pediatrician's guide to vitamins and dietary supplements in pharmacies and supermarkets. 健康通道？儿科医生的维生素和膳食补充剂指南在药店和超市。

IF 2.5 3区医学

Current opinion in pediatrics Pub Date : 2025-08-01 Epub Date: 2025-05-21 DOI: 10.1097/MOP.0000000000001475

Mary Lowance, Eric Wang, Mia Graybow, Ruth L Milanaik

{"title":"Aisles of health? A pediatrician's guide to vitamins and dietary supplements in pharmacies and supermarkets.","authors":"Mary Lowance, Eric Wang, Mia Graybow, Ruth L Milanaik","doi":"10.1097/MOP.0000000000001475","DOIUrl":"10.1097/MOP.0000000000001475","url":null,"abstract":"Purpose of review: In recent years, there have been increased discussions among parents about the use of Complementary and Alternative Medicine for kids, specifically dietary supplements and vitamins. While these were originally marketed to supplement nutrient needs, many families have begun to raise questions about the efficacy of vitamins and minerals to treat developmental conditions such as attention-hyperactivity deficit disorder, mood disorders, or sleep disturbances.Recent findings: Research investigating the use of vitamin supplements generally concludes that supplementation may be necessary in cases of deficiency; additional benefits are minimal. Some hormonal and mineral supplements like melatonin, fish oil, and magnesium have been found to reduce symptoms of hyperactivity, sleep disturbance, and conduct disorders in combination with other interventions. However, none of these therapies rival the efficacy of first-line treatment plans for these conditions. Additionally, overuse may lead to toxicity and adverse effects.Summary: While many parents may have concerns about their child's nutrient intake, much is still unknown about the dosing, safety, and efficacy of dietary supplements. For deficient children or patients resistant to eating certain food groups, mineral and vitamin supplements may be an effective way to meet nutritional needs. It is important to note that there is little evidence supporting the efficacy of dietary supplement use to treat other conditions nor any benefit for healthy children with a balanced diet.","PeriodicalId":10985,"journal":{"name":"Current opinion in pediatrics","volume":" ","pages":"408-417"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0