Current HIV/AIDS Reports最新文献_第8页

Intervention Approaches to Address Intimate Partner Violence and HIV: a Scoping Review of Recent Research. 应对亲密伴侣暴力和艾滋病毒的干预方法：最近研究的范围综述。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-10-01 Epub Date: 2023-09-28 DOI: 10.1007/s11904-023-00668-8

Kamila A Alexander, Gloria Mpundu, Brenice Duroseau, Nkemakolem Osian, Shadae Chambers, DaJaneil McCree, Karin E Tobin, Tiara C Willie

{"title":"Intervention Approaches to Address Intimate Partner Violence and HIV: a Scoping Review of Recent Research.","authors":"Kamila A Alexander, Gloria Mpundu, Brenice Duroseau, Nkemakolem Osian, Shadae Chambers, DaJaneil McCree, Karin E Tobin, Tiara C Willie","doi":"10.1007/s11904-023-00668-8","DOIUrl":"10.1007/s11904-023-00668-8","url":null,"abstract":"Purpose of review: Intimate partner violence (IPV) remains a critical challenge to HIV prevention and treatment efforts across the globe. We examined recently published (January 9, 2017-January 9, 2023) integrated behavioral interventions designed to address IPV and HIV across the care continuum.Recent findings: Fifteen studies (involving n = 10,947 participants) met the inclusion criteria for this review. Majority (n = 13) of studies focused on IPV and HIV prevention whereas two studies addressed IPV and HIV care engagement among women living with HIV. Ten studies were conducted on the African continent representing 5 countries. Most interventions (n = 11) focused on individual-level outcomes among cisgender women although two involved male partners. About half of the interventions reviewed (n = 8) showed effectiveness on both IPV and HIV outcomes compared to control groups. Integrated HIV/IPV interventions are needed to address the synergistic nature of these epidemics among marginalized populations. Future studies should focus on developing and implementing strength-based interventions among people living with HIV, men, transgender people, and Black women in the USA. Additionally, researchers and program managers should consider addressing structural and internalized stigma as potential behavioral mechanisms for improving health among people simultaneously experiencing or at-risk for HIV and IPV.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 5","pages":"296-311"},"PeriodicalIF":3.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41123338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The New Era of Long-Acting Antiretroviral Therapy: When and Why to Make the Switch. 长效抗逆转录病毒疗法的新时代：何时以及为什么要做出改变。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-10-01 Epub Date: 2023-09-21 DOI: 10.1007/s11904-023-00665-x

Melanie C Goebel, Emmanuel Guajardo, Thomas P Giordano, Shital M Patel

{"title":"The New Era of Long-Acting Antiretroviral Therapy: When and Why to Make the Switch.","authors":"Melanie C Goebel, Emmanuel Guajardo, Thomas P Giordano, Shital M Patel","doi":"10.1007/s11904-023-00665-x","DOIUrl":"https://doi.org/10.1007/s11904-023-00665-x","url":null,"abstract":"Purpose of review: Despite the availability of safe and effective oral combination antiretroviral therapy, barriers to maintaining viral suppression remain a challenge to ending the HIV epidemic. Long-acting injectable antiretroviral therapy was developed as an alternative to daily oral therapy. This review summarizes the current literature on the efficacy of long-acting cabotegravir plus rilpivirine for the treatment of HIV-1, reasons to switch to injectable therapy, and barriers to switching.Recent findings: Long-acting cabotegravir plus rilpivirine is safe and effective in maintaining HIV-1 virologic suppression. Ideal candidates for switching to long-acting cabotegravir plus rilpivirine are virologically suppressed on oral regimens with good adherence and no history of virologic failure or baseline resistance. Indications to switch to injectable therapy include patient preference, the potential for improved adherence, and avoidance of adverse effects. Implementation research is needed to assess and overcome system barriers. Long-acting cabotegravir plus rilpivirine is a novel alternative to oral antiretrovirals, with the potential to improve adherence and quality of life in people with HIV.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 5","pages":"271-285"},"PeriodicalIF":4.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Serious Gaming as an Intervention for HIV Prevention. 将严肃游戏作为艾滋病预防干预措施的综述。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-08-01 Epub Date: 2023-05-22 DOI: 10.1007/s11904-023-00659-9

Ariel U Smith, Gabriella M Khawly, Janna Jann, Ana Paola Mata Zetina, Janeth Padilla, Rebecca Schnall

{"title":"A Review of Serious Gaming as an Intervention for HIV Prevention.","authors":"Ariel U Smith, Gabriella M Khawly, Janna Jann, Ana Paola Mata Zetina, Janeth Padilla, Rebecca Schnall","doi":"10.1007/s11904-023-00659-9","DOIUrl":"10.1007/s11904-023-00659-9","url":null,"abstract":"Purposeof review: Young people face the highest number of new HIV infections globally. With today's increasing access to smartphones, serious games have been viewed as an effective means of improving knowledge and behavioral outcomes. This systematic review describes current HIV prevention serious games and their relationship with HIV-related knowledge and behavioral outcomes.Recent findings: A search of HIV prevention serious games was conducted using PubMed, CINAL, IEEE, Web of Science, and Google Scholar. A total of 31 papers were identified, which consist of 20 studies and 11 protocols. Results for knowledge, attitudes, intentions, and behaviors were mixed. Two interventions reported improvement in PrEP usage and optimal dosing. Gaming appears to be a viable and engaging method to improve knowledge, attitudes, and behavioral outcomes to promote HIV prevention among diverse groups of adolescents and young adults globally. However, additional research is needed to understand how to implement this modality effectively.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 4","pages":"181-205"},"PeriodicalIF":4.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9967552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spiraling Risk: Visualizing the multilevel factors that socially pattern HIV risk among gay, bisexual & other men who have sex with men using Complex Systems Theory. 螺旋式风险:利用复杂系统理论可视化在同性恋、双性恋和其他男男性行为者中社会模式HIV风险的多层次因素。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-08-01 DOI: 10.1007/s11904-023-00664-y

K Stojanovski, E J King, S O'Connell, K S Gallagher, K P Theall, A T Geronimus

{"title":"Spiraling Risk: Visualizing the multilevel factors that socially pattern HIV risk among gay, bisexual & other men who have sex with men using Complex Systems Theory.","authors":"K Stojanovski, E J King, S O'Connell, K S Gallagher, K P Theall, A T Geronimus","doi":"10.1007/s11904-023-00664-y","DOIUrl":"https://doi.org/10.1007/s11904-023-00664-y","url":null,"abstract":"Purpose of review: Global disparities in HIV infection, particularly among gay, bisexual, and other men who have sex with men (GBMSM), indicate the importance of exploring the multi-level processes that shape HIV's spread. We used Complex Systems Theory and the PRISMA guidelines to conduct a systematic review of 63 global reviews to understand how HIV is socially patterned among GBMSM. The purpose was to conduct a thematic analysis of the reviews to (1) synthesize the multi-level risk factors of HIV risk, (2) categorize risk across the socioecological model, and (3) develop a conceptual model that visualizes the interrelated factors that shape GBMSMS's HIV \"risk.\"Recent findings: We included 49 studies of high and moderate quality studies. Results indicated that GBMSM's HIV risk stems from the individual, interpersonal, and structural levels of the socioecological model. We identified a few themes that shape GBMSM's risk of HIV infection related to biomedical prevention methods; sexual and sex-seeking behaviors; behavioral prevention methods; individual-level characteristics and syndemic infections; lived experiences and interpersonal relationships; country-level income; country-level HIV prevalence; and structural stigma. The multi-level factors, in tandem, serve to perpetuate GBMSM's risk of HIV infection globally. The amalgamation of our thematic analyses from our systematic reviews of reviews suggests that the risk of HIV infection operates in an emergent, dynamic, and complex nature across multiple levels of the socioecological model. Applying complex systems theory indicates how multilevel factors create a dynamic and reinforcing system of HIV risk among GBMSM.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 4","pages":"206-217"},"PeriodicalIF":4.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9971686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mpox and HIV: a Narrative Review. Mpox 与 HIV：叙述性综述。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-08-01 Epub Date: 2023-05-13 DOI: 10.1007/s11904-023-00661-1

Carlos S Saldana, Colleen F Kelley, Bruce M Aldred, Valeria D Cantos

{"title":"Mpox and HIV: a Narrative Review.","authors":"Carlos S Saldana, Colleen F Kelley, Bruce M Aldred, Valeria D Cantos","doi":"10.1007/s11904-023-00661-1","DOIUrl":"10.1007/s11904-023-00661-1","url":null,"abstract":"Purpose of review: We reviewed the available literature on mpox in People with HIV (PWH). We highlight special considerations of mpox infection related to epidemiology, clinical presentation, diagnostic and treatment considerations, prevention, and public health messaging in PWH.Recent findings: During the 2022 mpox outbreak, PWH were disproportionally impacted worldwide. Recent reports suggest that the disease presentation, management, and prognosis of these patients, especially those with advanced HIV disease, can widely differ from those without HIV-associated immunodeficiency. Mpox can often be mild and resolve on its own in PWH with controlled viremia and higher CD4 counts. However, it can be severe, with necrotic skin lesions and protracted healing; anogenital, rectal, and other mucosal lesions; and disseminated organ systems involvement. Higher rates of healthcare utilization are seen in PWH. Supportive, symptomatic care and single or combination mpox-directed antiviral drugs are commonly used in PWH with severe mpox disease. Data from randomized clinical control trials on the efficacy of therapeutic and preventive tools against mpox among PWH are needed to better guide clinical decisions.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 4","pages":"261-269"},"PeriodicalIF":3.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9967075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interventions to Improve Adolescent HIV Care Outcomes. 改善青少年艾滋病毒护理结果的干预措施。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-08-01 Epub Date: 2023-06-10 DOI: 10.1007/s11904-023-00663-z

Marta I Mulawa, Elizabeth T Knippler, Maryam Al-Mujtaba, T Harper Wilkinson, Venkata K Ravi, Leila S Ledbetter

{"title":"Interventions to Improve Adolescent HIV Care Outcomes.","authors":"Marta I Mulawa, Elizabeth T Knippler, Maryam Al-Mujtaba, T Harper Wilkinson, Venkata K Ravi, Leila S Ledbetter","doi":"10.1007/s11904-023-00663-z","DOIUrl":"10.1007/s11904-023-00663-z","url":null,"abstract":"Purpose of review: This review of recent studies evaluating interventions to improve HIV care outcomes among adolescents with HIV (AHIV) was conducted to provide a comprehensive overview of the recent evidence, highlight promising approaches, and suggest directions for future research.Recent findings: Our scoping review revealed 65 studies evaluating a variety of interventions and using a range of study designs at various stages of research. Effective approaches included community-based, integrated service delivery models with case management, trained community adolescent treatment supporters, and consideration of social determinants of health. Recent evidence also supports the feasibility, acceptability, and preliminary efficacy of other innovative approaches, including mental health interventions as well as technology-delivered approaches; however, more research is needed to build the evidence base for these interventions. Our review's findings suggest that interventions providing comprehensive, individualized support are essential to improving HIV care outcomes among adolescents. More research is needed to build the evidence base for such interventions and ensure effective, equitable implementation to support the global target of ending the AIDS epidemic by 2030.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 4","pages":"218-230"},"PeriodicalIF":3.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9970447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on the Impact of Depot Medroxyprogesterone Acetate on Vaginal Mucosal Endpoints and Relevance to Sexually Transmitted Infections. 醋酸甲羟孕酮注射液对阴道黏膜终点的影响及与性传播感染的相关性的最新进展。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-08-01 Epub Date: 2023-06-21 DOI: 10.1007/s11904-023-00662-0

Smritee Dabee, Christina Balle, Maricianah Onono, Steve Innes, Gonasagrie Nair, Thesla Palanee-Phillips, Adam D Burgener, Steven E Bosinger, Jo-Ann S Passmore, Renee Heffron, Heather Jaspan, Anna-Ursula Happel

{"title":"Update on the Impact of Depot Medroxyprogesterone Acetate on Vaginal Mucosal Endpoints and Relevance to Sexually Transmitted Infections.","authors":"Smritee Dabee, Christina Balle, Maricianah Onono, Steve Innes, Gonasagrie Nair, Thesla Palanee-Phillips, Adam D Burgener, Steven E Bosinger, Jo-Ann S Passmore, Renee Heffron, Heather Jaspan, Anna-Ursula Happel","doi":"10.1007/s11904-023-00662-0","DOIUrl":"10.1007/s11904-023-00662-0","url":null,"abstract":"Purpose of review: The long-acting reversible intramuscularly-injected contraceptive depot medroxyprogesterone acetate (DMPA-IM) is widely used by cisgender women in Africa. Although DMPA-IM provides reliable contraception, potential effects on the female genital tract (FGT) mucosa have raised concern, including risk of HIV infection. This review summarises and compares evidence from observational cohort studies and the randomised Evidence for Contraceptive Options in HIV Outcomes (ECHO) Trial.Recent findings: Although previous observational studies found women using DMPA-IM had higher abundance of bacterial vaginosis (BV)-associated bacteria, increased inflammation, increased cervicovaginal HIV target cell density, and epithelial barrier damage, sub-studies of the ECHO Trial found no adverse changes in vaginal microbiome, inflammation, proteome, transcriptome, and risk of viral and bacterial STIs, other than an increase in Th17-like cells. Randomised data suggest that DMPA-IM use does not adversely change mucosal endpoints associated with acquisition of infections. These findings support the safe use of DMPA-IM in women at high risk of acquiring STIs, including HIV.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 4","pages":"251-260"},"PeriodicalIF":3.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9973492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interventions to Reduce Alcohol Use and HIV Risk among Sexual and Gender Minority Populations: a Systematic Review. 减少性少数群体和性别少数群体中饮酒和 HIV 风险的干预措施：系统综述。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-08-01 Epub Date: 2023-05-25 DOI: 10.1007/s11904-023-00660-2

Carolyn Lauckner, Kimberly Haney, Fidelis Sesenu, Trace Kershaw

{"title":"Interventions to Reduce Alcohol Use and HIV Risk among Sexual and Gender Minority Populations: a Systematic Review.","authors":"Carolyn Lauckner, Kimberly Haney, Fidelis Sesenu, Trace Kershaw","doi":"10.1007/s11904-023-00660-2","DOIUrl":"10.1007/s11904-023-00660-2","url":null,"abstract":"Purpose of review: Sexual and gender minority (SGM) individuals are diagnosed with HIV at disproportionate rates, and hazardous alcohol use can increase their HIV risk. This review assessed the state of the literature examining interventions for addressing alcohol use and sexual HIV risk behaviors among SGM individuals.Recent findings: Fourteen manuscripts from 2012 to 2022 tested interventions that address both alcohol use and HIV risk behaviors among SGM populations, with only 7 randomized controlled trials (RCTs). Virtually all the interventions targeted men who have sex with men, with none focused on transgender populations or cisgender women. While they demonstrated some evidence of effectiveness in reducing alcohol use and/or sexual risk, the outcomes varied widely between studies. More research is needed that tests interventions in this area, particularly for transgender individuals. The use of larger-scale RCTs with diverse populations and standardized outcome measures are needed to strengthen the evidence base.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 4","pages":"231-250"},"PeriodicalIF":4.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436179/pdf/nihms-1922187.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10400317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical Perspectives in Using Technology-Enabled Research for Key HIV Populations in Rights-Constrained Settings. 在权利受限的环境中使用技术支持研究关键艾滋病毒人群的伦理观点。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 DOI: 10.1007/s11904-023-00654-0

Lidia Flores, Sean D Young

引用次数: 0

The End Is in Sight: Current Strategies for the Elimination of HIV Vertical Transmission. 终点在望:消除艾滋病毒垂直传播的当前战略。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 DOI: 10.1007/s11904-023-00655-z

Lanbo Yang, Mary Catherine Cambou, Karin Nielsen-Saines

{"title":"The End Is in Sight: Current Strategies for the Elimination of HIV Vertical Transmission.","authors":"Lanbo Yang, Mary Catherine Cambou, Karin Nielsen-Saines","doi":"10.1007/s11904-023-00655-z","DOIUrl":"https://doi.org/10.1007/s11904-023-00655-z","url":null,"abstract":"Purpose of review: The goal of this review is to highlight and interpret recent trends and developments in the diagnosis, treatment, and prevention of HIV vertical transmission from a clinical perspective.Recent findings: Universal third-trimester retesting and partner testing may better identify incident HIV among pregnant patients and result in early initiation of antiretroviral therapy to prevent vertical transmission. The proven safety and efficacy of integrase inhibitors such as dolutegravir may be particularly useful in suppressing viremia in pregnant persons who present late for ART treatment. Pre-exposure prophylaxis (PrEP) during pregnancy may play a role in preventing HIV acquisition; however, its role in preventing vertical transmission is difficult to elucidate. Substantial progress has been made in recent years to eliminate HIV perinatal transmission. Future research hinges upon a multipronged approach to improving HIV detection, risk-stratified treatment strategies, and prevention of primary HIV infection among pregnant persons.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 3","pages":"121-130"},"PeriodicalIF":4.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239317/pdf/nihms-1888021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9674630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0