Current HIV/AIDS Reports最新文献

Bolstering the HIV Surveillance System Through Innovative Methods, Technologic Advances, and Community-Driven Solutions to Inform Intervention Efforts and End the Epidemic.

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2024-12-17 DOI: 10.1007/s11904-024-00720-1

Sarah C Mann, Joshua A Barocas

{"title":"Bolstering the HIV Surveillance System Through Innovative Methods, Technologic Advances, and Community-Driven Solutions to Inform Intervention Efforts and End the Epidemic.","authors":"Sarah C Mann, Joshua A Barocas","doi":"10.1007/s11904-024-00720-1","DOIUrl":"10.1007/s11904-024-00720-1","url":null,"abstract":"An accurate and comprehensive HIV surveillance system is critical to understanding the burden of HIV infection. Reliable estimates into the surveillance system serve as the cornerstone for HIV prevention and treatment programs. PURPOSE OF REVIEW: In this article, we review the current structure and function of the HIV surveillance system in the US, identify gaps in reporting, and propose multiple potential interventions to augment the HIV surveillance system. RECENT FINDINGS: Recent literature demonstrate that substantial gaps in reporting to health departments from clinical providers exist. These gaps include stigma, knowledge of HIV reporting requirements, inaccurate direct testing estimates, reporting errors, and lack of community engagement. All of these gaps place a substantial burden on health departments, hinder responses, and effect funding. Leveraging community partnerships, technologic advances, and emerging methodologies may fill some of these gaps. Advancements in HIV self-testing, broad community HIV testing, indirect statistical methods, and machine learning bolstered by broad community engagement and oversight could modernize the HIV surveillance system to achieve the Ending the HIV Epidemic goals.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"11"},"PeriodicalIF":3.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disruptions to HIV Prevention During Armed Conflict in Ukraine and Other Settings. 乌克兰和其他地区武装冲突期间对艾滋病预防工作的干扰。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2024-12-14 DOI: 10.1007/s11904-024-00716-x

Benjamin M Nikitin, Daniel J Bromberg, Roman Ivasiy, Lynn Madden, Eteri Machavariani, Sergii Dvoriak, Danielle N Poole, David Otiashvilli, Frederick L Altice

{"title":"Disruptions to HIV Prevention During Armed Conflict in Ukraine and Other Settings.","authors":"Benjamin M Nikitin, Daniel J Bromberg, Roman Ivasiy, Lynn Madden, Eteri Machavariani, Sergii Dvoriak, Danielle N Poole, David Otiashvilli, Frederick L Altice","doi":"10.1007/s11904-024-00716-x","DOIUrl":"10.1007/s11904-024-00716-x","url":null,"abstract":"Purpose of review: This review evaluates recent literature to understand the ways in which war disrupts HIV prevention and creates conditions for HIV outbreaks, with a focus on Ukraine. We also examine potential responses that can be deployed to sustain HIV prevention services amid ongoing conflict.Recent findings: Recent studies and frameworks suggest that disruptions caused during war are comparable to other emergencies, like natural disasters. The most important disruptions included health system/infrastructure destabilization, displacement, and psychological and financial challenges for individuals in key populations. Wars in most settings, as exemplified by the recent war in Ukraine, demonstrate that these disruptions can be tempered through a coordinated, rapid response. Lesson learned from Ukraine show that adequate preparation and a rapid, collaborative response by providers is needed to ensure HIV prevention during war. Future research should develop comprehensive frameworks outlining how to facilitate this response.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"10"},"PeriodicalIF":3.7,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal Microbiota and Aging in People with HIV-What We Know and What We Don't.

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2024-12-12 DOI: 10.1007/s11904-024-00717-w

S M Shamsul Islam, Shalini Singh, Ali Keshavarzian, Mohamed Abdel-Mohsen

{"title":"Intestinal Microbiota and Aging in People with HIV-What We Know and What We Don't.","authors":"S M Shamsul Islam, Shalini Singh, Ali Keshavarzian, Mohamed Abdel-Mohsen","doi":"10.1007/s11904-024-00717-w","DOIUrl":"10.1007/s11904-024-00717-w","url":null,"abstract":"Purpose of review: People with HIV (PWH) experience premature aging and an elevated risk of age-related comorbidities, even with viral suppression through antiretroviral therapy (ART). We examine gastrointestinal disruptions, specifically impaired intestinal barrier integrity and microbial dysbiosis, as contributors to these comorbidities.Recent findings: HIV infection compromises the intestinal epithelial barrier, increasing permeability and microbial translocation, which trigger inflammation and cellular stress. ART does not fully restore gut barrier integrity, leading to persistent inflammation and cellular stress. Additionally, HIV-associated microbial dysbiosis favors pro-inflammatory bacteria, intensifying inflammation and tissue damage, which may contribute to premature aging in PWH. Understanding the interactions between intestinal microbiota, chronic inflammation, cellular stress, and aging is essential to developing therapies aimed at reducing inflammation and slowing age-related diseases in PWH. In this review, we discuss critical knowledge gaps and highlight the therapeutic potential of microbiota-targeted interventions to mitigate inflammation and delay age-associated pathologies in PWH.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"9"},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges of HIV Management in an Aging Population.

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2024-12-12 DOI: 10.1007/s11904-024-00718-9

Ashmitha Thomas, Jennifer F Hoy

引用次数: 0

Understanding the Drivers of CAB PrEP Uptake and Use among Women in sub-Saharan Africa to Build Demand for New PrEP Methods.

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2024-12-07 DOI: 10.1007/s11904-024-00715-y

Casey Bishopp, Zoe Mungai-Barris, Elmari Briedenhann, Emily Donaldson, Elizabeth Irungu, Katie Schwartz

{"title":"Understanding the Drivers of CAB PrEP Uptake and Use among Women in sub-Saharan Africa to Build Demand for New PrEP Methods.","authors":"Casey Bishopp, Zoe Mungai-Barris, Elmari Briedenhann, Emily Donaldson, Elizabeth Irungu, Katie Schwartz","doi":"10.1007/s11904-024-00715-y","DOIUrl":"10.1007/s11904-024-00715-y","url":null,"abstract":"Purpose of review: As injectable cabotegravir for pre-exposure prophylaxis (CAB PrEP) is introduced in sub-Saharan Africa, it is important to understand how behavioral drivers may influence women's decisions around whether or not to use it.Recent findings: Facilitating factors include prior familiarity with injections and the perceived efficacy of CAB PrEP, while barriers include a fear or dislike of needles and negative attitudes held by community members and influencers. Further research is needed to fully understand behavioral factors affecting African women's CAB PrEP use. HIV prevention policymakers, practitioners, advocates, and clients are optimistic about CAB PrEP, predicting that this long-acting method will be popular among women in sub-Saharan Africa. However, women may also face barriers to use. Knowledge of behavioral facilitators and barriers can enhance the adaptation or development of HIV prevention communication and demand generation strategies that support informed decision-making in a multi-method market.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"7"},"PeriodicalIF":3.7,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syndemic Theory and Its Use in Developing Health Interventions and Programming: A Scoping Review. 流行病学理论及其在制定卫生干预措施和计划中的应用：范围综述》。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2024-12-01 Epub Date: 2024-08-20 DOI: 10.1007/s11904-024-00707-y

Simon M Outram, Kimberly A Koester, Lissa Moran, Wayne T Steward, Emily A Arnold

{"title":"Syndemic Theory and Its Use in Developing Health Interventions and Programming: A Scoping Review.","authors":"Simon M Outram, Kimberly A Koester, Lissa Moran, Wayne T Steward, Emily A Arnold","doi":"10.1007/s11904-024-00707-y","DOIUrl":"10.1007/s11904-024-00707-y","url":null,"abstract":"Purpose of review: The central tenet of syndemics theory is that disease interactions are driven by social factors, and that these factors have to be understood in order to reduce the health burdens of local populations. Without an understanding of the theory and how it is being put into practice, there is a strong possibility of losing the potential for syndemic theory to positively impact change at community and individual level.Methods: Following an initial database search that produced 921 articles, we developed a multi-stage scoping review process identifying invention studies that employ syndemic theory. Inclusion was defined as the presence of healthcare interventions examining multiple social-biological outcomes, refering to a specific (local) at risk population, developing or attempting to develop interventions impacting upon multiple health and/or social targets, and explicit employment of syndemic theory in developing the intervention.Results: A total of 45 articles contained a substantial engagement with syndemic theory and an original healthcare intervention. However, only eleven studies out of all 921 articles met the inclusion criteria.Discussion/conclusion: It is strongly suggested that when employing syndemic theory researchers focus close attention to demonstrating disease interactions, providing evidence of the social drivers of these disease interactions, and constructing interventions grounded in these analytical findings. We conclude that although frequently referred to, syndemic theory is rarely employed in its entirety and recommend that interventions be developed using a more thorough grounding in this important and powerful theory.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"309-322"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Complications Associated with Use of Integrase Strand Transfer Inhibitors (InSTI) for the Treatment of HIV-1 Infection: Focus on Weight Changes, Lipids, Glucose and Bone Metabolism. 与使用整合酶链转移抑制剂 (InSTI) 治疗 HIV-1 感染有关的代谢并发症：关注体重变化、血脂、血糖和骨代谢。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2024-12-01 Epub Date: 2024-08-29 DOI: 10.1007/s11904-024-00708-x

Stefano Savinelli, Ellen Newman, Patrick W G Mallon

{"title":"Metabolic Complications Associated with Use of Integrase Strand Transfer Inhibitors (InSTI) for the Treatment of HIV-1 Infection: Focus on Weight Changes, Lipids, Glucose and Bone Metabolism.","authors":"Stefano Savinelli, Ellen Newman, Patrick W G Mallon","doi":"10.1007/s11904-024-00708-x","DOIUrl":"10.1007/s11904-024-00708-x","url":null,"abstract":"Purpose of review: This review aims to summarize recently published peer reviewed papers on the influence of treatment with Integrase Strand Transfer Inhibitors (InSTI) in people with HIV (HIV) on metabolic health, including weight gain, lipid parameters, glucose homeostasis, and bone health.Recent findings: InSTI have a mild/moderate effect on weight gain in both antiretroviral (ART) naïve and ART experienced PWH, which is more pronounced in certain groups (i.e. women, people of Black African ethnicity, those with lower socioeconomic status, and older people). The effect on weight is also driven by other components of the ART regimen as well as previous exposure to certain ART. InSTI have a relatively safe profile in terms of lipid parameters and bone health, compared to other ART classes, although some studies suggest a greater risk of insulin resistance and diabetes in PWH using InSTI, especially 2nd generation InSTI. While there is some evidence suggesting a negative impact of InSTI on some aspects of metabolic health (weight gain and glucose homeostasis), they remain the preferred treatment option for most PWH, due to their high efficacy and tolerability. However, an individualised approach to ART choice in PWH should be used in order to avoid negative outcomes in populations at higher risks of metabolic complications.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"293-308"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate Immune Cell Functions Contribute to Spontaneous HIV Control.

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2024-11-30 DOI: 10.1007/s11904-024-00713-0

Alisa Huber, Floor S Baas, Andre J A M van der Ven, Jéssica C Dos Santos

引用次数: 0

Medicinal Plant and Traditional Knowledge-guided Strategies to Combat HIV Persistence.

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2024-11-29 DOI: 10.1007/s11904-024-00712-1

Khumoekae Richard, Adi N R Poli, Kerstin Andrae-Marobela, Ian Tietjen

{"title":"Medicinal Plant and Traditional Knowledge-guided Strategies to Combat HIV Persistence.","authors":"Khumoekae Richard, Adi N R Poli, Kerstin Andrae-Marobela, Ian Tietjen","doi":"10.1007/s11904-024-00712-1","DOIUrl":"10.1007/s11904-024-00712-1","url":null,"abstract":"Purpose of review: Combination antiretroviral therapy (cART) does not act on latent HIV reservoirs, and no latency-reversing agent (LRA) to date consistently reduces viral reservoirs in humans. In Sub-Saharan Africa and elsewhere, complementary and alternative medicines (CAM) are traditionally used to manage HIV/AIDS, including a subset with LRA properties.Recent findings: Several plants from the Euphorbiaceae and Thymelaeaceae families have been recently documented for traditional HIV/AIDS management and contain LRAs that function through protein kinase C activation. These CAM are increasingly validated in HIV-infected primary cells and humanized mice. Engagement with traditional health practitioners (THPs) which prioritizes data and benefits sharing can improve trust relations, build long-term collaborations, and advance mutual knowledge on these unique CAM. CAM used traditionally for HIV/AIDS management include LRAs already used by humans, but more study and collaboration with THPs are needed to understand their potential to support global cART-free HIV remission and cure efforts.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"5"},"PeriodicalIF":3.7,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Implementation Strategies to Enhance PrEP Delivery for People Experiencing Housing Insecurity: Advancing a Multifaceted High-Touch, Low-Barrier Approach. 加强向住房无保障者提供 PrEP 的实施策略综述：推进多方面、高接触、低障碍的方法。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2024-11-22 DOI: 10.1007/s11904-024-00714-z

Jennifer Velloza, Nicky J Mehtani, Matthew D Hickey, Elizabeth Imbert, Ayesha Appa, Elise D Riley

{"title":"A Review of Implementation Strategies to Enhance PrEP Delivery for People Experiencing Housing Insecurity: Advancing a Multifaceted High-Touch, Low-Barrier Approach.","authors":"Jennifer Velloza, Nicky J Mehtani, Matthew D Hickey, Elizabeth Imbert, Ayesha Appa, Elise D Riley","doi":"10.1007/s11904-024-00714-z","DOIUrl":"10.1007/s11904-024-00714-z","url":null,"abstract":"Purpose of review: This review summarizes key implementation strategies to advance oral and long-acting PrEP delivery for unstably housed people in the United States.Recent findings: People experiencing homelessness and housing instability face barriers to PrEP uptake and adherence including lack of safe medication storage, competing basic needs, insurances issues, and/or mental health or substance use disorders. Recent advancements in HIV treatment and prevention provide evidence on high-touch, low-barrier implementation approaches to address these challenges. We compiled these approaches into a multi-component implementation strategy, \"SHELTER\", which includes: low-barrier primary care, case management, incentives, outreach, care coordination, multidisciplinary provider collaboration, data tracking, and robust provider-patient relationships. The US has fallen short of our Ending the Epidemic targets, in part due to challenges in PrEP delivery for people experiencing housing instability. SHELTER provides a comprehensive approach for considering critical components of HIV prevention for this population that can be used in future oral and long-acting PrEP programs.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"4"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0