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Current HIV/AIDS Reports最新文献

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Expanding PrEP Access Through Decentralized Delivery Models. 通过分散交付模式扩大PrEP的可及性。
IF 4.4 2区 医学
Current HIV/AIDS Reports Pub Date : 2026-04-17 DOI: 10.1007/s11904-026-00784-1
Angela Tembo, Tarryn Collings, Tsitsi Nyamuzihwa, Samanta Tresha Lalla Edward, Elzette Rousseau, W D Francois Venter, Linda-Gail Bekker, Danielle Giovenco
{"title":"Expanding PrEP Access Through Decentralized Delivery Models.","authors":"Angela Tembo, Tarryn Collings, Tsitsi Nyamuzihwa, Samanta Tresha Lalla Edward, Elzette Rousseau, W D Francois Venter, Linda-Gail Bekker, Danielle Giovenco","doi":"10.1007/s11904-026-00784-1","DOIUrl":"https://doi.org/10.1007/s11904-026-00784-1","url":null,"abstract":"","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Changing Spectrum of Cognitive Impairment in People with HIV; Establishment and Updates of the International HIV-Cognition Working Group. HIV感染者认知功能障碍谱的变化国际艾滋病毒认识工作组的建立和更新。
IF 4.4 2区 医学
Current HIV/AIDS Reports Pub Date : 2026-04-09 DOI: 10.1007/s11904-026-00779-y
Sam Nightingale
{"title":"The Changing Spectrum of Cognitive Impairment in People with HIV; Establishment and Updates of the International HIV-Cognition Working Group.","authors":"Sam Nightingale","doi":"10.1007/s11904-026-00779-y","DOIUrl":"10.1007/s11904-026-00779-y","url":null,"abstract":"","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Barriers and Facilitators of Oral PrEP Uptake Against HIV Among Selected Priority Populations: A Global Perspective. 在选定的重点人群中口服PrEP预防艾滋病毒的障碍和促进因素：全球视角。
IF 4.4 2区 医学
Current HIV/AIDS Reports Pub Date : 2026-03-30 DOI: 10.1007/s11904-026-00783-2
Ifeanyi Ngwoke, Adepeju Mary Adedire, Nengak Precious Danladi, Chinemerem Cynthia Eze, Oluwasogo Kehinde Dada, Olalekan John Okesanya
{"title":"Barriers and Facilitators of Oral PrEP Uptake Against HIV Among Selected Priority Populations: A Global Perspective.","authors":"Ifeanyi Ngwoke, Adepeju Mary Adedire, Nengak Precious Danladi, Chinemerem Cynthia Eze, Oluwasogo Kehinde Dada, Olalekan John Okesanya","doi":"10.1007/s11904-026-00783-2","DOIUrl":"10.1007/s11904-026-00783-2","url":null,"abstract":"","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13035875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic aging is a hallmark of HIV pathogenesis and phenotypic outcomes. 表观遗传老化是HIV发病机制和表型结果的标志。
IF 4.4 2区 医学
Current HIV/AIDS Reports Pub Date : 2026-03-28 DOI: 10.1007/s11904-026-00781-4
Carrie D Johnston, Kalen J Petersen, Michael J Corley
{"title":"Epigenetic aging is a hallmark of HIV pathogenesis and phenotypic outcomes.","authors":"Carrie D Johnston, Kalen J Petersen, Michael J Corley","doi":"10.1007/s11904-026-00781-4","DOIUrl":"10.1007/s11904-026-00781-4","url":null,"abstract":"","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ain't I A Woman: Bridging Womanist Theory and HIV Implementation Science. 我不是女人吗：连接女性主义理论和艾滋病实施科学。
IF 4.4 2区 医学
Current HIV/AIDS Reports Pub Date : 2026-03-28 DOI: 10.1007/s11904-026-00785-0
Whitney C Irie, Juliet Iwelunmor
{"title":"Ain't I A Woman: Bridging Womanist Theory and HIV Implementation Science.","authors":"Whitney C Irie, Juliet Iwelunmor","doi":"10.1007/s11904-026-00785-0","DOIUrl":"https://doi.org/10.1007/s11904-026-00785-0","url":null,"abstract":"","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Implications of HIV-1 Subtypes on Pathogenesis, Reservoirs and Cure Strategies. HIV-1亚型对发病机制、储存库和治疗策略的影响。
IF 4.4 2区 医学
Current HIV/AIDS Reports Pub Date : 2026-03-27 DOI: 10.1007/s11904-026-00780-5
Kavidha Reddy, Nicole Reddy, Thumbi Ndung'u
{"title":"The Implications of HIV-1 Subtypes on Pathogenesis, Reservoirs and Cure Strategies.","authors":"Kavidha Reddy, Nicole Reddy, Thumbi Ndung'u","doi":"10.1007/s11904-026-00780-5","DOIUrl":"https://doi.org/10.1007/s11904-026-00780-5","url":null,"abstract":"","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To Switch or not to Switch: are there any Antiretroviral Strategies to Attenuate Weight Gain in People with HIV? 切换还是不切换：是否有抗逆转录病毒策略可以减轻艾滋病毒感染者的体重增加？
IF 4.4 2区 医学
Current HIV/AIDS Reports Pub Date : 2026-03-25 DOI: 10.1007/s11904-026-00782-3
Paula Debroy, Jordan E Lake
{"title":"To Switch or not to Switch: are there any Antiretroviral Strategies to Attenuate Weight Gain in People with HIV?","authors":"Paula Debroy, Jordan E Lake","doi":"10.1007/s11904-026-00782-3","DOIUrl":"10.1007/s11904-026-00782-3","url":null,"abstract":"","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T-Cell Profiles in HBV Functional Cure and People Living With HIV: Known Knowns, Known Unknowns, and Unknown Unknowns. HBV功能性治愈和HIV感染者的t细胞谱：已知的已知，已知的未知，和未知的未知。
IF 4.4 2区 医学
Current HIV/AIDS Reports Pub Date : 2026-03-21 DOI: 10.1007/s11904-026-00777-0
Martin Feuerherd, Jasmin Mischke, Georg M Lauer
{"title":"T-Cell Profiles in HBV Functional Cure and People Living With HIV: Known Knowns, Known Unknowns, and Unknown Unknowns.","authors":"Martin Feuerherd, Jasmin Mischke, Georg M Lauer","doi":"10.1007/s11904-026-00777-0","DOIUrl":"https://doi.org/10.1007/s11904-026-00777-0","url":null,"abstract":"","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Timing and Duration of ART on the Composition of HIV Reservoirs: Implications for HIV Cure Strategies. 抗逆转录病毒治疗的时间和持续时间对HIV病毒库组成的影响：对HIV治愈策略的影响。
IF 4.4 2区 医学
Current HIV/AIDS Reports Pub Date : 2026-03-20 DOI: 10.1007/s11904-026-00778-z
Sukeshani Salwe, Ashwini Shete
{"title":"Effect of Timing and Duration of ART on the Composition of HIV Reservoirs: Implications for HIV Cure Strategies.","authors":"Sukeshani Salwe, Ashwini Shete","doi":"10.1007/s11904-026-00778-z","DOIUrl":"https://doi.org/10.1007/s11904-026-00778-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>Antiretroviral therapy (ART) has transformed HIV from a fatal disease into a manageable condition by effectively suppressing viral replication. However, ART does not eradicate HIV due to the persistence of latent reservoirs-mainly replication-competent proviruses in resting CD4⁺ T cells and tissue sanctuaries-that reignite infection upon treatment interruption. This review examines how ART timing and duration influence the size, composition, and stability of the HIV reservoir.</p><p><strong>Recent findings: </strong>Initiating ART during acute infection limits reservoir seeding, reduces genetic diversity, and promotes faster decay of intact proviruses compared to delayed ART, which permits widespread viral integration into long-lived memory T cells and clonal expansion of replication-competent viruses. Anatomical sites such as lymph nodes, gut-associated lymphoid tissue, and the central nervous system act as critical reservoir niches. These insights are central to current HIV cure efforts, which aim for either a sterilizing cure (complete eradication of the virus) or a functional cure (durable remission without ART). Cure strategies-such as \"shock-and-kill,\"\"block-and-lock,\" gene editing, and immunotherapy-are being optimized based on reservoir dynamics. Evidence suggests that early-treated individuals, with smaller and more homogeneous reservoirs, are better candidates for these interventions. Although no strategy has yet achieved a cure, combining early ART with targeted interventions may improve outcomes. Understanding how ART influences reservoir dynamics is essential for developing effective HIV cure strategies. We emphasize the importance of prioritizing early-treated individuals in cure trials and advocate for integrated therapeutic approaches to achieve lasting viral remission or complete eradication.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytomegalovirus in HIV: A Modifiable Driver of Inflammation, Frailty, and Aging. HIV中的巨细胞病毒：炎症、虚弱和衰老的可改变驱动因素。
IF 4.4 2区 医学
Current HIV/AIDS Reports Pub Date : 2026-03-20 DOI: 10.1007/s11904-026-00775-2
Alfonso Cabello Ubeda, Kristine M Erlandson, Michael L Freeman, Scott L Letendre, Celestine N Wanjalla, John R Koethe, Michael J Corley, Peter W Hunt, Sara Gianella
{"title":"Cytomegalovirus in HIV: A Modifiable Driver of Inflammation, Frailty, and Aging.","authors":"Alfonso Cabello Ubeda, Kristine M Erlandson, Michael L Freeman, Scott L Letendre, Celestine N Wanjalla, John R Koethe, Michael J Corley, Peter W Hunt, Sara Gianella","doi":"10.1007/s11904-026-00775-2","DOIUrl":"10.1007/s11904-026-00775-2","url":null,"abstract":"","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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