Current HIV/AIDS Reports最新文献

The Role of Integrated HBV DNA in the Quest for a Cure in HIV/HBV co-infection. 整合HBV DNA在寻求治愈HIV/HBV合并感染中的作用

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-10-08 DOI: 10.1007/s11904-025-00755-y

Monika Mani, Chloe L Thio, Ashwin Balagopal

{"title":"The Role of Integrated HBV DNA in the Quest for a Cure in HIV/HBV co-infection.","authors":"Monika Mani, Chloe L Thio, Ashwin Balagopal","doi":"10.1007/s11904-025-00755-y","DOIUrl":"https://doi.org/10.1007/s11904-025-00755-y","url":null,"abstract":"Purpose: This review highlights the importance of Hepatitis B virus (HBV) integrated into the host genome (iDNA) to functional cure and how human immunodeficiency virus (HIV) may affect HBV integration.Recent findings: Functional cure of chronic hepatitis B infection is characterized by durable loss of hepatitis B surface antigen (HBsAg) from blood after treatment discontinuation. Because HBsAg is transcribed from two intrahepatic sources, covalently closed circular DNA (cccDNA) or iDNA, functional cure requires elimination or silencing of both sources. It is not clear how HIV affects HBV integration, but since HIV enhances HBV replication and leads to increased DNA breaks through oxidative stress, people with HIV and HBV may have more integration events. HBV integration into the human genome is a random and ongoing process that occurs during all phases of chronic HBV infection (CHB). iDNA is important for maintaining HBsAg expression despite antiviral therapy. In studies without HIV, higher levels of HBV replication are associated with increased integration events. Higher HBV DNA levels in HIV/HBV co-infected individuals may contribute to increased HBV integration. HIV worsens CHB by weakening immune responses, promoting oxidative stress, and activating cellular pathways that enhance HBV replication and integration.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"48"},"PeriodicalIF":4.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Tools to Diagnose and Predict Hepatocellular Carcinoma: Relevance to HIV and Hepatitis B Virus Coinfection. 当前诊断和预测肝细胞癌的工具：与HIV和乙型肝炎病毒合并感染的相关性。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-10-06 DOI: 10.1007/s11904-025-00757-w

Edwin Wilbur Woodhouse, Tzu-Hao Lee, Susanna Naggie

{"title":"Current Tools to Diagnose and Predict Hepatocellular Carcinoma: Relevance to HIV and Hepatitis B Virus Coinfection.","authors":"Edwin Wilbur Woodhouse, Tzu-Hao Lee, Susanna Naggie","doi":"10.1007/s11904-025-00757-w","DOIUrl":"https://doi.org/10.1007/s11904-025-00757-w","url":null,"abstract":"Purpose of review: People with HIV and HBV coinfection have increased risk of developing liver fibrosis and hepatocellular carcinoma (HCC) compared to either infection alone. We review current and emerging tools for HCC diagnosis and prediction in the context of HIV-HBV coinfection.Recent findings: Treatment with antiviral therapy and the goal of full viral suppression of both HBV and HIV remains foundational to care for people with HIV-HBV coinfection. All patients with chronic HBV and elevated risk, including cirrhosis or HIV infection, should undergo HCC screening. Tools exist to risk stratify patients with HBV without cirrhosis include PAGE-B, AFP-based tests, GALAD, and ct-DNA liquid biopsy. A limitation is that only PAGE-B has been validated in people with HIV-HBV coinfection. Current tools for HCC detection in people with HIV-HBV coinfection are generally limited to those developed in people with HBV monoinfection, with exception of PAGE-B. Future development of tools to predict and diagnose HCC are needed for people with HIV-HBV coinfection.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"47"},"PeriodicalIF":4.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current and Investigational Biomarkers of Liver Disease in HIV-HBV Co-infection. HIV-HBV合并感染中肝脏疾病的当前和研究生物标志物。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-09-27 DOI: 10.1007/s11904-025-00756-x

Keyur Patel, Giada Sebastiani

引用次数: 0

The Role of Liver Biopsy and Fine Needle Aspiration in Novel HBV Therapeutics in HIV and HBV Coinfection. 肝活检和细针抽吸在HIV和HBV合并感染的新型HBV治疗中的作用。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-09-15 DOI: 10.1007/s11904-025-00754-z

Alexandra N Willauer, Kenneth E Sherman

引用次数: 0

Long-Acting Injectable Antiretroviral Drugs for Pregnant and Breastfeeding Women: Current Advances, Challenges, and Future Directions. 孕妇和哺乳期妇女长效注射抗逆转录病毒药物：当前进展、挑战和未来方向。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-08-15 DOI: 10.1007/s11904-025-00751-2

Friday Saidi, Mina C Hosseinipour, Benjamin H Chi

{"title":"Long-Acting Injectable Antiretroviral Drugs for Pregnant and Breastfeeding Women: Current Advances, Challenges, and Future Directions.","authors":"Friday Saidi, Mina C Hosseinipour, Benjamin H Chi","doi":"10.1007/s11904-025-00751-2","DOIUrl":"10.1007/s11904-025-00751-2","url":null,"abstract":"Purpose of review: This review explores the promise and challenges of integrating long-acting antiretroviral agents-cabotegravir, lenacapavir, and cabotegravir-rilpivirine-into HIV prevention and treatment programs for pregnant and breastfeeding populations. It aims to examine current evidence, implementation experiences, and barriers to equitable access.Recent findings: Emerging data support the efficacy and safety of long-acting agents during pregnancy and breastfeeding. Recent clinical trials have begun to include pregnant women by design, and national demonstration projects have successfully introduced injectable PrEP in maternal health settings. These developments signal growing recognition of the need for inclusive research and service delivery models. Long-acting antiretrovirals have the potential to transform maternal HIV prevention and treatment. However, challenges such as delayed inclusion in trials, policy constraints, limited product choice, high costs, and funding limitations persist. Addressing these gaps is critical to ensuring equitable access and informing future research and implementation strategies.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"44"},"PeriodicalIF":4.4,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging Electronic Health Records and Claims Data to Improve HIV and Comorbidity Care Trajectories: A Scoping Review. 利用电子健康记录和索赔数据来改善艾滋病毒和共病护理轨迹：范围审查。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-08-15 DOI: 10.1007/s11904-025-00753-0

Olivia K Sugarman

{"title":"Leveraging Electronic Health Records and Claims Data to Improve HIV and Comorbidity Care Trajectories: A Scoping Review.","authors":"Olivia K Sugarman","doi":"10.1007/s11904-025-00753-0","DOIUrl":"10.1007/s11904-025-00753-0","url":null,"abstract":"Purpose of review: Big Data sources, specifically electronic health records (EHR) and insurance claims data, are key in advancing HIV research. This scoping review summarizes recent research using EHR/claims to understand the evolving relationship between HIV and comorbidities.Recent findings: Data sources ranged from individual health system EHR to multi-system integrated datasets. Datasets that linked insurance claims or EHR with external sources (e.g. public health HIV surveillance, social systems) had the richest findings. PLWH who maintained care for HIV and comorbidities, including COVID-19, had similar health outcomes to peers living without HIV. Mental health, substance use disorders, and HPV-related cancers remain prevalent in PLWH. HIV stigma and racial disparities in non-HIV comorbidity care were detected. These findings reinforce evidence of improving general health for PLWH as research and evidence-based treatment progress, and the utility of Big Data for PLWH in public health emergencies like COVID-19. There is continued need for tailored interventions for co-morbid mental health and some cancers. Linking EHR/claims data to external sources are critical to research and practice innovations in approaching whole-person care on the path to HIV elimination.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"43"},"PeriodicalIF":4.4,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social and Structural Interventions to Reduce Strikingly High Post-Hospital Mortality for People Living with HIV in Sub-Saharan Africa. 社会和结构干预措施降低撒哈拉以南非洲艾滋病毒感染者极高的住院后死亡率。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-08-07 DOI: 10.1007/s11904-025-00752-1

Cassidy W Claassen, Tonderai Mabuto, Kate Shearer, Jane Park, Megan Willkens, Chiti Bwalya, Benson Issarow, Cecilia Kanyama, Rob N Peck, Michael Vinikoor, Christopher J Hoffmann

{"title":"Social and Structural Interventions to Reduce Strikingly High Post-Hospital Mortality for People Living with HIV in Sub-Saharan Africa.","authors":"Cassidy W Claassen, Tonderai Mabuto, Kate Shearer, Jane Park, Megan Willkens, Chiti Bwalya, Benson Issarow, Cecilia Kanyama, Rob N Peck, Michael Vinikoor, Christopher J Hoffmann","doi":"10.1007/s11904-025-00752-1","DOIUrl":"https://doi.org/10.1007/s11904-025-00752-1","url":null,"abstract":"Purpose of review: Death following hospitalization remains strikingly high for people living with HIV (PLHIV) in sub-Saharan Africa. Hospitalization represents a key opportunity for targeted interventions, yet evidence for effective approaches remains limited. We conducted a best-evidence narrative review, framed by the Andersen Model of Health Care Utilization, to examine factors contributing to post-hospital mortality and assess recent interventions.Recent findings: PLHIV in sub-Saharan Africa have a 12-26% risk of death within 3-6 months of discharge. Social and structural barriers-including poverty, stigma, food insecurity, and low self-efficacy-are central mediating factors. We reviewed three disease-neutral interventions (HomeLink, Daraja, ReCharge) providing home-based support, counseling, and care linkage. While feasible and acceptable, mortality impact was mixed due to small sample sizes and advanced illness. The hospital-to-home transition is a critical window for intensified differentiated services to reduce mortality among PLHIV. Further research is needed to define scalable and cost-effective models to improve survival and close gaps in HIV care.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"42"},"PeriodicalIF":4.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of Trauma-Informed Care into Clinical HIV Prevention and Care Settings: A Decade of Limited Progress. 实施创伤知情护理到临床艾滋病毒预防和护理设置：十年有限的进展。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-07-23 DOI: 10.1007/s11904-025-00750-3

Katherine M Anderson, Madelyn Carlson, Sophia C Garbarino, Ameeta Kalokhe, Jessica M Sales

{"title":"Implementation of Trauma-Informed Care into Clinical HIV Prevention and Care Settings: A Decade of Limited Progress.","authors":"Katherine M Anderson, Madelyn Carlson, Sophia C Garbarino, Ameeta Kalokhe, Jessica M Sales","doi":"10.1007/s11904-025-00750-3","DOIUrl":"10.1007/s11904-025-00750-3","url":null,"abstract":"Purpose of the review: Trauma is common among people living with or at risk for HIV and associated with increased HIV risk and worse HIV care outcomes. Trauma-informed care (TIC) may improve clinical interactions and support care engagement yet may be difficult to implement as a multi-component organizational intervention. We aimed to identify research on implementation of TIC in HIV prevention and treatment settings and assess barriers and facilitators to implementation.Recent findings: We identified 13 peer-reviewed articles implementing trauma-informed HIV prevention or treatment in clinical settings. Barriers and facilitators to implementation were identified across all five Consolidated Framework for Implementation Research 2.0 domains, with most falling in inner and outer setting domains. We identified consistently influential system-level factors to enable deployment of targeted implementation strategies for TIC integration. Suggested strategies include training, capacity building, technical assistance, and workflow integration strategies that reduce resource strain.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"41"},"PeriodicalIF":4.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexually Transmitted Infections and Risk of Human Immunodeficiency Virus Transmission. 性传播感染和人类免疫缺陷病毒传播的风险。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2025-07-02 DOI: 10.1007/s11904-025-00749-w

Amanda Maguire Wilkerson, Jun Tao, Philip A Chan

{"title":"Sexually Transmitted Infections and Risk of Human Immunodeficiency Virus Transmission.","authors":"Amanda Maguire Wilkerson, Jun Tao, Philip A Chan","doi":"10.1007/s11904-025-00749-w","DOIUrl":"https://doi.org/10.1007/s11904-025-00749-w","url":null,"abstract":"Purpose of the review: Sexually transmitted infections (STIs) include a diverse set of bacteria, viruses, parasites, and other pathogens that can facilitate transmission of Human Immunodeficiency Virus (HIV). However, the extent to which STIs increase HIV risk and public health approaches to address this are still evolving.Recent findings: Compelling evidence suggests STIs increase the risk of HIV acquisition and transmission. STIs may lead to higher rates of HIV infection through multiple mechanisms including inflammation and disruption of the epithelium, facilitating immune cells which are targets of HIV, and increased viral load shedding in those that have HIV. While previous STI control efforts have shown mixed effectiveness in reducing HIV incidence, the success of doxycycline prophylaxis for preventing bacterial STIs offers a promising approach that may help prevent HIV at the population-level. STIs significantly increase the risk of HIV acquisition and transmission. Increased understanding of public health approaches, which both contribute to STI control and also prevent HIV transmission, is needed.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"40"},"PeriodicalIF":3.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Guide to the Evolving Clinical Landscape of Low-Level Viremia Among Persons with HIV in the Modern Treatment Era. 现代治疗时代HIV感染者低水平病毒血症临床发展指南

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-06-26 DOI: 10.1007/s11904-025-00743-2

Amalia Aldredge, Corrina Patel, Anandi N Sheth, Lauren F Collins

{"title":"A Guide to the Evolving Clinical Landscape of Low-Level Viremia Among Persons with HIV in the Modern Treatment Era.","authors":"Amalia Aldredge, Corrina Patel, Anandi N Sheth, Lauren F Collins","doi":"10.1007/s11904-025-00743-2","DOIUrl":"10.1007/s11904-025-00743-2","url":null,"abstract":"Purpose of review: Low-level viremia (LLV) remains common in the modern HIV treatment era. We sought to clarify a unified definition of LLV, examine current LLV risk factors, assess outcomes for people with LLV, explore sex and gender differences, and evaluate management updates for people who develop LLV.Recent findings: There continue to be varied definitions of LLV without standardization, making comparison of clinical research findings challenging. Potential LLV risk factors have expanded and early data suggest that poor antiretroviral therapy adherence is unlikely to be the cause of most LLV; further, integrase strand transfer inhibitor use may be protective. Recent studies confirm that LLV is associated with virologic failure among other negative outcomes including a trend toward development of non-AIDS comorbidities; these effects may be more pronounced among women. Additional research, including randomized clinical trials, evaluating different strategies for managing LLV is urgently needed to prevent negative outcomes in persons with HIV.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"39"},"PeriodicalIF":4.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0