Current HIV/AIDS Reports最新文献

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Current Status of HIV-Stigma Reduction Interventions: A Need to Address the Root Causes at Multiple Levels. 减少艾滋病毒污名化干预措施的现状:需要在多个层面解决根本原因。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2025-05-29 DOI: 10.1007/s11904-025-00740-5
Déjà N Clement, Christopher Chiu, Pamela Ruiz, Abigail W Batchelder
{"title":"Current Status of HIV-Stigma Reduction Interventions: A Need to Address the Root Causes at Multiple Levels.","authors":"Déjà N Clement, Christopher Chiu, Pamela Ruiz, Abigail W Batchelder","doi":"10.1007/s11904-025-00740-5","DOIUrl":"https://doi.org/10.1007/s11904-025-00740-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>Stigma and discrimination remain critical determinants of HIV inequities among people with and vulnerable to HIV (PWAVH), as they are key drivers of HIV outcomes by restricting access to health-enabling resources.</p><p><strong>Recent findings: </strong>As the preponderance of HIV-related stigma interventions have mostly targeted individual and/or interpersonal psycho-social spheres, there remains a critical need for increased HIV-related stigma interventions at community and structural levels concurrently. Structural and multi-level HIV stigma interventions, though challenging to implement and underfunded, may be more effective in reducing HIV-related stigma by targeting underlying systemic issues perpetuating inequitable access to social determinants of health. Eradicating HIV and overcoming HIV-related stigma will require systemic changes intended to pursue health equity. This commentary emphasizes expanding our focus from developing interventions that not only reduce the ramifications of stigma but also work to eradicate stigma through multi-level efforts, including structural change.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"35"},"PeriodicalIF":3.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Future of bNAbs in HIV Treatment. bnab在HIV治疗中的未来
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2025-05-27 DOI: 10.1007/s11904-025-00744-1
Pablo Tebas
{"title":"Future of bNAbs in HIV Treatment.","authors":"Pablo Tebas","doi":"10.1007/s11904-025-00744-1","DOIUrl":"10.1007/s11904-025-00744-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>Broadly neutralizing antibodies (bNAbs) represent a novel approach to HIV treatment, prevention, and cure strategies. As research advances, the clinical application of bNAbs continues to evolve. This review explores the potential role of bNAbs in HIV management, addressing their mechanisms of action, current limitations, and future directions.</p><p><strong>Recent findings: </strong>Recent studies have demonstrated that bNAbs can effectively neutralize a broad range of HIV strains by targeting conserved epitopes on the viral envelope. Clinical trials have shown that bNAb combinations can maintain viral supression in the absence of antiretroviral therapy (ART), though pre-existing resistance remains a major challenge. Strategies such as Fc engineering and alternative delivery mechanisms (e.g., AAV, mRNA, DNA) are being explored to enhance bNAb efficacy and durability. Despite promising data, bNAbs have not yet demonstrated superior effectiveness compared to existing ART or pre-exposure prophylaxis (PrEP) options. While bNAbs offer exciting possibilities for long-acting HIV therapy, their widespread use is limited by logistical challenges, high production costs, and pre-existing viral resistance. The future of bNAbs may lie in combination strategies with small-molecule antiretrovirals in maintenance strategies, genetic delivery systems, and vaccine-based approaches to induce endogenous bNAb production. Further research is needed to refine these strategies and determine the optimal role of bNAbs in HIV care.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"34"},"PeriodicalIF":3.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing HIV Prevention Efforts in the Criminal Legal System: A Comprehensive Review and Recommendations. 在刑事法律体系中加强艾滋病毒预防工作:全面审查和建议。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2025-05-06 DOI: 10.1007/s11904-025-00737-0
Karen A Johnson, Alexander J Perkins, Charity Obuya, Sherron K Wilkes
{"title":"Enhancing HIV Prevention Efforts in the Criminal Legal System: A Comprehensive Review and Recommendations.","authors":"Karen A Johnson, Alexander J Perkins, Charity Obuya, Sherron K Wilkes","doi":"10.1007/s11904-025-00737-0","DOIUrl":"https://doi.org/10.1007/s11904-025-00737-0","url":null,"abstract":"<p><strong>Background: </strong>Despite encouraging declines in the overall rate of new transmission globally, HIV prevention efforts targeting individuals in the criminal legal system continue to significantly lag behind rates identified in the general population. Prevention efforts targeting this group worldwide remain geographically uneven and differ across the continuum of legal system involvement (diversion, arrests, community supervision, and post-release), which is attributed to social, structural, and systemic barriers. These gaps are noted to disproportionately impact minoritized and other transmission-burdened populations within the criminal legal system (e.g., men who have sex with men).</p><p><strong>Objective: </strong>Given these challenges, this literature review examines HIV prevention efforts targeting individuals in the criminal legal system across the globe.</p><p><strong>Methods: </strong>This review identifies current reach and gaps in prevention care and proposes strategies for improvement.</p><p><strong>Results: </strong>Recommendations include updating and utilizing long-term platforms for sustained HIV prevention interventions, developing a global compendium for regions outside the U.S., enhancing targeted interventions in high-risk areas, and integrating HIV prevention with other health services while addressing stigma.</p><p><strong>Conclusions: </strong>These actions are critical for ensuring that interventions remain up-to-date, sustainable, and culturally responsive, effectively addressing the unique needs of diverse populations and criminal legal system contexts. These measures are also vital for meeting the U.N. 95-95-95 targets for HIV testing, treatment, and viral suppression, ultimately contributing to the goal of ending the HIV epidemic among this high-need population.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"33"},"PeriodicalIF":3.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Acting Injectable Antiretroviral Therapy for Treatment of Human Immunodeficiency Virus: A Review. 长效注射抗逆转录病毒治疗人类免疫缺陷病毒的研究进展
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2025-04-23 DOI: 10.1007/s11904-025-00741-4
Jennie E Johnson, Amy L Brotherton, Michael R Rossi, Martha C Sanchez, Curt G Beckwith
{"title":"Long-Acting Injectable Antiretroviral Therapy for Treatment of Human Immunodeficiency Virus: A Review.","authors":"Jennie E Johnson, Amy L Brotherton, Michael R Rossi, Martha C Sanchez, Curt G Beckwith","doi":"10.1007/s11904-025-00741-4","DOIUrl":"https://doi.org/10.1007/s11904-025-00741-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Long-acting injectable (LAI) antiretroviral therapy (ART) for treatment of HIV-1 are approved both as a complete treatment regimen (cabotegravir/rilpivirine) and as an additional treatment option (lenacapavir) for those with multidrug resistant HIV-1. Here, we review the data supporting these approvals, pharmacokinetics, and additional patient populations that many benefit from LAI ART.</p><p><strong>Recent findings: </strong>Persons with HIV and adherence challenges as well as those in low-and-middle income countries have high rates of adherence and viral suppression with LAI ART. LAI cabotegravir/rilpivirine (CAB/RPV) offers an alternative treatment approach to daily oral ART for people with HIV-1 infection that is associated with high rates of patient satisfaction when compared to daily oral ART. LAI CAB/RPV is currently only approved in those with HIV-1 viral suppression, however recent data support the use of LAI ART in populations with adherence challenges. Furthermore, given high rates of NNRTI resistance globally, CAB/RPV is not recommended in low-and-middle income countries presently, although this recommendation is likely to change based on recently published data. More research is needed among groups that may benefit from long-acting treatments for HIV-1.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"31"},"PeriodicalIF":3.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Communication: A Narrative Synthesis of Interventions for HIV Disclosure to Pediatric Populations. 改善沟通:向儿科人群披露艾滋病毒干预措施的叙述综合。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2025-04-23 DOI: 10.1007/s11904-025-00742-3
Emmanuel Kumah, Dorothy Serwaa Boakye, Richard Boateng, Godfred Otchere, Eunice Agyei, Peter Bachela Ndewini
{"title":"Improving Communication: A Narrative Synthesis of Interventions for HIV Disclosure to Pediatric Populations.","authors":"Emmanuel Kumah, Dorothy Serwaa Boakye, Richard Boateng, Godfred Otchere, Eunice Agyei, Peter Bachela Ndewini","doi":"10.1007/s11904-025-00742-3","DOIUrl":"https://doi.org/10.1007/s11904-025-00742-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>HIV remains a significant global public health concern, affecting millions worldwide, including children. Disclosure of HIV status to infected children holds several benefits, yet rates of disclosure remain low, posing challenges globally. Whereas existing interventions and strategies offering insights into the process of HIV disclosure to pediatric populations are sparse, there is a gap in synthesizing these approaches comprehensively to shed light on effective practices and areas requiring further research and development. This study aims to address this gap by providing a narrative overview of interventions and strategies utilized to empower parents, caregivers, and healthcare providers in the process of disclosing HIV status to children living with HIV.</p><p><strong>Recent findings: </strong>Our review of 26 publications identified various pediatric HIV disclosure interventions and strategies, including provider-informed frameworks, process-oriented models, and multidisciplinary approaches. Common themes that emerged include developmental appropriateness, gradual disclosure, education through visual aids, training and capacity building, cultural sensitivity, and post-disclosure monitoring and support. Overall, the majority of the interventions and strategies showed positive outcomes in improving disclosure rates and supporting children's well-being. This study provides valuable insights for policymakers, healthcare providers, and researchers, informing strategies to improve communication and support for children living with HIV and their families. By emphasizing the importance of age-appropriate and culturally sensitive disclosure methods, we can strive to enhance the well-being and quality of life for children living with HIV.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"32"},"PeriodicalIF":3.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opportunities to Optimize Outcomes of Diagnosis and Treatment of HIV and Syphilis in Pregnancy: the Quest to Eliminate Maternal and Vertical Transmission. 优化妊娠期HIV和梅毒诊断和治疗结果的机会:寻求消除母体传播和垂直传播。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2025-04-23 DOI: 10.1007/s11904-025-00739-y
Dvora Joseph Davey, Alex de Voux, Natalie Shaetonhodi, Michael Marks, Lisa Frigati, Tendesayi Kufa
{"title":"Opportunities to Optimize Outcomes of Diagnosis and Treatment of HIV and Syphilis in Pregnancy: the Quest to Eliminate Maternal and Vertical Transmission.","authors":"Dvora Joseph Davey, Alex de Voux, Natalie Shaetonhodi, Michael Marks, Lisa Frigati, Tendesayi Kufa","doi":"10.1007/s11904-025-00739-y","DOIUrl":"https://doi.org/10.1007/s11904-025-00739-y","url":null,"abstract":"<p><strong>Background: </strong>There is an urgent need to improve interventions for HIV and syphilis in pregnancy to achieve elimination.</p><p><strong>Results: </strong>The tenets of vertical transmission strategies for HIV and syphilis overlap but have varying success due to differences in their transmission dynamics, diagnoses, and treatment. Key principles include prevention of maternal infection, screening and diagnosis early and throughout antenatal care, curative treatment (syphilis), viral load suppression (HIV), early infant diagnosis and treatment (HIV and congenital syphilis). We recommend improved guidelines, provider training and focused research and surveillance, including implementation studies to align HIV and syphilis screening and treatment during pregnancy. Opportunities to integrate syphilis screening and treatment into antenatal and HIV care enable providers to offer comprehensive maternal care.</p><p><strong>Conclusion: </strong>Integrated HIV/syphilis services ensure a cohesive and person-centered approach, improving health outcomes through streamlined, efficient, and family-centered care pathways. We recommend key interventions to reduce HIV and syphilis in pregnancy and prevent vertical transmission.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"30"},"PeriodicalIF":3.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing HIV and Substance Use Health Disparities among Racial/Ethnic Minority Individuals. 解决种族/少数民族个人的艾滋病毒和药物使用健康差异。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2025-04-04 DOI: 10.1007/s11904-025-00738-z
Jamie V Saunt, Kate M Kelley, Corrilynn O Hileman, David L Hussey, Ann K Avery
{"title":"Addressing HIV and Substance Use Health Disparities among Racial/Ethnic Minority Individuals.","authors":"Jamie V Saunt, Kate M Kelley, Corrilynn O Hileman, David L Hussey, Ann K Avery","doi":"10.1007/s11904-025-00738-z","DOIUrl":"10.1007/s11904-025-00738-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>Advances in HIV testing, prevention, and treatment, alongside increased awareness and harm reduction efforts for substance use disorder (SUD) have improved care and treatment access over the past decade. However, racial and ethnic minorities with SUD and HIV or at risk for HIV still face disproportionately high health disparities. Understanding and addressing the reasons behind these disparities is crucial.</p><p><strong>Recent findings: </strong>Structural and systemic barriers continue to negatively impact minoritized communities, due to lack of access to care, mistrust, and feelings of ostracization. Disconnected systems for HIV and SUD treatment complicate combined care. Delays in HIV diagnosis and viral suppression reduce life expectancy for minority populations by around 10 years. Healthcare systems need to become more integrated, accessible, and culturally welcoming to marginalized communities. Promising interventions utilizing technology, harm reduction, and mobile service delivery can reduce barriers and improve outcomes for minority individuals.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"29"},"PeriodicalIF":3.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Point-of-Care Syphilis Testing: Implementation and Future Direction. 即时梅毒检测:实施和未来方向。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2025-03-28 DOI: 10.1007/s11904-025-00728-1
Philip A Chan, Leandro Mena
{"title":"Point-of-Care Syphilis Testing: Implementation and Future Direction.","authors":"Philip A Chan, Leandro Mena","doi":"10.1007/s11904-025-00728-1","DOIUrl":"10.1007/s11904-025-00728-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>Syphilis is caused by Treponema Pallidum and continues to be a significant cause of morbidity across the world with an increase in prevalence over the past two decades. This review aims to highlight rapid, point-of-care (POC) syphilis testing, which offers an innovative approach to improve access to syphilis testing among underserved communities.</p><p><strong>Recent findings: </strong>POC syphilis testing can potentially shorten the time to treatment. Currently available tests generally have high sensitivity and specificity and report the presence or absence of treponemal antibodies and are not designed to perform non-treponemal antibody testing. Therefore, the main challenge of POC syphilis testing is the inability to distinguish between current infection and a past treated infection. In real-world settings, syphilis POC testing has been acceptable and generally accurate. POC syphilis testing has significant potential to improve access to care and would be most effective in non-clinical settings without readily available access to clinical services. This includes rural settings and other areas that have populations with significant barriers to healthcare, and especially among populations with a historically lower rate of diagnosed syphilis, including pregnant women. Keys to successful implementation include awareness and education on how to perform the test and interpret results, as well as use in suitable settings and among appropriate populations.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"28"},"PeriodicalIF":3.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increasing Access To Sexually Transmitted Infection Testing: The Promise of Point-of-Care and Over-the-Counter Tests. 增加获得性传播感染检测的机会:即时检测和非处方检测的前景。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2025-03-25 DOI: 10.1007/s11904-025-00736-1
Stephany Ma, William O Osburn, Yukari C Manabe
{"title":"Increasing Access To Sexually Transmitted Infection Testing: The Promise of Point-of-Care and Over-the-Counter Tests.","authors":"Stephany Ma, William O Osburn, Yukari C Manabe","doi":"10.1007/s11904-025-00736-1","DOIUrl":"10.1007/s11904-025-00736-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>Rapid, simple, inexpensive tests that can be used to detect sexually transmitted infections (STI) in symptomatic patients and for asymptomatic screening, especially in women, is a global critical unmet need in all income settings. We sought to review the STI diagnostic unmet need and current landscape of diagnostic tests that are either approved or in development.</p><p><strong>Recent findings: </strong>Diagnostic certainty will be required to decrease the global burden of STI's particularly in low-resource settings where empiric algorithmic care predominates. Lateral flow assays for syphilis and HIV have been successfully used in low- and middle-income countries. Although the performance of reference lab nucleic acid amplification tests is excellent for the detection of Neisseria gonorrhoeae and Chlamydia trachomatis, such tests remain expensive and globally unavailable due to lack of existing clinical lab infrastructure. Importantly, diagnostic innovations from the COVID-19 pandemic are being leveraged for developing molecular STI point-of-care tests and over-the-counter (OTC) self-tests. In the US and other high-income countries, point-of-care testing of both symptomatic and asymptomatic people would allow for a definitive STI diagnosis, appropriate treatment within a clinical encounter, and decreased antibiotic overuse, a significant global public health problem. Most exciting is the possibility for rapid, high performance self-tests. Inexpensive and rapid STI self-test could significantly increase access to STI care and help decrease health inequity.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"27"},"PeriodicalIF":3.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Challenges in Access To Transplantation for Persons with HIV. 评估艾滋病毒感染者获得移植的挑战。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2025-03-21 DOI: 10.1007/s11904-025-00735-2
Ruth O Adekunle, Moreno Rodrigues, Christine M Durand
{"title":"Evaluating Challenges in Access To Transplantation for Persons with HIV.","authors":"Ruth O Adekunle, Moreno Rodrigues, Christine M Durand","doi":"10.1007/s11904-025-00735-2","DOIUrl":"10.1007/s11904-025-00735-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Antiretroviral therapy has significantly improved the life expectancy of people with HIV (PWH), leading to an increased prevalence of comorbidities such as end-stage organ diseases. PWH with end-stage disease face a significantly higher risk of mortality compared to those without HIV, highlighting the urgent need to improve access to organ transplantation for this vulnerable group. This review examines barriers to organ transplantation for PWH, utilizing a modified five A's model (acceptability, availability, accessibility, affordability, accommodation).</p><p><strong>Recent findings: </strong>Despite comparable post-transplant outcomes to the general population, PWH are less likely to receive organ transplants. The HIV Organ Policy and Equity (HOPE) Act has expanded the donor pool by permitting organ transplants from donors with HIV to recipients with HIV. However, factors limiting expansion include policy, logistical constraints, and HIV-related stigma. Despite pivotal advancements in HIV organ transplantation, multilevel challenges continue to limit access for PWH. Addressing these barriers is essential to ensuring equitable access to this life-saving therapy.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"26"},"PeriodicalIF":3.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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