Opportunities to Optimize Outcomes of Diagnosis and Treatment of HIV and Syphilis in Pregnancy: the Quest to Eliminate Maternal and Vertical Transmission.

IF 3.7 2区医学 Q2 INFECTIOUS DISEASES

Current HIV/AIDS Reports Pub Date : 2025-04-23 DOI:10.1007/s11904-025-00739-y

Dvora Joseph Davey, Alex de Voux, Natalie Shaetonhodi, Michael Marks, Lisa Frigati, Tendesayi Kufa

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引用次数: 0

Abstract

Background: There is an urgent need to improve interventions for HIV and syphilis in pregnancy to achieve elimination.

Results: The tenets of vertical transmission strategies for HIV and syphilis overlap but have varying success due to differences in their transmission dynamics, diagnoses, and treatment. Key principles include prevention of maternal infection, screening and diagnosis early and throughout antenatal care, curative treatment (syphilis), viral load suppression (HIV), early infant diagnosis and treatment (HIV and congenital syphilis). We recommend improved guidelines, provider training and focused research and surveillance, including implementation studies to align HIV and syphilis screening and treatment during pregnancy. Opportunities to integrate syphilis screening and treatment into antenatal and HIV care enable providers to offer comprehensive maternal care.

Conclusion: Integrated HIV/syphilis services ensure a cohesive and person-centered approach, improving health outcomes through streamlined, efficient, and family-centered care pathways. We recommend key interventions to reduce HIV and syphilis in pregnancy and prevent vertical transmission.

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优化妊娠期HIV和梅毒诊断和治疗结果的机会：寻求消除母体传播和垂直传播。

背景：迫切需要改进对妊娠期艾滋病毒和梅毒的干预措施，以实现消除。结果：艾滋病毒和梅毒的垂直传播策略的原则重叠，但由于其传播动力学，诊断和治疗的差异，取得了不同的成功。主要原则包括预防孕产妇感染、早期和整个产前保健的筛查和诊断、治愈性治疗（梅毒）、病毒载量抑制（艾滋病毒）、婴儿早期诊断和治疗（艾滋病毒和先天性梅毒）。我们建议改进指导方针，对医务人员进行培训，并开展重点研究和监测，包括实施研究，使妊娠期间的艾滋病毒和梅毒筛查与治疗保持一致。将梅毒筛查和治疗纳入产前和艾滋病毒护理的机会使提供者能够提供全面的孕产妇保健。结论：艾滋病毒/梅毒综合服务确保了凝聚力和以人为本的方法，通过精简、高效和以家庭为中心的护理途径改善了健康结果。我们建议采取关键干预措施，以减少怀孕期间的艾滋病毒和梅毒，并防止垂直传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current HIV/AIDS Reports INFECTIOUS DISEASES-

CiteScore

8.10

自引率

2.20%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.