Current HIV/AIDS Reports最新文献_第2页

Obesity and Weight Management in HIV: Epidemiology, Complications, and Emerging Treatments. HIV的肥胖和体重管理：流行病学、并发症和新兴治疗方法。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-02-24 DOI: 10.1007/s11904-026-00776-1

Luke Pryke, John R Koethe, Samuel Bailin

{"title":"Obesity and Weight Management in HIV: Epidemiology, Complications, and Emerging Treatments.","authors":"Luke Pryke, John R Koethe, Samuel Bailin","doi":"10.1007/s11904-026-00776-1","DOIUrl":"10.1007/s11904-026-00776-1","url":null,"abstract":"Purpose of review: People living with HIV (PLWH) on contemporary antiretroviral therapy experience high rates of overweight/obesity, which predisposes to cardiometabolic disease and multiple other conditions with negative health consequences in this aging population. We aim to summarize the epidemiology and pathophysiology of obesity in PLWH and review recent advances in the therapeutic management of obesity.Recent findings: The prevalence of overweight/obesity in PLWH mirrors long-standing trends in the general population. Obesity and weight gain have a complex, multifactorial pathogenesis and directly mediate detrimental metabolic changes that are common in PLWH. While lifestyle changes are important, surgical weight loss and recent advances in medical therapeutics are more effective at reducing obesity and obesity-related complications. Obesity in PLWH substantially increases the risk for cardiometabolic complications and poor health outcomes. Surgical and medical weight loss interventions are effective treatments to reduce obesity and obesity-related complications, though further research in PLWH is needed to define optimal management.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12932276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic CD4 T Cells: Dual Agents in HIV-1 Pathogenesis and Persistence. 细胞毒性CD4 T细胞：HIV-1发病机制和持久性的双重因素。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-02-16 DOI: 10.1007/s11904-026-00773-4

Kaylee L Mickens, Stephanie M Dillon, Kejun Guo, Cara C Wilson, Mario L Santiago

引用次数: 0

Adolescent and Young Adult Leadership and Engagement in HIV Strategy and Policy Development: Experiences from the UNICEF/WHO/UNAIDS Blueprint Collaborative. 青少年和青年在艾滋病毒战略和政策制定方面的领导和参与：来自儿童基金会/世卫组织/艾滋病规划署蓝图合作的经验。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-02-14 DOI: 10.1007/s11904-026-00774-3

Dorian Ho, Takhona Hlatshwako, Kelechi P Chima, Yusha Tao, Chisom Obiezu-Umeh, Ifeoma Obionu, Susan Vorkoper, Rachel Sturke, Juliet Lwelunmor, Damilola Walker, Joseph D Tucker

{"title":"Adolescent and Young Adult Leadership and Engagement in HIV Strategy and Policy Development: Experiences from the UNICEF/WHO/UNAIDS Blueprint Collaborative.","authors":"Dorian Ho, Takhona Hlatshwako, Kelechi P Chima, Yusha Tao, Chisom Obiezu-Umeh, Ifeoma Obionu, Susan Vorkoper, Rachel Sturke, Juliet Lwelunmor, Damilola Walker, Joseph D Tucker","doi":"10.1007/s11904-026-00774-3","DOIUrl":"https://doi.org/10.1007/s11904-026-00774-3","url":null,"abstract":"Purpose of review: Adolescents and young adults (AYA) face disproportionately worse outcomes along the HIV prevention and care continuum. Despite global commitments to AYA engagement, AYA remain underrepresented in research, programming, and policy development. We summarize recent innovations in AYA engagement within the HIV literature and reflect on the 2023 Blueprint Collaborative, a UNICEF/WHO/UNAIDS initiative where AYA (ages 10-30) shaped global adolescent HIV strategy.Recent findings: Our review found examples of AYA engagement across the intervention life cycle, including in shaping research agendas, designing interventions, and building AYA capacity for sustainability. For the Blueprint Collaborative, which featured a AYA-led evidence synthesis and global open call, we assessed AYA engagement using the RIGHTS framework. A major strength of the Blueprint Collaborative was the robust AYA engagement, moving beyond AYA consultations to AYA leadership. AYA shared decision-making authority with adults as researchers, organizers, and open call judges. Through a \"learning by doing\" approach, AYA gained skills in research and multidisciplinary collaboration. Blueprint results were presented to senior leadership, developed into strategy, and disseminated through publications and AYA networks. AYA leadership can provide several benefits for AYA research and programming, such as institutionalizing community engagement, improving research relevance, and advancing equity. AYA are eager and capable of driving HIV strategy and policy, but senior partners should step back to enable these opportunities. Senior partners might better serve to support AYA leadership in strategic planning to align programming with AYA priorities and build research and advocacy skills.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":"4"},"PeriodicalIF":4.4,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpes Simplex Virus Type 2 Screening in Persons with and Without HIV: Evidence, Challenges, and Future Directions. 单纯疱疹病毒2型筛查的人与没有艾滋病毒：证据，挑战，和未来的方向。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-02-02 DOI: 10.1007/s11904-026-00771-6

Laith J Abu-Raddad, Hiam Chemaitelly, Anna Wald, Christine Johnston

引用次数: 0

Geospatial Approaches to HIV Care: a Scoping Review of Asset Mapping. 艾滋病毒护理的地理空间方法：资产映射的范围审查。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-01-19 DOI: 10.1007/s11904-025-00770-z

Karin Tobin, Abigail Winiker, Sara Bartlett, Connor Volpi

{"title":"Geospatial Approaches to HIV Care: a Scoping Review of Asset Mapping.","authors":"Karin Tobin, Abigail Winiker, Sara Bartlett, Connor Volpi","doi":"10.1007/s11904-025-00770-z","DOIUrl":"10.1007/s11904-025-00770-z","url":null,"abstract":"Purpose of review: Asset mapping aims to engage members of a community to explore and map assets that are solutions to social issues such as homelessness or access to health care. The purpose of this scoping review was to determine the scope of asset mapping as an approach to HIV care cascade outcomes, synthesize available evidence on this method's application in research, and identify opportunities for future interventions and research based in this methodology. This scoping review follows the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for Scoping Reviews checklist. Databases used were: PubMed, CINAHL, EMBASE, and Scopus. Only articles featuring studies targeting the HIV care cascade were included. Our focus was studies that explored, described, or mapped tangible or intangible assets, employed a strengths-based approach, and addressed capacity to develop solutions. Several researchers independently reviewed all abstracts and full text articles.Recent findings: A total of 305 articles were found. After removal of duplicates, 207 articles remained. From the title and abstract review, 189 articles (91%) were excluded, leaving 18 studies to be assessed for inclusion. Of these, 10 studies were included. Five studies intentionally conducted asset mapping and 5 were not intentional but results revealed assets. Tangible assets included churches, transportation routes, libraries, and parks. Intangible assets included strengthening health routines, self-reflection, social relationships, and community engagement. Future research should shift to methods that identify strengths and assets of communities affected by HIV and AIDS.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":"2"},"PeriodicalIF":4.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145997380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR Applications in HIV Management - Prevention, Diagnosis, Monitoring and Treatment. CRISPR在HIV管理中的应用——预防、诊断、监测和治疗。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-01-12 DOI: 10.1007/s11904-025-00769-6

Bárbara S Marques, Carla Vitorino, Fátima V Ventura

{"title":"CRISPR Applications in HIV Management - Prevention, Diagnosis, Monitoring and Treatment.","authors":"Bárbara S Marques, Carla Vitorino, Fátima V Ventura","doi":"10.1007/s11904-025-00769-6","DOIUrl":"https://doi.org/10.1007/s11904-025-00769-6","url":null,"abstract":"Despite global efforts to combat the human immunodeficiency virus (HIV) epidemic, acquired immunodeficiency syndrome (AIDS) still claims one life every minute, underscoring the persistent need for improved control strategies. Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated protein (Cas) technologies have emerged as promising tools that may transform HIV management. The objective of this review is to summarise recent advancements in CRISPR/Cas-based approaches for HIV prevention, diagnosis, monitoring, and treatment, and to evaluate their potential and current challenges. A systematic literature search was conducted to identify relevant CRISPR/Cas applications in HIV infection. In prevention, CRISPR/Cas strategies aim to hinder viral integration and enhance host immune response, although substantial development is required before clinical translation. In diagnosis, CRISPR/Cas methods show high specificity and sensitivity, yet their reliance on specialised equipment and expertise limits their accessibility. In HIV monitoring, CRISPR/Cas-based methods have not yet demonstrated superiority over the quantitative PCR. In treatment, two ongoing clinical trials - one targeting a viral co-receptor on hematopoietic stem cells (HSCs) and the other excising proviral DNA - illustrate the potential of CRISPR/Cas-mediated cures, despite challenges such as low editing efficiency and off-target effects. Overall, CRISPR/Cas technologies hold considerable promise for advancing HIV management, but issues of accessibility, affordability, and scalability must be addressed to ensure global impact.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":"1"},"PeriodicalIF":4.4,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycoplasma Genitalium - Where are we at? 生殖器支原体-我们在哪里？

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-12-24 DOI: 10.1007/s11904-025-00768-7

Catriona S Bradshaw, Kay Htaik, Ryan Horn, Lenka A Vodstrcil

引用次数: 0

Role of cccDNA in the Quest for HBV Cure- Implications for HIV-HBV Coinfection. cccDNA在寻求HBV治愈中的作用-对HIV-HBV合并感染的影响。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-12-17 DOI: 10.1007/s11904-025-00766-9

Guillaume Giraud, Barbara Testoni

引用次数: 0

The State of the Science on Chronic Comorbidities and Aging in Children and Adolescents with perinatally-acquired HIV. 围产期获得性艾滋病毒儿童和青少年慢性合并症和衰老的科学现状。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-12-06 DOI: 10.1007/s11904-025-00761-0

Modupe O Coker, Ryan Kreutzberg, Nadia A Sam-Agudu, Eilleen Macodiyo, Jibreel Jumare, Juliette Madan, Vaishali Singhal, Zhigang Li, Reuben Robbins, Stephanie Shiau

{"title":"The State of the Science on Chronic Comorbidities and Aging in Children and Adolescents with perinatally-acquired HIV.","authors":"Modupe O Coker, Ryan Kreutzberg, Nadia A Sam-Agudu, Eilleen Macodiyo, Jibreel Jumare, Juliette Madan, Vaishali Singhal, Zhigang Li, Reuben Robbins, Stephanie Shiau","doi":"10.1007/s11904-025-00761-0","DOIUrl":"10.1007/s11904-025-00761-0","url":null,"abstract":"The availability and global scale-up of suppressive antiretroviral therapy (ART) has transformed HIV from a fatal infection to a chronic disease. While long-term survival is a positive development for people living with HIV (PLWH), the increased life expectancy comes with age-related comorbidities. These comorbidities affect PLWH at relatively earlier ages than the general population, and examples include cardiometabolic conditions, renal toxicity, lung and respiratory dysfunction, neurocognitive deficits, malignancy, and oral/dental pathology. Anticipatory management of early markers of non-communicable diseases (NCDs) can be especially advantageous for children and adolescents with perinatally-acquired HIV (CAPHIV), the vast majority of whom live in low-and middle-income countries. However, evidence for the mechanisms underlying age-related comorbidities in PLWH and implications for CAPHIV represent a still-emerging area of investigation. In this article, we review the current literature on comorbidities and age-related conditions experienced by CAPHIV, discuss the role of inflammation and chronic immune activation, and highlight accelerated biological aging and/or disruptions to the microbiome as underlying mechanisms. We recommend that HIV clinical care and health policy should reflect evidence on aging and comorbidities to optimize growth, development, and long-term health for CAPHIV globally.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"56"},"PeriodicalIF":4.4,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12681470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytic Methods to Investigate HIV-Related Digital Communication: A Scoping Review. 研究hiv相关数字通信的分析方法：范围综述。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-11-13 DOI: 10.1007/s11904-025-00765-w

Parisa Ayoubi, Bailey Holmes Spencer, Ohemaa B Poku, Philip Kreniske, Michelle R Kaufman, Evan L Eschliman

{"title":"Analytic Methods to Investigate HIV-Related Digital Communication: A Scoping Review.","authors":"Parisa Ayoubi, Bailey Holmes Spencer, Ohemaa B Poku, Philip Kreniske, Michelle R Kaufman, Evan L Eschliman","doi":"10.1007/s11904-025-00765-w","DOIUrl":"10.1007/s11904-025-00765-w","url":null,"abstract":"Purpose of review: This scoping review aims to identify and characterize analytic methods used to investigate digital communication related to HIV.Recent findings: Of the 106 articles detailed in this review published before February 2025, just over half of the articles investigated HIV prevention, and the vast majority used social media data. Articles primarily employed qualitative methods, most often thematic analysis. Articles employing quantitative methods used a range of methods including topic modeling, training classifiers, and sentiment analysis. There were also many articles that employed both qualitative and quantitative methods. A wide range of methods have been employed to analyze HIV-related digital communication. As best practices continue to be established, future research can innovate in the application of both qualitative and quantitative methods, leverage digital communication to better understand lived experience of HIV treatment and HIV-related stigma, and ensure this research is done in accordance with high ethical standards.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"55"},"PeriodicalIF":4.4,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145502521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0