Current HIV/AIDS Reports最新文献

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Implementation Science of Integrating Pre-Exposure Prophylaxis in Pharmacist-Led Services in the United States. 美国将暴露前预防纳入药剂师主导服务的实施科学。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2024-08-01 Epub Date: 2024-05-22 DOI: 10.1007/s11904-024-00700-5
Christina Chandra, Alexis F Hudson, Daniel I Alohan, Henry N Young, Natalie D Crawford
{"title":"Implementation Science of Integrating Pre-Exposure Prophylaxis in Pharmacist-Led Services in the United States.","authors":"Christina Chandra, Alexis F Hudson, Daniel I Alohan, Henry N Young, Natalie D Crawford","doi":"10.1007/s11904-024-00700-5","DOIUrl":"10.1007/s11904-024-00700-5","url":null,"abstract":"<p><strong>Background: </strong>Racial inequities in HIV in the United States (US) are pervasive. Pre-exposure prophylaxis (PrEP) is one of the most effective yet underutilized HIV prevention strategies, and stark inequities in PrEP uptake exist. Lack of access to PrEP clinics is a major barrier to access that could be overcome by integrating pharmacists into the provision of PrEP services including prescribing and dispensing.</p><p><strong>Methods: </strong>A number of reviews have shown promise in folding pharmacies into the expansion of PrEP services, but this review extends those by examining the implementation science evidence of pharmacist-led PrEP services in the US. We reviewed literature over the past five years of the implementation science of pharmacist PrEP services (2018-2023) and present seminal findings in this area.</p><p><strong>Results: </strong>Only two studies are anchored within an implementation science framework despite all studies assessing common implementation science constructs. Overwhelming evidence supports feasibility and adoption of PrEP services in pharmacies yet gaps in workflow integration, scalability and sustainability exist.</p><p><strong>Conclusion: </strong>Continuing to build the implementation science evidence of pharmacy-based PrEP services is critical to standardize our measures across varying contexts and inform policy efforts that support pharmacy-based PrEP services.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"197-207"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and Opportunities in Big Data Science to Address Health Inequities and Focus the HIV Response. 大数据科学在解决健康不平等问题和集中应对艾滋病毒方面的挑战与机遇。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2024-08-01 Epub Date: 2024-06-25 DOI: 10.1007/s11904-024-00702-3
Katherine Rucinski, Jesse Knight, Kalai Willis, Linwei Wang, Amrita Rao, Mary Anne Roach, Refilwe Phaswana-Mafuya, Le Bao, Safiatou Thiam, Peter Arimi, Sharmistha Mishra, Stefan Baral
{"title":"Challenges and Opportunities in Big Data Science to Address Health Inequities and Focus the HIV Response.","authors":"Katherine Rucinski, Jesse Knight, Kalai Willis, Linwei Wang, Amrita Rao, Mary Anne Roach, Refilwe Phaswana-Mafuya, Le Bao, Safiatou Thiam, Peter Arimi, Sharmistha Mishra, Stefan Baral","doi":"10.1007/s11904-024-00702-3","DOIUrl":"10.1007/s11904-024-00702-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>Big Data Science can be used to pragmatically guide the allocation of resources within the context of national HIV programs and inform priorities for intervention. In this review, we discuss the importance of grounding Big Data Science in the principles of equity and social justice to optimize the efficiency and effectiveness of the global HIV response.</p><p><strong>Recent findings: </strong>Social, ethical, and legal considerations of Big Data Science have been identified in the context of HIV research. However, efforts to mitigate these challenges have been limited. Consequences include disciplinary silos within the field of HIV, a lack of meaningful engagement and ownership with and by communities, and potential misinterpretation or misappropriation of analyses that could further exacerbate health inequities. Big Data Science can support the HIV response by helping to identify gaps in previously undiscovered or understudied pathways to HIV acquisition and onward transmission, including the consequences for health outcomes and associated comorbidities. However, in the absence of a guiding framework for equity, alongside meaningful collaboration with communities through balanced partnerships, a reliance on big data could continue to reinforce inequities within and across marginalized populations.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"208-219"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Policies and Practices Facilitating Access to and Uptake of HIV Testing Services among Adolescents in Sub-Sahara Africa: A Narrative Review. 促进撒哈拉以南非洲青少年获得和接受 HIV 检测服务的政策与实践:叙述性综述》。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1007/s11904-024-00701-4
Dorothy Serwaa Boakye, Emmanuel Kumah, Samuel Adjorlolo
{"title":"Policies and Practices Facilitating Access to and Uptake of HIV Testing Services among Adolescents in Sub-Sahara Africa: A Narrative Review.","authors":"Dorothy Serwaa Boakye, Emmanuel Kumah, Samuel Adjorlolo","doi":"10.1007/s11904-024-00701-4","DOIUrl":"10.1007/s11904-024-00701-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Expanding access to HIV testing services and linking newly diagnosed positive adolescents to antiretroviral therapy is critical to epidemic control. However, testing coverage and treatment initiation rates continue to lag behind adult counterparts. This article synthesizes evidence on facilitative policies and service delivery practices focused on adolescents to inform programming.</p><p><strong>Recent findings: </strong>Our narrative review found that national policies are growing more adolescent-inclusive but barriers around the age of consent, waiver frameworks and dissemination constrain translate into practice. Facility-based provider-initiated testing through integrated sexual health services and dedicated youth centres demonstrates uptake effectiveness if confidentiality and youth-friendly adaptations are assured. Supportive policies, youth-responsive adaptations across testing models and strengthening age-disaggregated monitoring are vital to improving adolescents' engagement across the HIV testing and treatment cascade. Further implementation research is imperative to expand the reach of adolescent HIV testing in sub-Saharan Africa.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"220-236"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Getting HIV Pre-exposure Prophylaxis (PrEP) into Private Pharmacies: Global Delivery Models and Research Directions. 将艾滋病毒暴露前预防疗法(PrEP)引入私人药房:全球交付模式与研究方向》。
IF 3.7 2区 医学
Current HIV/AIDS Reports Pub Date : 2024-06-01 Epub Date: 2024-03-22 DOI: 10.1007/s11904-024-00696-y
Stephanie D Roche, Daniel Were, Natalie D Crawford, Angela Tembo, Jillian Pintye, Elizabeth Bukusi, Kenneth Ngure, Katrina F Ortblad
{"title":"Getting HIV Pre-exposure Prophylaxis (PrEP) into Private Pharmacies: Global Delivery Models and Research Directions.","authors":"Stephanie D Roche, Daniel Were, Natalie D Crawford, Angela Tembo, Jillian Pintye, Elizabeth Bukusi, Kenneth Ngure, Katrina F Ortblad","doi":"10.1007/s11904-024-00696-y","DOIUrl":"10.1007/s11904-024-00696-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>To provide an overview of the current state of HIV pre-exposure prophylaxis (PrEP) delivery via private sector pharmacies globally, to discuss the context-specific factors that have influenced the design and implementation of different pharmacy-based PrEP delivery models in three example settings, and to identify future research directions.</p><p><strong>Recent findings: </strong>Multiple high- and low-income countries are implementing or pilot testing PrEP delivery via private pharmacies using a variety of delivery models, tailored to the context. Current evidence indicates that pharmacy-based PrEP services are in demand and generally acceptable to clients and pharmacy providers. Additionally, the evidence suggests that with proper training and oversight, pharmacy providers are capable of safely initiating and managing clients on PrEP. The delivery of PrEP services at private pharmacies also achieves similar levels of PrEP initiation and continuation as traditional health clinics, but additionally reach individuals underserved by such clinics (e.g., young men; minorities), making pharmacies well-positioned to increase overall PrEP coverage. Implementation of pharmacy-based PrEP services will look different in each context and depend not only on the state of the private pharmacy sector, but also on the extent to which key needs related to governance, financing, and regulation are addressed. Private pharmacies are a promising delivery channel for PrEP in diverse settings. Countries with robust private pharmacy sectors and populations at HIV risk should focus on aligning key areas related to governance, financing, and regulation that have proven critical to pharmacy-based PrEP delivery while pursuing an ambitious research agenda to generate information for decision-making. Additionally, the nascency of pharmacy-based PrEP delivery in both high- and low-and-middle-income settings presents a prime opportunity for shared learning and innovation.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"116-130"},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140189580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital Strategies Supporting Social Network Approaches to HIV Testing: A Scoping Review. 支持艾滋病毒检测社交网络方法的数字战略:范围审查。
IF 4.6 2区 医学
Current HIV/AIDS Reports Pub Date : 2024-06-01 Epub Date: 2024-05-11 DOI: 10.1007/s11904-024-00699-9
Zhuoheng Yin, Yumeng Du, Weibin Cheng, Weiming Tang
{"title":"Digital Strategies Supporting Social Network Approaches to HIV Testing: A Scoping Review.","authors":"Zhuoheng Yin, Yumeng Du, Weibin Cheng, Weiming Tang","doi":"10.1007/s11904-024-00699-9","DOIUrl":"10.1007/s11904-024-00699-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review captured how digital strategies support social network approaches to promote HIV testing.</p><p><strong>Recent finding: </strong>Overall, 29 studies were identified by searching PubMed and Embase for studies published up to June 2023. Existing studies revealed three types of digital strategies (social media (n = 28), online information channels (n = 4), and multifunctional digital platforms (n = 4)) split into four major modes of digital strategy-supported social-network-based HIV testing promotion: 1) Online outreach and recruiting, 2) gathering and identifying key populations for HIV testing, 3) communicating and disseminating online HIV testing health interventions, and 4) assisting and facilitating HIV testing uptake and distribution. Social network approaches supported by digital strategies yielded advantages in HIV testing education and distribution, which increases HIV testing coverage among key populations. Studies are needed on how to facilitate the use of digital strategies for social network-based HIV testing, as well as how to integrate them with existing HIV testing approaches.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"168-195"},"PeriodicalIF":4.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140908411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic Controls for Implementation Science: Opportunities for HIV Program Evaluation Using Routinely Collected Data. 实施科学的合成控制:利用常规收集的数据进行艾滋病项目评估的机会。
IF 4.6 2区 医学
Current HIV/AIDS Reports Pub Date : 2024-06-01 Epub Date: 2024-03-13 DOI: 10.1007/s11904-024-00695-z
Sara Wallach, Suzue Saito, Harriet Nuwagaba-Biribonwoha, Lenhle Dube, Matthew R Lamb
{"title":"Synthetic Controls for Implementation Science: Opportunities for HIV Program Evaluation Using Routinely Collected Data.","authors":"Sara Wallach, Suzue Saito, Harriet Nuwagaba-Biribonwoha, Lenhle Dube, Matthew R Lamb","doi":"10.1007/s11904-024-00695-z","DOIUrl":"10.1007/s11904-024-00695-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>HIV service delivery programs are some of the largest funded public health programs in the world. Timely, efficient evaluation of these programs can be enhanced with methodologies designed to estimate the effects of policy. We propose using the synthetic control method (SCM) as an implementation science tool to evaluate these HIV programs.</p><p><strong>Recent findings: </strong>SCM, introduced in econometrics, shows increasing utility across fields. Key benefits of this methodology over traditional design-based approaches for evaluation stem from directly approximating pre-intervention trends by weighting of candidate non-intervention units. We demonstrate SCM to evaluate the effectiveness of a public health intervention targeting HIV health facilities with high numbers of recent infections on trends in pre-exposure prophylaxis (PrEP) enrollment. This test case demonstrates SCM's feasibility for effectiveness evaluations of site-level HIV interventions. HIV programs collecting longitudinal, routine service delivery data for many facilities, with only some receiving a time-specified intervention, are well-suited for evaluation using SCM.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"140-151"},"PeriodicalIF":4.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11129924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140118984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies 使用大麻对 HIV 感染者认知能力的影响:来自临床和临床前研究的功能依赖效应和机制证据
IF 4.6 2区 医学
Current HIV/AIDS Reports Pub Date : 2024-04-11 DOI: 10.1007/s11904-024-00698-w
Samantha M. Ayoub, Breanna M. Holloway, Alannah H. Miranda, Benjamin Z. Roberts, Jared W. Young, Arpi Minassian, Ronald J. Ellis
{"title":"The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies","authors":"Samantha M. Ayoub, Breanna M. Holloway, Alannah H. Miranda, Benjamin Z. Roberts, Jared W. Young, Arpi Minassian, Ronald J. Ellis","doi":"10.1007/s11904-024-00698-w","DOIUrl":"https://doi.org/10.1007/s11904-024-00698-w","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3><p>Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population’s high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable to the deleterious effects of cannabis on cognition. Here, we present a systematic scoping review of clinical and preclinical studies evaluating the effects of cannabinoid exposure on cognition in HIV.</p><h3 data-test=\"abstract-sub-heading\">Recent Findings</h3><p>Results revealed little evidence to support a harmful impact of cannabis use on cognition in HIV, with few eligible preclinical data existing. Furthermore, the beneficial/harmful effects of cannabis use observed on cognition were function-dependent and confounded by several factors (e.g., age, frequency of use).</p><h3 data-test=\"abstract-sub-heading\">Summary</h3><p>Results are discussed alongside potential mechanisms of cannabis effects on cognition in HIV (e.g., anti-inflammatory), and considerations are outlined for screening PWH that may benefit from cannabis interventions. We further highlight the value of accelerating research discoveries in this area by utilizing translatable cross-species tasks to facilitate comparisons across human and animal work.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"305 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 5-Year Review of the Impact of Lottery Incentives on HIV-Related Services 彩票奖励对艾滋病相关服务影响的五年回顾
IF 4.6 2区 医学
Current HIV/AIDS Reports Pub Date : 2024-04-04 DOI: 10.1007/s11904-024-00694-0
{"title":"A 5-Year Review of the Impact of Lottery Incentives on HIV-Related Services","authors":"","doi":"10.1007/s11904-024-00694-0","DOIUrl":"https://doi.org/10.1007/s11904-024-00694-0","url":null,"abstract":"<h3>Abstract</h3> <span> <h3>Purpose of review</h3> <p>Lottery incentives are an innovative approach to encouraging HIV prevention, treatment initiation, and adherence behaviours. This paper reviews the latest research on lottery incentives’ impact on HIV-related services, and their effectiveness for motivating behaviours to improve HIV service engagement and HIV health outcomes.</p> </span> <span> <h3>Recent findings</h3> <p>Our review of ten articles, related to lottery incentives, published between 2018 and 2023 (inclusive) shows that lottery incentives have promise for promoting HIV-related target behaviours. The review highlights that lottery incentives may be better for affecting simpler behaviours, rather than more complex ones, such as voluntary medical male circumcision. This review recommends tailoring lottery incentives, ensuring contextual-relevance, to improve the impact on HIV-related services.</p> </span> <span> <h3>Summary</h3> <p>Lottery incentives offer tools for improving uptake of HIV-related services. The success of lottery incentives appears to be mediated by context, the value and nature of the incentives, and the complexity of the target behaviour.</p> </span>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"50 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex Decisions in HIV-Related Cryptococcosis: Addressing Second Episodes of Cryptococcal Meningitis. 艾滋病相关隐球菌病的复杂决策:应对隐球菌性脑膜炎的二次发作。
IF 4.6 2区 医学
Current HIV/AIDS Reports Pub Date : 2024-04-01 Epub Date: 2024-02-24 DOI: 10.1007/s11904-024-00691-3
Abdu Musubire, Enock Kagimu, Timothy Mugabi, David B Meya, David R Boulware, Nathan C Bahr
{"title":"Complex Decisions in HIV-Related Cryptococcosis: Addressing Second Episodes of Cryptococcal Meningitis.","authors":"Abdu Musubire, Enock Kagimu, Timothy Mugabi, David B Meya, David R Boulware, Nathan C Bahr","doi":"10.1007/s11904-024-00691-3","DOIUrl":"10.1007/s11904-024-00691-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review highlights the difficulties in diagnosing and treating persons with a prior history of cryptococcal meningitis who improve but suffer from a recurrence of symptoms. This scenario is well known to those who frequently care for patients with cryptococcal meningitis but is not well understood. We highlight major gaps in knowledge.</p><p><strong>Recent findings: </strong>We recently summarized our experience with 28 persons with paradoxical immune reconstitution inflammatory syndrome (IRIS) and 81 persons with microbiological relapse. CD4 count and cerebrospinal fluid white blood cell count were higher in IRIS than relapse but neither was reliable enough to routinely differentiate these conditions. Second-episode cryptococcal meningitis remains a difficult clinical scenario as cryptococcal antigen, while excellent for initial diagnosis has no value in differentiating relapse of infection from other causes of recurrent symptoms. Updated research definitions are proposed and rapid, accurate diagnostic tests are urgently needed.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"75-85"},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HIV-1 Myeloid Reservoirs - Contributors to Viral Persistence and Pathogenesis. HIV-1 髓细胞储库--病毒持续存在和发病机制的贡献者。
IF 4.6 2区 医学
Current HIV/AIDS Reports Pub Date : 2024-04-01 Epub Date: 2024-02-27 DOI: 10.1007/s11904-024-00692-2
Edna A Ferreira, Janice E Clements, Rebecca T Veenhuis
{"title":"HIV-1 Myeloid Reservoirs - Contributors to Viral Persistence and Pathogenesis.","authors":"Edna A Ferreira, Janice E Clements, Rebecca T Veenhuis","doi":"10.1007/s11904-024-00692-2","DOIUrl":"10.1007/s11904-024-00692-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>HIV reservoirs are the main barrier to cure. CD4+ T cells have been extensively studied as the primary HIV-1 reservoir. However, there is substantial evidence that HIV-1-infected myeloid cells (monocytes/macrophages) also contribute to viral persistence and pathogenesis.</p><p><strong>Recent findings: </strong>Recent studies in animal models and people with HIV-1 demonstrate that myeloid cells are cellular reservoirs of HIV-1. HIV-1 genomes and viral RNA have been reported in circulating monocytes and tissue-resident macrophages from the brain, urethra, gut, liver, and spleen. Importantly, viral outgrowth assays have quantified persistent infectious virus from monocyte-derived macrophages and tissue-resident macrophages. The myeloid cell compartment represents an important target of HIV-1 infection. While myeloid reservoirs may be more difficult to measure than CD4+ T cell reservoirs, they are long-lived, contribute to viral persistence, and, unless specifically targeted, will prevent an HIV-1 cure.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":" ","pages":"62-74"},"PeriodicalIF":4.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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