Current HIV/AIDS Reports最新文献_第3页

To Switch or not to Switch: are there any Antiretroviral Strategies to Attenuate Weight Gain in People with HIV? 切换还是不切换：是否有抗逆转录病毒策略可以减轻艾滋病毒感染者的体重增加？

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-03-25 DOI: 10.1007/s11904-026-00782-3

Paula Debroy, Jordan E Lake

引用次数: 0

T-Cell Profiles in HBV Functional Cure and People Living With HIV: Known Knowns, Known Unknowns, and Unknown Unknowns. HBV功能性治愈和HIV感染者的t细胞谱：已知的已知，已知的未知，和未知的未知。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-03-21 DOI: 10.1007/s11904-026-00777-0

Martin Feuerherd, Jasmin Mischke, Georg M Lauer

{"title":"T-Cell Profiles in HBV Functional Cure and People Living With HIV: Known Knowns, Known Unknowns, and Unknown Unknowns.","authors":"Martin Feuerherd, Jasmin Mischke, Georg M Lauer","doi":"10.1007/s11904-026-00777-0","DOIUrl":"10.1007/s11904-026-00777-0","url":null,"abstract":"PURPOSE OF REVIEW: HIV further complicates the already complex clinical course of chronic HBV infection. Here we present a personal view of the current state of HBV-specific T-cell immunology and key questions about how T-cell immunity is altered during HBV/HIV co-infection. RECENT FINDINGS: While HIV usually exacerbates liver disease and increases mortality, higher rates of HBV functional cure – defined as HBsAg loss – are observed after initiation of antiretroviral therapy compared to HBV monoinfection. This creates an exciting opportunity to observe the mechanisms of HBV control during treatment induced immune reconstitution in real time. We discuss how HIV-induced immune CD4 depletion and altered CD8 T-cell differentiation might intersect in distinct ways with the complex natural history of chronic hepatitis B and the different scenarios of co-infection. We also propose how innovative T-cell studies applied to well-designed prospective co-infection cohorts could dramatically enhance our insights into the mechanisms of HBV control and persistence and inform development of novel immunotherapies for people living with HBV and HIV. ","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytomegalovirus in HIV: A Modifiable Driver of Inflammation, Frailty, and Aging. HIV中的巨细胞病毒：炎症、虚弱和衰老的可改变驱动因素。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-03-20 DOI: 10.1007/s11904-026-00775-2

Alfonso Cabello Ubeda, Kristine M Erlandson, Michael L Freeman, Scott L Letendre, Celestine N Wanjalla, John R Koethe, Michael J Corley, Peter W Hunt, Sara Gianella

{"title":"Cytomegalovirus in HIV: A Modifiable Driver of Inflammation, Frailty, and Aging.","authors":"Alfonso Cabello Ubeda, Kristine M Erlandson, Michael L Freeman, Scott L Letendre, Celestine N Wanjalla, John R Koethe, Michael J Corley, Peter W Hunt, Sara Gianella","doi":"10.1007/s11904-026-00775-2","DOIUrl":"10.1007/s11904-026-00775-2","url":null,"abstract":"PURPOSE: Cytomegalovirus (CMV) infection is nearly universal among people with HIV (PWH) and contributes to chronic inflammation, immune senescence, and accelerated biological aging despite suppressive antiretroviral therapy (ART). This review summarizes recent advances in understanding the role of CMV in multimorbidity and aging in PWH, focusing on immune and tissue-based mechanisms, comorbidities, and emerging interventions. RECENT FINDINGS: CMV reactivation drives clonal T-cell expansion, innate immune reprogramming, adipose tissue inflammation, metabolic rewiring, and durable cellular epigenetic changes that amplify risks for vascular disease, frailty, brain health disorders, diabetes mellitus, and cancer. Early interventional data indicate that letermovir can reduce inflammation and improve immune and frailty outcomes in PWH, while vaccines are advancing in clinical evaluation. CMV is a modifiable driver of immune dysfunction and aging in PWH. Targeted antiviral, vaccine, and host-directed approaches may reduce multimorbidity and promote healthy aging, particularly in populations at greatest risk. ","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Timing and Duration of ART on the Composition of HIV Reservoirs: Implications for HIV Cure Strategies. 抗逆转录病毒治疗的时间和持续时间对HIV病毒库组成的影响：对HIV治愈策略的影响。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-03-20 DOI: 10.1007/s11904-026-00778-z

Sukeshani Salwe, Ashwini Shete

{"title":"Effect of Timing and Duration of ART on the Composition of HIV Reservoirs: Implications for HIV Cure Strategies.","authors":"Sukeshani Salwe, Ashwini Shete","doi":"10.1007/s11904-026-00778-z","DOIUrl":"10.1007/s11904-026-00778-z","url":null,"abstract":"Purpose of review: Antiretroviral therapy (ART) has transformed HIV from a fatal disease into a manageable condition by effectively suppressing viral replication. However, ART does not eradicate HIV due to the persistence of latent reservoirs-mainly replication-competent proviruses in resting CD4⁺ T cells and tissue sanctuaries-that reignite infection upon treatment interruption. This review examines how ART timing and duration influence the size, composition, and stability of the HIV reservoir.Recent findings: Initiating ART during acute infection limits reservoir seeding, reduces genetic diversity, and promotes faster decay of intact proviruses compared to delayed ART, which permits widespread viral integration into long-lived memory T cells and clonal expansion of replication-competent viruses. Anatomical sites such as lymph nodes, gut-associated lymphoid tissue, and the central nervous system act as critical reservoir niches. These insights are central to current HIV cure efforts, which aim for either a sterilizing cure (complete eradication of the virus) or a functional cure (durable remission without ART). Cure strategies-such as \"shock-and-kill,\"\"block-and-lock,\" gene editing, and immunotherapy-are being optimized based on reservoir dynamics. Evidence suggests that early-treated individuals, with smaller and more homogeneous reservoirs, are better candidates for these interventions. Although no strategy has yet achieved a cure, combining early ART with targeted interventions may improve outcomes. Understanding how ART influences reservoir dynamics is essential for developing effective HIV cure strategies. We emphasize the importance of prioritizing early-treated individuals in cure trials and advocate for integrated therapeutic approaches to achieve lasting viral remission or complete eradication.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity and Weight Management in HIV: Epidemiology, Complications, and Emerging Treatments. HIV的肥胖和体重管理：流行病学、并发症和新兴治疗方法。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-02-24 DOI: 10.1007/s11904-026-00776-1

Luke Pryke, John R Koethe, Samuel Bailin

{"title":"Obesity and Weight Management in HIV: Epidemiology, Complications, and Emerging Treatments.","authors":"Luke Pryke, John R Koethe, Samuel Bailin","doi":"10.1007/s11904-026-00776-1","DOIUrl":"10.1007/s11904-026-00776-1","url":null,"abstract":"Purpose of review: People living with HIV (PLWH) on contemporary antiretroviral therapy experience high rates of overweight/obesity, which predisposes to cardiometabolic disease and multiple other conditions with negative health consequences in this aging population. We aim to summarize the epidemiology and pathophysiology of obesity in PLWH and review recent advances in the therapeutic management of obesity.Recent findings: The prevalence of overweight/obesity in PLWH mirrors long-standing trends in the general population. Obesity and weight gain have a complex, multifactorial pathogenesis and directly mediate detrimental metabolic changes that are common in PLWH. While lifestyle changes are important, surgical weight loss and recent advances in medical therapeutics are more effective at reducing obesity and obesity-related complications. Obesity in PLWH substantially increases the risk for cardiometabolic complications and poor health outcomes. Surgical and medical weight loss interventions are effective treatments to reduce obesity and obesity-related complications, though further research in PLWH is needed to define optimal management.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12932276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic CD4 T Cells: Dual Agents in HIV-1 Pathogenesis and Persistence. 细胞毒性CD4 T细胞：HIV-1发病机制和持久性的双重因素。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-02-16 DOI: 10.1007/s11904-026-00773-4

Kaylee L Mickens, Stephanie M Dillon, Kejun Guo, Cara C Wilson, Mario L Santiago

{"title":"Cytotoxic CD4 T Cells: Dual Agents in HIV-1 Pathogenesis and Persistence.","authors":"Kaylee L Mickens, Stephanie M Dillon, Kejun Guo, Cara C Wilson, Mario L Santiago","doi":"10.1007/s11904-026-00773-4","DOIUrl":"10.1007/s11904-026-00773-4","url":null,"abstract":"PURPOSE OF REVIEW: Cytotoxic CD4 T cells (CD4 CTL) have long been recognized for their potentially protective role in people with HIV, but only recently have their contributions in HIV-1 pathogenesis and viral persistence been appreciated. This review summarizes evidence highlighting their critical role in HIV-1-mediated CD4 T cell depletion and in maintaining the viral reservoir, with special consideration for their abundance and development in the gut. RECENT FINDINGS: CD4 CTL are increased in frequency in people with HIV (PWH). Granzyme B activity in CD4 CTL promotes HIV-1 mediated death of gut CD4 T cells. CD4 CTL that express survival markers such as BCL-2, TNFR2/CD120b, and OX40 appear to resist HIV-1 mediated cell death, potentially contributing to the viral reservoir. Multiple cytokine (IL-2, IL-15) and transcriptional (BACH2, EOMES) pathways were implicated in CD4 CTL differentiation and maintenance. In the gut, CD4 CTL activity appears to be intricately linked to the microbiome, as cytotoxic protein expression can develop in response to bacterial exposure. CD4 CTL from the gut, induced by the presence of bacteria in vitro, are highly infectable by HIV-1. CD4 CTL may act as dual agents in HIV-1 infection, amplifying tissue damage and serving as resilient cellular reservoirs. Understanding the mechanisms regulating their differentiation, cytotoxicity, and survival could inform new therapeutic strategies aimed at restoring gut mucosal integrity, resolving chronic inflammation, and targeting the persistent HIV-1 reservoir. ","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":"5"},"PeriodicalIF":4.4,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12909476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adolescent and Young Adult Leadership and Engagement in HIV Strategy and Policy Development: Experiences from the UNICEF/WHO/UNAIDS Blueprint Collaborative. 青少年和青年在艾滋病毒战略和政策制定方面的领导和参与：来自儿童基金会/世卫组织/艾滋病规划署蓝图合作的经验。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-02-14 DOI: 10.1007/s11904-026-00774-3

Dorian Ho, Takhona Hlatshwako, Kelechi P Chima, Yusha Tao, Chisom Obiezu-Umeh, Ifeoma Obionu, Susan Vorkoper, Rachel Sturke, Juliet Lwelunmor, Damilola Walker, Joseph D Tucker

{"title":"Adolescent and Young Adult Leadership and Engagement in HIV Strategy and Policy Development: Experiences from the UNICEF/WHO/UNAIDS Blueprint Collaborative.","authors":"Dorian Ho, Takhona Hlatshwako, Kelechi P Chima, Yusha Tao, Chisom Obiezu-Umeh, Ifeoma Obionu, Susan Vorkoper, Rachel Sturke, Juliet Lwelunmor, Damilola Walker, Joseph D Tucker","doi":"10.1007/s11904-026-00774-3","DOIUrl":"10.1007/s11904-026-00774-3","url":null,"abstract":"Purpose of review: Adolescents and young adults (AYA) face disproportionately worse outcomes along the HIV prevention and care continuum. Despite global commitments to AYA engagement, AYA remain underrepresented in research, programming, and policy development. We summarize recent innovations in AYA engagement within the HIV literature and reflect on the 2023 Blueprint Collaborative, a UNICEF/WHO/UNAIDS initiative where AYA (ages 10-30) shaped global adolescent HIV strategy.Recent findings: Our review found examples of AYA engagement across the intervention life cycle, including in shaping research agendas, designing interventions, and building AYA capacity for sustainability. For the Blueprint Collaborative, which featured a AYA-led evidence synthesis and global open call, we assessed AYA engagement using the RIGHTS framework. A major strength of the Blueprint Collaborative was the robust AYA engagement, moving beyond AYA consultations to AYA leadership. AYA shared decision-making authority with adults as researchers, organizers, and open call judges. Through a \"learning by doing\" approach, AYA gained skills in research and multidisciplinary collaboration. Blueprint results were presented to senior leadership, developed into strategy, and disseminated through publications and AYA networks. AYA leadership can provide several benefits for AYA research and programming, such as institutionalizing community engagement, improving research relevance, and advancing equity. AYA are eager and capable of driving HIV strategy and policy, but senior partners should step back to enable these opportunities. Senior partners might better serve to support AYA leadership in strategic planning to align programming with AYA priorities and build research and advocacy skills.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":"4"},"PeriodicalIF":4.4,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpes Simplex Virus Type 2 Screening in Persons with and Without HIV: Evidence, Challenges, and Future Directions. 单纯疱疹病毒2型筛查的人与没有艾滋病毒：证据，挑战，和未来的方向。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-02-02 DOI: 10.1007/s11904-026-00771-6

Laith J Abu-Raddad, Hiam Chemaitelly, Anna Wald, Christine Johnston

{"title":"Herpes Simplex Virus Type 2 Screening in Persons with and Without HIV: Evidence, Challenges, and Future Directions.","authors":"Laith J Abu-Raddad, Hiam Chemaitelly, Anna Wald, Christine Johnston","doi":"10.1007/s11904-026-00771-6","DOIUrl":"10.1007/s11904-026-00771-6","url":null,"abstract":"PURPOSE OF REVIEW: Herpes simplex virus type 2 (HSV-2) infection is one of the most prevalent sexually transmitted infections worldwide, with implications for HIV acquisition, transmission, and disease progression. This review synthesizes current evidence and guidance on HSV-2 serologic screening, emphasizing its relevance for HIV prevention and care. RECENT FINDINGS: International guidelines advise against routine general population-level serologic screening for HSV-2 in asymptomatic persons. Key limitations include poor test specificity, the absence of potent antivirals or therapeutic vaccines, lack of curative therapy, no demonstrated population-level benefit, and psychosocial harms associated with diagnosis. Current practice instead emphasizes diagnostic testing in symptomatic persons and targeted screening in defined contexts—such as among people with HIV in specific clinical situations, sex partners of those with HSV-2 infection, certain pregnant women, persons seeking sexual health care, and persons with recurrent or atypical symptoms—where results may directly inform management. Emerging technologies, including highly specific assays, novel potent antivirals, therapeutic vaccines, and curative strategies, may eventually shift the cost–benefit balance of general screening. Evidence supports targeted rather than general population-level screening to maximize clinical benefit while minimizing harm. New evidence demonstrating that interventions can achieve measurable population-level reductions in disease burden or transmission, together with future advances in diagnostics and therapeutics, may eventually justify integrating routine HSV-2 screening into broader contexts, including into HIV prevention and care. ","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":"3"},"PeriodicalIF":4.4,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12864370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geospatial Approaches to HIV Care: a Scoping Review of Asset Mapping. 艾滋病毒护理的地理空间方法：资产映射的范围审查。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-01-19 DOI: 10.1007/s11904-025-00770-z

Karin Tobin, Abigail Winiker, Sara Bartlett, Connor Volpi

{"title":"Geospatial Approaches to HIV Care: a Scoping Review of Asset Mapping.","authors":"Karin Tobin, Abigail Winiker, Sara Bartlett, Connor Volpi","doi":"10.1007/s11904-025-00770-z","DOIUrl":"10.1007/s11904-025-00770-z","url":null,"abstract":"Purpose of review: Asset mapping aims to engage members of a community to explore and map assets that are solutions to social issues such as homelessness or access to health care. The purpose of this scoping review was to determine the scope of asset mapping as an approach to HIV care cascade outcomes, synthesize available evidence on this method's application in research, and identify opportunities for future interventions and research based in this methodology. This scoping review follows the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for Scoping Reviews checklist. Databases used were: PubMed, CINAHL, EMBASE, and Scopus. Only articles featuring studies targeting the HIV care cascade were included. Our focus was studies that explored, described, or mapped tangible or intangible assets, employed a strengths-based approach, and addressed capacity to develop solutions. Several researchers independently reviewed all abstracts and full text articles.Recent findings: A total of 305 articles were found. After removal of duplicates, 207 articles remained. From the title and abstract review, 189 articles (91%) were excluded, leaving 18 studies to be assessed for inclusion. Of these, 10 studies were included. Five studies intentionally conducted asset mapping and 5 were not intentional but results revealed assets. Tangible assets included churches, transportation routes, libraries, and parks. Intangible assets included strengthening health routines, self-reflection, social relationships, and community engagement. Future research should shift to methods that identify strengths and assets of communities affected by HIV and AIDS.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":"2"},"PeriodicalIF":4.4,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145997380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR Applications in HIV Management - Prevention, Diagnosis, Monitoring and Treatment. CRISPR在HIV管理中的应用——预防、诊断、监测和治疗。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2026-01-12 DOI: 10.1007/s11904-025-00769-6

Bárbara S Marques, Carla Vitorino, Fátima V Ventura

{"title":"CRISPR Applications in HIV Management - Prevention, Diagnosis, Monitoring and Treatment.","authors":"Bárbara S Marques, Carla Vitorino, Fátima V Ventura","doi":"10.1007/s11904-025-00769-6","DOIUrl":"10.1007/s11904-025-00769-6","url":null,"abstract":"Despite global efforts to combat the human immunodeficiency virus (HIV) epidemic, acquired immunodeficiency syndrome (AIDS) still claims one life every minute, underscoring the persistent need for improved control strategies. Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated protein (Cas) technologies have emerged as promising tools that may transform HIV management. The objective of this review is to summarise recent advancements in CRISPR/Cas-based approaches for HIV prevention, diagnosis, monitoring, and treatment, and to evaluate their potential and current challenges. A systematic literature search was conducted to identify relevant CRISPR/Cas applications in HIV infection. In prevention, CRISPR/Cas strategies aim to hinder viral integration and enhance host immune response, although substantial development is required before clinical translation. In diagnosis, CRISPR/Cas methods show high specificity and sensitivity, yet their reliance on specialised equipment and expertise limits their accessibility. In HIV monitoring, CRISPR/Cas-based methods have not yet demonstrated superiority over the quantitative PCR. In treatment, two ongoing clinical trials - one targeting a viral co-receptor on hematopoietic stem cells (HSCs) and the other excising proviral DNA - illustrate the potential of CRISPR/Cas-mediated cures, despite challenges such as low editing efficiency and off-target effects. Overall, CRISPR/Cas technologies hold considerable promise for advancing HIV management, but issues of accessibility, affordability, and scalability must be addressed to ensure global impact.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"23 1","pages":"1"},"PeriodicalIF":4.4,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0