Current HIV/AIDS Reports最新文献_第3页

An Integrative Review of PrEP Promotion Strategies at Historically Black Colleges and Universities To Reduce HIV Disparities. 传统黑人学院和大学PrEP推广策略的综合评价，以减少艾滋病毒差异。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-11-10 DOI: 10.1007/s11904-025-00764-x

Deja Knight, James Gilbreath, Tiara C Willie, Jessica Corcoran

{"title":"An Integrative Review of PrEP Promotion Strategies at Historically Black Colleges and Universities To Reduce HIV Disparities.","authors":"Deja Knight, James Gilbreath, Tiara C Willie, Jessica Corcoran","doi":"10.1007/s11904-025-00764-x","DOIUrl":"10.1007/s11904-025-00764-x","url":null,"abstract":"Purpose of review: We searched PubMed, CINAHL Plus, Embase, Scopus, Web of Science, and ERIC to identify peer-reviewed studies published between 2015 and 2025 that discussed PrEP at HBCUs. We sought to examine PrEP research, with a focus on PrEP implementation strategies, at HBCUs. Two authors reviewed titles, abstracts, and full texts against the inclusion criteria. Six articles were included in this review.Recent findings: Two studies focused on formative PrEP research, two on organizational readiness, and three on post-implementation outcomes. Formative research showed PrEP is acceptable to HBCU students, though barriers like stigma and side effects, along with facilitators such as personal PrEP stories, impact intention. Organizational readiness to implement PrEP varied, with resource levels affecting implementation. Despite challenges, PrEP interventions were shown to be effective at increasing PrEP knowledge and behavioral intention. There is a need to enhance PrEP implementation at HBCUs, while considering varying campus resources.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"54"},"PeriodicalIF":4.4,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Envisioning a Multidisciplinary HBV Cure Research Agenda. 设想一个多学科HBV治疗研究议程。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-11-08 DOI: 10.1007/s11904-025-00763-y

Karine Dubé, Ali Ahmed, Chari Cohen, Yasmin Ibrahim, George A Yendewa, Edward R Cachay, Su Wang, Kristen Marks, Arthur Y Kim, Jeremy Sugarman, David L Thomas, Chloe L Thio, Debika Bhattacharya

引用次数: 0

Growing Up with HIV: A Comprehensive Review of Treatment and Care in Low- and Middle-Income Countries. 与艾滋病毒一起成长：低收入和中等收入国家治疗和护理的全面审查。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-11-07 DOI: 10.1007/s11904-025-00762-z

Brigid E O'Brien, Elizabeth Maidl, Jacob L Todd, Miriam Abadie, Moses Mugerwa, Katherine R Simon, Sarah Perry

{"title":"Growing Up with HIV: A Comprehensive Review of Treatment and Care in Low- and Middle-Income Countries.","authors":"Brigid E O'Brien, Elizabeth Maidl, Jacob L Todd, Miriam Abadie, Moses Mugerwa, Katherine R Simon, Sarah Perry","doi":"10.1007/s11904-025-00762-z","DOIUrl":"10.1007/s11904-025-00762-z","url":null,"abstract":"Purpose of review: Despite declining numbers of new pediatric HIV infections and advancements in treatment for children and adolescents living with HIV (CALHIV), barriers remain. Comprehensive care for CALHIV in low- and middle-income countries is challenged by limited treatment options, unique psychosocial challenges, and caregiver reliance. Successful care relies on understanding the unique developmental needs, as well as their vulnerabilities to treatment failure and HIV drug resistance.Recent findings: CALHIV lag behind adults in meeting global UNAIDS targets. Increasing availability of pediatric fixed dose combinations (FDC) of abacavir/lamivudine/dolutegravir (ABC/3TC/DTG) may address some challenges but providing alternatives should be prioritized. Emerging evidence has demonstrated pre-treatment and acquired HIV drug resistance (HIVDR) are more prevalent in CALHIV. While novel therapies are in development, access remains a concern. Increased child and adolescent-friendly treatment options are needed to provide quality life-long comprehensive care to CALHIV in low- and middle-income countries (LMIC). Expanded research and access to novel therapies is key to close treatment gaps between CALHIV and their adult counterparts and address emerging HIV drug resistance.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"52"},"PeriodicalIF":4.4,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between Neuroimaging Measures and Cognitive Performance in Children, Adolescents, and Youth Living With HIV-a Systematic Review. 儿童、青少年和青少年艾滋病毒感染者的神经影像学测量与认知表现之间的关系——系统综述。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-11-03 DOI: 10.1007/s11904-025-00760-1

Isaac L Khobo, Frances C Robertson, Barbara Laughton, Ernesta M Meintjes

引用次数: 0

Human Immunodeficiency Virus and Hepatitis B Virus Co-infection in Pregnancy: A Review. 妊娠期人类免疫缺陷病毒和乙型肝炎病毒合并感染：综述。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-10-27 DOI: 10.1007/s11904-025-00759-8

Alison Craik, Rebecca Scott, Eleanor Hamlyn

{"title":"Human Immunodeficiency Virus and Hepatitis B Virus Co-infection in Pregnancy: A Review.","authors":"Alison Craik, Rebecca Scott, Eleanor Hamlyn","doi":"10.1007/s11904-025-00759-8","DOIUrl":"10.1007/s11904-025-00759-8","url":null,"abstract":"Purpose of the review: This article presents an overview of the global consensus of the management of pregnant women living with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infection. We summarise findings from the most recent and relevant literature on this topic with a focus on epidemiology, obstetric and pharmacological management and neonatal care.Recent findings: Guidelines have been revised to reflect the most recent evidence published on the safety and efficacy of both dolutegravir and tenofovir alafenamide in pregnancy. There are encouraging data to suggest that obstetric outcomes in women with HIV/HBV co-infection are comparable to those with HIV or HBV mono-infection. Recent advances in our understanding of the safety profile and efficacy of tenofovir disoproxil/alafenamide and dolutegravir has resulted in these being recommended as first line antiretrovirals, alongside Lamivudine, for HIV/HBV co-infection in pregnancy in United Kingdom, European and the United States guidelines. Appropriate antiretroviral therapy in pregnancy, along with prompt treatment of the neonate, combine to ensure very low rates of perinatal transmission of both HIV and HBV.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"50"},"PeriodicalIF":4.4,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Interventions for Stimulant Use Among People Living with HIV: A Narrative Review. 艾滋病毒感染者兴奋剂使用的数字干预：叙述回顾。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-10-13 DOI: 10.1007/s11904-025-00758-9

Michael P Barry, Francis A Slaughter, Ann E Richey, Neil Gleason, Nicky Cotta, Kaitlin A Zinsli

{"title":"Digital Interventions for Stimulant Use Among People Living with HIV: A Narrative Review.","authors":"Michael P Barry, Francis A Slaughter, Ann E Richey, Neil Gleason, Nicky Cotta, Kaitlin A Zinsli","doi":"10.1007/s11904-025-00758-9","DOIUrl":"10.1007/s11904-025-00758-9","url":null,"abstract":"Purpose of review: Stimulant use, which includes use of cocaine and methamphetamine, is known to worsen care outcomes among people living with HIV (PLWH). The rise of stimulant use in the United States (US) in the last decade is a threat to the US plan of Ending the HIV Epidemic. Digital interventions - including those delivered through web- and mobile phone-based modalities - may mitigate the scale of stimulant use among PLWH, thereby disrupting HIV transmission attributable to it. We sought to understand the state of digital interventions for stimulant use among populations of PLWH, with the goal of highlighting opportunities to expand such public health responses to stimulant use.Recent findings: Overall, digital interventions for stimulant use among PLWH appear feasible, clinically effective, and cost-effective. The state of these advancements has not been thoroughly examined or summarized to date. Since 2010, 17 publications have examined the feasibility, acceptability, and/or effectiveness of digital interventions for stimulant use among PLWH. The ubiquity of smartphones and opportunity to offer such interventions alongside HIV care services highlight the need for future research in this area, particularly those that target populations with suboptimal HIV care outcomes and who may benefit most from digital intervention modalities.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"49"},"PeriodicalIF":4.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13035053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Integrated HBV DNA in the Quest for a Cure in HIV/HBV co-infection. 整合HBV DNA在寻求治愈HIV/HBV合并感染中的作用

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-10-08 DOI: 10.1007/s11904-025-00755-y

Monika Mani, Chloe L Thio, Ashwin Balagopal

{"title":"The Role of Integrated HBV DNA in the Quest for a Cure in HIV/HBV co-infection.","authors":"Monika Mani, Chloe L Thio, Ashwin Balagopal","doi":"10.1007/s11904-025-00755-y","DOIUrl":"10.1007/s11904-025-00755-y","url":null,"abstract":"Purpose: This review highlights the importance of Hepatitis B virus (HBV) integrated into the host genome (iDNA) to functional cure and how human immunodeficiency virus (HIV) may affect HBV integration.Recent findings: Functional cure of chronic hepatitis B infection is characterized by durable loss of hepatitis B surface antigen (HBsAg) from blood after treatment discontinuation. Because HBsAg is transcribed from two intrahepatic sources, covalently closed circular DNA (cccDNA) or iDNA, functional cure requires elimination or silencing of both sources. It is not clear how HIV affects HBV integration, but since HIV enhances HBV replication and leads to increased DNA breaks through oxidative stress, people with HIV and HBV may have more integration events. HBV integration into the human genome is a random and ongoing process that occurs during all phases of chronic HBV infection (CHB). iDNA is important for maintaining HBsAg expression despite antiviral therapy. In studies without HIV, higher levels of HBV replication are associated with increased integration events. Higher HBV DNA levels in HIV/HBV co-infected individuals may contribute to increased HBV integration. HIV worsens CHB by weakening immune responses, promoting oxidative stress, and activating cellular pathways that enhance HBV replication and integration.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"48"},"PeriodicalIF":4.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12850494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Tools to Diagnose and Predict Hepatocellular Carcinoma: Relevance to HIV and Hepatitis B Virus Coinfection. 当前诊断和预测肝细胞癌的工具：与HIV和乙型肝炎病毒合并感染的相关性。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-10-06 DOI: 10.1007/s11904-025-00757-w

Edwin Wilbur Woodhouse, Tzu-Hao Lee, Susanna Naggie

引用次数: 0

Current and Investigational Biomarkers of Liver Disease in HIV-HBV Co-infection. HIV-HBV合并感染中肝脏疾病的当前和研究生物标志物。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-09-27 DOI: 10.1007/s11904-025-00756-x

Keyur Patel, Giada Sebastiani

引用次数: 0

The Role of Liver Biopsy and Fine Needle Aspiration in Novel HBV Therapeutics in HIV and HBV Coinfection. 肝活检和细针抽吸在HIV和HBV合并感染的新型HBV治疗中的作用。