Current HIV/AIDS Reports最新文献_第4页

Mycoplasma Genitalium - Where are we at? 生殖器支原体-我们在哪里？

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-12-24 DOI: 10.1007/s11904-025-00768-7

Catriona S Bradshaw, Kay Htaik, Ryan Horn, Lenka A Vodstrcil

引用次数: 0

Role of cccDNA in the Quest for HBV Cure- Implications for HIV-HBV Coinfection. cccDNA在寻求HBV治愈中的作用-对HIV-HBV合并感染的影响。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-12-17 DOI: 10.1007/s11904-025-00766-9

Guillaume Giraud, Barbara Testoni

引用次数: 0

The State of the Science on Chronic Comorbidities and Aging in Children and Adolescents with perinatally-acquired HIV. 围产期获得性艾滋病毒儿童和青少年慢性合并症和衰老的科学现状。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-12-06 DOI: 10.1007/s11904-025-00761-0

Modupe O Coker, Ryan Kreutzberg, Nadia A Sam-Agudu, Eilleen Macodiyo, Jibreel Jumare, Juliette Madan, Vaishali Singhal, Zhigang Li, Reuben Robbins, Stephanie Shiau

{"title":"The State of the Science on Chronic Comorbidities and Aging in Children and Adolescents with perinatally-acquired HIV.","authors":"Modupe O Coker, Ryan Kreutzberg, Nadia A Sam-Agudu, Eilleen Macodiyo, Jibreel Jumare, Juliette Madan, Vaishali Singhal, Zhigang Li, Reuben Robbins, Stephanie Shiau","doi":"10.1007/s11904-025-00761-0","DOIUrl":"10.1007/s11904-025-00761-0","url":null,"abstract":"The availability and global scale-up of suppressive antiretroviral therapy (ART) has transformed HIV from a fatal infection to a chronic disease. While long-term survival is a positive development for people living with HIV (PLWH), the increased life expectancy comes with age-related comorbidities. These comorbidities affect PLWH at relatively earlier ages than the general population, and examples include cardiometabolic conditions, renal toxicity, lung and respiratory dysfunction, neurocognitive deficits, malignancy, and oral/dental pathology. Anticipatory management of early markers of non-communicable diseases (NCDs) can be especially advantageous for children and adolescents with perinatally-acquired HIV (CAPHIV), the vast majority of whom live in low-and middle-income countries. However, evidence for the mechanisms underlying age-related comorbidities in PLWH and implications for CAPHIV represent a still-emerging area of investigation. In this article, we review the current literature on comorbidities and age-related conditions experienced by CAPHIV, discuss the role of inflammation and chronic immune activation, and highlight accelerated biological aging and/or disruptions to the microbiome as underlying mechanisms. We recommend that HIV clinical care and health policy should reflect evidence on aging and comorbidities to optimize growth, development, and long-term health for CAPHIV globally.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"56"},"PeriodicalIF":4.4,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12681470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytic Methods to Investigate HIV-Related Digital Communication: A Scoping Review. 研究hiv相关数字通信的分析方法：范围综述。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-11-13 DOI: 10.1007/s11904-025-00765-w

Parisa Ayoubi, Bailey Holmes Spencer, Ohemaa B Poku, Philip Kreniske, Michelle R Kaufman, Evan L Eschliman

{"title":"Analytic Methods to Investigate HIV-Related Digital Communication: A Scoping Review.","authors":"Parisa Ayoubi, Bailey Holmes Spencer, Ohemaa B Poku, Philip Kreniske, Michelle R Kaufman, Evan L Eschliman","doi":"10.1007/s11904-025-00765-w","DOIUrl":"10.1007/s11904-025-00765-w","url":null,"abstract":"Purpose of review: This scoping review aims to identify and characterize analytic methods used to investigate digital communication related to HIV.Recent findings: Of the 106 articles detailed in this review published before February 2025, just over half of the articles investigated HIV prevention, and the vast majority used social media data. Articles primarily employed qualitative methods, most often thematic analysis. Articles employing quantitative methods used a range of methods including topic modeling, training classifiers, and sentiment analysis. There were also many articles that employed both qualitative and quantitative methods. A wide range of methods have been employed to analyze HIV-related digital communication. As best practices continue to be established, future research can innovate in the application of both qualitative and quantitative methods, leverage digital communication to better understand lived experience of HIV treatment and HIV-related stigma, and ensure this research is done in accordance with high ethical standards.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"55"},"PeriodicalIF":4.4,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145502521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Integrative Review of PrEP Promotion Strategies at Historically Black Colleges and Universities To Reduce HIV Disparities. 传统黑人学院和大学PrEP推广策略的综合评价，以减少艾滋病毒差异。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-11-10 DOI: 10.1007/s11904-025-00764-x

Deja Knight, James Gilbreath, Tiara C Willie, Jessica Corcoran

{"title":"An Integrative Review of PrEP Promotion Strategies at Historically Black Colleges and Universities To Reduce HIV Disparities.","authors":"Deja Knight, James Gilbreath, Tiara C Willie, Jessica Corcoran","doi":"10.1007/s11904-025-00764-x","DOIUrl":"10.1007/s11904-025-00764-x","url":null,"abstract":"Purpose of review: We searched PubMed, CINAHL Plus, Embase, Scopus, Web of Science, and ERIC to identify peer-reviewed studies published between 2015 and 2025 that discussed PrEP at HBCUs. We sought to examine PrEP research, with a focus on PrEP implementation strategies, at HBCUs. Two authors reviewed titles, abstracts, and full texts against the inclusion criteria. Six articles were included in this review.Recent findings: Two studies focused on formative PrEP research, two on organizational readiness, and three on post-implementation outcomes. Formative research showed PrEP is acceptable to HBCU students, though barriers like stigma and side effects, along with facilitators such as personal PrEP stories, impact intention. Organizational readiness to implement PrEP varied, with resource levels affecting implementation. Despite challenges, PrEP interventions were shown to be effective at increasing PrEP knowledge and behavioral intention. There is a need to enhance PrEP implementation at HBCUs, while considering varying campus resources.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"54"},"PeriodicalIF":4.4,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Envisioning a Multidisciplinary HBV Cure Research Agenda. 设想一个多学科HBV治疗研究议程。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-11-08 DOI: 10.1007/s11904-025-00763-y

Karine Dubé, Ali Ahmed, Chari Cohen, Yasmin Ibrahim, George A Yendewa, Edward R Cachay, Su Wang, Kristen Marks, Arthur Y Kim, Jeremy Sugarman, David L Thomas, Chloe L Thio, Debika Bhattacharya

引用次数: 0

Growing Up with HIV: A Comprehensive Review of Treatment and Care in Low- and Middle-Income Countries. 与艾滋病毒一起成长：低收入和中等收入国家治疗和护理的全面审查。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-11-07 DOI: 10.1007/s11904-025-00762-z

Brigid E O'Brien, Elizabeth Maidl, Jacob L Todd, Miriam Abadie, Moses Mugerwa, Katherine R Simon, Sarah Perry

{"title":"Growing Up with HIV: A Comprehensive Review of Treatment and Care in Low- and Middle-Income Countries.","authors":"Brigid E O'Brien, Elizabeth Maidl, Jacob L Todd, Miriam Abadie, Moses Mugerwa, Katherine R Simon, Sarah Perry","doi":"10.1007/s11904-025-00762-z","DOIUrl":"10.1007/s11904-025-00762-z","url":null,"abstract":"Purpose of review: Despite declining numbers of new pediatric HIV infections and advancements in treatment for children and adolescents living with HIV (CALHIV), barriers remain. Comprehensive care for CALHIV in low- and middle-income countries is challenged by limited treatment options, unique psychosocial challenges, and caregiver reliance. Successful care relies on understanding the unique developmental needs, as well as their vulnerabilities to treatment failure and HIV drug resistance.Recent findings: CALHIV lag behind adults in meeting global UNAIDS targets. Increasing availability of pediatric fixed dose combinations (FDC) of abacavir/lamivudine/dolutegravir (ABC/3TC/DTG) may address some challenges but providing alternatives should be prioritized. Emerging evidence has demonstrated pre-treatment and acquired HIV drug resistance (HIVDR) are more prevalent in CALHIV. While novel therapies are in development, access remains a concern. Increased child and adolescent-friendly treatment options are needed to provide quality life-long comprehensive care to CALHIV in low- and middle-income countries (LMIC). Expanded research and access to novel therapies is key to close treatment gaps between CALHIV and their adult counterparts and address emerging HIV drug resistance.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"52"},"PeriodicalIF":4.4,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between Neuroimaging Measures and Cognitive Performance in Children, Adolescents, and Youth Living With HIV-a Systematic Review. 儿童、青少年和青少年艾滋病毒感染者的神经影像学测量与认知表现之间的关系——系统综述。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-11-03 DOI: 10.1007/s11904-025-00760-1

Isaac L Khobo, Frances C Robertson, Barbara Laughton, Ernesta M Meintjes

{"title":"Associations between Neuroimaging Measures and Cognitive Performance in Children, Adolescents, and Youth Living With HIV-a Systematic Review.","authors":"Isaac L Khobo, Frances C Robertson, Barbara Laughton, Ernesta M Meintjes","doi":"10.1007/s11904-025-00760-1","DOIUrl":"10.1007/s11904-025-00760-1","url":null,"abstract":"PURPOSE OF REVIEW: Neurodevelopmental delays and neuroimaging abnormalities continue to be found in children, adolescents, and youth living with HIV despite the administration of effective combination antiretroviral therapy (cART). However, there are no clear criteria for the diagnosis of HIV-related cognitive impairment in the paediatric cohort as there are for HIV-associated cognitive disorders (HAND) in adults. Neuroimaging could be a useful tool for assessing the extent of HIV-related effects on the brain, but it is not clear how subtle deficits seen on neuroimaging are related to cognitive performance in children, adolescents and youth. RECENT FINDINGS: We identified 33 studies investigating relationships between cognitive outcomes assessed by cognitive testing and brain changes measured with neuroimaging. Frequently used imaging techniques were structural MRI (sMRI) and diffusion tensor imaging (DTI), while cognitive tests primarily assessed attention, executive function, and general intelligence. Due to methodological heterogeneity, meta-analyses were not performed. Key findings indicate that perinatal HIV may alter brain volumes and white matter integrity, leading to deficits in memory and problem-solving. Most studies were cross-sectional (91%) and had small sample sizes (82% included fewer than 80 subjects), and few utilized qualitative neuroimaging analyses (9%). Neuroimaging has the potential to provide insights into cognitive function in paediatric HIV, yet further research using integrated imaging techniques is needed to clarify underlying neural mechanisms and improve intervention strategies. ","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"51"},"PeriodicalIF":4.4,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12580442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Immunodeficiency Virus and Hepatitis B Virus Co-infection in Pregnancy: A Review. 妊娠期人类免疫缺陷病毒和乙型肝炎病毒合并感染：综述。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-10-27 DOI: 10.1007/s11904-025-00759-8

Alison Craik, Rebecca Scott, Eleanor Hamlyn

{"title":"Human Immunodeficiency Virus and Hepatitis B Virus Co-infection in Pregnancy: A Review.","authors":"Alison Craik, Rebecca Scott, Eleanor Hamlyn","doi":"10.1007/s11904-025-00759-8","DOIUrl":"10.1007/s11904-025-00759-8","url":null,"abstract":"Purpose of the review: This article presents an overview of the global consensus of the management of pregnant women living with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infection. We summarise findings from the most recent and relevant literature on this topic with a focus on epidemiology, obstetric and pharmacological management and neonatal care.Recent findings: Guidelines have been revised to reflect the most recent evidence published on the safety and efficacy of both dolutegravir and tenofovir alafenamide in pregnancy. There are encouraging data to suggest that obstetric outcomes in women with HIV/HBV co-infection are comparable to those with HIV or HBV mono-infection. Recent advances in our understanding of the safety profile and efficacy of tenofovir disoproxil/alafenamide and dolutegravir has resulted in these being recommended as first line antiretrovirals, alongside Lamivudine, for HIV/HBV co-infection in pregnancy in United Kingdom, European and the United States guidelines. Appropriate antiretroviral therapy in pregnancy, along with prompt treatment of the neonate, combine to ensure very low rates of perinatal transmission of both HIV and HBV.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"50"},"PeriodicalIF":4.4,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Interventions for Stimulant Use Among People Living with HIV: A Narrative Review. 艾滋病毒感染者兴奋剂使用的数字干预：叙述回顾。

IF 4.4 2区医学

Current HIV/AIDS Reports Pub Date : 2025-10-13 DOI: 10.1007/s11904-025-00758-9

Michael P Barry, Francis A Slaughter, Ann E Richey, Neil Gleason, Nicky Cotta, Kaitlin A Zinsli

{"title":"Digital Interventions for Stimulant Use Among People Living with HIV: A Narrative Review.","authors":"Michael P Barry, Francis A Slaughter, Ann E Richey, Neil Gleason, Nicky Cotta, Kaitlin A Zinsli","doi":"10.1007/s11904-025-00758-9","DOIUrl":"10.1007/s11904-025-00758-9","url":null,"abstract":"Purpose of review: Stimulant use, which includes use of cocaine and methamphetamine, is known to worsen care outcomes among people living with HIV (PLWH). The rise of stimulant use in the United States (US) in the last decade is a threat to the US plan of Ending the HIV Epidemic. Digital interventions - including those delivered through web- and mobile phone-based modalities - may mitigate the scale of stimulant use among PLWH, thereby disrupting HIV transmission attributable to it. We sought to understand the state of digital interventions for stimulant use among populations of PLWH, with the goal of highlighting opportunities to expand such public health responses to stimulant use.Recent findings: Overall, digital interventions for stimulant use among PLWH appear feasible, clinically effective, and cost-effective. The state of these advancements has not been thoroughly examined or summarized to date. Since 2010, 17 publications have examined the feasibility, acceptability, and/or effectiveness of digital interventions for stimulant use among PLWH. The ubiquity of smartphones and opportunity to offer such interventions alongside HIV care services highlight the need for future research in this area, particularly those that target populations with suboptimal HIV care outcomes and who may benefit most from digital intervention modalities.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"49"},"PeriodicalIF":4.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13035053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0