Current HIV/AIDS Reports最新文献_第10页

The End Is in Sight: Current Strategies for the Elimination of HIV Vertical Transmission. 终点在望:消除艾滋病毒垂直传播的当前战略。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 DOI: 10.1007/s11904-023-00655-z

Lanbo Yang, Mary Catherine Cambou, Karin Nielsen-Saines

{"title":"The End Is in Sight: Current Strategies for the Elimination of HIV Vertical Transmission.","authors":"Lanbo Yang, Mary Catherine Cambou, Karin Nielsen-Saines","doi":"10.1007/s11904-023-00655-z","DOIUrl":"https://doi.org/10.1007/s11904-023-00655-z","url":null,"abstract":"Purpose of review: The goal of this review is to highlight and interpret recent trends and developments in the diagnosis, treatment, and prevention of HIV vertical transmission from a clinical perspective.Recent findings: Universal third-trimester retesting and partner testing may better identify incident HIV among pregnant patients and result in early initiation of antiretroviral therapy to prevent vertical transmission. The proven safety and efficacy of integrase inhibitors such as dolutegravir may be particularly useful in suppressing viremia in pregnant persons who present late for ART treatment. Pre-exposure prophylaxis (PrEP) during pregnancy may play a role in preventing HIV acquisition; however, its role in preventing vertical transmission is difficult to elucidate. Substantial progress has been made in recent years to eliminate HIV perinatal transmission. Future research hinges upon a multipronged approach to improving HIV detection, risk-stratified treatment strategies, and prevention of primary HIV infection among pregnant persons.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 3","pages":"121-130"},"PeriodicalIF":4.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239317/pdf/nihms-1888021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9674630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The human microbiome and gut-liver axis in people living with HIV. 艾滋病毒感染者的人体微生物组和肠道-肝脏轴。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 Epub Date: 2023-05-02 DOI: 10.1007/s11904-023-00657-x

Maria J Duarte, Phyllis C Tien, Ma Somsouk, Jennifer C Price

引用次数: 0

Implementing Geospatial Science and Technology to Get to Zero New HIV Infections. 利用地理空间科学技术实现艾滋病毒零新增感染。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 DOI: 10.1007/s11904-023-00658-w

Enbal Shacham, Stephen E Scroggins, Matthew Ellis

引用次数: 0

Reporting Individual-Level Research Results from Neurocognitive and Psychological Research in People Living with HIV: Lessons from Dementia Research. 报告艾滋病毒感染者神经认知和心理研究的个体水平研究结果:来自痴呆症研究的经验教训。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 DOI: 10.1007/s11904-023-00650-4

Holly L Peay, Stuart Rennie, Gail E Henderson

{"title":"Reporting Individual-Level Research Results from Neurocognitive and Psychological Research in People Living with HIV: Lessons from Dementia Research.","authors":"Holly L Peay, Stuart Rennie, Gail E Henderson","doi":"10.1007/s11904-023-00650-4","DOIUrl":"https://doi.org/10.1007/s11904-023-00650-4","url":null,"abstract":"Purpose of review: There are growing expectations for the return of individual-level research results (RoR), which promotes autonomy and potential clinical and personal benefits. There are ethical and practical challenges, however, that may be exacerbated in research that assesses neurocognitive and psychological outcomes, including HIV-associated neurocognitive disorder (HAND). This paper reviews central concepts for RoR and recent empirical and conceptual articles from Alzheimer's disorder (AD) as a model for HIV.Recent findings: Data from AD studies indicate high participant interest and low risk of harm from RoR, though additional research is needed. Investigators report a range of benefits, potential risks, and feasibility concerns. Standardized, evidence-based approaches are needed for RoR. For HIV research, we recommend a default position of offering RoR for cognitive and psychological outcomes. Investigators should justify decisions not to return results after assessing the potential value and feasibility of RoR. Longitudinal research is needed for feasible and evidence-based best practices.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 3","pages":"131-138"},"PeriodicalIF":4.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9669333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping Community-Engaged Implementation Strategies with Transgender Scientists, Stakeholders, and Trans-Led Community Organizations. 与跨性别科学家、利益相关者和跨性别领导的社区组织一起制定社区参与实施战略。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 Epub Date: 2023-04-04 DOI: 10.1007/s11904-023-00656-y

Arjee Restar, Brian J Minalga, Ma Irene Quilantang, Tyler Adamson, Emerson Dusic, Leigh-Ann van der Merwe, Greg Millet, Danvic Rosadiño, Tanya Laguing, Elle Lett, Avery Everhart, Gregory Phillips, Rena Janamnuaysook, Pich Seekaew, Kellan Baker, Florence Ashley, Jeffrey Wickersham, Stephaun E Wallace, Don Operario, Kristi E Gamarel

{"title":"Mapping Community-Engaged Implementation Strategies with Transgender Scientists, Stakeholders, and Trans-Led Community Organizations.","authors":"Arjee Restar, Brian J Minalga, Ma Irene Quilantang, Tyler Adamson, Emerson Dusic, Leigh-Ann van der Merwe, Greg Millet, Danvic Rosadiño, Tanya Laguing, Elle Lett, Avery Everhart, Gregory Phillips, Rena Janamnuaysook, Pich Seekaew, Kellan Baker, Florence Ashley, Jeffrey Wickersham, Stephaun E Wallace, Don Operario, Kristi E Gamarel","doi":"10.1007/s11904-023-00656-y","DOIUrl":"10.1007/s11904-023-00656-y","url":null,"abstract":"Purpose of review: Pre-exposure prophylaxis (PrEP) represents one of the most effective methods of prevention for HIV, but remains inequitable, leaving many transgender and nonbinary (trans) individuals unable to benefit from this resource. Deploying community-engaged PrEP implementation strategies for trans populations will be crucial for ending the HIV epidemic.Recent findings: While most PrEP studies have progressed in addressing pertinent research questions about gender-affirming care and PrEP at the biomedical and clinical levels, research on how to best implement gender-affirming PrEP systems at the social, community, and structural levels remains outstanding. The science of community-engaged implementation to build gender-affirming PrEP systems must be more fully developed. Most published PrEP studies with trans people report on outcomes rather than processes, leaving out important lessons learned about how to design, integrate, and implement PrEP in tandem with gender-affirming care. The expertise of trans scientists, stakeholders, and trans-led community organizations is essential to building gender-affirming PrEP systems.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 3","pages":"160-169"},"PeriodicalIF":3.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological Aging in People Living with HIV on Successful Antiretroviral Therapy: Do They Age Faster? 成功接受抗逆转录病毒治疗的艾滋病毒感染者的生物衰老:他们衰老得更快吗?

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-04-01 DOI: 10.1007/s11904-023-00646-0

Sara Svensson Akusjärvi, Ujjwal Neogi

{"title":"Biological Aging in People Living with HIV on Successful Antiretroviral Therapy: Do They Age Faster?","authors":"Sara Svensson Akusjärvi, Ujjwal Neogi","doi":"10.1007/s11904-023-00646-0","DOIUrl":"https://doi.org/10.1007/s11904-023-00646-0","url":null,"abstract":"Purpose of review: In the absence of a prophylactic/therapeutic vaccine or cure, the most amazing achievement in the battle against HIV was the discovery of effective, well-tolerated combination antiretroviral therapy (cART). The primary research question remains whether PLWH on prolonged successful therapy has accelerated, premature, or accentuated biological aging. In this review, we discuss the current understanding of the immunometabolic profile in PLWH, potentially associated with biological aging, and a better understanding of the mechanisms and temporal dynamics of biological aging in PLWH.Recent findings: Biological aging, defined by the epigenetic alterations analyzed by the DNA methylation pattern, has been reported in PLWH with cART that points towards epigenetic age acceleration. The hastened development of specific clinical geriatric syndromes like cardiovascular diseases, metabolic syndrome, cancers, liver diseases, neurocognitive diseases, persistent low-grade inflammation, and a shift toward glutamate metabolism in PLWH may potentiate a metabolic profile at-risk for accelerated aging.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 2","pages":"42-50"},"PeriodicalIF":4.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9426754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

HIV Reservoir: How to Measure It? HIV病毒库:如何测量?

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-04-01 DOI: 10.1007/s11904-023-00653-1

Xinyu Zhang, Jun Chen

引用次数: 1

Immunologic Interplay Between HIV/AIDS and COVID-19: Adding Fuel to the Flames? 艾滋病毒/艾滋病与新冠肺炎之间的免疫相互作用：火上浇油？

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-04-01 Epub Date: 2023-01-21 DOI: 10.1007/s11904-023-00647-z

Matteo Augello, Valeria Bono, Roberta Rovito, Camilla Tincati, Giulia Marchetti

{"title":"Immunologic Interplay Between HIV/AIDS and COVID-19: Adding Fuel to the Flames?","authors":"Matteo Augello, Valeria Bono, Roberta Rovito, Camilla Tincati, Giulia Marchetti","doi":"10.1007/s11904-023-00647-z","DOIUrl":"10.1007/s11904-023-00647-z","url":null,"abstract":"Purpose of review: HIV/AIDS and COVID-19 have been the major pandemics overwhelming our times. Given the enduring immune disfunction featuring people living with HIV (PLWH) despite combination antiretroviral therapy (cART), concerns for higher incidence and severity of SARS-CoV-2 infection as well as for suboptimal responses to the newly developed vaccines in this population arose early during the pandemics. Herein, we discuss the complex interplay between HIV and SARS-CoV-2, with a special focus on the immune responses to SARS-CoV-2 natural infection and vaccination in PLWH.Recent findings: Overall, current literature shows that COVID-19 severity and outcomes may be worse and immune responses to infection or vaccination lower in PLWH with poor CD4 + T-cell counts and/or uncontrolled HIV viremia. Data regarding the risk of post-acute sequelae of SARS-CoV-2 infection (PASC) among PLWH are extremely scarce, yet they seem to suggest a higher incidence of such condition. Scarce immunovirological control appears to be the major driver of weak immune responses to SARS-CoV-2 infection/vaccination and worse COVID-19 outcomes in PLWH. Therefore, such individuals should be prioritized for vaccination and should receive additional vaccine doses. Furthermore, given the potentially higher risk of developing long-term sequelae, PLWH who experienced COVID-19 should be ensured a more careful and prolonged follow-up.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 2","pages":"51-75"},"PeriodicalIF":3.7,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9482050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates on HIV and Kidney Disease. 艾滋病毒和肾脏疾病的最新情况。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-04-01 DOI: 10.1007/s11904-023-00645-1

C Elena Cervantes, Mohamed G Atta

引用次数: 1

Advances in HIV Research Using Mass Cytometry. 细胞计数技术在HIV研究中的应用进展

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-04-01 Epub Date: 2023-01-23 DOI: 10.1007/s11904-023-00649-x

Ashley F George, Nadia R Roan

{"title":"Advances in HIV Research Using Mass Cytometry.","authors":"Ashley F George, Nadia R Roan","doi":"10.1007/s11904-023-00649-x","DOIUrl":"10.1007/s11904-023-00649-x","url":null,"abstract":"Purpose of review: This review describes how advances in CyTOF and high-dimensional analysis methods have furthered our understanding of HIV transmission, pathogenesis, persistence, and immunity.Recent findings: CyTOF has generated important insight on several aspects of HIV biology: (1) the differences between cells permissive to productive vs. latent HIV infection, and the HIV-induced remodeling of infected cells; (2) factors that contribute to the persistence of the long-term HIV reservoir, in both blood and tissues; and (3) the impact of HIV on the immune system, in the context of both uncontrolled and controlled infection. CyTOF and high-dimensional analysis tools have enabled in-depth assessment of specific host antigens remodeled by HIV, and have revealed insights into the features of HIV-infected cells enabling them to survive and persist, and of the immune cells that can respond to and potentially control HIV replication. CyTOF and other related high-dimensional phenotyping approaches remain powerful tools for translational research, and applied HIV to cohort studies can inform on mechanisms of HIV pathogenesis and persistence, and potentially identify biomarkers for viral eradication or control.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 2","pages":"76-85"},"PeriodicalIF":4.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9761188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0