Current HIV/AIDS Reports最新文献_第10页

Overcoming Vaccine Hesitancy for Future COVID-19 and HIV Vaccines: Lessons from Measles and HPV Vaccines. 克服对未来COVID-19和艾滋病毒疫苗的疫苗犹豫:麻疹和HPV疫苗的经验教训。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2022-10-01 DOI: 10.1007/s11904-022-00622-0

Obianuju G Aguolu, Amyn A Malik, Noureen Ahmed, Saad B Omer

{"title":"Overcoming Vaccine Hesitancy for Future COVID-19 and HIV Vaccines: Lessons from Measles and HPV Vaccines.","authors":"Obianuju G Aguolu, Amyn A Malik, Noureen Ahmed, Saad B Omer","doi":"10.1007/s11904-022-00622-0","DOIUrl":"https://doi.org/10.1007/s11904-022-00622-0","url":null,"abstract":"Background: The discovery of vaccines significantly reduced morbidity and mortality of infectious diseases and led to the elimination and eradication of some. Development of safe and effective vaccines is a critical step to the control of infectious diseases; however, there is the need to address vaccine hesitancy because of its potential impact on vaccine uptake.Methods: We conducted a narrative review of studies on interventions to address measles and human papillomavirus vaccine hesitancy. We discussed how lessons learned from these studies could be applied towards COVID-19 and future human immunodeficiency virus vaccines.Results: We found that there are several successful approaches to improving vaccine acceptance. Interventions should be context specific and build on the challenges highlighted in various settings.Conclusion: Strategies could be used alone or in combination with others. The most successful interventions directly targeted the population for vaccination. Use of financial incentives could be a potential tool to improve vaccine uptake.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"19 5","pages":"328-343"},"PeriodicalIF":4.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9537068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Running with Scissors: a Systematic Review of Substance Use and the Pre-exposure Prophylaxis Care Continuum Among Sexual Minority Men 用剪刀跑步：对性少数群体男性物质使用和暴露前预防护理持续性的系统评价

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2022-06-14 DOI: 10.1007/s11904-022-00608-y

M. Viamonte, Delaram Ghanooni, John M Reynolds, C. Grov, A. Carrico

引用次数: 7

Interventions Designed to Improve HIV Continuum of Care Outcomes for Persons with HIV in Contact with the Carceral System in the USA 干预措施旨在改善与美国监狱系统接触的艾滋病毒感染者的艾滋病毒连续护理结果

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2022-06-08 DOI: 10.1007/s11904-022-00609-x

Emily F. Dauria, P. Kulkarni, A. Clemenzi-allen, L. Brinkley-Rubinstein, C. Beckwith

引用次数: 2

Trauma-Informed HIV Care Interventions: Towards a Holistic Approach. 创伤知情艾滋病毒护理干预:朝着一个整体的方法。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2022-06-01 DOI: 10.1007/s11904-022-00603-3

Monique J Brown, Oluwafemi Adeagbo

{"title":"Trauma-Informed HIV Care Interventions: Towards a Holistic Approach.","authors":"Monique J Brown, Oluwafemi Adeagbo","doi":"10.1007/s11904-022-00603-3","DOIUrl":"https://doi.org/10.1007/s11904-022-00603-3","url":null,"abstract":"Purpose of review: The prevalence of trauma is higher among people living with HIV compared to the general population and people living without HIV. Trauma may be a major barrier in attaining HIV treatment outcomes, such as linkage to HIV care, engagement in HIV care, adherence to antiretroviral therapy (ART), and viral suppression. The purpose of this review was to highlight trauma-informed interventions that are geared towards improving treatment outcomes among people living with HIV.Recent findings: Recent studies suggest that a trauma-informed approach to developing interventions may help to improve treatment outcomes, such as engagement in care and adherence to ART. However, studies have also shown that depending on the operationalization of usual care, a trauma-informed approach may result in similar outcomes. Very few studies have examined the impact of trauma-informed interventions on HIV care and treatment outcomes. Additional research is needed on the acceptability, feasibility, and efficacy of trauma-informed interventions among affected populations such as older adults, and racial/ethnic and sexual minorities living with HIV.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"19 3","pages":"177-183"},"PeriodicalIF":4.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084732/pdf/nihms-1885034.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9547858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Viral and Host Biomarkers of HIV Remission Post Treatment Interruption. HIV治疗中断后缓解的病毒和宿主生物标志物。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2022-06-01 Epub Date: 2022-04-19 DOI: 10.1007/s11904-022-00607-z

Leila B Giron, Mohamed Abdel-Mohsen

引用次数: 1

HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure Strategies. 中枢神经系统中HIV的分区及其对治疗结果和治疗策略的影响。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2022-06-01 Epub Date: 2022-05-10 DOI: 10.1007/s11904-022-00605-1

Phillip Chan, Serena Spudich

{"title":"HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure Strategies.","authors":"Phillip Chan, Serena Spudich","doi":"10.1007/s11904-022-00605-1","DOIUrl":"10.1007/s11904-022-00605-1","url":null,"abstract":"Purpose of review: This review focuses on the cerebrospinal fluid (CSF) findings in connection to the central nervous system (CNS) reservoir in treatment-naïve and virally suppressed PLWH, followed by the findings in CSF HIV-1 escape and analytical treatment interruption studies.Recent findings: Compared to chronic infection, initiating antiretroviral therapy (ART) during acute HIV-1 infection results in more homogeneous longitudinal benefits in the CNS. Viral variants in CSF HIV-1 escape are independently linked to infected cells from the systemic reservoir and in the CNS, highlighting the phenomenon as a consequence of different mechanisms. HIV-infected cells persist in CSF in nearly half of the individuals on stable ART and are associated with worse neurocognitive performance. Future studies should probe into the origin of the HIV-infected cells in the CSF. Examining the capacity for viral replication would provide new insight into the CNS reservoir and identify strategies to eradicate it or compensate for the insufficiency of ART.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"19 3","pages":"207-216"},"PeriodicalIF":4.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590959/pdf/nihms-1937040.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41194251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review. 中国hiv感染者COVID-19临床表现的系统评价

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2022-06-01 DOI: 10.1007/s11904-022-00606-0

Dayong Huang, Jiawulan Zunong, Menglong Li, Dan Li, JiaJian Gong, Sten H Vermund, Yifei Hu

{"title":"COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review.","authors":"Dayong Huang, Jiawulan Zunong, Menglong Li, Dan Li, JiaJian Gong, Sten H Vermund, Yifei Hu","doi":"10.1007/s11904-022-00606-0","DOIUrl":"https://doi.org/10.1007/s11904-022-00606-0","url":null,"abstract":"Purpose of review: The impact of HIV infection on the natural history of COVID-19 is unknown, given the recency of the human spread of SARS-CoV-2 (CoV). We reviewed published case series/reports of CoV-HIV coinfections to clarify epidemiologic and clinical features in China, the first nation with pandemic experience.Recent findings: Assuming that HIV-infected persons were at average risk of CoV infection in Wuhan, we estimated HIV-CoV coinfected persons to number 412 (95%CI: 381-442); our review encompassed an estimated 16.7% (69/412) of Wuhan. Men (many of whom reported sex with other men) accounted for 71.1% (54/76) of the cases reported in China. The median age was 48.0 years old (range 24-77, interquartile:37-57). The median CD4+ cell count at the last clinical visit was 421 cells/μL; 83.0% had an undetectable viral load. Among 31 patients with clinical details reported, fatigue (41.9%), respiratory distress (41.9%), and gastrointestinal symptoms (26.7%) were most common. Among the 52 cases reporting COVID-19 clinical severity, 46.2% were severe, 44.2% mild, and 9.6% asymptomatic COVID-19. Late antiretroviral therapy (ART) was reported by 30.4% (7/23) among whom 57.1% (4/7) were confirmed as severe COVID-19. The case fatality rate was 9.1% (3/33). Severe disease and death were less common among persons who took ART prior to the COVID-19 diagnosis. Of 16 reported IL-6 results, 68.7% were within the normal range. Earlier use of ART was associated with a better COVID-19 prognosis with CoV-HIV co-infection reported from China through early 2021, but small sample sizes limit definitive conclusions.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"19 3","pages":"167-176"},"PeriodicalIF":4.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9221939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

HIV-1 Reservoir Persistence and Decay: Implications for Cure Strategies. HIV-1 储库的持续存在和衰减：对治疗策略的影响

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2022-06-01 Epub Date: 2022-04-11 DOI: 10.1007/s11904-022-00604-2

Edward F Kreider, Katharine J Bar

{"title":"HIV-1 Reservoir Persistence and Decay: Implications for Cure Strategies.","authors":"Edward F Kreider, Katharine J Bar","doi":"10.1007/s11904-022-00604-2","DOIUrl":"10.1007/s11904-022-00604-2","url":null,"abstract":"Purpose of review: Despite suppressive antiretroviral therapy (ART), a viral reservoir persists in individuals living with HIV that can reignite systemic replication should treatment be interrupted. Understanding how HIV-1 persists through effective ART is essential to develop cure strategies to induce ART-free virus remission.Recent findings: The HIV-1 reservoir resides in a pool of CD4-expressing cells as a range of viral species, a subset of which is genetically intact. Recent studies suggest that the reservoir on ART is highly dynamic, with expansion and contraction of virus-infected cells over time. Overall, the intact proviral reservoir declines faster than defective viruses, suggesting enhanced immune clearance or cellular turnover. Upon treatment interruption, rebound viruses demonstrate escape from adaptive and innate immune responses, implicating these selective pressures in restriction of virus reactivation. Cure strategies employing immunotherapy are poised to test whether host immune pressure can be augmented to enhance reservoir suppression or clearance. Alternatively, genomic engineering approaches are being applied to directly eliminate intact viruses and shrink the replication-competent virus pool. New evidence suggests host immunity exerts selective pressure on reservoir viruses and clears HIV-1 infected cells over years on ART. Efforts to build on the detectable, but insufficient, reservoir clearance via empiric testing in clinical trials will inform our understanding of mechanisms of viral persistence and the direction of future cure strategies.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"19 3","pages":"194-206"},"PeriodicalIF":4.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443186/pdf/nihms-1880426.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10398319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interventions to Increase HIV Testing Uptake in Global Settings 在全球环境中增加艾滋病毒检测接受率的干预措施

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2022-04-20 DOI: 10.1007/s11904-022-00602-4

R. Sundararajan, Matthew Ponticiello, D. Nansera, K. Jeremiah, W. Muyindike

引用次数: 1

Risk-Based Screening Tools to Optimise HIV Testing Services: a Systematic Review. 基于风险的筛查工具优化 HIV 检测服务：系统综述。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2022-04-01 Epub Date: 2022-02-11 DOI: 10.1007/s11904-022-00601-5

J J Ong, K Coulthard, C Quinn, M J Tang, T Huynh, M S Jamil, R Baggaley, C Johnson

{"title":"Risk-Based Screening Tools to Optimise HIV Testing Services: a Systematic Review.","authors":"J J Ong, K Coulthard, C Quinn, M J Tang, T Huynh, M S Jamil, R Baggaley, C Johnson","doi":"10.1007/s11904-022-00601-5","DOIUrl":"10.1007/s11904-022-00601-5","url":null,"abstract":"Purpose of review: Effective ways to diagnose the remaining people living with HIV who do not know their status are a global priority. We reviewed the use of risk-based tools, a set of criteria to identify individuals who would not otherwise be tested (screen in) or excluded people from testing (screen out).Recent findings: Recent studies suggest that there may be value in risk-based tools to improve testing efficiency (i.e. identifying those who need to be tested). However, there has not been any systematic reviews to synthesize these studies. We identified 18,238 citations, and 71 were included. The risk-based tools identified were most commonly from high-income (51%) and low HIV (<5%) prevalence countries (73%). The majority were for \"screening in\" (70%), with the highest performance tools related to identifying MSM with acute HIV. Screening in tools may be helpful in settings where it is not feasible or recommended to offer testing routinely. Caution is needed for screening out tools, where there is a trade-off between reducing costs of testing with missing cases of people living with HIV.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"19 2","pages":"154-165"},"PeriodicalIF":3.7,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8832417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39910204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0