Current HIV/AIDS Reports最新文献_第9页

Mpox and HIV: a Narrative Review. Mpox 与 HIV：叙述性综述。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-08-01 Epub Date: 2023-05-13 DOI: 10.1007/s11904-023-00661-1

Carlos S Saldana, Colleen F Kelley, Bruce M Aldred, Valeria D Cantos

{"title":"Mpox and HIV: a Narrative Review.","authors":"Carlos S Saldana, Colleen F Kelley, Bruce M Aldred, Valeria D Cantos","doi":"10.1007/s11904-023-00661-1","DOIUrl":"10.1007/s11904-023-00661-1","url":null,"abstract":"Purpose of review: We reviewed the available literature on mpox in People with HIV (PWH). We highlight special considerations of mpox infection related to epidemiology, clinical presentation, diagnostic and treatment considerations, prevention, and public health messaging in PWH.Recent findings: During the 2022 mpox outbreak, PWH were disproportionally impacted worldwide. Recent reports suggest that the disease presentation, management, and prognosis of these patients, especially those with advanced HIV disease, can widely differ from those without HIV-associated immunodeficiency. Mpox can often be mild and resolve on its own in PWH with controlled viremia and higher CD4 counts. However, it can be severe, with necrotic skin lesions and protracted healing; anogenital, rectal, and other mucosal lesions; and disseminated organ systems involvement. Higher rates of healthcare utilization are seen in PWH. Supportive, symptomatic care and single or combination mpox-directed antiviral drugs are commonly used in PWH with severe mpox disease. Data from randomized clinical control trials on the efficacy of therapeutic and preventive tools against mpox among PWH are needed to better guide clinical decisions.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 4","pages":"261-269"},"PeriodicalIF":3.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9967075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interventions to Improve Adolescent HIV Care Outcomes. 改善青少年艾滋病毒护理结果的干预措施。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-08-01 Epub Date: 2023-06-10 DOI: 10.1007/s11904-023-00663-z

Marta I Mulawa, Elizabeth T Knippler, Maryam Al-Mujtaba, T Harper Wilkinson, Venkata K Ravi, Leila S Ledbetter

{"title":"Interventions to Improve Adolescent HIV Care Outcomes.","authors":"Marta I Mulawa, Elizabeth T Knippler, Maryam Al-Mujtaba, T Harper Wilkinson, Venkata K Ravi, Leila S Ledbetter","doi":"10.1007/s11904-023-00663-z","DOIUrl":"10.1007/s11904-023-00663-z","url":null,"abstract":"Purpose of review: This review of recent studies evaluating interventions to improve HIV care outcomes among adolescents with HIV (AHIV) was conducted to provide a comprehensive overview of the recent evidence, highlight promising approaches, and suggest directions for future research.Recent findings: Our scoping review revealed 65 studies evaluating a variety of interventions and using a range of study designs at various stages of research. Effective approaches included community-based, integrated service delivery models with case management, trained community adolescent treatment supporters, and consideration of social determinants of health. Recent evidence also supports the feasibility, acceptability, and preliminary efficacy of other innovative approaches, including mental health interventions as well as technology-delivered approaches; however, more research is needed to build the evidence base for these interventions. Our review's findings suggest that interventions providing comprehensive, individualized support are essential to improving HIV care outcomes among adolescents. More research is needed to build the evidence base for such interventions and ensure effective, equitable implementation to support the global target of ending the AIDS epidemic by 2030.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 4","pages":"218-230"},"PeriodicalIF":3.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9970447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on the Impact of Depot Medroxyprogesterone Acetate on Vaginal Mucosal Endpoints and Relevance to Sexually Transmitted Infections. 醋酸甲羟孕酮注射液对阴道黏膜终点的影响及与性传播感染的相关性的最新进展。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-08-01 Epub Date: 2023-06-21 DOI: 10.1007/s11904-023-00662-0

Smritee Dabee, Christina Balle, Maricianah Onono, Steve Innes, Gonasagrie Nair, Thesla Palanee-Phillips, Adam D Burgener, Steven E Bosinger, Jo-Ann S Passmore, Renee Heffron, Heather Jaspan, Anna-Ursula Happel

{"title":"Update on the Impact of Depot Medroxyprogesterone Acetate on Vaginal Mucosal Endpoints and Relevance to Sexually Transmitted Infections.","authors":"Smritee Dabee, Christina Balle, Maricianah Onono, Steve Innes, Gonasagrie Nair, Thesla Palanee-Phillips, Adam D Burgener, Steven E Bosinger, Jo-Ann S Passmore, Renee Heffron, Heather Jaspan, Anna-Ursula Happel","doi":"10.1007/s11904-023-00662-0","DOIUrl":"10.1007/s11904-023-00662-0","url":null,"abstract":"Purpose of review: The long-acting reversible intramuscularly-injected contraceptive depot medroxyprogesterone acetate (DMPA-IM) is widely used by cisgender women in Africa. Although DMPA-IM provides reliable contraception, potential effects on the female genital tract (FGT) mucosa have raised concern, including risk of HIV infection. This review summarises and compares evidence from observational cohort studies and the randomised Evidence for Contraceptive Options in HIV Outcomes (ECHO) Trial.Recent findings: Although previous observational studies found women using DMPA-IM had higher abundance of bacterial vaginosis (BV)-associated bacteria, increased inflammation, increased cervicovaginal HIV target cell density, and epithelial barrier damage, sub-studies of the ECHO Trial found no adverse changes in vaginal microbiome, inflammation, proteome, transcriptome, and risk of viral and bacterial STIs, other than an increase in Th17-like cells. Randomised data suggest that DMPA-IM use does not adversely change mucosal endpoints associated with acquisition of infections. These findings support the safe use of DMPA-IM in women at high risk of acquiring STIs, including HIV.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 4","pages":"251-260"},"PeriodicalIF":3.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10403392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9973492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interventions to Reduce Alcohol Use and HIV Risk among Sexual and Gender Minority Populations: a Systematic Review. 减少性少数群体和性别少数群体中饮酒和 HIV 风险的干预措施：系统综述。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-08-01 Epub Date: 2023-05-25 DOI: 10.1007/s11904-023-00660-2

Carolyn Lauckner, Kimberly Haney, Fidelis Sesenu, Trace Kershaw

{"title":"Interventions to Reduce Alcohol Use and HIV Risk among Sexual and Gender Minority Populations: a Systematic Review.","authors":"Carolyn Lauckner, Kimberly Haney, Fidelis Sesenu, Trace Kershaw","doi":"10.1007/s11904-023-00660-2","DOIUrl":"10.1007/s11904-023-00660-2","url":null,"abstract":"Purpose of review: Sexual and gender minority (SGM) individuals are diagnosed with HIV at disproportionate rates, and hazardous alcohol use can increase their HIV risk. This review assessed the state of the literature examining interventions for addressing alcohol use and sexual HIV risk behaviors among SGM individuals.Recent findings: Fourteen manuscripts from 2012 to 2022 tested interventions that address both alcohol use and HIV risk behaviors among SGM populations, with only 7 randomized controlled trials (RCTs). Virtually all the interventions targeted men who have sex with men, with none focused on transgender populations or cisgender women. While they demonstrated some evidence of effectiveness in reducing alcohol use and/or sexual risk, the outcomes varied widely between studies. More research is needed that tests interventions in this area, particularly for transgender individuals. The use of larger-scale RCTs with diverse populations and standardized outcome measures are needed to strengthen the evidence base.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 4","pages":"231-250"},"PeriodicalIF":4.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436179/pdf/nihms-1922187.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10400317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical Perspectives in Using Technology-Enabled Research for Key HIV Populations in Rights-Constrained Settings. 在权利受限的环境中使用技术支持研究关键艾滋病毒人群的伦理观点。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 DOI: 10.1007/s11904-023-00654-0

Lidia Flores, Sean D Young

引用次数: 0

The End Is in Sight: Current Strategies for the Elimination of HIV Vertical Transmission. 终点在望:消除艾滋病毒垂直传播的当前战略。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 DOI: 10.1007/s11904-023-00655-z

Lanbo Yang, Mary Catherine Cambou, Karin Nielsen-Saines

{"title":"The End Is in Sight: Current Strategies for the Elimination of HIV Vertical Transmission.","authors":"Lanbo Yang, Mary Catherine Cambou, Karin Nielsen-Saines","doi":"10.1007/s11904-023-00655-z","DOIUrl":"https://doi.org/10.1007/s11904-023-00655-z","url":null,"abstract":"Purpose of review: The goal of this review is to highlight and interpret recent trends and developments in the diagnosis, treatment, and prevention of HIV vertical transmission from a clinical perspective.Recent findings: Universal third-trimester retesting and partner testing may better identify incident HIV among pregnant patients and result in early initiation of antiretroviral therapy to prevent vertical transmission. The proven safety and efficacy of integrase inhibitors such as dolutegravir may be particularly useful in suppressing viremia in pregnant persons who present late for ART treatment. Pre-exposure prophylaxis (PrEP) during pregnancy may play a role in preventing HIV acquisition; however, its role in preventing vertical transmission is difficult to elucidate. Substantial progress has been made in recent years to eliminate HIV perinatal transmission. Future research hinges upon a multipronged approach to improving HIV detection, risk-stratified treatment strategies, and prevention of primary HIV infection among pregnant persons.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 3","pages":"121-130"},"PeriodicalIF":4.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239317/pdf/nihms-1888021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9674630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The human microbiome and gut-liver axis in people living with HIV. 艾滋病毒感染者的人体微生物组和肠道-肝脏轴。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 Epub Date: 2023-05-02 DOI: 10.1007/s11904-023-00657-x

Maria J Duarte, Phyllis C Tien, Ma Somsouk, Jennifer C Price

引用次数: 0

Implementing Geospatial Science and Technology to Get to Zero New HIV Infections. 利用地理空间科学技术实现艾滋病毒零新增感染。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 DOI: 10.1007/s11904-023-00658-w

Enbal Shacham, Stephen E Scroggins, Matthew Ellis

引用次数: 0

Reporting Individual-Level Research Results from Neurocognitive and Psychological Research in People Living with HIV: Lessons from Dementia Research. 报告艾滋病毒感染者神经认知和心理研究的个体水平研究结果:来自痴呆症研究的经验教训。

IF 4.6 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 DOI: 10.1007/s11904-023-00650-4

Holly L Peay, Stuart Rennie, Gail E Henderson

{"title":"Reporting Individual-Level Research Results from Neurocognitive and Psychological Research in People Living with HIV: Lessons from Dementia Research.","authors":"Holly L Peay, Stuart Rennie, Gail E Henderson","doi":"10.1007/s11904-023-00650-4","DOIUrl":"https://doi.org/10.1007/s11904-023-00650-4","url":null,"abstract":"Purpose of review: There are growing expectations for the return of individual-level research results (RoR), which promotes autonomy and potential clinical and personal benefits. There are ethical and practical challenges, however, that may be exacerbated in research that assesses neurocognitive and psychological outcomes, including HIV-associated neurocognitive disorder (HAND). This paper reviews central concepts for RoR and recent empirical and conceptual articles from Alzheimer's disorder (AD) as a model for HIV.Recent findings: Data from AD studies indicate high participant interest and low risk of harm from RoR, though additional research is needed. Investigators report a range of benefits, potential risks, and feasibility concerns. Standardized, evidence-based approaches are needed for RoR. For HIV research, we recommend a default position of offering RoR for cognitive and psychological outcomes. Investigators should justify decisions not to return results after assessing the potential value and feasibility of RoR. Longitudinal research is needed for feasible and evidence-based best practices.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 3","pages":"131-138"},"PeriodicalIF":4.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9669333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping Community-Engaged Implementation Strategies with Transgender Scientists, Stakeholders, and Trans-Led Community Organizations. 与跨性别科学家、利益相关者和跨性别领导的社区组织一起制定社区参与实施战略。

IF 3.7 2区医学

Current HIV/AIDS Reports Pub Date : 2023-06-01 Epub Date: 2023-04-04 DOI: 10.1007/s11904-023-00656-y

Arjee Restar, Brian J Minalga, Ma Irene Quilantang, Tyler Adamson, Emerson Dusic, Leigh-Ann van der Merwe, Greg Millet, Danvic Rosadiño, Tanya Laguing, Elle Lett, Avery Everhart, Gregory Phillips, Rena Janamnuaysook, Pich Seekaew, Kellan Baker, Florence Ashley, Jeffrey Wickersham, Stephaun E Wallace, Don Operario, Kristi E Gamarel

{"title":"Mapping Community-Engaged Implementation Strategies with Transgender Scientists, Stakeholders, and Trans-Led Community Organizations.","authors":"Arjee Restar, Brian J Minalga, Ma Irene Quilantang, Tyler Adamson, Emerson Dusic, Leigh-Ann van der Merwe, Greg Millet, Danvic Rosadiño, Tanya Laguing, Elle Lett, Avery Everhart, Gregory Phillips, Rena Janamnuaysook, Pich Seekaew, Kellan Baker, Florence Ashley, Jeffrey Wickersham, Stephaun E Wallace, Don Operario, Kristi E Gamarel","doi":"10.1007/s11904-023-00656-y","DOIUrl":"10.1007/s11904-023-00656-y","url":null,"abstract":"Purpose of review: Pre-exposure prophylaxis (PrEP) represents one of the most effective methods of prevention for HIV, but remains inequitable, leaving many transgender and nonbinary (trans) individuals unable to benefit from this resource. Deploying community-engaged PrEP implementation strategies for trans populations will be crucial for ending the HIV epidemic.Recent findings: While most PrEP studies have progressed in addressing pertinent research questions about gender-affirming care and PrEP at the biomedical and clinical levels, research on how to best implement gender-affirming PrEP systems at the social, community, and structural levels remains outstanding. The science of community-engaged implementation to build gender-affirming PrEP systems must be more fully developed. Most published PrEP studies with trans people report on outcomes rather than processes, leaving out important lessons learned about how to design, integrate, and implement PrEP in tandem with gender-affirming care. The expertise of trans scientists, stakeholders, and trans-led community organizations is essential to building gender-affirming PrEP systems.","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"20 3","pages":"160-169"},"PeriodicalIF":3.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0