Mpox and HIV: a Narrative Review.

IF 3.7 2区医学 Q2 INFECTIOUS DISEASES

Current HIV/AIDS Reports Pub Date : 2023-08-01 Epub Date: 2023-05-13 DOI:10.1007/s11904-023-00661-1

Carlos S Saldana, Colleen F Kelley, Bruce M Aldred, Valeria D Cantos

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Abstract

Purpose of review: We reviewed the available literature on mpox in People with HIV (PWH). We highlight special considerations of mpox infection related to epidemiology, clinical presentation, diagnostic and treatment considerations, prevention, and public health messaging in PWH.

Recent findings: During the 2022 mpox outbreak, PWH were disproportionally impacted worldwide. Recent reports suggest that the disease presentation, management, and prognosis of these patients, especially those with advanced HIV disease, can widely differ from those without HIV-associated immunodeficiency. Mpox can often be mild and resolve on its own in PWH with controlled viremia and higher CD4 counts. However, it can be severe, with necrotic skin lesions and protracted healing; anogenital, rectal, and other mucosal lesions; and disseminated organ systems involvement. Higher rates of healthcare utilization are seen in PWH. Supportive, symptomatic care and single or combination mpox-directed antiviral drugs are commonly used in PWH with severe mpox disease. Data from randomized clinical control trials on the efficacy of therapeutic and preventive tools against mpox among PWH are needed to better guide clinical decisions.

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Mpox 与 HIV：叙述性综述。

综述目的：我们回顾了有关艾滋病病毒感染者（PWH）水痘的现有文献。我们强调了感染天花的流行病学、临床表现、诊断和治疗注意事项、预防以及针对艾滋病感染者的公共卫生信息等方面的特殊考虑：在 2022 年麻风腮疫情爆发期间，全世界感染麻风腮疫情的威尔士和威尔士族人数不成比例。最新报告显示，这些患者（尤其是晚期艾滋病患者）的疾病表现、管理和预后可能与未患艾滋病相关免疫缺陷的患者大不相同。在病毒血症得到控制、CD4 细胞计数较高的感染者中，麻疹通常是轻微的，并可自行缓解。然而，它也可能很严重，出现皮肤坏死和长期愈合；肛门、直肠和其他粘膜病变；以及器官系统受累。公共卫生人员的医疗保健使用率较高。对于患有严重水痘的威斯康星人，通常采用支持性对症治疗和单一或联合水痘导向抗病毒药物。为了更好地指导临床决策，需要从随机临床对照试验中获得有关治疗和预防水痘工具在威尔士人中疗效的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current HIV/AIDS Reports INFECTIOUS DISEASES-

CiteScore

8.10

自引率

2.20%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.