{"title":"The Role of Liver Biopsy and Fine Needle Aspiration in Novel HBV Therapeutics in HIV and HBV Coinfection.","authors":"Alexandra N Willauer, Kenneth E Sherman","doi":"10.1007/s11904-025-00754-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Liver biopsy and FNA in persons with HIV-HBV coinfection can aid in the assessment of intrahepatic milieu, direct functional cure strategies, and facilitate development of novel therapeutics.</p><p><strong>Recent findings: </strong>Liver tissue sampling provides important insight into the intrahepatic viral reservoir and complex immune microenvironment in HIV-HBV coinfection. Additionally, the development of tissue-based viral markers, specifically cccDNA and integrated HBV DNA, paired with novel, noninvasive biomarkers and advanced techniques for tissue processing and analysis have been instrumental in this process. Hepatic tissue sampling also offers unique insights into treatment responses and understanding deficiencies of existing therapies that cannot be assessed by noninvasive means alone, which informs the development of novel therapeutics. Liver biopsy and liver tissue fine needle aspiration represent important modalities that will continue to drive research and innovation leading to HBV cure strategies.</p>","PeriodicalId":10930,"journal":{"name":"Current HIV/AIDS Reports","volume":"22 1","pages":"45"},"PeriodicalIF":4.4000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current HIV/AIDS Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11904-025-00754-z","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: Liver biopsy and FNA in persons with HIV-HBV coinfection can aid in the assessment of intrahepatic milieu, direct functional cure strategies, and facilitate development of novel therapeutics.
Recent findings: Liver tissue sampling provides important insight into the intrahepatic viral reservoir and complex immune microenvironment in HIV-HBV coinfection. Additionally, the development of tissue-based viral markers, specifically cccDNA and integrated HBV DNA, paired with novel, noninvasive biomarkers and advanced techniques for tissue processing and analysis have been instrumental in this process. Hepatic tissue sampling also offers unique insights into treatment responses and understanding deficiencies of existing therapies that cannot be assessed by noninvasive means alone, which informs the development of novel therapeutics. Liver biopsy and liver tissue fine needle aspiration represent important modalities that will continue to drive research and innovation leading to HBV cure strategies.
期刊介绍：
This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS.
We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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