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Innate immune responses and monocyte-derived phagocyte recruitment in protective immunity to pathogenic bacteria: insights from Legionella pneumophila 致病菌保护性免疫中的先天性免疫反应和单核细胞源性吞噬细胞招募：嗜肺军团菌的启示
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-06-21 DOI: 10.1016/j.mib.2024.102495
Danielle PA Mascarenhas, Dario S Zamboni
{"title":"Innate immune responses and monocyte-derived phagocyte recruitment in protective immunity to pathogenic bacteria: insights from Legionella pneumophila","authors":"Danielle PA Mascarenhas,&nbsp;Dario S Zamboni","doi":"10.1016/j.mib.2024.102495","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102495","url":null,"abstract":"<div><p><em>Legionella</em> species are Gram-negative intracellular bacteria that evolved in soil and freshwater environments, where they infect and replicate within various unicellular protozoa. The primary virulence factor of <em>Legionella</em> is the expression of a type IV secretion system (T4SS), which contributes to the translocation of effector proteins that subvert biological processes of the host cells. Because of its evolution in unicellular organisms, T4SS effector proteins are not adapted to subvert specific mammalian signaling pathways and immunity. Consequently, <em>Legionella pneumophila</em> has emerged as an interesting infection model for investigating immune responses against pathogenic bacteria in multicellular organisms. This review highlights recent advances in our understanding of mammalian innate immunity derived from studies involving <em>L. pneumophila</em>. This includes recent insights into inflammasome-mediated mechanisms restricting bacterial replication in macrophages, mechanisms inducing cell death in response to infection, induction of effector-triggered immunity, activation of specific pulmonary cell types in mammalian lungs, and the protective role of recruiting monocyte-derived cells to infected lungs.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102495"},"PeriodicalIF":5.9,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic structural determinants in bacterial microcompartment shells 细菌微室外壳的动态结构决定因素
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-06-21 DOI: 10.1016/j.mib.2024.102497
Daniel S Trettel , Cheryl A Kerfeld , Cesar R Gonzalez-Esquer
{"title":"Dynamic structural determinants in bacterial microcompartment shells","authors":"Daniel S Trettel ,&nbsp;Cheryl A Kerfeld ,&nbsp;Cesar R Gonzalez-Esquer","doi":"10.1016/j.mib.2024.102497","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102497","url":null,"abstract":"<div><p>Bacterial microcompartments (BMCs) are polyhedral structures that segregate enzymatic cargo from the cytosol via encapsulation within a protein shell. Unlike other biological polyhedra, such as viral capsids and encapsulins, BMC shells can exhibit a highly advantageous structural and functional plasticity, conforming to a variety of anabolic (CO<sub>2</sub> fixation in carboxysomes) and catabolic (nutrient assimilation in metabolosomes) roles. Consequently, understanding the subunit properties and associated protein–protein interaction processes that guide shell assembly and function is a necessary step to fully harness BMCs as modular, biotechnological nanomachines. Here, we describe the recent insights into the dynamics of structural features of the key BMC domain (Pfam00936)-containing proteins, which serve as a structural template for BMC-H and BMC-T shell building blocks.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102497"},"PeriodicalIF":5.9,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000730/pdfft?md5=2e910502ba77b4682b331f3fa92fcb86&pid=1-s2.0-S1369527424000730-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symbioses between fungi and bacteria: from mechanisms to impacts on biodiversity 真菌与细菌共生：从机制到对生物多样性的影响
IF 5.4 2区 生物学
Current opinion in microbiology Pub Date : 2024-06-13 DOI: 10.1016/j.mib.2024.102496
Teresa E Pawlowska
{"title":"Symbioses between fungi and bacteria: from mechanisms to impacts on biodiversity","authors":"Teresa E Pawlowska","doi":"10.1016/j.mib.2024.102496","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102496","url":null,"abstract":"<div><p>Symbiotic interactions between fungi and bacteria range from positive to negative. They are ubiquitous in free-living as well as host-associated microbial communities worldwide. Yet, the impact of fungal–bacterial symbioses on the organization and dynamics of microbial communities is uncertain. There are two reasons for this uncertainty: (1) knowledge gaps in the understanding of the genetic mechanisms underpinning fungal–bacterial symbioses and (2) prevailing interpretations of ecological theory that favor antagonistic interactions as drivers stabilizing biological communities despite the existence of models emphasizing contributions of positive interactions. This review synthesizes information on fungal–bacterial symbioses common in the free-living microbial communities of the soil as well as in host-associated polymicrobial biofilms. The interdomain partnerships are considered in the context of the relevant community ecology models, which are discussed critically.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102496"},"PeriodicalIF":5.4,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000729/pdfft?md5=24e0b032b3b712dbea8582e2ff01c98c&pid=1-s2.0-S1369527424000729-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141314917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gear up! An overview of the molecular equipment used by Myxococcus to move, kill, and divide in prey colonies 装备！概述粘球菌在猎物群中移动、杀戮和分裂所使用的分子设备
IF 5.4 2区 生物学
Current opinion in microbiology Pub Date : 2024-06-05 DOI: 10.1016/j.mib.2024.102492
Julien Herrou, Dorothée Murat, Tâm Mignot
{"title":"Gear up! An overview of the molecular equipment used by Myxococcus to move, kill, and divide in prey colonies","authors":"Julien Herrou,&nbsp;Dorothée Murat,&nbsp;Tâm Mignot","doi":"10.1016/j.mib.2024.102492","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102492","url":null,"abstract":"<div><p><em>Myxococcus</em> relies on motility to efficiently invade and predate a prey colony. Upon contact with prey, <em>Myxococcus</em> temporarily halts its motility and initiates prey cell lysis, which involves two contact-dependent predatory machineries, the Kil system and the needleless T3SS*. Predatory cells grow as they invade and feed on prey cells. When dividing, <em>Myxococcus</em> cells systematically pause their movements before division. This highlights a high level of co-ordination between motility and contact-dependent killing but also with cell division. In this review, we give an overview of the different nanomachines used by <em>Myxococcus</em> to move on surfaces, kill by contact, and divide, and we discuss the potential regulatory mechanisms at play during these different processes.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102492"},"PeriodicalIF":5.4,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000687/pdfft?md5=c4fbf779d81e3dbb8ec0b85aebc6f54c&pid=1-s2.0-S1369527424000687-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Candida albicans natural diversity: a resource to dissect fungal commensalism and pathogenesis 白色念珠菌的自然多样性：剖析真菌共生和致病机理的资源
IF 5.4 2区 生物学
Current opinion in microbiology Pub Date : 2024-06-03 DOI: 10.1016/j.mib.2024.102493
Elena Lindemann-Perez, J. Christian Perez
{"title":"Candida albicans natural diversity: a resource to dissect fungal commensalism and pathogenesis","authors":"Elena Lindemann-Perez,&nbsp;J. Christian Perez","doi":"10.1016/j.mib.2024.102493","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102493","url":null,"abstract":"<div><p><em>Candida albicans</em> is a ubiquitous fungus of humans. It is not only a component of the oral and intestinal microbiota of most healthy adults but also a major cause of mucosal disorders and life-threatening disseminated infections. Until recently, research on the biology and pathogenesis of the fungus was largely based on a single clinical isolate. We review investigations that have started to dissect a diverse set of <em>C. albicans</em> strains. Using different approaches to leverage the species’ phenotypic and/or genetic diversity, these studies illuminate the wide range of interactions between fungus and host. While connecting genetic variants to phenotypes of interest remains challenging, research on <em>C. albicans</em>’ natural diversity is central to understand fungal commensalism and pathogenesis.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102493"},"PeriodicalIF":5.4,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrids unleashed: exploring the emergence and genomic insights of pathogenic yeast hybrids 释放杂交种：探索病原酵母杂交种的出现和基因组见解
IF 5.4 2区 生物学
Current opinion in microbiology Pub Date : 2024-06-03 DOI: 10.1016/j.mib.2024.102491
Valentina del Olmo , Toni Gabaldón
{"title":"Hybrids unleashed: exploring the emergence and genomic insights of pathogenic yeast hybrids","authors":"Valentina del Olmo ,&nbsp;Toni Gabaldón","doi":"10.1016/j.mib.2024.102491","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102491","url":null,"abstract":"<div><p>Hybridisation is the crossing of two divergent lineages that give rise to offspring carrying an admixture of both parental genomes. Genome sequencing has revealed that this process is common in the Saccharomycotina, where a growing number of hybrid strains or species, including many pathogenic ones, have been recently described. Hybrids can display unique traits that may drive adaptation to new niches, and some pathogenic hybrids have been shown to have higher prevalence over their parents in human and environmental niches, suggesting a higher fitness and potential to colonise humans. Here, we discuss how hybridisation and its genomic and phenotypic outcomes can shape the evolution of fungal species and may play a role in the emergence of new pathogens.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102491"},"PeriodicalIF":5.4,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000675/pdfft?md5=441a67007d4a4dbc5cc5874b3d06c1ba&pid=1-s2.0-S1369527424000675-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host–microbe interactions: communication in the microbiota–gut–brain axis 宿主与微生物的相互作用：微生物群-肠-脑轴的交流。
IF 5.4 2区 生物学
Current opinion in microbiology Pub Date : 2024-06-01 DOI: 10.1016/j.mib.2024.102494
Aryan Shekarabi, Izhan Qureishy, Chloe H Puglisi, Marge Dalseth, Helen E Vuong
{"title":"Host–microbe interactions: communication in the microbiota–gut–brain axis","authors":"Aryan Shekarabi,&nbsp;Izhan Qureishy,&nbsp;Chloe H Puglisi,&nbsp;Marge Dalseth,&nbsp;Helen E Vuong","doi":"10.1016/j.mib.2024.102494","DOIUrl":"10.1016/j.mib.2024.102494","url":null,"abstract":"<div><p>Animals harbor a diverse array of symbiotic micro-organisms that coexist in communities across different body sites. These microbes maintain host homeostasis and respond to environmental insults to impact host physiological processes. Trillions of indigenous microbes reside in the gastrointestinal tract and engage with the host central nervous system (microbiota–gut–brain axis) by modulating immune responses, interacting with gut intrinsic and extrinsic nervous system, and regulating neuromodulators and biochemicals. These gut microbiota to brain signaling pathways are constantly informed by each other and are hypothesized to mediate brain health across the lifespan. In this review, we will examine the crosstalk of gut microbiota to brain communications in neurological pathologies, with an emphasis on microbial metabolites and neuromodulators, and provide a discussion of recent advances that help elucidate the microbiota as a therapeutic target for treating brain and behavioral disorders.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102494"},"PeriodicalIF":5.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141198994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stay on track — revelations of bacterial cell wall synthesis enzymes and things that go by single-molecule imaging 继续前进--揭示细菌细胞壁合成酶和单分子成像技术。
IF 5.4 2区 生物学
Current opinion in microbiology Pub Date : 2024-06-01 DOI: 10.1016/j.mib.2024.102490
Amilcar J. Perez, Jie Xiao
{"title":"Stay on track — revelations of bacterial cell wall synthesis enzymes and things that go by single-molecule imaging","authors":"Amilcar J. Perez,&nbsp;Jie Xiao","doi":"10.1016/j.mib.2024.102490","DOIUrl":"10.1016/j.mib.2024.102490","url":null,"abstract":"<div><p>In this review, we explore the regulation of septal peptidoglycan (sPG) synthesis in bacterial cell division, a critical process for cell viability and proper morphology. Recent single-molecule imaging studies have revealed the processive movement of the FtsW:bPBP synthase complex along the septum, shedding light on the spatiotemporal dynamics of sPG synthases and their regulators. In diderm bacteria (<em>E. coli</em> and <em>C. crescentus</em>), the movement occurs at two distinct speeds, reflecting active synthesis or inactivity driven by FtsZ-treadmilling. In monoderm bacteria (<em>B. subtilis, S. pneumoniae</em>, and <em>S. aureus</em>), however, these enzymes exhibit only the active sPG-track-coupled processive movement. By comparing the dynamics of sPG synthases in these organisms and that of class-A penicillin-binding proteins <em>in vivo</em> and <em>in vitro</em>, we propose a unifying model for septal cell wall synthesis regulation across species, highlighting the roles of the sPG- and Z-tracks in orchestrating a robust bacterial cell wall constriction process.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102490"},"PeriodicalIF":5.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of CO2 in fungi 二氧化碳对真菌的影响
IF 5.4 2区 生物学
Current opinion in microbiology Pub Date : 2024-05-17 DOI: 10.1016/j.mib.2024.102488
Benjamin J Chadwick, Xiaorong Lin
{"title":"Effects of CO2 in fungi","authors":"Benjamin J Chadwick,&nbsp;Xiaorong Lin","doi":"10.1016/j.mib.2024.102488","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102488","url":null,"abstract":"<div><p>Carbon dioxide supplies carbon for photosynthetic species and is a major product of respiration for all life forms. Inside the human body where CO<sub>2</sub> is a by-product of the tricarboxylic acid cycle, its level reaches 5% or higher. In the ambient atmosphere, ∼.04% of the air is CO<sub>2</sub>. Different organisms can tolerate different CO<sub>2</sub> levels to various degrees, and experiencing higher CO<sub>2</sub> is toxic and can lead to death. The fungal kingdom shows great variations in response to CO<sub>2</sub> that has been documented by different researchers at different time periods. This literature review aims to connect these studies, highlight mechanisms underlying tolerance to high levels of CO<sub>2</sub>, and emphasize the effects of CO<sub>2</sub> on fungal metabolism and morphogenesis.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102488"},"PeriodicalIF":5.4,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140951027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The many roles of sulfur in the fungal–host interaction 硫在真菌与寄主相互作用中的多种作用
IF 5.4 2区 生物学
Current opinion in microbiology Pub Date : 2024-05-15 DOI: 10.1016/j.mib.2024.102489
Jorge Amich
{"title":"The many roles of sulfur in the fungal–host interaction","authors":"Jorge Amich","doi":"10.1016/j.mib.2024.102489","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102489","url":null,"abstract":"<div><p>Sulfur is an essential macronutrient for life, and consequently, all living organisms must acquire it from external sources to thrive and grow. Sulfur is a constituent of a multitude of crucial molecules, such as the S-containing proteinogenic amino acids cysteine and methionine; cofactors and prosthetic groups, such as coenzyme-A and iron–sulfur (Fe–S) clusters; and other essential organic molecules, such as glutathione or S-adenosylmethionine. Additionally, sulfur in cysteine thiols is an active redox group that plays paramount roles in protein stability, enzyme catalysis, and redox homeostasis. Furthermore, H<sub>2</sub>S is gaining more attention as a crucial signaling molecule that influences metabolism and physiological functions. Given its importance, it is not surprising that sulfur plays key roles in the host–pathogen interaction. However, in contrast to its well-recognized involvement in the plant–pathogen interaction, the specific contributions of sulfur to the human–fungal interaction are much less understood. In this short review, I highlight some of the most important known mechanisms and propose directions for further research.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102489"},"PeriodicalIF":5.4,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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