Current opinion in microbiology最新文献_第7页

Natural product discovery in soil actinomycetes: unlocking their potential within an ecological context 土壤放线菌中的天然产物发现：在生态环境中发掘其潜力

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-05-11 DOI: 10.1016/j.mib.2024.102487

Jana K Schniete , Lorena T Fernández-Martínez

引用次数: 0

Archaea oxidizing alkanes through alkyl-coenzyme M reductases 古菌通过烷基辅酶 M 还原酶氧化烷烃

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-05-10 DOI: 10.1016/j.mib.2024.102486

Florin Musat , Kasper U Kjeldsen , Amelia E Rotaru , Song-Can Chen , Niculina Musat

{"title":"Archaea oxidizing alkanes through alkyl-coenzyme M reductases","authors":"Florin Musat , Kasper U Kjeldsen , Amelia E Rotaru , Song-Can Chen , Niculina Musat","doi":"10.1016/j.mib.2024.102486","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102486","url":null,"abstract":"<div><p>This review synthesizes recent discoveries of novel archaea clades capable of oxidizing higher alkanes, from volatile ones like ethane to longer-chain alkanes like hexadecane. These archaea, termed anaerobic multicarbon alkane-oxidizing archaea (ANKA), initiate alkane oxidation using alkyl-coenzyme M reductases, enzymes similar to the methyl-coenzyme M reductases of methanogenic and anaerobic methanotrophic archaea (ANME). The polyphyletic alkane-oxidizing archaea group (ALOX), encompassing ANME and ANKA, harbors increasingly complex alkane degradation pathways, correlated with the alkane chain length. We discuss the evolutionary trajectory of these pathways emphasizing metabolic innovations and the acquisition of metabolic modules via lateral gene transfer. Additionally, we explore the mechanisms by which archaea couple alkane oxidation with the reduction of electron acceptors, including electron transfer to partner sulfate-reducing bacteria (SRB). The phylogenetic and functional constraints that shape ALOX–SRB associations are also discussed. We conclude by highlighting the research needs in this emerging research field and its potential applications in biotechnology.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102486"},"PeriodicalIF":5.4,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000626/pdfft?md5=c52b2cc3a7c1334a57966620f316f82b&pid=1-s2.0-S1369527424000626-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alpha- and betacoronavirus cis-acting RNA elements α-和β-冠状病毒顺式作用 RNA 元件

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-05-08 DOI: 10.1016/j.mib.2024.102483

Ramakanth Madhugiri, Hoang Viet Nguyen, Heiko Slanina, John Ziebuhr

{"title":"Alpha- and betacoronavirus cis-acting RNA elements","authors":"Ramakanth Madhugiri, Hoang Viet Nguyen, Heiko Slanina, John Ziebuhr","doi":"10.1016/j.mib.2024.102483","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102483","url":null,"abstract":"<div><p>Coronaviruses have exceptionally large RNA genomes and employ multiprotein replication/transcription complexes to orchestrate specific steps of viral RNA genome replication and expression. Most of these processes involve viral <em>cis</em>-acting RNA elements that are engaged in vital RNA–RNA and/or RNA–protein interactions. Over the past years, a large number of studies provided interesting new insight into the structures and, to a lesser extent, functions of specific RNA elements for representative coronaviruses, and there is evidence to suggest that (a majority of) these RNA elements are conserved across genetically divergent coronavirus genera. It is becoming increasingly clear that at least some of these elements do not function in isolation but operate through complex and highly dynamic RNA–RNA interactions. This article reviews structural and functional aspects of <em>cis</em>-acting RNA elements conserved in alpha- and betacoronavirus 5'- and 3'-terminal genome regions, focusing on their critical roles in viral RNA synthesis and gene expression.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102483"},"PeriodicalIF":5.4,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000596/pdfft?md5=5a9e94b6d45e63012dfb94dddc8e7d50&pid=1-s2.0-S1369527424000596-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positioning of cellular components by the ParA/MinD family of ATPases ParA/MinD ATP 酶家族确定细胞成分的位置

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-05-08 DOI: 10.1016/j.mib.2024.102485

Lisa T Pulianmackal , Anthony G Vecchiarelli

引用次数: 0

Co-ordinated assembly of the multilayered cell envelope of Gram-negative bacteria 革兰氏阴性细菌多层细胞包膜的协调组装

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-05-07 DOI: 10.1016/j.mib.2024.102479

Elayne M Fivenson , Laurent Dubois , Thomas G Bernhardt

{"title":"Co-ordinated assembly of the multilayered cell envelope of Gram-negative bacteria","authors":"Elayne M Fivenson , Laurent Dubois , Thomas G Bernhardt","doi":"10.1016/j.mib.2024.102479","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102479","url":null,"abstract":"<div><p>Bacteria surround themselves with complex cell envelopes to maintain their integrity and protect against external insults. The envelope of Gram-negative organisms is multilayered, with two membranes sandwiching the periplasmic space that contains the peptidoglycan cell wall. Understanding how this complicated surface architecture is assembled during cell growth and division is a major fundamental problem in microbiology. Additionally, because the envelope is an important antibiotic target and determinant of intrinsic antibiotic resistance, understanding the mechanisms governing its assembly is relevant to therapeutic development. In the last several decades, most of the factors required to build the Gram-negative envelope have been identified. However, surprisingly, little is known about how the biogenesis of the different cell surface layers is co-ordinated. Here, we provide an overview of recent work that is beginning to uncover the links connecting the different envelope biosynthetic pathways and assembly machines to ensure uniform envelope growth.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102479"},"PeriodicalIF":5.4,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000559/pdfft?md5=3f5c644d39239dd0fd9c9e8d7e64fb19&pid=1-s2.0-S1369527424000559-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140880357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Entering deeper into the mysteries of the GroEL–GroES nanomachine 深入探索 GroEL-GroES 纳米机械的奥秘

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-05-06 DOI: 10.1016/j.mib.2024.102480

Emile Dupuy , Jean-François Collet

引用次数: 0

Implications of lytic phage infections inducing persistence 裂解噬菌体感染诱导持久性的影响

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-05-06 DOI: 10.1016/j.mib.2024.102482

Viviana Sanchez-Torres , Joy Kirigo , Thomas K. Wood

引用次数: 0

Bacterial synthase-dependent exopolysaccharide secretion: a focus on cellulose 细菌合成酶依赖性外多糖分泌：聚焦纤维素

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-04-29 DOI: 10.1016/j.mib.2024.102476

Petya V. Krasteva

{"title":"Bacterial synthase-dependent exopolysaccharide secretion: a focus on cellulose","authors":"Petya V. Krasteva","doi":"10.1016/j.mib.2024.102476","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102476","url":null,"abstract":"<div><p>Bacterial biofilms are a prevalent multicellular life form in which individual members can undergo significant functional differentiation and are typically embedded in a complex extracellular matrix of proteinaceous fimbriae, extracellular DNA, and exopolysaccharides (EPS). Bacteria have evolved at least four major mechanisms for EPS biosynthesis, of which the synthase-dependent systems for bacterial cellulose secretion (Bcs) represent not only key biofilm determinants in a wide array of environmental and host-associated microbes, but also an important model system for the studies of processive glycan polymerization, cyclic diguanylate (c-di-GMP)-dependent synthase regulation, and biotechnological polymer applications. The secreted cellulosic chains can be decorated with additional chemical groups or can pack with various degrees of crystallinity depending on dedicated enzymatic complexes and/or cytoskeletal scaffolds. Here, I review recent progress in our understanding of synthase-dependent EPS biogenesis with a focus on common and idiosyncratic molecular mechanisms across diverse cellulose secretion systems.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102476"},"PeriodicalIF":5.4,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000523/pdfft?md5=f855e430bf5684a61eb904490302374b&pid=1-s2.0-S1369527424000523-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140813284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to switch gears: how long noncoding RNAs function as epigenetic regulators in Apicomplexan parasites 换挡时间：长非编码 RNA 如何在表皮复合寄生虫中发挥表观遗传调节作用

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-04-29 DOI: 10.1016/j.mib.2024.102484

Vera Mitesser, Karina Simantov, Ron Dzikowski

引用次数: 0

PII-like signaling proteins: a new paradigm in orchestrating cellular homeostasis 类 PII 信号蛋白：协调细胞平衡的新范例

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-04-27 DOI: 10.1016/j.mib.2024.102453

Khaled A. Selim , Vikram Alva

{"title":"PII-like signaling proteins: a new paradigm in orchestrating cellular homeostasis","authors":"Khaled A. Selim , Vikram Alva","doi":"10.1016/j.mib.2024.102453","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102453","url":null,"abstract":"<div><p>Members of the PII superfamily are versatile, multitasking signaling proteins ubiquitously found in all domains of life. They adeptly monitor and synchronize the cell's carbon, nitrogen, energy, redox, and diurnal states, primarily by binding interdependently to adenyl-nucleotides, including charged nucleotides (ATP, ADP, and AMP) and second messengers such as Cyclic adenosine monophosphate, Cyclic di-adenosine monophosphate, and S-adenosylmethionine–AMP (SAM-AMP). These proteins also undergo a variety of posttranslational modifications, such as phosphorylation, adenylation, uridylation, carboxylation, and disulfide bond formation, which further provide cues on the metabolic state of the cell. Serving as precise metabolic sensors, PII superfamily proteins transmit this information to diverse cellular targets, establishing dynamic regulatory assemblies that fine-tune cellular homeostasis. Recently discovered, PII-like proteins are emerging families of signaling proteins that, while related to canonical PII proteins, have evolved to fulfill a diverse range of cellular functions, many of which remain elusive. In this review, we focus on the evolution of PII-like proteins and summarize the molecular mechanisms governing the assembly dynamics of PII complexes, with a special emphasis on the PII-like protein SbtB.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102453"},"PeriodicalIF":5.4,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140807154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0