Current opinion in microbiology最新文献_第10页

Regulation of sexual commitment in malaria parasites — a complex affair 疟疾寄生虫的性承诺调控--一件复杂的事情

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-04-04 DOI: 10.1016/j.mib.2024.102469

Till S Voss , Nicolas MB Brancucci

引用次数: 0

Proteomic composition of eukaryotic and bacterial RNA decay condensates suggests convergent evolution 真核生物和细菌 RNA 衰变凝聚物的蛋白质组组成表明它们在趋同进化

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-04-03 DOI: 10.1016/j.mib.2024.102467

IW Rathnayaka-Mudiyanselage , V Nandana , JM Schrader

{"title":"Proteomic composition of eukaryotic and bacterial RNA decay condensates suggests convergent evolution","authors":"IW Rathnayaka-Mudiyanselage , V Nandana , JM Schrader","doi":"10.1016/j.mib.2024.102467","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102467","url":null,"abstract":"<div><p>Bacterial cells have a unique challenge to organize their cytoplasm without the use of membrane-bound organelles. Biomolecular condensates (henceforth BMCs) are a class of nonmembrane-bound organelles, which, through the physical process of phase separation, can form liquid-like droplets with proteins/nucleic acids. BMCs have been broadly characterized in eukaryotic cells, and BMCs have been recently identified in bacteria, with the first and best studied example being bacterial ribonucleoprotein bodies (BR-bodies). BR-bodies contain the RNA decay machinery and show functional parallels to eukaryotic P-bodies (PBs) and stress granules (SGs). Due to the finding that mRNA decay machinery is compartmentalized in BR-bodies and in eukaryotic PBs/SGs, we will explore the functional similarities in the proteins, which are known to enrich in these structures based on recent proteomic studies. Interestingly, despite the use of different mRNA decay and post-transcriptional regulatory machinery, this analysis has revealed evolutionary convergence in the classes of enriched enzymes in these structures.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102467"},"PeriodicalIF":5.4,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140341197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Getting to the point: unipolar growth of Hyphomicrobiales 切入正题：单极生长的半知菌纲动物

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-04-03 DOI: 10.1016/j.mib.2024.102470

Jennifer Amstutz , Elizaveta Krol , Audrey Verhaeghe , Xavier De Bolle , Anke Becker , Pamela JB Brown

{"title":"Getting to the point: unipolar growth of Hyphomicrobiales","authors":"Jennifer Amstutz , Elizaveta Krol , Audrey Verhaeghe , Xavier De Bolle , Anke Becker , Pamela JB Brown","doi":"10.1016/j.mib.2024.102470","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102470","url":null,"abstract":"<div><p>The governing principles and suites of genes for lateral elongation or incorporation of new cell wall material along the length of a rod-shaped cell are well described. In contrast, relatively little is known about unipolar elongation or incorporation of peptidoglycan at one end of the rod. Recent work in three related model systems of unipolar growth (<em>Agrobacterium tumefaciens</em>, <em>Brucella abortus,</em> and <em>Sinorhizobium meliloti</em>) has clearly established that unipolar growth in the Hyphomicrobiales order relies on a set of genes distinct from the canonical elongasome. Polar incorporation of envelope components relies on homologous proteins shared by the Hyphomicrobiales, reviewed here. Ongoing and future work will reveal how unipolar growth is integrated into the alphaproteobacterial cell cycle and coordinated with other processes such as chromosome segregation and cell division.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102470"},"PeriodicalIF":5.4,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000468/pdfft?md5=d6f05b89d34f4ca9ad052ee50a625c18&pid=1-s2.0-S1369527424000468-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140341196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virulence-associated factors as targets for phage infection 作为噬菌体感染目标的病毒相关因子

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-04-03 DOI: 10.1016/j.mib.2024.102471

Alessandra G de Melo , Carlee Morency , Sylvain Moineau

{"title":"Virulence-associated factors as targets for phage infection","authors":"Alessandra G de Melo , Carlee Morency , Sylvain Moineau","doi":"10.1016/j.mib.2024.102471","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102471","url":null,"abstract":"<div><p>Bacterial pathogens can infect a wide range of hosts and pose a threat to public and animal health as well as to agriculture. The emergence of antibiotic-resistant strains has increased this risk by making the treatment of bacterial infections even more challenging. Pathogenic bacteria thrive in various ecological niches, but they can also be specifically targeted and killed by bacteriophages (phages). Lytic phages are now investigated and even used, in some cases, as alternatives or complements to antibiotics for preventing or treating bacterial infections (phage therapy). As such, it is key to identify factors responsible for phage specificity and efficiency. Here, we review recent advances in virulence-associated factors that are targeted by phages. We highlight components of the bacterial cell surface, effector systems, and motility structures exploited by phages and the effects of phages on cell aggregation and communication. We also look at the fitness trade-off of phage resistance.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102471"},"PeriodicalIF":5.4,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S136952742400047X/pdfft?md5=39a1ff368d77b41ac7fbece60a957e90&pid=1-s2.0-S136952742400047X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140341198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences and similarities between innate immune evasion strategies of human coronaviruses 人类冠状病毒先天免疫逃避策略的异同

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-03-30 DOI: 10.1016/j.mib.2024.102466

Helene Hoenigsperger, Rinu Sivarajan, Konstantin MJ Sparrer

引用次数: 0

Function of autophagy genes in innate immune defense against mucosal pathogens 自噬基因在抵御粘膜病原体的先天免疫防御中的功能

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-03-29 DOI: 10.1016/j.mib.2024.102456

Xiaoyan Cui , Ya-Ting Wang

引用次数: 0

Host determinants and responses underlying SARS-CoV-2 liver tropism SARS-CoV-2肝脏趋向性的宿主决定因素和反应

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-03-23 DOI: 10.1016/j.mib.2024.102455

Natalie Heinen , Mara Klöhn , Saskia Westhoven , Richard JP Brown , Stephanie Pfaender

{"title":"Host determinants and responses underlying SARS-CoV-2 liver tropism","authors":"Natalie Heinen , Mara Klöhn , Saskia Westhoven , Richard JP Brown , Stephanie Pfaender","doi":"10.1016/j.mib.2024.102455","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102455","url":null,"abstract":"<div><p>Hepatic sequelae are frequently reported in coronavirus disease 2019 cases and are correlated with increased disease severity. Therefore, a detailed exploration of host factors contributing to hepatic impairment and ultimately infection outcomes in patients is essential for improved clinical management. The causes of hepatic injury are not limited to drug-mediated toxicity or aberrant host inflammatory responses. Indeed, multiple studies report the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in liver autopsies and the susceptibility of explanted human hepatocytes to infection. In this review, we confirm that hepatic cells express an extensive range of factors implicated in SARS-CoV-2 entry. We also provide an overview of studies reporting evidence for direct infection of liver cell types and the infection-induced cell-intrinsic processes that likely contribute to hepatic impairment.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102455"},"PeriodicalIF":5.4,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000316/pdfft?md5=be8a9242d8d75e7631712a2491018c57&pid=1-s2.0-S1369527424000316-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The expanding universe of contractile injection systems in bacteria 细菌收缩注射系统的不断扩展

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-03-22 DOI: 10.1016/j.mib.2024.102465

Lin Lin

引用次数: 0

Upping the ante: enhanced expression of interferon-antagonizing ORF6 and ORF9b proteins by SARS-CoV-2 variants of concern 更上一层楼：值得关注的 SARS-CoV-2 变体增强了干扰素拮抗 ORF6 和 ORF9b 蛋白的表达量

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-03-21 DOI: 10.1016/j.mib.2024.102454

Allen Caobi , Mohsan Saeed

{"title":"Upping the ante: enhanced expression of interferon-antagonizing ORF6 and ORF9b proteins by SARS-CoV-2 variants of concern","authors":"Allen Caobi , Mohsan Saeed","doi":"10.1016/j.mib.2024.102454","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102454","url":null,"abstract":"<div><p>SARS-CoV-2 exhibits a remarkable capability to subvert the host antiviral innate immune system. This adeptness is orchestrated by viral proteins, which initially attempt to obstruct the activation of the antiviral immune program and then act as a fail-safe mechanism to mitigate the downstream effects of the activated immune response. This dual strategy leads to delayed expression and enfeebled action of type-I and -III interferons at the infection site, enabling the virus to replicate extensively in the lungs and subsequently disseminate to other organs. Throughout the course of the COVID-19 pandemic, SARS-CoV-2 has undergone evolution, giving rise to several variants of concern, some with exceedingly higher transmission and virulence. These improved features have been linked, at least in part, to the heightened expression or activity of specific viral proteins involved in circumventing host defense mechanisms. In this review, we aim to provide a concise summary of two SARS-CoV-2 proteins, ORF6 and ORF9b, which provided selective advantage to certain variants, affecting their biology and pathogenesis.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102454"},"PeriodicalIF":5.4,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140180088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ecology and evolution of algal–fungal symbioses 藻菌共生的生态与进化

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-03-10 DOI: 10.1016/j.mib.2024.102452

Gregory Bonito

引用次数: 0