Current opinion in microbiology最新文献_第10页

The ‘ins and outs’ of Brucella intracellular journey 布鲁氏菌细胞内旅程的 "来龙去脉

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-02-02 DOI: 10.1016/j.mib.2024.102427

María I Marchesini , Juan M Spera , Diego J Comerci

引用次数: 0

Co-opting bacterial viruses for DNA exchange: structure and regulation of gene transfer agents 与细菌病毒合作进行 DNA 交换：基因转移剂的结构与调控

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-02-02 DOI: 10.1016/j.mib.2024.102431

Emma J Banks, Tung B K Le

引用次数: 0

Phage fibers and spikes: a nanoscale Swiss army knife for host infection 噬菌体纤维和尖刺：宿主感染的纳米级瑞士军刀

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-02-01 DOI: 10.1016/j.mib.2024.102429

Ruochen Ouyang , Véronique Ongenae , Alise Muok , Dennis Claessen , Ariane Briegel

{"title":"Phage fibers and spikes: a nanoscale Swiss army knife for host infection","authors":"Ruochen Ouyang , Véronique Ongenae , Alise Muok , Dennis Claessen , Ariane Briegel","doi":"10.1016/j.mib.2024.102429","DOIUrl":"10.1016/j.mib.2024.102429","url":null,"abstract":"<div><p>Bacteriophages are being rediscovered as potent agents for medical and industrial applications. However, finding a suitable phage relies on numerous factors, including host specificity, burst size, and infection cycle. The host range of a phage is, besides phage defense systems, initially determined by the recognition and attachment of receptor-binding proteins (RBPs) to the target receptors of susceptible bacteria. RBPs include tail (or occasionally head) fibers and tailspikes. Owing to the potential flexibility and heterogeneity of these structures, they are often overlooked during structural studies. Recent advances in cryo-electron microscopy studies and computational approaches have begun to unravel their structural and fundamental mechanisms during phage infection. In this review, we discuss the current state of research on different phage tail and head fibers, spike models, and molecular mechanisms. These details may facilitate the manipulation of phage-host specificity, which in turn will have important implications for science and society.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"77 ","pages":"Article 102429"},"PeriodicalIF":5.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000055/pdfft?md5=52a26981688fdc4c736c5d85e770ac4e&pid=1-s2.0-S1369527424000055-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the role of the respiratory tract microbiome in defense against bacterial pneumonia 透视呼吸道微生物组在防御细菌性肺炎中的作用

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-02-01 DOI: 10.1016/j.mib.2024.102428

Zoe G Drigot, Sarah E Clark

{"title":"Insights into the role of the respiratory tract microbiome in defense against bacterial pneumonia","authors":"Zoe G Drigot, Sarah E Clark","doi":"10.1016/j.mib.2024.102428","DOIUrl":"10.1016/j.mib.2024.102428","url":null,"abstract":"<div><p>The respiratory tract microbiome (RTM) is a microbial ecosystem inhabiting different niches throughout the airway. A critical role for the RTM in dictating lung infection outcomes is underlined by recent efforts to identify community members benefiting respiratory tract health. Obligate anaerobes common in the oropharynx and lung such as <em>Prevotella</em> and <em>Veillonella</em> are associated with improved pneumonia outcomes and activate several immune defense pathways in the lower airway. Colonizers of the nasal cavity, including <em>Corynebacterium</em> and <em>Dolosigranulum</em>, directly impact the growth and virulence of lung pathogens, aligning with robust clinical correlations between their upper airway abundance and reduced respiratory tract infection risk. Here, we highlight recent work identifying respiratory tract bacteria that promote airway health and resilience against disease, with a focus on lung infections and the underlying mechanisms driving RTM-protective benefits.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"77 ","pages":"Article 102428"},"PeriodicalIF":5.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000043/pdfft?md5=8540557d334a37f486df6563c071f1e4&pid=1-s2.0-S1369527424000043-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139554832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the transcriptional landscape of phage–host interactions using novel high-throughput approaches 利用新型高通量方法探索噬菌体-宿主相互作用的转录景观

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-01-24 DOI: 10.1016/j.mib.2023.102419

Leena Putzeys , Laura Wicke , Ana Brandão , Maarten Boon , Diana P Pires , Joana Azeredo , Jörg Vogel , Rob Lavigne , Milan Gerovac

{"title":"Exploring the transcriptional landscape of phage–host interactions using novel high-throughput approaches","authors":"Leena Putzeys , Laura Wicke , Ana Brandão , Maarten Boon , Diana P Pires , Joana Azeredo , Jörg Vogel , Rob Lavigne , Milan Gerovac","doi":"10.1016/j.mib.2023.102419","DOIUrl":"https://doi.org/10.1016/j.mib.2023.102419","url":null,"abstract":"<div><p>In the last decade, powerful high-throughput sequencing approaches have emerged to analyse microbial transcriptomes at a global scale. However, to date, applications of these approaches to microbial viruses such as phages remain scarce. Tailoring these techniques to virus-infected bacteria promises to obtain a detailed picture of the underexplored RNA biology and molecular processes during infection. In addition, transcriptome study of stress and perturbations induced by phages in their infected bacterial hosts is likely to reveal new fundamental mechanisms of bacterial metabolism and gene regulation. Here, we provide references and blueprints to implement emerging transcriptomic approaches towards addressing transcriptome architecture, RNA–RNA and RNA–protein interactions, RNA modifications, structures and heterogeneity of transcription profiles in infected cells that will provide guides for future directions in phage-centric therapeutic applications and microbial synthetic biology.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"77 ","pages":"Article 102419"},"PeriodicalIF":5.4,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S136952742300156X/pdfft?md5=68ae94f65b7eef1b60034302106aa4b4&pid=1-s2.0-S136952742300156X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139549231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Posttranslational modifications in bacteria during phage infection 噬菌体感染过程中细菌的翻译后修饰。

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-01-23 DOI: 10.1016/j.mib.2024.102425

Hannelore Longin , Nand Broeckaert , Vera van Noort , Rob Lavigne , Hanne Hendrix

引用次数: 0

Biological and bioinformatic tools for the discovery of unknown phage–host combinations 发现未知噬菌体-宿主组合的生物学和生物信息学工具

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-01-20 DOI: 10.1016/j.mib.2024.102426

Jennifer Mahony

{"title":"Biological and bioinformatic tools for the discovery of unknown phage–host combinations","authors":"Jennifer Mahony","doi":"10.1016/j.mib.2024.102426","DOIUrl":"https://doi.org/10.1016/j.mib.2024.102426","url":null,"abstract":"<div><p>The field of microbial ecology has been transformed by metagenomics in recent decades and has culminated in vast datasets that facilitate the bioinformatic dissection of complex microbial communities. Recently, attention has turned from defining the microbiota composition to the interactions and relationships that occur between members of the microbiota. Within complex microbiota, the identification of bacteriophage–host combinations has been a major challenge. Recent developments in artificial intelligence tools to predict protein structure and function as well as the relationships between bacteria and their infecting bacteriophages allow a strategic approach to identifying and validating phage–host relationships. However, biological validation of these predictions remains essential and will serve to improve the existing predictive tools. In this review, I provide an overview of the most recent developments in both bioinformatic and experimental approaches to predicting and experimentally validating unknown phage–host combinations.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"77 ","pages":"Article 102426"},"PeriodicalIF":5.4,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S136952742400002X/pdfft?md5=2a2e4045eb97531af003a3c101e2bb4a&pid=1-s2.0-S136952742400002X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139505421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads 生命早期抗菌药耐药性基因的纵向和横向微生物传播的作用：从母婴双亲中获得的启示

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-01-17 DOI: 10.1016/j.mib.2023.102424

Manuel Bernabeu , Elena Cabello-Yeves , Eduard Flores , Anna Samarra , Joanna Kimberley Summers , Alberto Marina , M Carmen Collado

引用次数: 0

Host range and cell recognition of archaeal viruses 古细菌病毒的宿主范围和细胞识别

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-01-16 DOI: 10.1016/j.mib.2023.102423

Emine Rabia Sensevdi , Zaloa Aguirre Sourrouille , Tessa EF Quax

引用次数: 0

Group A Streptococcus interactions with the host across time and space A 群链球菌与宿主的跨时空互动

IF 5.4 2区生物学

Current opinion in microbiology Pub Date : 2024-01-14 DOI: 10.1016/j.mib.2023.102420

Stephanie Guerra , Christopher LaRock

{"title":"Group A Streptococcus interactions with the host across time and space","authors":"Stephanie Guerra , Christopher LaRock","doi":"10.1016/j.mib.2023.102420","DOIUrl":"10.1016/j.mib.2023.102420","url":null,"abstract":"<div><p>Group A <em>Streptococcus</em> (GAS) has a fantastically wide tissue tropism in humans, manifesting as different diseases depending on the strain’s virulence factor repertoire and the tissue involved. Activation of immune cells and pro-inflammatory signaling has historically been considered an exclusively host-protective response that a pathogen would seek to avoid. However, recent advances in human and animal models suggest that in some tissues, GAS will activate and manipulate specific pro-inflammatory pathways to promote growth, nutrient acquisition, persistence, recurrent infection, competition with other microbial species, dissemination, and transmission. This review discusses molecular interactions between the host and pathogen to summarize how infection varies across tissue and stages of inflammation. A need for inflammation for GAS survival during common, mild infections may drive selection for mechanisms that cause pathological and excess inflammation severe diseases such as toxic shock syndrome, necrotizing fasciitis, and rheumatic heart disease.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"77 ","pages":"Article 102420"},"PeriodicalIF":5.4,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527423001571/pdfft?md5=10cf33b63e80cf800ddabeaa01e93275&pid=1-s2.0-S1369527423001571-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139463667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0