Current opinion in microbiology最新文献

The complex developmental mechanisms of nucleus-forming jumbo phages 巨核噬菌体的复杂发育机制

IF 7.5 2区生物学

Current opinion in microbiology Pub Date : 2025-09-27 DOI: 10.1016/j.mib.2025.102676

Deepto Mozumdar , David A. Agard , Joseph Bondy-Denomy

{"title":"The complex developmental mechanisms of nucleus-forming jumbo phages","authors":"Deepto Mozumdar , David A. Agard , Joseph Bondy-Denomy","doi":"10.1016/j.mib.2025.102676","DOIUrl":"10.1016/j.mib.2025.102676","url":null,"abstract":"<div><div>Bacteriophages related to the jumbo phage ΦKZ (Family: <em>Chimalliviridae</em>) exhibit a complex developmental cycle. First, two large macromolecular compartments are assembled that surround and protect the bacteriophage genome. Upon infection, the injected phage genomic DNA (gDNA) is rapidly enclosed within a lipid-based ‘early phage infection (EPI) vesicle’, assembled with bacterial membrane components and injected phage proteins. The EPI vesicle serves as a hub for early transcription and localized protein synthesis. One early-expressed protein, <u>Ch</u>i<u>m</u>allin <u>A</u> (ChmA)/<u>Ph</u>age N<u>u</u>clear E<u>n</u>closure (PhuN), assembles a distinct proteinaceous ‘phage nucleus’ that receives the phage gDNA from the EPI vesicle. Within this phage nucleus, phage DNA is replicated and transcribed by selectively imported phage and host enzymes. The EPI vesicle, phage nucleus, and packaged capsid completely isolate the phage gDNA from nucleases in the bacterial cytoplasm. Here, we review the complex jumbo phage infection cycle, anti-immune strategies, their respective roles in supporting infection, and recent tools used to dissect these intricate processes.</div></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"88 ","pages":"Article 102676"},"PeriodicalIF":7.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of mobile genetic elements in adaptation of the microbiota to the dynamic human gut ecosystem 移动遗传因子在微生物群适应动态人类肠道生态系统中的作用

IF 7.5 2区生物学

Current opinion in microbiology Pub Date : 2025-09-27 DOI: 10.1016/j.mib.2025.102675

Katherine Schubert, Teni Shosanya, Leonor García-Bayona

引用次数: 0

New frontiers in short-chain alkyl-coenzyme M reductases 短链烷基辅酶M还原酶的新进展。

IF 7.5 2区生物学

Current opinion in microbiology Pub Date : 2025-09-18 DOI: 10.1016/j.mib.2025.102665

Disha Jawadekar , Olivier N Lemaire , Tristan Wagner

引用次数: 0

Transient microbial architects: tracing the legacy effects of ephemeral taxa during plant microbiome assembly 瞬时微生物建筑师：在植物微生物组组装过程中追踪短暂分类群的遗留效应

IF 7.5 2区生物学

Current opinion in microbiology Pub Date : 2025-09-11 DOI: 10.1016/j.mib.2025.102664

Logan Suteau , Louna Colaert-Sentenac , Simon R Law , Marie Simonin

{"title":"Transient microbial architects: tracing the legacy effects of ephemeral taxa during plant microbiome assembly","authors":"Logan Suteau , Louna Colaert-Sentenac , Simon R Law , Marie Simonin","doi":"10.1016/j.mib.2025.102664","DOIUrl":"10.1016/j.mib.2025.102664","url":null,"abstract":"<div><div>Plant microbiota assembly is a dynamic process shaped by a succession of microbial dispersal events, interactions, and environmental fluctuations. While most research emphasizes the roles of resident and core taxa in driving microbiome structure and plant health, the ecological significance of transient microbial members (taxa temporarily present in plant tissue and then disappearing from microbiota) remains underexplored. In this opinion article, we propose that these ephemeral microorganisms may act as ‘transient microbial architects’, capable of generating legacy effects that influence the trajectory of microbiota assembly and long-term plant fitness. By reviewing the available temporal studies, we show that transient taxa often collectively represent the most diverse and abundant plant microbiota members compared to core taxa. We highlight how priority effects, niche modification, and microbe–microbe interactions mediated by transient taxa, can alter community composition, modulate the recruitment of symbionts, and shape plant responses to biotic and abiotic stressors. We identify outstanding questions and propose methodological advances to address them, including high-resolution longitudinal sampling and integrative omics approaches, that will enable the detection and functional characterization of these elusive taxa. Finally, we discuss the potential for harnessing transient microbial architects in microbiome engineering strategies for sustainable agriculture, emphasizing the need for targeted interventions during critical plant developmental windows. By recognizing and harnessing the legacy effects of these transient members, we gain access to previously overlooked ecological levers for shaping plant–microbe interactions.</div></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"88 ","pages":"Article 102664"},"PeriodicalIF":7.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trace gas oxidation as a novel microbial dispersal trait 微量气体氧化是一种新的微生物扩散特性

IF 7.5 2区生物学

Current opinion in microbiology Pub Date : 2025-09-10 DOI: 10.1016/j.mib.2025.102666

Lucas Barbieri Oliveri , Pok Man Leung

引用次数: 0

The cycad coralloid root: is there evidence for plant-microbe coevolution? 苏铁珊瑚根：有证据表明植物与微生物共同进化吗？

IF 7.5 2区生物学

Current opinion in microbiology Pub Date : 2025-09-10 DOI: 10.1016/j.mib.2025.102660

Kimber L Zonneveld , Edder D Bustos-Diaz , Barona-Gómez Francisco , Cibrian-Jaramillo Angelica

引用次数: 0

Diversity and evolution of alphaproteobacterial dimorphism α变形菌二态性的多样性和进化

IF 7.5 2区生物学

Current opinion in microbiology Pub Date : 2025-09-09 DOI: 10.1016/j.mib.2025.102661

Joel Hallgren , Kristina Jonas

{"title":"Diversity and evolution of alphaproteobacterial dimorphism","authors":"Joel Hallgren , Kristina Jonas","doi":"10.1016/j.mib.2025.102661","DOIUrl":"10.1016/j.mib.2025.102661","url":null,"abstract":"<div><div>Many bacteria have complex pleomorphic lifecycles — a feature particularly widespread across the class <em>Alphaproteobacteria</em> of the phylum <em>Pseudomonadota</em>. While research on bacteria with pleomorphic lifecycles has for many years focused on the dimorphic bacterium <em>Caulobacter crescentus</em>, more recent studies on less established alphaproteobacterial model bacteria have uncovered diverse variations of bacterial pleomorphism. Here, we provide an overview of the diversity and evolution of the complex lifecycles among dimorphic <em>Alphaproteobacteria</em> and highlight the presence of analogous lifecycles in unrelated bacteria across the bacterial domain. We discuss the commonalities and differences between dimorphic species, as well as the selective pressures that might have sculpted their lifecycles. Furthermore, we exemplify how the cellular appendages common among dimorphic <em>Alphaproteobacteria</em>, referred to as prosthecae, are not inherently linked to dimorphism. Finally, we highlight how the large diversity of dimorphic <em>Alphaproteobacteria</em> can be used to shed light onto the evolution of bacterial cell biology.</div></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"88 ","pages":"Article 102661"},"PeriodicalIF":7.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why transport matters: an update on carrier proteins in Apicomplexan parasites 为什么运输很重要：顶复合体寄生虫载体蛋白的最新进展

IF 7.5 2区生物学

Current opinion in microbiology Pub Date : 2025-09-08 DOI: 10.1016/j.mib.2025.102663

Silvia Haase, Adam Sateriale

{"title":"Why transport matters: an update on carrier proteins in Apicomplexan parasites","authors":"Silvia Haase, Adam Sateriale","doi":"10.1016/j.mib.2025.102663","DOIUrl":"10.1016/j.mib.2025.102663","url":null,"abstract":"<div><div>The movement of molecules across the membranous barriers of a cell is fundamental to cellular homeostasis in every living organism. This vital process is facilitated through a mechanistically diverse class of proteins, collectively known as membrane transporters. Among these are so-called carrier proteins that can function in passive and active transport mechanisms. They exhibit high substrate specificity and undergo conformational changes to transfer a specific solute across the membrane, thereby facilitating diffusion or actively transporting a molecule under energy expenditure or against an established electrochemical gradient. Apicomplexan parasites invest up to 5% of their genome to encode for membrane transporters; however, only a few have been fully characterised, and their specific mechanisms remain largely unknown. Recent advances in structural biology and the application of state-of-the-art genomic editing tools have greatly accelerated investigations into the intricate mechanisms of Apicomplexan carrier proteins. Understanding the molecular ‘ins and outs’ of membrane transporters is fundamental to inform the rational design of inhibitors, as well as to overcome antimicrobial resistance.</div></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"88 ","pages":"Article 102663"},"PeriodicalIF":7.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mass spectrometry of microbiome-mediated metabolism of food: challenges and opportunities. 微生物介导的食物代谢的质谱分析：挑战与机遇。

IF 7.5 2区生物学

Current opinion in microbiology Pub Date : 2025-09-01 Epub Date: 2025-08-08 DOI: 10.1016/j.mib.2025.102640

Harsha Gouda, Julius Agongo, Andrés Mauricio Caraballo-Rodríguez, Pieter C Dorrestein

引用次数: 0

Physiology of atmospheric methane-oxidizing bacteria 大气甲烷氧化细菌的生理学

IF 7.5 2区生物学

Current opinion in microbiology Pub Date : 2025-08-30 DOI: 10.1016/j.mib.2025.102656

Alexander Tøsdal Tveit , Marc G. Dumont , Tilman Schmider

引用次数: 0