对白色念珠菌的先天免疫反应

IF 5.9 2区生物学 Q1 MICROBIOLOGY

Current opinion in microbiology Pub Date : 2024-07-03 DOI:10.1016/j.mib.2024.102510

Ashley M Holt , Jeniel E Nett

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引用次数: 0

摘要

念珠菌是一种新出现的真菌物种，它在医疗系统中不断蔓延，并造成危及生命的感染。完好的先天性免疫对于抵御包括念珠菌病在内的多种侵袭性真菌感染至关重要。在此，我们重点介绍了最近探索与念珠菌免疫相互作用的研究，包括使用动物模型和体外免疫细胞进行的调查。我们总结了比较 C. auris 和常见真菌病原体白色念珠菌的先天性免疫研究。我们还讨论了球孢子菌细胞壁的结构如何影响免疫识别、可溶性宿主因子在免疫识别中的作用以及未来的研究领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Innate immune response to Candida auris

Candida auris, a newly emergent fungal species, has been spreading in health care systems and causing life-threatening infections. Intact innate immunity is essential for protection against many invasive fungal infections, including candidiasis. Here, we highlight recent studies exploring immune interactions with C. auris, including investigations using animal models and ex vivo immune cells. We summarize innate immune studies comparing C. auris and the common fungal pathogen Candida albicans. We also discuss how structures of the C. auris cell wall influence immune recognition, the role of soluble host factors in immune recognition, and areas of future study.

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来源期刊

Current opinion in microbiology 生物-微生物学

CiteScore

10.00

自引率

0.00%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Microbiology is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of microbiology. It consists of 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Host-microbe interactions: bacteria Cell regulation Environmental microbiology Host-microbe interactions: fungi/parasites/viruses Antimicrobials Microbial systems biology Growth and development: eukaryotes/prokaryotes