{"title":"宿主对真菌生物膜的免疫反应。","authors":"Mohammad Mannan , Sunna Nabeela , Reetakshi Mishra , Priya Uppuluri","doi":"10.1016/j.mib.2024.102520","DOIUrl":null,"url":null,"abstract":"<div><p>Fungal biofilms are a multilayered community of cells attached to mucosal or abiotic surfaces enclosed in a coating of self-produced extracellular polymeric matrix. The sheer density of cells protected by a polymeric shield not only makes the biofilm impermeable to antimicrobials or immune cells but also hidden from host recognition. Biofilms also serve as a reservoir of drug-resistant persister cells and dispersal cells armored with virulence factors adept at evading the immune system. Here, we summarize the latest knowledge on the immunomodulatory properties of biofilms formed by <em>Candida</em> species and by other biofilm-forming fungal pathogens such as <em>Aspergillus</em> and <em>Cryptococcus</em>. Finally, we deliberate on promising strategies to help activate the immune system for combating fungal biofilms.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"81 ","pages":"Article 102520"},"PeriodicalIF":5.9000,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000961/pdfft?md5=d1b3631d18ad1cf50b233ae1db6be79e&pid=1-s2.0-S1369527424000961-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Host immune response against fungal biofilms\",\"authors\":\"Mohammad Mannan , Sunna Nabeela , Reetakshi Mishra , Priya Uppuluri\",\"doi\":\"10.1016/j.mib.2024.102520\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Fungal biofilms are a multilayered community of cells attached to mucosal or abiotic surfaces enclosed in a coating of self-produced extracellular polymeric matrix. The sheer density of cells protected by a polymeric shield not only makes the biofilm impermeable to antimicrobials or immune cells but also hidden from host recognition. Biofilms also serve as a reservoir of drug-resistant persister cells and dispersal cells armored with virulence factors adept at evading the immune system. Here, we summarize the latest knowledge on the immunomodulatory properties of biofilms formed by <em>Candida</em> species and by other biofilm-forming fungal pathogens such as <em>Aspergillus</em> and <em>Cryptococcus</em>. Finally, we deliberate on promising strategies to help activate the immune system for combating fungal biofilms.</p></div>\",\"PeriodicalId\":10921,\"journal\":{\"name\":\"Current opinion in microbiology\",\"volume\":\"81 \",\"pages\":\"Article 102520\"},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2024-08-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1369527424000961/pdfft?md5=d1b3631d18ad1cf50b233ae1db6be79e&pid=1-s2.0-S1369527424000961-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1369527424000961\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in microbiology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1369527424000961","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Fungal biofilms are a multilayered community of cells attached to mucosal or abiotic surfaces enclosed in a coating of self-produced extracellular polymeric matrix. The sheer density of cells protected by a polymeric shield not only makes the biofilm impermeable to antimicrobials or immune cells but also hidden from host recognition. Biofilms also serve as a reservoir of drug-resistant persister cells and dispersal cells armored with virulence factors adept at evading the immune system. Here, we summarize the latest knowledge on the immunomodulatory properties of biofilms formed by Candida species and by other biofilm-forming fungal pathogens such as Aspergillus and Cryptococcus. Finally, we deliberate on promising strategies to help activate the immune system for combating fungal biofilms.
期刊介绍：
Current Opinion in Microbiology is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of microbiology. It consists of 6 issues per year covering the following 11 sections, each of which is reviewed once a year:
Host-microbe interactions: bacteria
Cell regulation
Environmental microbiology
Host-microbe interactions: fungi/parasites/viruses
Antimicrobials
Microbial systems biology
Growth and development: eukaryotes/prokaryotes
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