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Fungal effectors: past, present, and future 真菌效应器：过去、现在和未来
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-08-23 DOI: 10.1016/j.mib.2024.102526
Gengtan Li , Madison Newman , Houlin Yu , Maryam Rashidzade , Domingo Martínez-Soto , Ana Caicedo , Kelly S Allen , Li-Jun Ma
{"title":"Fungal effectors: past, present, and future","authors":"Gengtan Li ,&nbsp;Madison Newman ,&nbsp;Houlin Yu ,&nbsp;Maryam Rashidzade ,&nbsp;Domingo Martínez-Soto ,&nbsp;Ana Caicedo ,&nbsp;Kelly S Allen ,&nbsp;Li-Jun Ma","doi":"10.1016/j.mib.2024.102526","DOIUrl":"10.1016/j.mib.2024.102526","url":null,"abstract":"<div><p>Fungal effector proteins function at the interfaces of diverse interactions between fungi and their plant and animal hosts, facilitating interactions that are pathogenic or mutualistic. Recent advancements in protein structure prediction have significantly accelerated the identification and functional predictions of these rapidly evolving effector proteins. This development enables scientists to generate testable hypotheses for functional validation using experimental approaches. Research frontiers in effector biology include understanding pathways through which effector proteins are secreted or translocated into host cells, their roles in manipulating host microbiomes, and their contribution to interacting with host immunity. Comparative effector repertoires among different fungal–host interactions can highlight unique adaptations, providing insights for the development of novel antifungal therapies and biocontrol strategies.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"81 ","pages":"Article 102526"},"PeriodicalIF":5.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424001024/pdfft?md5=92a5fec3391cf18a402141961b4ad94d&pid=1-s2.0-S1369527424001024-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
D-galactonate metabolism in enteric bacteria: a molecular and physiological perspective 肠道细菌的 D-半乳糖醛酸代谢：分子和生理学视角。
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-08-12 DOI: 10.1016/j.mib.2024.102524
Swati Singh , Chetna Gola , Bhupinder Singh , Vishal Agrawal , Rachna Chaba
{"title":"D-galactonate metabolism in enteric bacteria: a molecular and physiological perspective","authors":"Swati Singh ,&nbsp;Chetna Gola ,&nbsp;Bhupinder Singh ,&nbsp;Vishal Agrawal ,&nbsp;Rachna Chaba","doi":"10.1016/j.mib.2024.102524","DOIUrl":"10.1016/j.mib.2024.102524","url":null,"abstract":"<div><p><span>D</span>-galactonate, a widely prevalent sugar acid, was first reported as a nutrient source for enteric bacteria in the 1970s. Since then, decades of research enabled a description of the modified Entner-Doudoroff pathway involved in its degradation and reported the structural and biochemical features of its metabolic enzymes, primarily in <em>Escherichia coli</em> K-12. However, only in the last few years, the <span>D</span>-galactonate transporter has been characterized, and the regulation of the <em>dgo</em> operon, encoding the structural genes for the transporter and enzymes of <span>D</span>-galactonate metabolism, has been detailed. Notably, in recent years, multiple evolutionary studies have identified the <em>dgo</em> operon as a dominant target for adaptation of <em>E. coli</em> in the mammalian gut. Despite considerable research on <em>dgo</em> operon, numerous fundamental questions remain to be addressed. The emerging relevance of the <em>dgo</em> operon in host–bacterial interactions further necessitates the study of <span>D</span>-galactonate metabolism in other enterobacterial strains.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"81 ","pages":"Article 102524"},"PeriodicalIF":5.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host immune response against fungal biofilms 宿主对真菌生物膜的免疫反应。
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-08-09 DOI: 10.1016/j.mib.2024.102520
Mohammad Mannan , Sunna Nabeela , Reetakshi Mishra , Priya Uppuluri
{"title":"Host immune response against fungal biofilms","authors":"Mohammad Mannan ,&nbsp;Sunna Nabeela ,&nbsp;Reetakshi Mishra ,&nbsp;Priya Uppuluri","doi":"10.1016/j.mib.2024.102520","DOIUrl":"10.1016/j.mib.2024.102520","url":null,"abstract":"<div><p>Fungal biofilms are a multilayered community of cells attached to mucosal or abiotic surfaces enclosed in a coating of self-produced extracellular polymeric matrix. The sheer density of cells protected by a polymeric shield not only makes the biofilm impermeable to antimicrobials or immune cells but also hidden from host recognition. Biofilms also serve as a reservoir of drug-resistant persister cells and dispersal cells armored with virulence factors adept at evading the immune system. Here, we summarize the latest knowledge on the immunomodulatory properties of biofilms formed by <em>Candida</em> species and by other biofilm-forming fungal pathogens such as <em>Aspergillus</em> and <em>Cryptococcus</em>. Finally, we deliberate on promising strategies to help activate the immune system for combating fungal biofilms.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"81 ","pages":"Article 102520"},"PeriodicalIF":5.9,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000961/pdfft?md5=d1b3631d18ad1cf50b233ae1db6be79e&pid=1-s2.0-S1369527424000961-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: emerging avenues in antimicrobial research 编辑综述：抗菌研究的新途径。
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-08-07 DOI: 10.1016/j.mib.2024.102522
Toni Gabaldón , Luiz Pedro Sório de Carvalho
{"title":"Editorial overview: emerging avenues in antimicrobial research","authors":"Toni Gabaldón ,&nbsp;Luiz Pedro Sório de Carvalho","doi":"10.1016/j.mib.2024.102522","DOIUrl":"10.1016/j.mib.2024.102522","url":null,"abstract":"","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"81 ","pages":"Article 102522"},"PeriodicalIF":5.9,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Coronaviruses 2024 编辑综述：冠状病毒 2024》。
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-08-03 DOI: 10.1016/j.mib.2024.102523
Stephanie Pfaender , Eike Steinmann
{"title":"Editorial overview: Coronaviruses 2024","authors":"Stephanie Pfaender ,&nbsp;Eike Steinmann","doi":"10.1016/j.mib.2024.102523","DOIUrl":"10.1016/j.mib.2024.102523","url":null,"abstract":"","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"81 ","pages":"Article 102523"},"PeriodicalIF":5.9,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New developments in Aspergillus fumigatus and host reactive oxygen species responses 烟曲霉与宿主活性氧反应的新进展。
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-08-01 DOI: 10.1016/j.mib.2024.102521
Matthew R James, Katherine E Doss, Robert A Cramer
{"title":"New developments in Aspergillus fumigatus and host reactive oxygen species responses","authors":"Matthew R James,&nbsp;Katherine E Doss,&nbsp;Robert A Cramer","doi":"10.1016/j.mib.2024.102521","DOIUrl":"10.1016/j.mib.2024.102521","url":null,"abstract":"<div><p><em>Aspergillus fumigatus</em> is a filamentous fungus abundant in the environment and the most common causative agent of a spectrum of human diseases collectively termed aspergillosis. Invasive pulmonary aspergillosis is caused by deficiencies in innate immune function that result in the inability of the host to clear inhaled <em>Aspergillus</em> conidia that then germinate and form invasive hyphae. Myeloid cells, and their ability to generate reactive oxygen species (ROS), are essential for conidia clearance from the host. To combat ROS, <em>A. fumigatus</em> employs an expansive antioxidant system, though how these canonical antioxidant mechanisms contribute to infection initiation and disease progression remain to be fully defined. Recent research has identified noncanonical pathways in the <em>A. fumigatus</em> ROS response and new host populations with ROS deficiencies that are at-risk for invasive aspergillosis. Here, we highlight recent developments in the understanding of ROS at the interface of the dynamic <em>A. fumigatus</em>–host interaction.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102521"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phage small proteins play large roles in phage–bacterial interactions 噬菌体小蛋白在噬菌体与细菌的相互作用中发挥着重要作用。
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-08-01 DOI: 10.1016/j.mib.2024.102519
Grace A Beggs , Bonnie L Bassler
{"title":"Phage small proteins play large roles in phage–bacterial interactions","authors":"Grace A Beggs ,&nbsp;Bonnie L Bassler","doi":"10.1016/j.mib.2024.102519","DOIUrl":"10.1016/j.mib.2024.102519","url":null,"abstract":"<div><p>Phages have wide influence on bacterial physiology, and likewise, bacterial processes impinge on phage biology. Key to these interactions are phage small proteins (&lt;100 aa). Long underappreciated, recent work has revealed millions of phage small proteins, and increasingly, mechanisms by which they function to dictate phage and/or bacterial behavior and evolution. Here, we describe select phage small proteins that mediate phage–bacterial interactions by modulating phage lifestyle decision-making components or by altering host gene expression.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102519"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S136952742400095X/pdfft?md5=6d844c860d56b858dad4083fd7e235f3&pid=1-s2.0-S136952742400095X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: There and back again: a phage’s tale 编辑综述：往返：噬菌体的故事。
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-08-01 DOI: 10.1016/j.mib.2024.102518
Julia Frunzke , Rob Lavigne
{"title":"Editorial overview: There and back again: a phage’s tale","authors":"Julia Frunzke ,&nbsp;Rob Lavigne","doi":"10.1016/j.mib.2024.102518","DOIUrl":"10.1016/j.mib.2024.102518","url":null,"abstract":"","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102518"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How c-di-GMP controls progression through the Streptomyces life cycle c-di-GMP 如何控制链霉菌生命周期的进展。
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-08-01 DOI: 10.1016/j.mib.2024.102516
Kelley A Gallagher , Natalia Tschowri , Richard G Brennan , Maria A Schumacher , Mark J Buttner
{"title":"How c-di-GMP controls progression through the Streptomyces life cycle","authors":"Kelley A Gallagher ,&nbsp;Natalia Tschowri ,&nbsp;Richard G Brennan ,&nbsp;Maria A Schumacher ,&nbsp;Mark J Buttner","doi":"10.1016/j.mib.2024.102516","DOIUrl":"10.1016/j.mib.2024.102516","url":null,"abstract":"<div><p>Members of the antibiotic-producing bacterial genus <em>Streptomyces</em> undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3′, 5′-cyclic diguanylic acid (c-di-GMP). So far<em>,</em> three proteins that are directly controlled by c-di-GMP in <em>Streptomyces</em> have been functionally and structurally characterized: the key developmental regulators BldD and σ<sup>WhiG</sup>, and the glycogen-degrading enzyme GlgX. c-di-GMP signals through BldD and σ<sup>WhiG</sup>, respectively, to control the two most dramatic transitions of the <em>Streptomyces</em> life cycle, the formation of the reproductive aerial hyphae and their differentiation into spore chains. Later in development, c-di-GMP activates GlgX-mediated degradation of glycogen, releasing stored carbon for spore maturation.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102516"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000924/pdfft?md5=442a6b014b52e3deb82bc7b7cec49506&pid=1-s2.0-S1369527424000924-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Rise of the bacterial nanomachines 编辑综述：细菌纳米机器的崛起
IF 5.9 2区 生物学
Current opinion in microbiology Pub Date : 2024-07-21 DOI: 10.1016/j.mib.2024.102515
Susan Schlimpert , Martin Thanbichler
{"title":"Editorial overview: Rise of the bacterial nanomachines","authors":"Susan Schlimpert ,&nbsp;Martin Thanbichler","doi":"10.1016/j.mib.2024.102515","DOIUrl":"10.1016/j.mib.2024.102515","url":null,"abstract":"","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"80 ","pages":"Article 102515"},"PeriodicalIF":5.9,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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