Critical Reviews in Toxicology最新文献

{"title":"Can I buy you a drop? A perspective on communicating cancer risk from alcoholic beverages.","authors":"Robert A Roth","doi":"10.1080/10408444.2026.2724719","DOIUrl":"https://doi.org/10.1080/10408444.2026.2724719","url":null,"abstract":"<p><p>Consumption of alcoholic beverages is common around the world, and its risks and benefits continue to be debated. In the last several years, meta-analyses of human epidemiological data have provided strong evidence for risk of alcohol-associated cancers at seven body sites. It is now well accepted that several cancers are associated with alcohol consumption, and that risk increases with dose. In publications of epidemiological studies, statements like, \"…the safest level of drinking is none\" (Lancet 2018; 392: 1015-1035) have been interpreted to mean that any level of alcoholic beverage consumption is harmful. An official of the World Health Organization-Europe declared that \"It doesn't matter how much you drink - the risk to the drinker's health starts from the first drop of any alcoholic beverage.\" Recently, \"one-drop\" statements like this have been echoed by news outlets and in social media posts. If such pronouncements are unfounded, potential outcomes are that they raise unnecessary fear and hysteria among the alcohol-consuming public and sow distrust of respected sources. This commentary addresses the likelihood that very small amounts (e.g. one drop) of alcohol increase cancer risk. Examples of results from meta-analyses of human epidemiological studies that link alcohol consumption with human cancers are presented, with a focus on dose-response relationships. Next, what animal and <i>in vitro</i> studies suggest about alcohol-associated cancer thresholds is discussed. Thirdly, alcohol contents in common foods and production of alcohol from intestinal fermentation are explored, and how exposures from these compare to one drop of an alcoholic beverage is addressed. Finally, comments are offered on the consequences of issuing unsupported claims of cancer risk from consuming alcoholic beverages in moderation, and perspectives are shared on the responsibilities of researchers, public health agencies and the lay press to issue pronouncements that are evidence-based.</p>","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"1-13"},"PeriodicalIF":5.6,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between environmental endocrine disruptors and depression risk: a meta-analysis.","authors":"Chengxing Wang, Jie Xu, Yuzhu Xu, Xiao Yang, Jie Yu","doi":"10.1080/10408444.2026.2724694","DOIUrl":"https://doi.org/10.1080/10408444.2026.2724694","url":null,"abstract":"<p><p>Environmental endocrine disruptors (EEDs) are common environmental pollutants. A close association exists between EEDs exposure and depression. However, related research findings have shown inconsistencies due to the wide variety of EEDs. This study aimed to evaluate, through a systematic meta-analysis, the associations between exposure to Phthalate Esters (PAEs), Per- and polyfluoroalkyl substances (PFAs), Bisphenol A (BPA), and Hexachlorobenzene (HCB) and the risk of depression. We systematically searched PubMed, Web of Science, and Embase, and finally enrolled 28 eligible studies involving 81,154 participants who underwent assessment of EEDs exposure and were evaluated for incident depression or depression-related outcomes. Relevant studies published between 2004 and December 2024 were included in this study. The biological samples used for human exposure assessment in the included studies included peripheral serum, urine, breast milk, maternal serum, and umbilical cord serum. A meta-analysis was then conducted, and the results showed that: Mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) (Odds Ratio [OR] = 1.19, 95% Confidence intervals [CI]: 1.06, 1.33), Mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) (OR = 1.21, 95% CI: 1.07, 1.36), Mono-benzyl phthalate (MBzP) (OR = 1.14, 95% CI: 1.07, 1.22), Mono-N-butyl phthalate (MnBP) (OR = 1.18, 95% CI: 1.02, 1.37), Mono-isobutyl phthalate (MiBP) (OR = 1.16, 95% CI: 1.07, 1.25), Mono-n-butyl phthalate (MBP) (OR = 1.28, 95% CI: 1.13, 1.45), and Mono (2-ethyl-5-carboxypentyl) phthalate (MECPP) (OR = 1.22,95% CI: 1.04, 1.43) were all positively associated with the risk of depression. Additionally, exposure to ∑ PAEs (OR = 1.11, 95% CI: 1.08, 1.14) was identified as a risk factor for depression. The exposure to Perfluorononanoic acid (PFNA) (OR = 1.24, 95% CI: 1.01, 1.51) and ∑ PFAs (OR = 1.09, 95% CI: 1.01, 1.17) was significantly positively associated with postpartum depression among women. Human exposure to PAEs significantly increases the prevalence of depression, and a significant positive association exists between PFAs exposure in women and postpartum depression.</p>","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"1-22"},"PeriodicalIF":5.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity of hair dyes in experimental <i>in vivo</i> animal models: a systematic review.","authors":"Ênio Pereira Telles, Caroline Martins Leal de Almeida, Marina Dos Santos Barreto, Jussara Secundo Dos Santos, Danielle Gomes Santana, Guilherme Rodolfo Souza de Araujo, Ana Amélia Moreira Lira, Paulo Ricardo Martins-Filho, Adriana Gibara Guimarães, Mairim Russo Serafini, Adriano Antunes de Souza Araújo","doi":"10.1080/10408444.2026.2727807","DOIUrl":"https://doi.org/10.1080/10408444.2026.2727807","url":null,"abstract":"<p><p>The increasing use of hair dyes reinforces the need to identify potential toxicological hazards associated with their constituents and formulations. These products may release aromatic amines that, after dermal absorption, can induce oxidative stress and cellular damage, with potential cytotoxic, mutagenic, and carcinogenic effects. We reviewed <i>in vivo</i> evidence on toxicological hazards associated with isolated hair dye ingredients and finished commercial formulations in experimental animal models. Searches were conducted in PubMed, Web of Science, Embase, and Scopus, without language or year restrictions. Eligible studies assessed toxicity related to hair dye ingredients or formulations; secondary studies were excluded. Risk of bias was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Twenty-five articles were included. The evidence indicated multifactorial toxicity affecting cardiac, hepatic, renal, testicular, respiratory, dermatological, hematological, genotoxic, hormonal, and developmental endpoints. However, relevance varied according to exposure route, dose, species, model, publication period, and whether the tested material was an isolated ingredient or complete formulation. Topical studies were the most relevant to cosmetic exposure, whereas oral, subcutaneous, intravenous, and embryo immersion models primarily supported hazard identification under non-usual or high-bioavailability conditions. SYRCLE assessment showed a predominance of unclear risk of bias, with methodological weaknesses in nearly all studies. Hair dye ingredients and finished formulations can produce toxicological hazard signals under specific experimental conditions. Nevertheless, these findings should not be interpreted as direct estimates of real-world consumer risk. More standardized, exposure-relevant, and robust studies are needed to improve hazard characterization and support risk interpretation, particularly for occupational exposure scenarios.</p>","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"1-18"},"PeriodicalIF":5.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The formaldehyde dispute - Part A: acute and chronic inhalation toxicity and the evolution of scientific knowledge.","authors":"Jacob Siracusa, Quincy Perry, Michael Stevens, Dennis J Paustenbach","doi":"10.1080/10408444.2026.2630665","DOIUrl":"10.1080/10408444.2026.2630665","url":null,"abstract":"<p><p>Formaldehyde is a simple, highly reactive aldehyde whose inhalation toxicity has been characterized through more than five decades of human, animal, and mechanistic research. Across this literature, inhalation was illustrated to follow a concentration-dependent continuum of effects confined to the tissues of initial contact. Controlled human chamber studies reported no measurable pulmonary impairment below 0.3 ppm, the onset of mild ocular and nasal irritation at 0.3 to 0.5 ppm, and reversible sensory irritation observed at concentrations approaching 1 ppm. These findings were consistent with observations from community and occupational investigations. Chronic inhalation bioassays in rats and mice identified a sharp transition between adaptive epithelial responses and sustained cytotoxic injury within the nasal epithelium. Continuous exposure to concentrations ≤2 ppm produced minimal and reversible histopathologic changes, whereas exposures ≥6 ppm were associated with persistent epithelial necrosis, regenerative proliferation, and nasal squamous cell carcinomas localized to regions of highest vapor flux in the rat nasal cavity. In these studies, tumors were not observed at concentrations that did not overwhelm local tissue repair capacity. Computational dosimetry, DNA-protein crosslink kinetics, and biologically based dose-response (BBDR) modeling indicated that these outcomes arose from localized tissue injury rather than from cumulative systemic dose. Despite the extensive experimental database, disagreement has persisted for several decades regarding the appropriate approach for conducting a quantitative risk assessment of formaldehyde. Its non-linear, concentration-response, high endogenous background levels, and pronounced interspecies differences would indicate that the use of the Linear-No-Threshold (LNT) model is not appropriate for identifying acceptable levels of exposure. Nonetheless, EPA proposed an 8-hour occupational exposure value (OEV) of 0.11 ppm and 0.17 ppm for a 15-minute OEV. This review synthesizes the human, experimental, and mechanistic evidence underlying formaldehyde's acute and chronic inhalation toxicity. Using a classic approach to risk assessment, we propose that an OEV of 0.3 ppm (8 hr TWA) and a short-term limit (15 min) of 1.0 ppm are sufficiently low to protect the vast majority of workers from temporary irritation, as well as chronic effects (such as cancer). This recommendation is supported by three significant reviews of formaldehyde and at least seven rigorous human exposure studies conducted over the past 35 years.</p>","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"157-175"},"PeriodicalIF":4.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight-of-evidence assessment of the endocrine-disrupting properties of propylene oxide.","authors":"Quan Shi, Erin Maloney, Satinder S Sarang, Peter J Boogaard, Benjamin Spielmann, Karen Smet, Joanna Klapacz, Wade T Barranco","doi":"10.1080/10408444.2026.2649597","DOIUrl":"10.1080/10408444.2026.2649597","url":null,"abstract":"<p><p>Propylene oxide (PO) is a high-production-volume chemical widely used as an industrial intermediate and classified as carcinogen and mutagen in humans. Despite its regulatory significance, a comprehensive evaluation of its endocrine-disrupting (ED) potential has not been previously conducted. This review applies a weight-of-evidence (WoE) approach, integrating data from regulatory dossiers, peer-reviewed literature, publicly accessible databases, and <i>in silico</i> predictions to assess whether PO meets internationally accepted ED criteria. Available evidence indicates that PO does not exhibit endocrine activity via estrogenic, androgenic, steroidogenic, thyroid (EATS), or non-EATS pathways, as supported by negative quantitative structure-activity relationship (QSAR) predictions and absence of mechanistic effects <i>in vivo</i>. Similarly, adverse outcomes observed in repeated-dose, reproductive, and developmental toxicity studies were either secondary to systemic toxicity, inconsistent, or unrelated to endocrine modes of action. Epidemiological findings suggesting associations with breast cancer, diabetes, or obesity were limited by methodological uncertainties and lack of causal inference. Collectively, the WoE demonstrates that PO should not be classified as an endocrine-disrupting chemical for humans or wildlife, although data gaps remain for environmental receptors and metabolites.</p>","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"204-228"},"PeriodicalIF":4.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of antioxidants on antineoplastic-induced male reproductive system damage: a systematic review of experimental studies.","authors":"Hale Bayram, Yaprak Dönmez Çakıl, Mustafa Erinç Sitar","doi":"10.1080/10408444.2026.2649599","DOIUrl":"10.1080/10408444.2026.2649599","url":null,"abstract":"<p><p>Antineoplastic agents exacerbate oxidative stress and trigger inflammatory responses in the testis. Numerous studies have proposed antioxidants as a therapeutic approach to ameliorate chemotherapy-induced damage and improve reproductive outcomes. This systematic review aims to evaluate the potential therapeutic value of antioxidants in mitigating chemotherapy-induced male reproductive damage and address knowledge gaps to guide future research efforts. A comprehensive literature search was conducted in accordance with the PRISMA guidelines using the Google Scholar and Web of Science databases to identify experimental studies published between 2012 and 2025. The search strategy employed the following keywords: \"antioxidant\" AND \"oxidative stress\" AND \"spermatozoa\" AND \"testosterone\" AND \"histopathology\" AND (\"rat\" OR \"mice\") AND (\"chemotherapy\" OR \"chemotherapeutic\" OR \"antineoplastic\"). The study design was guided by the PICO framework. Data extraction focused on reproductive histopathological changes, testosterone levels, and sperm parameters. A total of 28 studies were deemed eligible for inclusion. The methodological quality and risk of bias of the included studies were assessed using SYRCLE's Risk of Bias tool. The majority of findings suggest that antioxidant administration mitigated male reproductive toxicity by improving sperm parameters, testicular histopathology, and testosterone levels; however, a small number of studies reported no significant effects. Additionally, a number of the included studies also presented the beneficial effects of several antioxidants on other endocrine parameters and oxidative stress markers. Current preclinical evidence suggests that antioxidants may mitigate chemotherapy-induced reproductive toxicity; however, clinical studies are required to clarify their clinical applicability, optimal dosing, and long-term safety.</p>","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"235-251"},"PeriodicalIF":5.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for the ovarian toxicity of industrial chemicals - ovarian follicles and corpora lutea counts in rats, an inter- and intra-laboratory comparison.","authors":"Olena Kucheryavenko, Karine Angeli, Vincent Bonnomet, Muhammad Waqar Ashraf, Ingo Bichlmaier, Ulla Simanainen","doi":"10.1080/10408444.2026.2664517","DOIUrl":"10.1080/10408444.2026.2664517","url":null,"abstract":"<p><p>The aim of this study was to identify the methodologies currently used by contract research organizations (CROs) for counting ovarian follicles and corpora lutea (CL) in the OECD Test Guideline (TG) 443 (Extended One-Generation Reproductive Toxicity, EOGRT) studies. The current study further sought to characterize variability and its sources in follicle and CL counts. A database of 73 EOGRT studies with information on methodology, reporting and numerical data of follicular and CL counts was assembled and analyzed, revealing that quantitative follicle enumeration was conducted in 97% of studies, while quantitative CL evaluation was performed in 59%. Only 27% of studies provided details on sampling procedures related to location within the ovary, section thickness, step length, number of steps as well as type of histological staining. The percentage coefficient of variation (%CV) for follicle counts in control females ranged from 7.7% to 78.5%, indicating high variability. The median study-specific %CVs for primordial follicles and for combined primordial and growing follicles were 36% and 33%, respectively, while the median %CV for CL was 29%. The intra‑laboratory %CV decreased, indicating improved precision of the follicle‑count method, when a greater number of sections were evaluated but was also influenced by the number of studies performed within the laboratory, based on the dataset included in this evaluation. While the ratios of primordial to growing follicles are not a requirement in the OECD TG 443, they can reveal differences in follicle identification if the variability in ratios between the studies is high. Accordingly, the high variability in the ratios across studies demonstrated that well-defined criteria for follicle identification and validation of antibodies are necessary. The overall conclusion is that the lack of information on follicle identification criteria, and inconsistencies in terminology and reporting practices further complicate the interpretation of results of follicle and CL counts in the EOGRT studies. Our results highlight that clarification of the ovarian follicle terminology and identification criteria at the OECD level as well as clarity on best practices for follicle and CL counting are essential to improve the consistency and reliability of ovarian toxicity testing in EOGRT studies.</p>","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"279-298"},"PeriodicalIF":5.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastic trafficking in maternal-fetal system: a systematic review and quantitative profiling linking particle characteristics to developmental biology.","authors":"Syed Shabi Ul Hassan Kazmi, Syeda Mutyyeba Batool, Paolo Pastorino, Luís Miguel Nunes, Gang Li","doi":"10.1080/10408444.2026.2692120","DOIUrl":"10.1080/10408444.2026.2692120","url":null,"abstract":"<p><p>Microplastics (MPs) have been detected across multiple maternal and neonatal biological matrices, suggesting widespread exposure during critical developmental stages. However, the mechanisms shaping their distribution and accumulation within the maternal-fetal system remain poorly understood. This systematic review and quantitative synthesis provides a comprehensive quantitative profiling of MP burden across six maternal and neonatal biological matrices placenta, breast milk, endometrium, amniotic fluid, meconium, and feces. Our analysis reveals three critical insights: (1) Tissue‑specific MP signatures, with placental samples showing a 2.3‑fold higher fragment proportion and polypropylene (PP) dominance, suggesting selective barrier permeation; (2) A striking endometrial MP accumulation, implicating this tissue as a potential reservoir for intergenerational transfer; and (3) Distinct polymer clustering in perinatal matrices (polyamide/polyurethane (PA/PU) in breast milk vs. polyethylene terephthalate/polycarbonate (PET/PC) in amniotic fluid), indicating distinct exposure windows. Multivariate modeling confirms size‑dependent transport transplacental passage correlates strongly with <100 µm polymers. Crucially, we demonstrates that the majority of the variance in MP distribution stems from interactions between particle characteristics and developmental biology, thereby challenging conventional exposure paradigms based on environmental concentration alone. These findings establish a quantitative framework for understanding MP trafficking in perinatal systems and highlight the importance of integrating particle characteristics and biological context into future exposure and risk assessments.</p>","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"352-363"},"PeriodicalIF":5.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics-PFAS interactions in environmental matrices: quantitative evidence for antagonistic and synergistic toxicity.","authors":"Niyati Kuriyal, Abhishek Nandan","doi":"10.1080/10408444.2026.2686292","DOIUrl":"10.1080/10408444.2026.2686292","url":null,"abstract":"<p><p>Microplastics (MPs) and per- and polyfluoroalkyl substances (PFAS) increasingly co-occur across aquatic, terrestrial, and biological systems, yet their combined toxicological behavior remains poorly resolved. To address this gap, we conducted a systematic review and meta-analysis of 47 controlled experimental studies encompassing aquatic organisms, soil invertebrates, and mammalian models. Using standardized mean differences (Hedges' <i>g</i>) under a random-effects REML framework, supported by subgroup analysis, meta-regression, and bias diagnostics, we quantitatively compared biological responses induced by MPs, PFAS, and their co-exposure. PFAS produced the strongest and most consistent toxic effects across systems (<i>g</i> = 4.71; 95% CI: 2.32-7.09), with pronounced impacts on oxidative balance, hepatic function, immune regulation, and reproductive performance. MPs also induced widespread biological stress, though with lower and more variable intensity (<i>g</i> = 2.19; 95% CI: -0.29-4.66), affecting oxidative, reproductive, and inflammatory pathways. Notably, co-exposure to MPs and PFAS frequently resulted in attenuated or antagonistic responses rather than additive toxicity (g = -2.98; 95% CI: -8.89-2.93), suggesting that PFAS adsorption onto MP surfaces can reduce bioavailability and tissue uptake. However, synergistic effects emerged under specific conditions, particularly at high PFAS concentrations, with small or weathered particles and prolonged exposure durations. Dose response relationships were evident across exposure categories, with aquatic species displaying the greatest sensitivity. Overall, these findings demonstrate that mixture toxicity is context-dependent and cannot be inferred from single-compound data alone. This study provides a quantitative foundation for advancing mixture-aware environmental risk assessment and regulatory frameworks.</p>","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"364-388"},"PeriodicalIF":5.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Comprehensive review of octocrylene toxicology data and human exposure assessment for personal care products.","authors":"Joseph C DiNardo","doi":"10.1080/10408444.2026.2640891","DOIUrl":"10.1080/10408444.2026.2640891","url":null,"abstract":"","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"229-230"},"PeriodicalIF":5.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}