Current Obesity Reports最新文献

{"title":"Optimizing the Postpartum Period to Support Lifelong Health for Women with Obesity.","authors":"Nicola L Hawley, Mary G Rossillo, Anagha Chundury, Pearl A McElfish, Nedghie Adrien, Angela M Bengtson","doi":"10.1007/s13679-026-00748-x","DOIUrl":"10.1007/s13679-026-00748-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>Obesity affects a growing proportion of reproductive-age women, yet the postpartum period remains underrecognized as an opportunity for improving long-term maternal health. Pregnancy induces metabolic, inflammatory, and behavioral changes that, combined with pre-pregnancy obesity, may predispose women to persistent postpartum weight retention, incomplete metabolic recovery, and elevated lifetime risk of type 2 diabetes and cardiovascular disease. This narrative review synthesizes current evidence on the biological, behavioral, and structural determinants of postpartum health among women with obesity, with an emphasis on modifiable intervention targets.</p><p><strong>Recent findings: </strong>Recent findings suggest that postpartum metabolic recovery is often incomplete or delayed in women with obesity, characterized by persistent insulin resistance, dyslipidemia, and inflammation. Postpartum weight retention is a major driver of long-term cardiometabolic risk and is influenced by lactation, sleep disruption, mental health, diet and physical activity, and caregiving demands. Lactation confers meaningful metabolic benefits, yet women with obesity face disproportionate barriers to breastfeeding. Lifestyle interventions demonstrate modest though clinically important benefits, but engagement, reach, and sustainability are limited by health system gaps, competing postpartum priorities, and social determinants of health. Emerging work highlights the promise of digital tools, supportive health policies, and individualized risk-stratification approaches, while the rapid expansion of pharmacologic treatment of obesity raises new, important questions. The postpartum period represents an important yet underutilized opportunity to support the lifelong health of women with obesity. Optimizing postpartum care through precision-informed strategies and supportive policies may improve maternal cardiometabolic health, reduce long-term disease risk, and interrupt intergenerational transmission of obesity.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acromegaly and Metabolic Dysfunction-Associated Steatotic Liver Disease: Clinical and Therapeutic Implications.","authors":"Stergios A Polyzos, Alessandro Mantovani, Giovanni Targher","doi":"10.1007/s13679-026-00747-y","DOIUrl":"10.1007/s13679-026-00747-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>This narrative review aims to critically summarize available data on the association between adult acromegaly and metabolic dysfunction-associated steatotic liver disease (MASLD), with a particular focus on clinical associations and treatment implications.</p><p><strong>Recent findings: </strong>From a pathophysiological perspective, growth hormone (GH) may improve hepatic steatosis, inflammation, and fibrosis by acting directly on hepatocytes and indirectly (through insulin-like growth factor-1) on hepatic stellate cells, thereby inducing their senescence. Nonetheless, GH excess may also favor the development of hepatocellular carcinoma, possibly through mechanisms unrelated to hepatic fibrosis. From a clinical perspective, individuals with acromegaly have low rates of hepatic steatosis and visceral adipose tissue (VAT), but high insulin resistance (IR), which contradicts the generally observed positive association between IR and VAT or hepatic steatosis. By contrast, limited data do not support lower rates of hepatic fibrosis in acromegaly, possibly because GH excess is controlled after diagnosis. From a therapeutic perspective, published evidence, derived mainly from case series, suggests that surgical or pharmacological management of acromegaly increases hepatic steatosis and VAT, despite decreasing IR. However, the long-term effect of acromegaly control on hepatic inflammation and fibrosis remains largely unknown. Acromegaly is associated with IR, type 2 diabetes mellitus, hypertension and cardiovascular disease; however, acromegaly is inversely associated with VAT and MASLD. Further mechanistic and clinical studies are warranted to better elucidate the intriguing association between acromegaly and MASLD.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose Tissue Browning in MASLD and Its Molecular Mechanisms and Metabolic Crosstalk.","authors":"Jonathan Jaime G Guerrero, Mark Angelo S Del Rosario, Paolo C Encarnacion, Chen-Sung Lin, Lu-Te Chuang, Kin Israel Notarte, Jiayan Zhou, Chih-Hao Wang, Ching-Wen Chang, Wan-Chun Li","doi":"10.1007/s13679-026-00746-z","DOIUrl":"10.1007/s13679-026-00746-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly prevalent complication of obesity and metabolic dysregulation, with limited therapies targeting upstream drivers of disease. Adipose tissue has emerged as a central regulator of systemic metabolic homeostasis, where dysfunction contributes to excess free fatty acid flux, chronic inflammation, and hepatic steatosis. In this context, adipose tissue browning-the induction of thermogenically active beige adipocytes within white adipose depots-has gained attention as a potential therapeutic mechanism.</p><p><strong>Recent findings: </strong>Recent advances highlight that adipose browning modulates multiple pathways relevant to MASLD. These include enhanced mitochondrial β-oxidation and energy expenditure, leading to reduced lipid delivery to the liver, as well as endocrine signaling mediated by batokines such as fibroblast growth factor 21 (FGF21), irisin, and neuregulin 4 (Nrg4). Collectively, these pathways influence hepatic lipid metabolism, insulin sensitivity, and inflammatory and fibrotic processes. The preclinical studies consistently demonstrate metabolic and hepatoprotective benefits of browning; however, translational evidence in humans remains limited and heterogeneous. Factors such as reduced thermogenic capacity in obesity, inter-individual variability, and challenges in sustaining browning activation constrain clinical applicability. Overall, adipose tissue browning represents a promising component of a systems-based approach to MASLD. Future work should focus on integrating mechanistic insights with clinical investigation to clarify its therapeutic potential and to identify strategies that enable durable and patient-specific metabolic benefits.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13427956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gut-brain-adipose Axis in Ultra-processed Food and Obesity: A Mechanistic Synthesis and Its Implications for Food Classification.","authors":"Jimmy Chun Yu Louie","doi":"10.1007/s13679-026-00745-0","DOIUrl":"10.1007/s13679-026-00745-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>Consumption of ultra-processed food (UPF) tracks closely with obesity across populations, and the Nova classification has become the dominant tool for capturing that exposure. Why UPF promotes weight gain is a separate question, and the biological answer has accumulated in fragments. I draw those strands together and ask whether three mechanisms usually studied in isolation: gut microbial disruption, hypothalamic inflammation, and adipose tissue dysfunction, are better understood as one connected system, and what that would mean for how UPF is classified.</p><p><strong>Recent findings: </strong>Three experimental literatures have converged on a shared pathway. Dietary emulsifiers and non-sugar sweeteners alter microbial composition and weaken the intestinal barrier, raising circulating lipopolysaccharide. In animal models this signal reaches the hypothalamus, where it activates inflammatory pathways, recruits glia, and blunts the leptin response that normally limits intake; though whether the same sequence operates in humans remains unestablished. Visceral fat that expands under this regime secretes its own inflammatory load, which feeds back onto both the gut and the brain. A 2025 UK Biobank analysis added a human imaging dimension, reporting structural differences in feeding-related brain regions that scaled with UPF intake and were only partly explained by adiposity. The evidence coheres best when the three arms are read as a single self-reinforcing loop in which each influences the others. Within that frame, the limitation of the Nova classification becomes specific and tractable: Group 4 mixes products that engage the loop strongly with products that barely touch it. This review sets out where the mechanistic evidence is firm, where it remains thin, and how an attribute-aware refinement of Group 4 might be tested.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13421199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"School-Focused Interventions for Weight-Based Victimization in Youth.","authors":"Rebecca L Pearl, David M Janicke","doi":"10.1007/s13679-026-00743-2","DOIUrl":"10.1007/s13679-026-00743-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>To summarize the evidence supporting interventions for weight-based victimization (WBV) among youth, particularly in school settings.</p><p><strong>Recent findings: </strong>Structural-level laws and policies to prevent and reduce bullying are effective but rarely include weight. Similarly, despite the high prevalence of WBV among students, weight is not commonly addressed in school anti-bullying interventions, including those that target bias-based bullying. School-based eating disorder prevention programs do not effectively prevent or reduce WBV, and interventions focused specifically on WBV lack rigorous testing. Evidence-based interventions to support youth who have experienced WBV are needed. Greater attention to WBV is warranted in anti-bullying laws, policies, and school-based interventions. Identifying opportunities to include weight in existing anti-bullying interventions and developing new interventions for WBV are needed to reduce weight-based disparities in youth victimization.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.","authors":"Jiayan Xie, Yujing Yang, Wanting Chen, Lu Wang, Siying Weng, Qiang Lyu, Gang Cao","doi":"10.1007/s13679-026-00742-3","DOIUrl":"https://doi.org/10.1007/s13679-026-00742-3","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacologic and Non-Pharmacologic Interventions for Hypothalamic Obesity: An Updated Review.","authors":"Anna Zenno, Melinda Pierce","doi":"10.1007/s13679-026-00744-1","DOIUrl":"10.1007/s13679-026-00744-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to provide a summary of treatment strategies for hypothalamic obesity (HO) and the latest data on pharmacologic interventions for HO.</p><p><strong>Recent findings: </strong>We summarize new consensus diagnostic criteria for acquired HO, non-pharmacologic interventions such as diet and physical activity, medications including the newly FDA approved setmelanotide, metabolic and bariatric surgery, and emerging treatment strategies that address the complex pathophysiology of HO. Hypothalamic obesity is caused by hypothalamic injury that impairs energy balance, metabolism, and satiety and leads to refractory obesity that is resistant to traditional diet and exercise interventions. Despite recent progress, effective long-term management of HO remains challenging, with few controlled trials, significant heterogeneity in patient response, and lack of long-term follow up data. A new medication targeting the melanocortin-4 receptor (MC4R) pathway was recently approved for treatment with additional newer drugs in development [1].</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Echocardiography in the Assessment of Epicardial Adipose Tissue: A Systematic Review and Meta-analysis.","authors":"Barbara Pala, Mariagrazia Piscione, Francesco Cribari, Serena De Mitri, Paola Gualtieri, Antonino De Lorenzo, Luigi Barrea, Marco Alfonso Perrone, Gianluca Iacobellis, Laura Di Renzo","doi":"10.1007/s13679-026-00734-3","DOIUrl":"10.1007/s13679-026-00734-3","url":null,"abstract":"<p><strong>Background: </strong>Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot implicated in cardiometabolic and cardiovascular (CV) disease. Although cardiac magnetic resonance (CMR) and cardiac computed tomography (cCT) enable accurate volumetric quantification of EAT, their cost, limited availability, and-particularly for cCT-radiation exposure, restrict their use in preventive and longitudinal settings. Transthoracic echocardiography (TTE) is widely accessible and radiation-free, but its validity as a surrogate of volumetric EAT assessment and its broader clinical role remain incompletely defined.</p><p><strong>Objectives: </strong>To systematically synthesize disease-specific evidence linking TTE-derived EAT thickness with major CV phenotypes and to quantitatively assess its association with volumetric EAT measured by CMR or cCT.</p><p><strong>Methods: </strong>A systematic search of PubMed and PubMed Central (January 2000-December 2025) identified adult studies evaluating associations between TTE-derived EAT thickness and coronary artery disease (CAD), atrial fibrillation (AF), or heart failure with preserved ejection fraction (HFpEF), and correlations between TTE-derived EAT thickness and CMR- or cCT-derived EAT volume. Correlation coefficients were pooled using a random-effects model after Fisher's z-transformation. An exploratory meta-analysis assessed associations with major adverse cardiovascular events (MACE).</p><p><strong>Results: </strong>Seventeen disease-specific studies consistently demonstrated associations between increased TTE-derived EAT thickness and CAD severity, AF burden and recurrence, and adverse HFpEF phenotypes. Five validation studies were included; four comparing TTE with CMR were pooled, yielding a moderate-to-strong correlation (r = 0.77, 95% CI 0.65-0.93; p < 0.01; I² = 92.9%). Several studies reported associations between TTE- EAT thickness and cCT-derived EAT parameters. However, only one cCT study met our predefined criteria for inclusion in the quantitative validation analysis, whereas the remaining cCT studies were retained in the qualitative synthesis because of substantial methodological heterogeneity in cCT acquisition, segmentation approaches, and outcome definitions. Exploratory prognostic analysis suggested a directional association between increased TTE-derived EAT thickness and MACE.</p><p><strong>Conclusions: </strong>TTE-derived EAT thickness correlates with volumetric EAT and is consistently associated with major CV phenotypes. Standardization and prospective outcome-driven validation are required before routine clinical implementation.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of Community-based Interventions to Promote Physical Activity or Reduce Sedentary Behavior among Adults in Low- and Middle-Income Countries.","authors":"Madhur Verma, Madhu Gupta, Gursimer Jeet, Hans Bosma, Annemarie Koster","doi":"10.1007/s13679-026-00741-4","DOIUrl":"10.1007/s13679-026-00741-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Community-based interventions (CBIs) are widely used to address behavioral risk factors for non-communicable diseases, yet evidence of their effectiveness in low- and middle-income countries (LMICs) remains limited. This study systematically reviewed evidence on the effectiveness of CBIs promoting physical activity (PA) and/or reducing sedentary behavior (SB) among community-dwelling adults in LMICs. We searched PubMed, Embase, Scopus, and the Cochrane Library (2000-2024) for CBIs in LMICs. Primary outcomes were changes in PA and/or SB. Descriptive and graphical depictions were used to draw inferences.</p><p><strong>Recent findings: </strong>We selected 24 studies (11 RCTs) from 15,396 for review. Most studies (n = 16) reported significant improvements in PA outcomes. Changes were observed in Metabolic Equivalents (+ 100 - +2,700), moderate-to-vigorous PA (+ 7 to + 60 min/week), and steps/day (+ 3,000). Broadly, interventions were delivered using digital/technology format (n = 10), peer-led/community health worker-facilitated (n = 8), and Environmental restructuring (n = 6), with the digital interventions depicting the most consistent significant improvements. Two studies directly measured SB as a primary outcome. Short- (≤ 6 months; n = 11) and medium-duration (6-12 months; n = 4) interventions more frequently reported significant PA improvements than long-duration interventions (> 12 months; n = 9). PA/SB-focused CBI demonstrated proportions of significant effects similar to those of broader lifestyle interventions (88.9% and 53.3%, respectively). CBIs can be effective in improving PA in LMICs, although evidence is heterogeneous and SB is less addressed. Digital interventions show more consistent positive signals, but high heterogeneity in studies precludes firm conclusions. The impact of duration on effectiveness looks counterintuitive but underscores the need for more rigorous evaluation of longer-duration interventions and SB outcomes. PROSPERO registration number: CRD42024579461.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13391703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Biological Sex on Metabolic and Adipokine Responses after Metabolic-Bariatric Surgery: A Narrative Review.","authors":"Gonzalo Rivero, Amaia Rodríguez, Victoria Catalán, Beatriz Ramírez, Federico Carbone, Fabrizio Montecucco, Javier Gómez-Ambrosi, Gema Frühbeck, Sara Becerril","doi":"10.1007/s13679-026-00740-5","DOIUrl":"10.1007/s13679-026-00740-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>Obesity is a multifactorial, chronic, and relapsing non-communicable disease characterized by excessive adipose tissue accumulation and metabolic dysfunction. Increasing evidence indicates that biological sex influences not only the development and distribution of adipose tissue but also responses to obesity treatments, including metabolic-bariatric surgery. This narrative review synthesizes current evidence on sex-related differences in metabolic outcomes after bariatric surgery.</p><p><strong>Recent findings: </strong>Bariatric surgery induces substantial weight loss and marked improvement of obesity-related complications in both men and women along sex-specific differences in body composition changes, adipose tissue remodeling, adipokine secretion, inflammatory responses, and thermogenic adaptations. Estrogen signaling contributes to a more favorable adipose tissue phenotype through anti-inflammatory effects, enhanced adipokine profiles, preservation of lean mass, and stimulation of white adipose tissue beiging, a process by which an inducible form of thermogenic adipocytes within white adipose tissue (beige adipocytes) acquire thermogenic characteristics similar to brown adipose tissue. In women, menopausal status represents a key biological modifier of these responses. In contrast, androgen excess is associated with visceral fat accumulation and insulin resistance. Despite largely comparable rates of remission of major obesity-related complications between sexes, variances in adiposity, hormonal milieu, and postoperative metabolic outcomes suggest different underlying mechanisms. Although remission rates of obesity-related complications appear broadly comparable between sexes, the underlying metabolic and endocrine adaptations differ. Biological sex represents a determinant of post-bariatric metabolic remodeling. This review highlights the relevance of biological sex in obesity and its treatment, emphasizing the need for sex-stratified studies to elucidate underlying mechanisms and support the development of more precise, personalized strategies in obesity management.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13391805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}