Current Obesity Reports最新文献

{"title":"Emotional Eating and Obesity: An Update and New Insights.","authors":"Abby Braden, Erica Ahlich, Afton M Koball","doi":"10.1007/s13679-025-00661-9","DOIUrl":"10.1007/s13679-025-00661-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>The current review aimed to (1) synthesize information regarding the association between emotional eating (EE) and BMI, as well as between EE and dietary intake and psychological symptoms; (2) describe factors thought to underlie and/or maintain EE; and (3) summarize recent evidence supporting behavioral treatments of EE in people with obesity.</p><p><strong>Recent findings: </strong>Adults with obesity frequently report EE. Emotion regulation and learning principles are key variables that may influence EE in adults with obesity. Behavioral treatments show promise for decreasing EE, in the short-term, especially cognitive-behavioral and mindfulness-based approaches. Although psychosocial factors are critical to the understanding of EE mechanisms and treatment, limitations include measurement of EE and construct definitions of proposed theoretical variables. Additionally, behavioral interventions overlap which obscures the relative utility of treatment components. Future work should clarify causal mechanisms of EE in the context of obesity to inform treatment development.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"70"},"PeriodicalIF":11.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weighty Consequences: Pollution's Hidden Weight in the Obesity Epidemic: A Narrative Review.","authors":"Seda Nur Köktürk, Hülya Yardımcı","doi":"10.1007/s13679-025-00659-3","DOIUrl":"https://doi.org/10.1007/s13679-025-00659-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to comprehensively examine the relationship between environmental pollution and obesity by integrating epidemiological evidence, biological mechanisms, and anthropometric measurements. It specifically focuses on how pollutants contribute to weight gain and metabolic disruptions, particularly in vulnerable populations.</p><p><strong>Recent findings: </strong>Environmental pollution, including air, noise, light, persistent organic pollutants, and microplastics/plastic additives, is increasingly recognized as a contributor to the global obesity epidemic. Epidemiological studies highlight the associations between pollution exposure and obesity risk, while mechanistic research reveals how pollutants disrupt metabolic processes, alter hormonal balance, and induce systemic inflammation. This review synthesizes current findings on the role of environmental pollutants in obesity, integrating both epidemiological and mechanistic perspectives. It explores how exposure to pollutants disrupts metabolic pathways, alters endocrine functions, and promotes systemic inflammation, ultimately contributing to obesity. Vulnerable groups, such as pregnant women, children, adolescents, and the elderly, are particularly at risk due to their heightened sensitivity to environmental exposures. By highlighting critical research gaps, it underscores the need for further longitudinal studies and interventional strategies aimed at mitigating pollution-induced metabolic risks. Public health policies targeting environmental pollution could serve as an effective approach to obesity prevention and control.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"69"},"PeriodicalIF":11.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Medical Nutrition Therapy in the Management of Patients with Obesity and Endometriosis: from the Mediterranean Diet To the Ketogenic Diet, Through Supplementation. The Role of the Nutritionist in Clinical Management.","authors":"Luigi Barrea, Ludovica Verde, Giuseppe Annunziata, Peter Chedraui, Felice Petraglia, Gabriela Cucalón, Elisabetta Camajani, Massimiliano Caprio, Stefania Gorini, Giuseppe Gabriele Iorio, Raffaella Di Girolamo, Luigi Carbone, Sebastian Chapela, Evelyn Frias-Toral, Giovanna Muscogiuri","doi":"10.1007/s13679-025-00662-8","DOIUrl":"10.1007/s13679-025-00662-8","url":null,"abstract":"<p><strong>Purpose of the review: </strong>This review aimed to summarize current evidence on the effectiveness of medical nutrition therapy (MNT) in the management of obesity and endometriosis, with a focus on dietary patterns such as the Mediterranean and Ketogenic diets, as well as nutritional supplementation. Additionally, it highlights the central role of the clinical nutritionist in implementing individualized, evidence-based interventions within multidisciplinary care.</p><p><strong>Recent findings: </strong>Although the literature reports the existence of an inverse relationship between risk of endometriosis and body mass index, clinical evidence jointly reports that a condition of obesity is associated with greater disease severity. This, therefore, implies the need to identify the different phenotypes of patients with endometriosis at which to target a precision MNT. Several dietary patterns and supplements have been investigated for their role in endometriosis management. The Mediterranean diet-rich in anti-inflammatory nutrients, fiber, and antioxidants-has been associated with decreased pain and improved quality of life. More recently, ketogenic diets have shown potential in modulating insulin signaling and inflammatory pathways, though clinical evidence remains limited. Supplementation with omega-3 fatty acids, N-acetylcysteine, resveratrol, vitamins C and E, and probiotics has demonstrated promising anti-inflammatory and antioxidative effects in both preclinical and clinical studies. Furthermore, attention is being directed toward the gut microbiota and its interaction with the immune and endocrine systems in women with endometriosis. Endometriosis is a chronic gynecological condition characterized by ectopic endometrial tissue, estrogen dependence, and persistent inflammation. It affects approximately 10% of women of reproductive age and is associated with pelvic pain, infertility, and reduced quality of life. While conventional treatment focuses on hormonal therapy and surgery, MNT is emerging as a non-invasive, supportive approach. Nutritional interventions can target key pathophysiological mechanisms of endometriosis, such as systemic inflammation, oxidative stress, and hormonal imbalance, offering potential symptom relief and improved clinical outcomes.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"68"},"PeriodicalIF":11.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose Tissue, at the Core of the Action of Incretin and Glucagon-Based Anti-Obesity Drugs.","authors":"Francesc Villarroya, Marion Peyrou, Marta Giralt","doi":"10.1007/s13679-025-00660-w","DOIUrl":"10.1007/s13679-025-00660-w","url":null,"abstract":"<p><strong>Purpose of the review: </strong>This review summarizes recent evidence highlighting the specific role of adipose tissue in the systemic effects of incretin agonist-based drugs used in the treatment of obesity.</p><p><strong>Recent findings: </strong>The development of incretin agonist-based drugs has achieved unprecedented success in the pharmacological treatment of obesity and the improvement of obesity-related comorbidities. While initially shown to significantly reduce adipose tissue through decreased food intake, incretin-based therapy is also increasingly reported to alter the properties of adipose tissue. Recent experimental and human studies indicate that these anti-obesity drugs induce significant changes in the metabolism and inflammatory state of adipose tissue, while also promoting its thermogenic plasticity. The direct and indirect actions of incretin-based anti-obesity drugs, which modify the properties of adipose tissue, are emerging as key contributors to the systemic health benefits of these treatments.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"67"},"PeriodicalIF":11.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Physical Activity in Minimizing Recurrence of Weight Gain Following Metabolic and Bariatric Surgery: Current Evidence and Suggestions for Advancing Future Research.","authors":"Dale S Bond, Yin Wu, Aurélie Baillot, Jason Lillis, Christine Sundgot-Borgen, Pavlos K Papasavas","doi":"10.1007/s13679-025-00658-4","DOIUrl":"https://doi.org/10.1007/s13679-025-00658-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Patients who undergo metabolic and bariatric surgery (MBS) are advised to increase physical activity (PA) to help minimize weight recurrence. This report reviews current evidence for this recommendation and offers suggestions for advancing future research.</p><p><strong>Recent findings: </strong>Most observational studies suggest a link between higher PA and lower weight recurrence, yet they often rely on cross-sectional designs, making it difficult to determine the direction of this relationship. Randomized intervention trials remain limited, and current strategies may not sufficiently address the motivational barriers that hinder patients from sustaining higher PA levels. While some initiatives to address these gaps are in progress, further research should focus on approaches that accurately capture nadir weight to measure weight recurrence, clarify whether PA is more effective at preventing or treating weight recurrence, explore interventions beyond exercise-centric strategies, examine individual differences in response to PA, and include other relevant clinical and patient-centered outcomes.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"66"},"PeriodicalIF":11.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Intriguing Roles of Cytokines in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review.","authors":"Ilias D Vachliotis, Stergios A Polyzos","doi":"10.1007/s13679-025-00657-5","DOIUrl":"10.1007/s13679-025-00657-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>This narrative review aims to critically summarize evidence on the potential contribution of cytokines, including members of the tumor necrosis factor (TNF) superfamily, interleukins (ILs), interferons (IFs), chemokines, lymphokines, and members of the transforming growth factor (TGF) superfamily to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). It also considers the translational relevance of cytokines, including their potential for non-invasive biomarkers or therapeutic targets of MASLD.</p><p><strong>Recent findings: </strong>MASLD and its inflammatory phenotype, metabolic dysfunction-associated steatohepatitis (MASH), are characterized by chronic, low-grade hepatic inflammation, primarily initiated by metabolic contributors and driven by various cytokines. Cytokines are major mediators of the transition from hepatic steatosis to MASH. Some of them seem to be predominantly protective (tumor necrosis factor weak inducer of apoptosis, IL-10, IL-22, IL-25, IL-27), others appear to exhibit a possibly dual-faceted effect, depending on the stage of MASLD (TNF-α, TNF-related apoptosis-inducing ligand, IL-2, IL-6, IL-18, IL-33, IFNs), whereas a third group of cytokines seems to be predominantly harmful, thus driving the progression of hepatic steatosis to MASH, fibrosis, cirrhosis, and possibly to hepatocellular carcinoma. In this regard, some cytokines may prove suitable non-invasive indices for distinguishing MASH or hepatic fibrosis from hepatic steatosis. Additionally, cytokine-based therapies, including anti-TNF-α agents (infliximab, adalimumab, etanercept), NLRP3 inhibitors, recombinant IL-1R antagonist (anakinra), selective C-C chemokine receptor type 2 inhibitors, anti-IL-17 (e.g., secukinumab and ixekizumab) or IL-17R (brodalumab) monoclonal antibodies, and recombinant IL-22, may prove promising pharmacological targets for the management of MASLD. Amounting evidence renders some cytokines key players in the pathophysiology of MASLD, which may possibly have diagnostic and therapeutic implications.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"65"},"PeriodicalIF":11.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of (Poly)phenols on Lipid and Glucose Metabolisms in 3T3-L1 Adipocytes: an Integrated Analysis of Mechanistic Approaches.","authors":"Marco Rendine, Mirko Marino, Daniela Martini, Patrizia Riso, Peter Møller, Cristian Del Bo'","doi":"10.1007/s13679-025-00656-6","DOIUrl":"10.1007/s13679-025-00656-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>This systematic review aims to elucidate the effects of (poly)phenols (PPs) on mature 3T3-L1 adipocytes via the regulation of lipid and glucose metabolism.</p><p><strong>Recent findings: </strong>PPs can modulate glucose uptake, reduce intracellular lipid content and enhance lipolytic activity in mature 3T3-L1 adipocytes. These effects are mediated through changes at both gene expression level (e.g. Ppara and Sirt1) and protein level (e.g. activation of AMPK and adiponectin levels). However, there is no consensus on the concentrations at which PPs exert their anti-lipogenic activity, and it remains unclear whether different PPs activate distinct molecular pathways. PPs are a diverse group of plant-derived secondary metabolites with recognized anti-obesogenic potential. While their inhibitory effects on adipogenesis are well established, their role in modulating lipid metabolism in fully differentiated adipocytes remains less well understood. Emerging evidence from studies on mature 3T3-L1 adipocytes indicates that PPs can influence key metabolic processes, including lipid storage and mobilization. These findings highlight the potential of PPs as modulators of adipose tissue metabolism, while also emphasizing the need for translational research to clarify their mechanisms of action and therapeutic efficacy in vivo.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"64"},"PeriodicalIF":11.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Telemedicine Nursing Interventions in the Management of Overweight and Obesity in Adults: A Systematic Review and Meta-Analysis.","authors":"Emanuele Colaone, Elisa Belluzzi, Assunta Pozzuoli, Enrico Roma, Elena Bortolato, Carlo Biz, Pietro Ruggieri","doi":"10.1007/s13679-025-00655-7","DOIUrl":"10.1007/s13679-025-00655-7","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a growing global health issue, linked to chronic conditions like type 2 diabetes, hypertension, and cardiovascular diseases. Nursing staff could play a significant role in managing obesity, with telemedicine being a potentially effective tool for monitoring weight and caloric intake. However, the effectiveness of telemedicine-based nursing interventions in managing obesity and overweight remains unclear.</p><p><strong>Objective: </strong>This systematic review with meta-analysis aimed to evaluate the effectiveness of nursing telemedicine interventions in managing overweight and obesity in adults.</p><p><strong>Method: </strong>This review followed PRISMA guidelines and involved a literature search in Scopus, PubMed, and Web of Science. Eligible studies were in English, involved adults with a BMI over 25, and evaluated nursing-led telemedicine interventions (non-randomized and randomized controlled studies). Study quality was assessed using the Down and Black checklist. A random-effects model was used for the meta-analysis.</p><p><strong>Results: </strong>Four moderate-quality articles were included. The nursing-led telemedicine interventions, delivered through digital platforms, mobile apps, and remote monitoring, focused on health education and motivational strategies to promote self-regulation and dietary improvements. The meta-analysis showed that, compared to traditional approaches, nursing-led interventions resulted in an average weight loss of 2.59 kg (95% CI: - 3.09 to - 2.08), a reduction of 1.05 kg/m² in BMI (95% CI: - 1.50 to - 0.60), and a decrease of 2.52 cm in waist circumference (95% CI: - 2.96 to - 2.09).</p><p><strong>Conclusion: </strong>Nursing telemedicine interventions are effective in promoting short-term weight loss and lifestyle changes. However, further research is needed to assess long-term effects and the impact of different interventions.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"63"},"PeriodicalIF":11.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Adipokines and Gene Polymorphisms in the Development of Obesity- Induced Depression.","authors":"Seyma Nur Ercan, Nevin Sanlier","doi":"10.1007/s13679-025-00652-w","DOIUrl":"10.1007/s13679-025-00652-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review examines the role of adipokines and gene polymorphisms in the development of depression and obesity. It is of great importance to understand the mechanisms that may be effective in the development of obesity and depression as their incidence increases.</p><p><strong>Recent findings: </strong>Adipokines are released from adipose tissues and primarily regulate the connection between the metabolic and inflammatory effects of obesity and the brain cells and adipose tissue. Adipokines may potentially contribute to the pathophysiology of depression by influencing the HPA axis and neurotransmitters. According to some estimates, the genetic overlap between obesity and depression is as high as 12 percent. Furthermore, these genes may be linked to significant interconnected signaling networks that have a role in the etiology of both disorders. Obesity and depression are both on the rise globally, and it is thought that there is a bidirectional relationship between these two conditions. Obesity and obesity-induced depression seriously limit the psychosocial functionality of individuals and impair their quality of life. Having a high body mass index (BMI) raises the likelihood of developing depression. On the other hand, as the BMI elevates in people suffering from depression, the possibility of developing obesity also rises.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"62"},"PeriodicalIF":11.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and the Gut-Brain Axis in Type 1 Diabetes Mellitus: Terra Incognita?","authors":"Georgia Argyrakopoulou, Evdoxia Gitsi, Maria Dalamaga, Alexander Kokkinos","doi":"10.1007/s13679-025-00654-8","DOIUrl":"10.1007/s13679-025-00654-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>The increasing prevalence of obesity among individuals with type 1 diabetes mellitus (T1DM) presents a significant clinical challenge, as it exacerbates insulin resistance, impairs glycemic control, and increases cardiometabolic risk. While obesity in T1DM is influenced by both genetic and environmental factors, recent evidence highlights the role of the gut-brain axis in metabolic regulation. This review explores the complex relationship between obesity and T1DM, the role of the gut-brain axis in metabolic dysregulation, and current weight management strategies, highlighting the need for further research to optimize treatment outcomes in this unique patient population.</p><p><strong>Recent findings: </strong>Key gastrointestinal hormones, including glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), and amylin, play essential roles in appetite control, energy balance, and glucose metabolism, yet their dysregulation in T1DM remains poorly understood. Addressing obesity requires a multifaceted approach, including lifestyle modifications, pharmacotherapy with GLP-1 receptor agonists (GLP-1RAs), and bariatric surgery (BS). Although limited, accumulating evidence regarding the use of liraglutide, semaglutide and tirzepatide in T1DM begin to highlight the safety and effectiveness of these molecules in this subset of patients as well. Lifestyle modifications, GLP-1 RAs based pharmacotherapy and BS have emerged as potential strategies to address obesity in patients with T1DM. Initial findings point to potential improvements in both metabolic health and glycemic control, but further exploration of their role in the co-occurrence of obesity and T1DM remains limited. Ongoing research is crucial to better understand how the gut-brain axis influences weight regulation in T1DM and to determine the sustained benefits and risks of these emerging therapies.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"61"},"PeriodicalIF":11.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}