Current Obesity Reports最新文献

Optimal Bilio-Pancreatic Limb (BPL) Length in One Anastomosis Gastric Bypass (OAGB) Surgery.

IF 9.5 2区医学

Current Obesity Reports Pub Date : 2025-01-25 DOI: 10.1007/s13679-025-00608-0

G Balamurugan, Piriyah Sinclair, O Sesby-Banjoh, Mayuri Vinod, Yitka Graham, Kamal Mahawar

{"title":"Optimal Bilio-Pancreatic Limb (BPL) Length in One Anastomosis Gastric Bypass (OAGB) Surgery.","authors":"G Balamurugan, Piriyah Sinclair, O Sesby-Banjoh, Mayuri Vinod, Yitka Graham, Kamal Mahawar","doi":"10.1007/s13679-025-00608-0","DOIUrl":"https://doi.org/10.1007/s13679-025-00608-0","url":null,"abstract":"Background: One Anastomosis Gastric Bypass (OAGB) is a modification of Mason's loop bypass procedure, which has become a well-established procedure in the field of Bariatric and Metabolic surgery (BMS). However, the optimal length of Biliopancreatic Limb (BPL) in OAGB remains an ongoing debate.Objective: This review aims to analyse the current trends and evidence regarding different BPL lengths in OAGB and their impact on outcomes.Methods: A comprehensive literature search using search terms, 'One Anastomosis Gastric Bypass', 'Mini-Gastric Bypass', 'Biliopancreatic Limb', and 'Small bowel limb' was conducted. The articles were extracted and critically appraised for various outcomes including weight loss, comorbidities resolution, nutritional deficiencies, complications and quality of life.Results: There appears to be a direct relationship between length of the BPL and the incidence of malnutrition. Longer BPL lengths (> 200 cm) are associated with a higher risk of malnutrition. Shorter BPL lengths (150-200 cm), particularly 150 cm, have shown promising outcomes.Conclusion: Shorter BPL lengths offer potential advantages by reducing nutritional risks associated with OAGB. Further research with long-term follow-up is needed to investigate the efficacy of even shorter BPL lengths (< 150 cm).","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"14"},"PeriodicalIF":9.5,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining Hyperphagia for Improved Diagnosis and Management of MC4R Pathway-Associated Disease: A Roundtable Summary.

IF 9.5 2区医学

Current Obesity Reports Pub Date : 2025-01-25 DOI: 10.1007/s13679-024-00601-z

Steven B Heymsfield, Karine Clément, Beatrice Dubern, Anthony P Goldstone, Andrea M Haqq, Peter Kühnen, Jesse Richards, Christian L Roth, Erica L T van den Akker, Martin Wabitsch, Jack A Yanovski

{"title":"Defining Hyperphagia for Improved Diagnosis and Management of MC4R Pathway-Associated Disease: A Roundtable Summary.","authors":"Steven B Heymsfield, Karine Clément, Beatrice Dubern, Anthony P Goldstone, Andrea M Haqq, Peter Kühnen, Jesse Richards, Christian L Roth, Erica L T van den Akker, Martin Wabitsch, Jack A Yanovski","doi":"10.1007/s13679-024-00601-z","DOIUrl":"10.1007/s13679-024-00601-z","url":null,"abstract":"Purpose of review: Hyperphagia is a condition associated with rare obesity-related diseases, presenting as a pathologic, insatiable hunger accompanied by abnormal food-seeking behaviors. In October 2023, a group of researchers and clinicians with expert knowledge on hyperphagia convened at the annual ObesityWeek meeting to discuss the need for a unified definition of hyperphagia and key items necessary to improve the identification, assessment, and treatment of hyperphagia in patients with melanocortin 4 receptor (MC4R) pathway-associated diseases.Recent findings: The definition of hyperphagia proposed by this group is a pathologic, insatiable hunger accompanied by abnormal food-seeking behaviors. Suggested methods to accurately identify patients with hyperphagia include increased physician and parent/caregiver education and standardized efficient screening procedures for use in the clinic. The etiology of hyperphagia as related to abnormal MC4R signaling was also reviewed and proposed as a central cause of the condition across several underlying diseases. Given this potential unified underlying pathology, the expert group recommends that patients with hyperphagia undergo genetic testing and that treatment include comprehensive weight-management strategies incorporating lifestyle and pharmacotherapies targeted at addressing hyperphagia.","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"13"},"PeriodicalIF":9.5,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hallmarks of Appetite: A Comprehensive Review of Hunger, Appetite, Satiation, and Satiety.

IF 9.5 2区医学

Current Obesity Reports Pub Date : 2025-01-24 DOI: 10.1007/s13679-024-00604-w

Mattia Garutti, Marianna Sirico, Claudia Noto, Lorenzo Foffano, Mark Hopkins, Fabio Puglisi

{"title":"Hallmarks of Appetite: A Comprehensive Review of Hunger, Appetite, Satiation, and Satiety.","authors":"Mattia Garutti, Marianna Sirico, Claudia Noto, Lorenzo Foffano, Mark Hopkins, Fabio Puglisi","doi":"10.1007/s13679-024-00604-w","DOIUrl":"https://doi.org/10.1007/s13679-024-00604-w","url":null,"abstract":"Purpose of review: The present review describes the available literature on the physiologic mechanisms that modulate hunger, appetite, satiation, and satiety with a particular focus on well-established and emerging factors involved in the classic satiety cascade model.Recent finding: Obesity is a significant risk factor for numerous chronic conditions like cancer, cardiovascular diseases, and diabetes. As excess energy intake is considered by some to be the primary driver of weight gain, tremendous collective effort should be directed toward reducing excessive feeding at the individual and population levels. From this perspective, detailed understanding of physiologic mechanisms that control appetite, and in turn, the design of effective interventions to manage appetite, may represent key strategies in controlling the obesity epidemic. With the obesity's prevalence on the rise worldwide, research on hunger, appetite, satiation and satiety is more relevant than ever. This research aims to provide practical insights for medical practitioners, nutrition professionals, and the broader scientific community in the fight against this global health challenge.","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"12"},"PeriodicalIF":9.5,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Weight Bias and Stigma Undermine Healthcare Access and Utilization. 体重偏见和耻辱如何破坏医疗保健的获取和利用。

IF 9.5 2区医学

Current Obesity Reports Pub Date : 2025-01-20 DOI: 10.1007/s13679-025-00605-3

Rebecca L Pearl, Miriam Sheynblyum

引用次数: 0

New Frontiers: Umbilical Cord Mesenchymal Stem Cells Uncover Developmental Roots and Biological Underpinnings of Obesity Susceptibility. 新领域：脐带间充质干细胞揭示肥胖易感性的发育根源和生物学基础。

IF 9.5 2区医学

Current Obesity Reports Pub Date : 2025-01-16 DOI: 10.1007/s13679-024-00599-4

Lauren E Gyllenhammer, Kristen E Boyle

{"title":"New Frontiers: Umbilical Cord Mesenchymal Stem Cells Uncover Developmental Roots and Biological Underpinnings of Obesity Susceptibility.","authors":"Lauren E Gyllenhammer, Kristen E Boyle","doi":"10.1007/s13679-024-00599-4","DOIUrl":"10.1007/s13679-024-00599-4","url":null,"abstract":"Purpose of review: To review evidence supporting human umbilical cord mesenchymal stem cells (UC-MSC) as an innovative model system advancing obesity precision medicine.Recent findings: Obesity prevalence is increasing rapidly and exposures during fetal development can impact individual susceptibility to obesity. UC-MSCs exhibit heterogeneous phenotypes associated with maternal exposures and predictive of child cardiometabolic outcomes. This recent evidence supports UC-MSCs as a precision model serving three purposes: (1) as a mechanistic tool to interrogate biological underpinnings of obesity in human studies, (2) as a sensitive index of early life causes and determinants of obesity, and (3) as a marker and transducer of susceptibility, highlighting populations most at risk for future obesity. Data from UC-MSCs emphasize nutrient sensing and lipid partitioning as phenotypes most relevant to neonatal and early childhood adiposity and implicate a role for these cell-autonomous features of mesodermal tissues in the biological underpinnings of obesity.","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"10"},"PeriodicalIF":9.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Marrow Adipocytes as Novel Regulators of Metabolic Homeostasis: Clinical Consequences of Bone Marrow Adiposity. 骨髓脂肪细胞作为代谢稳态的新调节因子：骨髓肥胖的临床后果。

IF 9.5 2区医学

Current Obesity Reports Pub Date : 2025-01-14 DOI: 10.1007/s13679-024-00594-9

Hanghang Liu, Linyi Liu, Clifford J Rosen

{"title":"Bone Marrow Adipocytes as Novel Regulators of Metabolic Homeostasis: Clinical Consequences of Bone Marrow Adiposity.","authors":"Hanghang Liu, Linyi Liu, Clifford J Rosen","doi":"10.1007/s13679-024-00594-9","DOIUrl":"https://doi.org/10.1007/s13679-024-00594-9","url":null,"abstract":"Purpose of review: Bone marrow adipose tissue is a distinctive fat depot located within the skeleton, with the potential to influence both local and systemic metabolic processes. Although significant strides have been made in understanding bone marrow adipose tissue over the past decade, many questions remain regarding their precise lineage and functional roles.Recent findings: Recent studies have highlighted bone marrow adipose tissue's involvement in continuous cross-talk with other organs and systems, exerting both endocrine and paracrine functions that play a crucial role in metabolic homeostasis, skeletal remodeling, hematopoiesis, and the progression of bone metastases. The advancement of imaging techniques, particularly cross-sectional imaging, has profoundly expanded our understanding of the complexities beyond the traditional view of bone marrow adipose tissue as an inert depot. Notably, marrow adipocytes are anatomically and functionally distinct from brown, beige, and classic white adipocytes. Emerging evidence suggests that bone marrow adipocytes, bone marrow adipose tissue originate from the differentiation of bone marrow mesenchymal stromal cells; however, they appear to be a heterogeneous population with varying metabolic profiles, lipid compositions, secretory properties, and functional responses depending on their specific location within the bone marrow. This review provides an up-to-date synthesis of current knowledge on bone marrow adipocytes, emphasizing the relationships between bone marrow adipogenesis and factors such as aging, osteoporosis, obesity, and bone marrow tumors or metastases, thereby elucidating the mechanisms underlying musculoskeletal pathophysiology.","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"9"},"PeriodicalIF":9.5,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates on Methods for Body Composition Analysis: Implications for Clinical Practice. 身体成分分析方法的最新进展：对临床实践的影响。

IF 9.5 2区医学

Current Obesity Reports Pub Date : 2025-01-11 DOI: 10.1007/s13679-024-00593-w

Diana M Thomas, Ira Crofford, John Scudder, Brittany Oletti, Ashok Deb, Steven B Heymsfield

{"title":"Updates on Methods for Body Composition Analysis: Implications for Clinical Practice.","authors":"Diana M Thomas, Ira Crofford, John Scudder, Brittany Oletti, Ashok Deb, Steven B Heymsfield","doi":"10.1007/s13679-024-00593-w","DOIUrl":"10.1007/s13679-024-00593-w","url":null,"abstract":"Background: Recent technological advances have introduced novel methods for measuring body composition, each with unique benefits and limitations. The choice of method often depends on the trade-offs between accuracy, cost, participant burden, and the ability to measure specific body composition compartments.Objective: To review the considerations of cost, accuracy, portability, and participant burden in reference and emerging body composition assessment methods, and to evaluate their clinical applicability.Methods: A narrative review was conducted comparing traditional reference methods like dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging (MRI), and computed tomography (CT) with emerging technologies such as smartphone camera applications, three-dimensional optical imaging scanners, smartwatch bioelectric impedance analysis (BIA), and ultrasound.Results: Reference methods like CT and MRI offer high accuracy and the ability to distinguish between specific body composition compartments (e.g., visceral, subcutaneous, skeletal muscle mass, and adipose tissue within lean mass) but are expensive and non-portable. Conversely, emerging methods, such as smartwatch BIA and smartphone-based technologies, provide greater accessibility and lower participant burden but with reduced accuracy. Methods like three-dimensional optical imaging scanners balance portability and accuracy, presenting promising potential for population-level applications.Conclusions: The selection of a body composition assessment method should be guided by the clinical context and specific application, considering trade-offs in cost, accuracy, and portability. Emerging methods provide valuable options for population-level assessments, while reference methods remain essential for detailed compartmental analysis.","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"8"},"PeriodicalIF":9.5,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management. 对抗肥胖相关肝病的营养策略：医学营养治疗在代谢功能障碍相关脂肪变性肝病（MASLD）管理中的作用

IF 9.5 2区医学

Current Obesity Reports Pub Date : 2025-01-11 DOI: 10.1007/s13679-024-00597-6

Daniel Simancas-Racines, Giuseppe Annunziata, Ludovica Verde, Federica Fascì-Spurio, Claudia Reytor-González, Giovanna Muscogiuri, Evelyn Frias-Toral, Luigi Barrea

{"title":"Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management.","authors":"Daniel Simancas-Racines, Giuseppe Annunziata, Ludovica Verde, Federica Fascì-Spurio, Claudia Reytor-González, Giovanna Muscogiuri, Evelyn Frias-Toral, Luigi Barrea","doi":"10.1007/s13679-024-00597-6","DOIUrl":"10.1007/s13679-024-00597-6","url":null,"abstract":"Purpose of review: This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine the effectiveness of specific nutritional strategies in preventing and treating this obesity-linked liver disease.Recent findings: Emerging evidence underscores the benefits of the Mediterranean diet, low-carbohydrate diets, and intermittent fasting in reducing liver fat, improving insulin sensitivity, and mitigating inflammation. Supplementing with vitamin E, omega-3 fatty acids, and silymarin can potentially reduce liver fibrosis and promote liver health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, and nutraceutical supplementation. Integrating these strategies with lifestyle modifications, including regular physical activity, offers a comprehensive approach to improving metabolic and liver outcomes in patients with MASLD. Further research is needed to refine and personalize these therapeutic interventions.","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"7"},"PeriodicalIF":9.5,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on Hypothalamic Inflammation and Gliosis: Expanding Evidence of Relevance Beyond Obesity. 下丘脑炎症和神经胶质瘤的最新进展：肥胖症以外的相关证据。

IF 9.5 2区医学

Current Obesity Reports Pub Date : 2025-01-08 DOI: 10.1007/s13679-024-00595-8

Alyssa Huang, Dabin Yeum, Leticia E Sewaybricker, Sandra Aleksic, Melbin Thomas, Susan J Melhorn, Yumei Feng Earley, Ellen A Schur

{"title":"Update on Hypothalamic Inflammation and Gliosis: Expanding Evidence of Relevance Beyond Obesity.","authors":"Alyssa Huang, Dabin Yeum, Leticia E Sewaybricker, Sandra Aleksic, Melbin Thomas, Susan J Melhorn, Yumei Feng Earley, Ellen A Schur","doi":"10.1007/s13679-024-00595-8","DOIUrl":"10.1007/s13679-024-00595-8","url":null,"abstract":"Purpose of review: To evaluate the role of hypothalamic inflammation and gliosis in human obesity pathogenesis and other disease processes influenced by obesity.Recent findings: Recent studies using established and novel magnetic resonance imaging (MRI) techniques to assess alterations in hypothalamic microarchitecture in humans support the presence of hypothalamic inflammation and gliosis in adults and children with obesity. Studies also identify prenatal exposure to maternal obesity or diabetes as a risk factor for hypothalamic inflammation and gliosis and increased obesity risk in offspring. Hypothalamic inflammation and gliosis have been further implicated in reproductive dysfunction (specifically polycystic ovarian syndrome and male hypogonadism), cardiovascular disease namely hypertension, and alterations in the gut microbiome, and may also accelerate neurocognitive aging. The most recent translational studies support the link between hypothalamic inflammation and gliosis and obesity pathogenesis in humans and expand our understanding of its influence on broader aspects of human health.","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"6"},"PeriodicalIF":9.5,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron-Mediated Regulation in Adipose Tissue: A Comprehensive Review of Metabolism and Physiological Effects. 脂肪组织中铁介导的调节：新陈代谢和生理效应综述》。

IF 9.5 2区医学

Current Obesity Reports Pub Date : 2025-01-03 DOI: 10.1007/s13679-024-00600-0

Xinyu Yang, Xianghong Wang, Zhe Yang, Hongyun Lu

{"title":"Iron-Mediated Regulation in Adipose Tissue: A Comprehensive Review of Metabolism and Physiological Effects.","authors":"Xinyu Yang, Xianghong Wang, Zhe Yang, Hongyun Lu","doi":"10.1007/s13679-024-00600-0","DOIUrl":"10.1007/s13679-024-00600-0","url":null,"abstract":"Purpose of review: Review the latest data regarding the intersection of adipose tissue (AT) and iron to meet the needs of AT metabolism and the progression of related diseases.Recent findings: Iron is involved in fundamental biological metabolic processes and is precisely fine-tuned within the body to maintain cellular, tissue and even systemic iron homeostasis. AT not only serves as an energy storage depot but also represents the largest endocrine organ in the human body, maintaining systemic metabolic homeostasis. It is involved in physiological processes such as energy storage, insulin sensitivity regulation and lipid metabolism. As a unique iron-sensing tissue, AT expresses related regulatory factors, including the classic hepcidin, ferroportin (FPN), iron regulatory protein/iron responsive element (IRP/IRE) and ferritin. Consequently, the interaction between AT and iron is intricately intertwined. Imbalance of iron homeostasis produces the potential risks of steatosis, impaired glucose tolerance and insulin resistance, leading to AT dysfunction diseases, including obesity, type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD). Despite the role of AT iron has garnered increasing attention in recent years, a comprehensive review that systematically organizes the connection between iron and AT remains lacking. Given the necessity of iron homeostasis, emphasizing its potential impact on AT function and metabolism regulation provides valuable insights into physiological effects such as adipocyte differentiation and thermogenesis. Futhermore, regulators including adipokines, mitochondria and macrophages have been mentioned, along with analyzing the novel perspective of iron as a key mediator influencing the fat-gut crosstalk.","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"4"},"PeriodicalIF":9.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0