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Current Obesity Reports最新文献

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Autophagy in Obesity and Type 2 Diabetes: Beyond the Protective Paradigm. 肥胖和2型糖尿病的自噬：超越保护范式。
IF 11 2区 医学
Current Obesity Reports Pub Date : 2026-05-08 DOI: 10.1007/s13679-026-00716-5
M Elena Angarita-Plánchez, Paula Sánchez-Rodríguez, Ana M Múnera-Rodríguez, Camila Leiva-Castro, Juan Manuel Benítez-Márquez, Icíar Reina-Pérez, Francisca Palomares, Soledad López-Enríquez
{"title":"Autophagy in Obesity and Type 2 Diabetes: Beyond the Protective Paradigm.","authors":"M Elena Angarita-Plánchez, Paula Sánchez-Rodríguez, Ana M Múnera-Rodríguez, Camila Leiva-Castro, Juan Manuel Benítez-Márquez, Icíar Reina-Pérez, Francisca Palomares, Soledad López-Enríquez","doi":"10.1007/s13679-026-00716-5","DOIUrl":"https://doi.org/10.1007/s13679-026-00716-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review examines the current evidence on autophagy dysregulation in obesity and type 2 diabetes mellitus (T2DM), with particular emphasis on its tissue-specific nature and implications for clinical translation.</p><p><strong>Recent findings: </strong>Recent human and preclinical evidence indicates that autophagic alterations in metabolic disease are not uniformly suppressed but vary according to tissue type and disease stage. In adipose tissue, liver, skeletal muscle, pancreatic β cells, and immune cells, dysregulated mTORC1-AMPK signaling, defective mitophagy, and impaired lysosomal function contribute to insulin resistance, ectopic lipid accumulation, and metaflammation. However, most human studies rely on static markers such as LC3, p62, and Beclin-1, which do not reliably reflect dynamic autophagic flux. Recent advances, including organelle-specific biomarkers, ex vivo functional assays, and circulating exosomal cargo, offer new translational opportunities, although standardization remains limited. Autophagy in metabolic disease represents a context-dependent maladaptation rather than a uniformly protective pathway. Future progress will depend on harmonized biomarker panels, functional assessment of autophagic flux in humans, and integration with metabolic phenotyping to enable precision-based therapeutic strategies.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Epidemiology of the Global Syndemic in Africa: New Evidence and Key Insights. 非洲全球流行病的流行病学：新证据和关键见解。
IF 11 2区 医学
Current Obesity Reports Pub Date : 2026-04-27 DOI: 10.1007/s13679-026-00717-4
Reuben Simfukwe, Felix P Chilunga, Charles Agyemang
{"title":"The Epidemiology of the Global Syndemic in Africa: New Evidence and Key Insights.","authors":"Reuben Simfukwe, Felix P Chilunga, Charles Agyemang","doi":"10.1007/s13679-026-00717-4","DOIUrl":"https://doi.org/10.1007/s13679-026-00717-4","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prioritising Indicators for Large-scale Monitoring and Assessment of Food Environments for Public Health. 为公共卫生对食品环境进行大规模监测和评估的优先指标。
IF 11 2区 医学
Current Obesity Reports Pub Date : 2026-04-22 DOI: 10.1007/s13679-026-00705-8
Lana Vanderlee, Kelly Garton, Mavra Ahmed, Kathryn Backholer, Carolina Batis, Marie A Bragg, Emma Boyland, Adrian J Cameron, Luciana Castronuovo, Elizabeth K Dunford, Clara Gómez-Donoso, Guanlan Hu, Alexandra Jones, Bridget Kelly, Amos Laar, Meron Lewis, Christiam Méndez-Lazarte, Sally Mackay, Christina M Pollard, Erica Reeve, Sally Schultz, Tailane Scapin, Suzanne Soares-Wynter, Rina Swart, Boyd Swinburn, Caroline Vaillancourt, Gary Sacks
{"title":"Prioritising Indicators for Large-scale Monitoring and Assessment of Food Environments for Public Health.","authors":"Lana Vanderlee, Kelly Garton, Mavra Ahmed, Kathryn Backholer, Carolina Batis, Marie A Bragg, Emma Boyland, Adrian J Cameron, Luciana Castronuovo, Elizabeth K Dunford, Clara Gómez-Donoso, Guanlan Hu, Alexandra Jones, Bridget Kelly, Amos Laar, Meron Lewis, Christiam Méndez-Lazarte, Sally Mackay, Christina M Pollard, Erica Reeve, Sally Schultz, Tailane Scapin, Suzanne Soares-Wynter, Rina Swart, Boyd Swinburn, Caroline Vaillancourt, Gary Sacks","doi":"10.1007/s13679-026-00705-8","DOIUrl":"https://doi.org/10.1007/s13679-026-00705-8","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic Dysfunction-Associated Steatotic Liver Disease and Respiratory Disorders: A Systematic Review of Clinical and Pathophysiological Associations. 代谢功能障碍相关的脂肪变性肝病和呼吸系统疾病：临床和病理生理关联的系统综述。
IF 11 2区 医学
Current Obesity Reports Pub Date : 2026-04-17 DOI: 10.1007/s13679-026-00713-8
Vasiliki Epameinondas Georgakopoulou, Paschalis Steiropoulos, Theodoros Androutsakos, Irena Karabella, Konstantinos Reppas, Evangelos Cholongitas, Maria Dalamaga
{"title":"Metabolic Dysfunction-Associated Steatotic Liver Disease and Respiratory Disorders: A Systematic Review of Clinical and Pathophysiological Associations.","authors":"Vasiliki Epameinondas Georgakopoulou, Paschalis Steiropoulos, Theodoros Androutsakos, Irena Karabella, Konstantinos Reppas, Evangelos Cholongitas, Maria Dalamaga","doi":"10.1007/s13679-026-00713-8","DOIUrl":"10.1007/s13679-026-00713-8","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intersectionality in Weight Stigma Research: A Systematic Review of Empirical Evidence. 体重病耻感研究的交叉性：经验证据的系统回顾。
IF 11 2区 医学
Current Obesity Reports Pub Date : 2026-04-15 DOI: 10.1007/s13679-026-00715-6
Abdul-Hanan Saani Inusah, Menglin Shang, Xiaoming Li, Shan Qiao
{"title":"Intersectionality in Weight Stigma Research: A Systematic Review of Empirical Evidence.","authors":"Abdul-Hanan Saani Inusah, Menglin Shang, Xiaoming Li, Shan Qiao","doi":"10.1007/s13679-026-00715-6","DOIUrl":"10.1007/s13679-026-00715-6","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13079528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Predictors of Guideline Concordant Pediatric Obesity Care: A Narrative Review. 指南一致性儿童肥胖护理的患病率和预测因素：一项叙述性综述。
IF 11 2区 医学
Current Obesity Reports Pub Date : 2026-04-14 DOI: 10.1007/s13679-026-00712-9
Colin J Orr, Aspen E Streetman, Ivan A Carruyo, Amy L Beck, Katie Queen, Tierra Sanders, William J Heerman
{"title":"Prevalence and Predictors of Guideline Concordant Pediatric Obesity Care: A Narrative Review.","authors":"Colin J Orr, Aspen E Streetman, Ivan A Carruyo, Amy L Beck, Katie Queen, Tierra Sanders, William J Heerman","doi":"10.1007/s13679-026-00712-9","DOIUrl":"10.1007/s13679-026-00712-9","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13079462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intelligence-driven Mechanomedicine for Weight Rebound in Obesity. 肥胖体重反弹的智力驱动机械医学。
IF 11 2区 医学
Current Obesity Reports Pub Date : 2026-04-11 DOI: 10.1007/s13679-026-00714-7
Shanshan Zhu, Bo Cheng, Bin Gao, Feng Xu
{"title":"Intelligence-driven Mechanomedicine for Weight Rebound in Obesity.","authors":"Shanshan Zhu, Bo Cheng, Bin Gao, Feng Xu","doi":"10.1007/s13679-026-00714-7","DOIUrl":"https://doi.org/10.1007/s13679-026-00714-7","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking Obesity Prevention: A Call for Strategic and Operational Clarity. 重新思考肥胖预防：战略和操作清晰度的呼吁。
IF 11 2区 医学
Current Obesity Reports Pub Date : 2026-04-07 DOI: 10.1007/s13679-026-00708-5
Ximena Ramos Salas, Brad Hussey, Angela S Alberga, Ted Kyle, Francine Small
{"title":"Rethinking Obesity Prevention: A Call for Strategic and Operational Clarity.","authors":"Ximena Ramos Salas, Brad Hussey, Angela S Alberga, Ted Kyle, Francine Small","doi":"10.1007/s13679-026-00708-5","DOIUrl":"10.1007/s13679-026-00708-5","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of GLP1 Receptor Agonists and Multi-agonist Incretin Therapies for Specific Obesity-related Health Conditions: Evidence and Rationale for Prioritisation. GLP1受体激动剂和多激动剂肠促胰岛素治疗特异性肥胖相关健康状况的作用：优先考虑的证据和理由
IF 11 2区 医学
Current Obesity Reports Pub Date : 2026-04-02 DOI: 10.1007/s13679-026-00707-6
Christo Albor, Oluwaseun Anyiam, Luke D Boyle, Janine Makaronidis, Rachael Tan, Sahar Iftikhar, Amna Burzic, Fannie Lajeunesse Trempe, Moira Stanley, Aniqah Bhatti, Jadine Scragg, Layla Badawy, Komal Moqeem, Iskandar Idris, Rob C Andrews, Piya Sen Gupta, David Hughes, Katherine McCullough, Tricia Tan, Barbara McGowan
{"title":"The Role of GLP1 Receptor Agonists and Multi-agonist Incretin Therapies for Specific Obesity-related Health Conditions: Evidence and Rationale for Prioritisation.","authors":"Christo Albor, Oluwaseun Anyiam, Luke D Boyle, Janine Makaronidis, Rachael Tan, Sahar Iftikhar, Amna Burzic, Fannie Lajeunesse Trempe, Moira Stanley, Aniqah Bhatti, Jadine Scragg, Layla Badawy, Komal Moqeem, Iskandar Idris, Rob C Andrews, Piya Sen Gupta, David Hughes, Katherine McCullough, Tricia Tan, Barbara McGowan","doi":"10.1007/s13679-026-00707-6","DOIUrl":"https://doi.org/10.1007/s13679-026-00707-6","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic and Bariatric Surgery: The Contraindications of the Past are the Indications of the Future. 代谢和减肥手术：过去的禁忌症是未来的适应症。
IF 11 2区 医学
Current Obesity Reports Pub Date : 2026-04-02 DOI: 10.1007/s13679-026-00711-w
Tala Abedalqader, Joseph Klim, Tony Boutros, Nour El Ghazal, Juan Ignacio Isaac, Andrew G Robertson, Mohammad Kermansaravi, Omar M Ghanem
{"title":"Metabolic and Bariatric Surgery: The Contraindications of the Past are the Indications of the Future.","authors":"Tala Abedalqader, Joseph Klim, Tony Boutros, Nour El Ghazal, Juan Ignacio Isaac, Andrew G Robertson, Mohammad Kermansaravi, Omar M Ghanem","doi":"10.1007/s13679-026-00711-w","DOIUrl":"https://doi.org/10.1007/s13679-026-00711-w","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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