Current Obesity Reports最新文献

{"title":"Opportunities and Challenges for Precision Nutrition in Gestational Obesity Management.","authors":"Emmie Söderström Shields, Nina Kaegi-Braun, Johanna Sandborg, Caroline Lilliecreutz, Marie Löf","doi":"10.1007/s13679-026-00710-x","DOIUrl":"10.1007/s13679-026-00710-x","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Flux Adaptations During GLP-1 Receptor Agonist Therapy: Redox Implications.","authors":"Jaewang Lee, Ji Hyeon You, Hyun Jin Park, Jong-Lyel Roh, Sun Ha Paek","doi":"10.1007/s13679-026-00709-4","DOIUrl":"10.1007/s13679-026-00709-4","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Scale: Setting Goals for Outcomes Beyond Weight in Evidence-based Obesity Treatment.","authors":"Leah M Schumacher, Jacqueline F Hayes, KayLoni L Olson, Samantha P Flanagan, Doria Wohler, Katherine E Darling","doi":"10.1007/s13679-026-00706-7","DOIUrl":"10.1007/s13679-026-00706-7","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13035647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Adipose Tissue Phenotypic Switching: From Mechanisms to Computational Drug Discovery.","authors":"Yuqing Ye, Ruxin Yin, Junjie Sun, Yuwei Dai, Di Zhao, Xiaoling Zou","doi":"10.1007/s13679-026-00701-y","DOIUrl":"10.1007/s13679-026-00701-y","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Potential Role of Spexin in Exercise-Induced Improvement of Cardiometabolic Health in Obesity and Diabetes.","authors":"Mei Yu, Xueshen Qian, Liang Wang, Chenhao Gu, Zhenwen Zhang, Wenbin Shang, Penghua Fang","doi":"10.1007/s13679-026-00704-9","DOIUrl":"https://doi.org/10.1007/s13679-026-00704-9","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Is Colorectal Cancer Occurring Earlier? Metabolic Dysfunction, Underrecognized Carcinogens, and Emerging Controversies.","authors":"Maria Dalamaga, Sofia Rozani, Dimitra Petropoulou","doi":"10.1007/s13679-026-00700-z","DOIUrl":"10.1007/s13679-026-00700-z","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fueling or Fighting Cancer? The Thermogenic Paradox of Brown Adipose Tissue.","authors":"Jonathan Jaime G Guerrero, Paolo C Encarnacion, Chih-Hao Wang, Mark Angelo S Del Rosario, Kin Israel Notarte, Jiayan Zhou, Yi-Ta Hsieh, Wan-Yu Wang, Ching-Wen Chang, Wan-Chun Li","doi":"10.1007/s13679-026-00699-3","DOIUrl":"10.1007/s13679-026-00699-3","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12999789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MASLD In Children - A Distinct Phenotype?","authors":"Pervej Alom Barbhuiya, Manash Pratim Pathak","doi":"10.1007/s13679-026-00698-4","DOIUrl":"https://doi.org/10.1007/s13679-026-00698-4","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Skeletal Muscle as an Endocrine Firewall: Mitigating Metabolic Endotoxemia and Insulin Resistance in Polycystic Ovary Syndrome.","authors":"Qianqian Li, Yini Wu, Leqin Chen, Ronghui Wang","doi":"10.1007/s13679-026-00703-w","DOIUrl":"https://doi.org/10.1007/s13679-026-00703-w","url":null,"abstract":"","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Medical Nutrition Therapy and Physical Exercise: The Future of Diabesity Care.","authors":"Ludovica Verde, Giuseppe Annunziata, Elisabetta Camajani, Maria Grazia Tarsitano, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri, Massimiliano Caprio, Luigi Barrea","doi":"10.1007/s13679-026-00688-6","DOIUrl":"10.1007/s13679-026-00688-6","url":null,"abstract":"<p><strong>Purpose of the review: </strong>Diabesity, the coexistence of type 2 diabetes mellitus (T2DM) and obesity, represents one of the major global health challenges. This review aims to synthesize current evidence on personalized medical nutrition therapy (MNT) and structured physical exercise as cornerstones of diabesity management, with a particular focus on very-low-energy ketogenic therapy (VLEKT).</p><p><strong>Recent findings: </strong>Conventional pharmacotherapies improve glycemic control and promote weight reduction but often fail to fully address the multifactorial pathophysiology of diabesity. MNT has demonstrated significant efficacy in improving glycemic regulation, reducing weight, and modulating cardiometabolic risk factors. Among dietary strategies, the Mediterranean diet provides sustainable benefits, while more intensive interventions such as low-energy diets and ketogenic diets can induce rapid and clinically meaningful improvements, with emerging evidence supporting favorable effects on gut microbiota and inflammation. Complementary lifestyle interventions, particularly structured exercise programs combining aerobic and resistance training, further enhance metabolic outcomes and may contribute to T2DM remission in selected patients. Integration of MNT with incretin-based therapies holds promise for optimizing efficacy while preserving nutritional adequacy and functional health. Effective management of diabesity requires a multidisciplinary, precision-based approach. Personalized MNT and structured exercise represent foundational strategies, while pharmacological therapies provide valuable adjuncts. Among available options, VLEKT stands out for its ability to target key mechanisms of diabesity, including insulin resistance, adiposity, and chronic inflammation. Future diabesity care will rely on integrating nutrition, physical exercise, and pharmacotherapy within individualized frameworks to achieve sustained metabolic control and improved quality of life.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12979325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}