Marwin A Farrugia, Enzo Pini, Albert Tran, Nicolas Chevalier, Rodolphe Anty, Philippe Gual
{"title":"肠促胰岛素和MASLD:在内分泌和肝脏疾病的十字路口。","authors":"Marwin A Farrugia, Enzo Pini, Albert Tran, Nicolas Chevalier, Rodolphe Anty, Philippe Gual","doi":"10.1007/s13679-025-00646-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>The aim of this paper is to provide an overview of metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis, focusing on how incretin analogues might affect liver function and disease. It also summarizes the latest preclinical studies and clinical trials evaluating the impact of incretin analogues (single or multi-agonists) on metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis.</p><p><strong>Recent findings: </strong>Incretin analogues have recently been added to the therapeutic arsenal of diabetologists, and their therapeutic effects on insulin resistance and T2DM are now well established. These treatments have also demonstrated beneficial effects on cardiovascular complications. In addition, the weight loss associated with these molecules has recently extended their indication to the treatment of obesity. On the other hand, pharmacological treatments for MASLD are still very limited, and mainly target liver functions. As weight loss is the cornerstone of MASLD treatment, studies evaluating these analogues and combinations with other compounds are very promising. Incretin analogues appear to be effective treatments for MASH and fibrosis in a large number of clinical trials. Phase 3 studies are currently ongoing to confirm these results. Further treatments may emerge, such as double and triple receptor agonists. A multidisciplinary approach, involving diabetologists and hepatologists, is optimal for the management of MASLD.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"56"},"PeriodicalIF":9.5000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198343/pdf/","citationCount":"0","resultStr":"{\"title\":\"Incretins and MASLD: at the Crossroads of Endocrine and Hepatic Disorders.\",\"authors\":\"Marwin A Farrugia, Enzo Pini, Albert Tran, Nicolas Chevalier, Rodolphe Anty, Philippe Gual\",\"doi\":\"10.1007/s13679-025-00646-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong>The aim of this paper is to provide an overview of metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis, focusing on how incretin analogues might affect liver function and disease. It also summarizes the latest preclinical studies and clinical trials evaluating the impact of incretin analogues (single or multi-agonists) on metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis.</p><p><strong>Recent findings: </strong>Incretin analogues have recently been added to the therapeutic arsenal of diabetologists, and their therapeutic effects on insulin resistance and T2DM are now well established. These treatments have also demonstrated beneficial effects on cardiovascular complications. In addition, the weight loss associated with these molecules has recently extended their indication to the treatment of obesity. On the other hand, pharmacological treatments for MASLD are still very limited, and mainly target liver functions. As weight loss is the cornerstone of MASLD treatment, studies evaluating these analogues and combinations with other compounds are very promising. Incretin analogues appear to be effective treatments for MASH and fibrosis in a large number of clinical trials. Phase 3 studies are currently ongoing to confirm these results. Further treatments may emerge, such as double and triple receptor agonists. A multidisciplinary approach, involving diabetologists and hepatologists, is optimal for the management of MASLD.</p>\",\"PeriodicalId\":10846,\"journal\":{\"name\":\"Current Obesity Reports\",\"volume\":\"14 1\",\"pages\":\"56\"},\"PeriodicalIF\":9.5000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198343/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Obesity Reports\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13679-025-00646-8\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Obesity Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13679-025-00646-8","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Incretins and MASLD: at the Crossroads of Endocrine and Hepatic Disorders.
Purpose of review: The aim of this paper is to provide an overview of metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis, focusing on how incretin analogues might affect liver function and disease. It also summarizes the latest preclinical studies and clinical trials evaluating the impact of incretin analogues (single or multi-agonists) on metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis.
Recent findings: Incretin analogues have recently been added to the therapeutic arsenal of diabetologists, and their therapeutic effects on insulin resistance and T2DM are now well established. These treatments have also demonstrated beneficial effects on cardiovascular complications. In addition, the weight loss associated with these molecules has recently extended their indication to the treatment of obesity. On the other hand, pharmacological treatments for MASLD are still very limited, and mainly target liver functions. As weight loss is the cornerstone of MASLD treatment, studies evaluating these analogues and combinations with other compounds are very promising. Incretin analogues appear to be effective treatments for MASH and fibrosis in a large number of clinical trials. Phase 3 studies are currently ongoing to confirm these results. Further treatments may emerge, such as double and triple receptor agonists. A multidisciplinary approach, involving diabetologists and hepatologists, is optimal for the management of MASLD.
期刊介绍:
The main objective of Current Obesity Reports is to provide expert review articles on recent advancements in the interdisciplinary field of obesity research. Our aim is to offer clear, insightful, and balanced contributions that will benefit all individuals involved in the treatment and prevention of obesity, as well as related conditions such as cardiovascular diseases, endocrine disorders, gynecological issues, cancer, mental health, respiratory complications, and rheumatological diseases. We strive to redefine the way knowledge is expressed and provide organized content for the benefit of our readership.