Current Obesity Reports最新文献

{"title":"Lac-Phe: An Emerging Appetite-Regulating Exerkine with Health and Therapeutic Benefits.","authors":"Ning Wang, Jingxing Zhang, Xinping Zhang, Dajun Xuan","doi":"10.1007/s13679-025-00683-3","DOIUrl":"10.1007/s13679-025-00683-3","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: This review provides an up-to-date overview of molecular mechanisms and translational potential of N-lactoyl-phenylalanine (Lac-Phe), highlighting recent advances and suggesting future research directions. RECENT FINDINGS: Recent studies have revealed the neurobiological mechanism of Lac-Phe, demonstrating its ability to suppress appetite through KATP channel-mediated inhibition of hypothalamic AgRP neurons. Furthermore, emerging research has highlighted its therapeutic potential in type 2 diabetes, inflammatory bowel disease, and spinal cord injury through metabolic and anti-inflammatory pathways. Current evidence establishes Lac-Phe as an exercise-responsive metabolite that suppresses appetite and correlates with exercise intensity, metformin use, and multiple disease states. Its biosynthesis via intestinal CNDP2 and appetite suppression through hypothalamic AgRP neuron inhibition are elucidated. However, clarifying its brain transporters, pharmacokinetics, and the discrepancy between its strong correlation with insulin resistance in healthy individuals and its role as a mediator of metformin’s weight loss effect will be essential to evaluate the diagnostic and therapeutic potential of Lac-Phe. </p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":"4"},"PeriodicalIF":17.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference Curves for Metabolic Syndrome Indicators in Children and Adolescents: A Global Systematic Review.","authors":"Khalid Iqbal, Ermioni Chatziangelousi, Maike Wolters, Timm Intemann, Katharina Englert, Antje Hebestreit, Krasimira Aleksandrova","doi":"10.1007/s13679-025-00679-z","DOIUrl":"10.1007/s13679-025-00679-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>We aimed to summarise recent evidence on age- and sex-specific reference curves for metabolic syndrome (MetS) indicators in paediatric populations.</p><p><strong>Recent findings: </strong>There is a lack of consensus regarding diagnostic thresholds for MetS in children and adolescents, leading to challenges in its early identification and intervention. A systematic search was performed in PubMed/Medline, Web of Science and Scopus, covering the period between January 2018 and February 2025. Three researchers evaluated 8,529 studies according to the inclusion criteria. Finally, 46 articles that reported reference values for at least one metabolic indicator: waist circumference, fasting glucose, glycated haemoglobin, homeostatic model assessment for insulin resistance, high-density lipoprotein cholesterol, triglycerides, systolic or diastolic blood pressure, in children aged 0 to 18 years were included in the review and data synthesis. The age-specific trends in each MetS indicator were assessed by calculating the median reference curves along with the lower and upper percentile bounds. Overall, there has been a substantial heterogeneity in the reported reference values for waist circumference and glucose metabolism biomarkers. Comparatively smaller variations were observed for blood pressure and lipid parameters. Limited data were available for young age groups (0-4 years) and there have been substantial differences in study methodologies including study design, assays and statistical approaches used to derive reference curves. This systematic review highlighted the substantial inconsistencies in the reported reference curves for MetS indicators in children and adolescents. There is a pressing need for deriving harmonized reference curves for paediatric MetS from diverse populations.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":"3"},"PeriodicalIF":11.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12769977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Impact of Preconception Physical Activity on Offspring Outcomes Linked to Obesity.","authors":"Nicholas O'Rourke, Luba Marderfeld, Arthur Dantas, Abbey E Corson, Meaghan MacDonald, Zachary M Ferraro, Taniya S Nagpal, Kristi B Adamo","doi":"10.1007/s13679-025-00677-1","DOIUrl":"10.1007/s13679-025-00677-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>Obesity in childhood remains a critical public health issue, with emerging evidence highlighting developmental origins rooted in parental behaviours before conception. While diet and weight status of birthing parents are well-established predictors of offspring health, the role of preconception physical activity (PA) remains understudied. This scoping review synthesizes current evidence between preconception PA and its association with adverse birth outcomes, and downstream infant and child obesity outcomes, contextualizing findings within the broader parental lifestyle influence. A systematic literature search across ten databases identified 41 relevant studies, predominantly cohort designs, analyzing PA effects on birth weight, gestational diabetes mellitus (GDM), excessive gestational weight gain (eGWG), and offspring adiposity.</p><p><strong>Recent findings: </strong>Findings revealed no consistent association between preconception PA and birth weight or preterm birth risk. However, studies suggest that preconception PA may lower the likelihood of GDM and eGWG, both of which are linked to increased obesity risk in offspring. A significant methodological limitation across studies was the widespread temporal discontinuity, with PA predominantly assessed through retrospective recall rather than objective measures. Additionally, inconsistencies in study design, PA intensity definitions, and confounding lifestyle factors limit definitive conclusions.  While obesity in birthing parents and suboptimal feeding practices dominate current etiological models, the potential preventive role of preconception PA warrants further investigation. Future research should implement intervention designs incorporating objective PA measures (e.g., accelerometry, wearable sensors) within life-course frameworks. Methodologically rigorous studies are critical for disentangling PA-specific effects from confounding lifestyle factors to inform evidence-based guidelines for preconception care.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":"2"},"PeriodicalIF":17.0,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of Longitudinal Studies Exploring the Link Between Physical Inactivity and Indicators of Childhood Overweight/Obesity and Metabolically Unhealthy Obesity Risk in Western Countries.","authors":"Michael Georgoulis, Ismini Grapsa, Giannis Arnaoutis, Alexandra Karachaliou, Demosthenes Panagiotakos, Georgios Saltaouras, Eirini Bathrellou, Mary Yannakoulia, George Dimitrakopoulos, Meropi D Kontogianni","doi":"10.1007/s13679-025-00680-6","DOIUrl":"10.1007/s13679-025-00680-6","url":null,"abstract":"<p><p>BACKGROUND: Physical inactivity (PI) is a major contributor to adiposity and cardiometabolic morbidity. OBJECTIVE: To synthesize evidence of the association between PI and childhood overweight/obesity (OV/OB) and metabolically unhealthy obesity (MUO; OB accompanied by cardiometabolic abnormalities) risk. METHODS: A systematic review and meta-analysis of prospective epidemiological studies and randomized controlled trials (RCTs) was performed following PRISMA guidelines (PROSPERO ID: CRD42023482960). Studies conducted in Western countries with 2-19-year-old participants, PI-related exposures (time/frequency of engagement in various sedentary behaviors) and interventions (targeting PI reduction), OV/OB-/MUO-related outcomes and ≥ 12-month follow-up were extracted from PubMed and Scopus (publication timeframe: 01/01/2013-30/06/2024). Study quality was assessed through risk of bias (RoB). RESULTS: Among 86 prospective epidemiological studies with OV/OB-related outcomes (42% high-RoB), PI was evaluated objectively (accelerometry) in 34 and subjectively (questionnaires) in 57 (29% and 68% reported detrimental associations, respectively). In random-effects meta-analysis, subjectively-assessed total screen time was positively associated with body mass index (BMI) [n = 4; beta (95%CI): 0.116 (0.037, 0.195) kg/m2] and BMI z-score [n = 8; beta (95%CI): 0.032 (0.002, 0.063)], while television viewing was positively associated with BMI [n = 3; beta (95%CI): 0.227 (0.025, 0.428) kg/m2], BMI z-score [n = 4; beta (95%CI): 0.042 (0.007, 0.077)] and OV/OB incidence [n = 5; logRR (95%CI): 0.089 (0.044, 0.133)]. The sole RCT (low-RoB) indicated a beneficial effect of reducing sedentariness on anthropometric indices. Two prospective epidemiological studies (high-RoB) suggested positive associations between subjectively-assessed total screen time and MUO-related outcomes. CONCLUSIONS: Screen time is positively associated with indicators of childhood OV/OB risk, while limited evidence also supports its detrimental role in MUO. </p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":"1"},"PeriodicalIF":17.0,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12764636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity, Olfaction and Cognition: A Systematic Review.","authors":"Lilian Benítez-Ruiz, Carolina Gutiérrez Repiso, Francisco J Tinahones, Natalia García-Casares","doi":"10.1007/s13679-025-00678-0","DOIUrl":"10.1007/s13679-025-00678-0","url":null,"abstract":"<p><p>OBJECTIVES: This systematic review sought to synthetize all the evidence about the relationship between olfactory function and overweight/obesity, and cognitive performance or brain structure. METHODS: We conducted a systematic review following the PRIMA methodology. PubMed and Embase were consulted up to January 2024. The articles considered eligible were those that included one group of subjects with overweight or obesity, and that performed at least one olfactory or imaging test to study olfactory function. To further understand the impact of obesity on olfaction, interventional studies focused on bariatric surgery were included. RESULTS: The initial database search identified a total of 11,311 studies. Thirty studies with a total of 2482 participants were selected. Twenty-one assessed olfactory function with no intervention, among these four included cognitive assessment or brain magnetic resonance imaging (MRI). Additionally, we found nine papers that offered insight into the effect of bariatric surgery on olfaction. Fourteen of the non-interventional studies showed impaired smell capacity in individuals with high weight. Six bariatric surgery studies reported significant postoperative improvement in olfaction. Moreover, two studies measured olfactory bulb volume (OBV) and found a significant correlation between body mass index (BMI) and OBV. CONCLUSIONS: Available evidence suggests that there is a relationship between olfaction and overweight/obesity, which points toward olfactory impairment in this population. OBV studies remain discordant, while the findings support the idea that high BMI and hyposmia have a negative impact on cognition. However, the data are heterogeneous. Future research is needed to further understand this possible connection. </p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"85"},"PeriodicalIF":17.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145833205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myosteatosis: Epidemiological Insights, Functional Decline, and Diagnostic Advances.","authors":"Yan Zhang, Yunju Jo, Shibo Wei, Yeongmin Kim, Wonyoung Park, Seung-Jun Jeong, Yingqi Xue, Sung Hyun Lee, Beom-Jun Kim, Chang-Myung Oh, Karim Gariani, Dongryeol Ryu","doi":"10.1007/s13679-025-00676-2","DOIUrl":"10.1007/s13679-025-00676-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Myosteatosis, defined as the pathological accumulation of fat within skeletal muscle, has emerged as a critical yet underrecognized feature of muscle aging and metabolic dysregulation. Despite its growing clinical relevance, the field remains constrained by fragmented definitions, heterogeneous diagnostic criteria, and limited mechanistic understanding, all of which hamper effective detection and intervention. This review synthesizes current evidence to delineate the epidemiological landscape and clinical ramifications of myosteatosis across organ systems, and to highlight emerging myokine-driven endocrine signaling, biomarker candidates, and diagnostic strategies.</p><p><strong>Recent findings: </strong>Population-level studies increasingly implicate myosteatosis in impaired mobility, heightened morbidity, and poor survival in chronic disease contexts. Susceptibility is influenced by age, sex, ethnicity, and genetic background, while pathological integration with sarcopenia, cardiometabolic dysfunction, malignancy, and systemic frailty is becoming evident. Additionally, dysregulated myokine-mediated endocrine signaling and altered muscle-adipose crosstalk are increasingly recognized as adjunct pathological signatures of myosteatosis, with potential relevance to its progression and metabolic complications. Advances in diagnostic strategies, including quantitative imaging modalities and circulating biomarkers, alongside ongoing progress toward laboratory determinants and assay standardization, have begun to refine disease characterization and translational potential, though consensus remains limited. Myosteatosis is a modifiable disease trait that bridges muscle quality decline with systemic metabolic risk. By outlining unresolved challenges and future research priorities, this review aims to reframe myosteatosis as a targetable axis in precision medicine, with implications for risk stratification, therapeutic development, and improved clinical outcomes.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"83"},"PeriodicalIF":17.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Obesity Care into Chronic Disease Management in Catalonia: Progress and Challenges in Health System Approaches.","authors":"Violeta Moizé, Ximena Ramos Salas, Brad Hussey, Gemma Salvador, Joan Escarrabill, Josep Vidal, Jaume Benavent-Areu, Silvia Roura, Toni Gilabert","doi":"10.1007/s13679-025-00675-3","DOIUrl":"10.1007/s13679-025-00675-3","url":null,"abstract":"<p><strong>Background: </strong>Obesity represents a significant public health challenge, particularly in the context of coexisting chronic diseases and multi-morbidity. In Spain, and specifically in Catalonia, primary care plays a central role in prevention and management, yet barriers such as weight-related stigma can compromise care delivery.</p><p><strong>Aim: </strong>To evaluate the current state of obesity prevention and management within the health system, with a focus on implications for primary care in Catalonia, including prevalence, stigma, and integration of chronic disease care.</p><p><strong>Methods: </strong>A narrative literature review was conducted, including studies, government reports, and policy documents relevant to obesity prevalence, psychosocial factors, and healthcare system strategies.</p><p><strong>Results: </strong>Persistent weight bias among healthcare professionals can delay diagnosis, reduce treatment adherence, and negatively affect patient experience. Integrated, patient-centered care models that consider physical, psychological, and social health have gained traction. Holistic assessment-including behavioral context, mental health, and social determinants alongside cardiorenal metabolic diseases-is central to these approaches.</p><p><strong>Conclusions: </strong>Effective obesity management requires integrated chronic disease management frameworks. Collaborative care models, community-based resources, and equitable health policies are essential. Incorporating patient experience helps identify unmet needs and improve care quality. A system-wide, holistic approach is critical to reducing the burden of obesity and related chronic diseases in Catalonia.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"84"},"PeriodicalIF":17.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mood Disorders, Metabolic Bariatric Surgery, and Weight Loss Pharmacotherapy: a Research Update.","authors":"Margherita Barbuti, Francesco Weiss, Giulio Perugi","doi":"10.1007/s13679-025-00674-4","DOIUrl":"10.1007/s13679-025-00674-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review explores the intricate and bidirectional relationship between mood disorders and obesity, focusing on the psychiatric implications of metabolic bariatric surgery and weight-loss pharmacotherapy. In particular, the review examines how these interventions impact psychiatric outcomes, identifying both benefits and risks.</p><p><strong>Recent findings: </strong>While metabolic bariatric surgery and incretin-based therapies improve metabolic health and, in some cases, mental well-being, they may also lead to psychiatric complications. Studies indicate increased risks of mood episodes, self-harm, and altered psychotropic drug metabolism post-surgery. Concerns have also emerged regarding glucagon like peptide-1 (GLP-1) receptor agonists and their potential link to depression and suicidality. Weight-loss interventions require thorough psychiatric assessment prior to treatment, as well as long-term psychiatric monitoring thereafter. Future research should prioritize longitudinal studies with standardized psychiatric assessments to refine risk stratification and optimize clinical outcomes. A multidisciplinary approach integrating endocrinology, psychiatry, and behavioral sciences is essential for improving both physical and mental health outcomes.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"82"},"PeriodicalIF":17.0,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145630974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Discrete Diagnoses: Conceptualizing Obesity-associated Metabolic Disorders as a Unified, Dynamic Continuum.","authors":"Cong Xie, Yulian Yuan, Yunjing Wang, Cong Qi, Wei Wang, Chuan An, Aifeila Aikepaer, Yaofu Zhang, Ge Zhang, Xingzhong Feng, Huijuan Gao","doi":"10.1007/s13679-025-00673-5","DOIUrl":"10.1007/s13679-025-00673-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>Obesity-related metabolic disorders such as metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic syndrome (MetS), and type 2 diabetes mellitus (T2DM) have traditionally been treated as separate conditions. This review aims to present a unified conceptual framework in which these disorders are viewed as progressive stages within a continuous and dynamic process of metabolic dysfunction. The goal is to clarify the shared mechanisms underlying this progression and to explore the clinical value of approaching them as a continuum.</p><p><strong>Recent findings: </strong>Insulin resistance, chronic low-grade inflammation, adipokine imbalance, and ectopic fat accumulation are common drivers across all stages of metabolic deterioration. These processes are reinforced by coordinated dysfunction in adipose tissue, liver, skeletal muscle, pancreas, and the gut microbiota. Longitudinal and genetic studies support a typical progression from individuals with obesity to MAFLD, then to MetS and T2DM, although individual trajectories vary. Certain phenotypes such as metabolically healthy individuals with obesity and normal-weight individuals with visceral adiposity illustrate the spectrum's heterogeneity. Early dysfunction is often reversible through lifestyle or pharmacologic intervention, underscoring the importance of timely detection. Reframing obesity-associated metabolic disorders as a continuous disease process enables more accurate risk assessment, earlier intervention, and coordinated care strategies. This integrated perspective supports a shift toward mechanism-based and individualized treatment, with the potential to reduce risk and delay progression to advanced metabolic disease and its complications.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"81"},"PeriodicalIF":17.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle Insulin Resistance Elicits Muscle Atrophy in Obesity.","authors":"Omid Razi, Nastaran Zamani, Ayoub Saeidi, Marios Hadjicharalambous, Khadija Ayed, Anthony C Hackney, Juan Del Coso, Ismail Laher, Giovanna Muscogiuri, Hassane Zouhal","doi":"10.1007/s13679-025-00672-6","DOIUrl":"10.1007/s13679-025-00672-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review comprehensively highlights the molecular and cellular pathways that link insulin resistance (IR) to muscle atrophy.</p><p><strong>Recent findings: </strong>Skeletal muscle IR is a key driver of muscle atrophy in obesity. It disrupts metabolic homeostasis, leading to impaired glucose uptake and utilization. Crucially, IR shifts the balance in skeletal muscle from anabolic to catabolic processes by simultaneously inhibiting protein synthesis and promoting proteolysis, resulting in a progressive decline of muscle mass and function. This review summarizes how defective insulin signaling activates a cascade of intracellular events that accelerate muscle wasting in obese individuals. The nexus between IR and muscle atrophy in obesity involves multiple interconnected mechanisms, including mitochondrial dysfunction, elevated inflammation and oxidative stress, and compromised satellite cell function-essential for muscle repair and regeneration. The prevalence of IR, which rises with age and is exacerbated by sedentary behavior and poor nutrition, underscores the importance of understanding these signaling pathways. Elucidating these mechanisms is critical for developing effective interventions to combat muscle loss and enhance metabolic health in the obese population.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"80"},"PeriodicalIF":17.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145548694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}