Phenotyping of Obesity Treatment Candidates: A Narrative Review.

IF 9.5 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Obesity Reports Pub Date : 2024-09-01 Epub Date: 2024-06-14 DOI:10.1007/s13679-024-00576-x

Shiri Sherf-Dagan, Rotem Refaeli, Assaf Buch

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Abstract

Purpose of review: This review explores characterizing candidates for obesity treatments including pharmacotherapy, endoscopic bariatric therapies, and metabolic bariatric surgery (MBS), focusing on established clinical parameters for diagnosing obesity beyond body mass index alone.

Recent findings: Existing literature primarily provides rates for fat mass percentage (i.e., a marker for adiposity quantity), waist circumference (i.e., a marker for adiposity distribution), and C-reactive protein levels (i.e., a marker for adiposity functionality) among obesity treatment candidates. Limited data on abnormal values and sex-based differentiation exist. The literature indicates high central-tendency measures for fat mass percentage and waist circumference, while C-reactive protein levels vary. Data on the Edmonton Obesity Staging System (i.e., a marker for adiposity-related disease severity) is predominantly available for MBS candidates. Future studies in obesity interventions should improve screening and diagnosis of obesity by incorporating sex-specific considerations and providing abnormal value rates for measurements to enhance understanding of patients' characteristics.

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肥胖症治疗候选者的表型分析：叙述性综述。

综述目的：本综述探讨了肥胖症治疗方法（包括药物疗法、内窥镜减肥疗法和代谢减肥手术（MBS））候选者的特征，重点关注除体重指数外诊断肥胖症的既定临床参数：现有文献主要提供了肥胖症治疗对象的脂肪质量百分比（即脂肪数量标记）、腰围（即脂肪分布标记）和 C 反应蛋白水平（即脂肪功能标记）的比率。有关异常值和性别差异的数据有限。文献显示，脂肪量百分比和腰围的测量结果具有较高的中心倾向性，而 C 反应蛋白水平则各不相同。埃德蒙顿肥胖分期系统（即脂肪相关疾病严重程度的标志物）的数据主要针对 MBS 候选者。未来的肥胖症干预研究应通过纳入性别特异性考虑和提供测量异常值率来改进肥胖症的筛查和诊断，从而加深对患者特征的了解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Obesity Reports Medicine-General Medicine

CiteScore

16.40

自引率

1.10%

发文量

期刊介绍： The main objective of Current Obesity Reports is to provide expert review articles on recent advancements in the interdisciplinary field of obesity research. Our aim is to offer clear, insightful, and balanced contributions that will benefit all individuals involved in the treatment and prevention of obesity, as well as related conditions such as cardiovascular diseases, endocrine disorders, gynecological issues, cancer, mental health, respiratory complications, and rheumatological diseases. We strive to redefine the way knowledge is expressed and provide organized content for the benefit of our readership.

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