Current pharmaceutical design最新文献

筛选
英文 中文
Nano-healing: Exploring the Therapeutic Potentials of Nanomedicine for CNS Disorders. 纳米治疗:探索纳米药物治疗中枢神经系统疾病的潜力。
IF 2.6 4区 医学
Current pharmaceutical design Pub Date : 2025-03-20 DOI: 10.2174/0113816128362577250227081919
Fazil Ahmad
{"title":"Nano-healing: Exploring the Therapeutic Potentials of Nanomedicine for CNS Disorders.","authors":"Fazil Ahmad","doi":"10.2174/0113816128362577250227081919","DOIUrl":"https://doi.org/10.2174/0113816128362577250227081919","url":null,"abstract":"<p><strong>Introduction: </strong>Nanomedicine offers immense potential in the field of Central Nervous System (CNS) disorder treatment, encompassing conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and stroke.</p><p><strong>Method: </strong>Through the utilization of nanotechnology-driven drug delivery systems, the efficacy of drugs can be amplified, their toxicity minimized, and their bioavailability increased, enabling them to effectively reach the intended site within the CNS. This review aims to examine the therapeutic possibilities that nanomedicine presents in addressing these debilitating disorders. This exploration entails an analysis of diverse nanotechnology- based approaches for CNS drug delivery, including polymeric nanoparticles, liposomes, dendrimers, and carbon nanotubes. Moreover, notable advancements in nanotechnology-based therapeutics for CNS disorders are highlighted, such as the application of nanoparticles for delivering curcumin in Alzheimer's disease, liposomes for delivering L-DOPA in Parkinson's disease, and dendrimers for delivering interferon-beta in multiple sclerosis.</p><p><strong>Results: </strong>Additionally, the potential of nanotechnology-based approaches in the treatment of epilepsy and stroke is discussed. The review concludes by addressing the challenges faced and emphasizes the significant potential of clinical trials in enhancing drug delivery and future prospects in the development of nanotechnology- based therapeutics for CNS disorders.</p><p><strong>Conclusion: </strong>Overall, the therapeutic potential of nanomedicine in CNS disorder treatment is vast, instilling optimism for the creation of safe and effective therapies for these devastating conditions.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational Screening of IL-1 and IL-6 Inhibitors for Rheumatoid Arthritis: Insights from Molecular Docking and Dynamics Analysis. 类风湿性关节炎IL-1和IL-6抑制剂的计算筛选:来自分子对接和动力学分析的见解。
IF 2.6 4区 医学
Current pharmaceutical design Pub Date : 2025-03-20 DOI: 10.2174/0113816128344776250222043907
Yunwei Li, Salam Pradeep Singh
{"title":"Computational Screening of IL-1 and IL-6 Inhibitors for Rheumatoid Arthritis: Insights from Molecular Docking and Dynamics Analysis.","authors":"Yunwei Li, Salam Pradeep Singh","doi":"10.2174/0113816128344776250222043907","DOIUrl":"https://doi.org/10.2174/0113816128344776250222043907","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Rheumatoid arthritis (RA) remains a significant therapeutic challenge due to its chronic inflammatory nature. Consequently, many patients turn to alternative therapies, such as herbal compounds and supplements, when conventional treatments prove relatively ineffective or cause adverse side effects. Some compounds are being investigated for their potential to alleviate RA symptoms or manage disease. This study aimed to evaluate the anti-inflammatory effects of selected herbal compounds targeting the Interleukin-1 (IL-1) and Interleukin-6 (IL-6) pathways, key inflammatory regulators in RA. Specifically, the study assessed the binding affinity, stability, and dynamics of IL-1 and IL-6 inhibitory compounds as potential therapeutic agents for RA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In silico experiments were conducted with herbal compounds to modulate IL-1 and IL-6 signaling. Computational techniques, including molecular docking, molecular dynamics (MD) simulations, Molecular Mechanics-Generalized Born Surface Area (MM-GBSA) calculations, Absorption, Distribution, Metabolism, and Excretion (ADME) analysis, toxicity predictions, and Density Functional Theory (DFT) analysis, were employed to investigate these interactions comprehensively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Neoglucobrassicin demonstrated the strongest binding affinity for IL-6 (Total score: -349.00 kJ/mol), followed by Galbelgin (-338.00 kJ/mol). For IL-1β, CID21722980 exhibited the highest binding affinity (-273.14 kJ/mol), with Eupaformosanin ranking second (-264.29 kJ/mol). Neoglucobrassicin formed interactions with multiple IL-6 residues, indicating a stable binding complex, while CID21722980 similarly interacted with key IL-1β residues, forming stable complexes. Both the Neoglucobrassicin-IL6 and CID21722980- IL1β complexes demonstrated structural stability, as evidenced by Root Mean Square Deviation (RMSD) and Root Mean Square Fluctuation (RMSF) stabilizing towards the end of the 100 ns molecular dynamics (MD) simulation. MM-GBSA analysis revealed the highest binding energy for the IL-6-Neoglucobrassicin complex (-43.70 kcal/mol), while CID21722980 showed strong affinity for IL-1β (-43.29 kcal/mol), suggesting enhanced binding potential. Additionally, Density Functional Theory (DFT) analysis of the Highest Occupied Molecular Orbital (HOMO) and Lowest Unoccupied Molecular Orbital (LUMO) energies revealed electron distribution patterns in Neoglucobrassicin and CID21722980 that support their potential therapeutic applications.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;The strong binding affinities, stable molecular dynamics (MD) simulations, and favorable ADMET and DFT properties of Neoglucobrassicin and CID21722980 underscore their potential as antiinflammatory agents targeting IL-6 and IL-1β. The mechanistic insights into their inhibitory effects on these targets suggest multifaceted anti-inflammatory properties, warranting further in vivo and clinical investigatio","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced Wound Healing with Rhodiola rosea Phytosomal Gel: Extraction, Formulation, and In vivo Evaluation. 红景天植物体凝胶促进伤口愈合:提取、配方和体内评价。
IF 2.6 4区 医学
Current pharmaceutical design Pub Date : 2025-03-20 DOI: 10.2174/0113816128359150250211053431
Anandarajagopal Kalusalingam, Abdullah Khan, Mahibub Mahamadsa Kanakal, Syed Atif Abbas, Chiau Ming Long, Tazneem B, Ching Siang Tan, Abubakar Salam Bawazir, Abdul Razak T K, Roshan S
{"title":"Enhanced Wound Healing with Rhodiola rosea Phytosomal Gel: Extraction, Formulation, and In vivo Evaluation.","authors":"Anandarajagopal Kalusalingam, Abdullah Khan, Mahibub Mahamadsa Kanakal, Syed Atif Abbas, Chiau Ming Long, Tazneem B, Ching Siang Tan, Abubakar Salam Bawazir, Abdul Razak T K, Roshan S","doi":"10.2174/0113816128359150250211053431","DOIUrl":"https://doi.org/10.2174/0113816128359150250211053431","url":null,"abstract":"<p><strong>Background: </strong>This study explores the formulation and effectiveness of a Rhodiola rosea phytosomal gel for enhancing wound healing.</p><p><strong>Object: </strong>The ethanolic extract of Rhodiola rosea roots, rich in bioactive compounds like alkaloids and flavonoids, was optimized into a phytosomal complex to improve absorption and dermal retention.</p><p><strong>Method: </strong>Characterization through GC-MS revealed compounds, such as 2-Heptadecenal and Bicyclo[ 4.1.0]Heptane and 7-Pentyl. FTIR confirmed the successful encapsulation within the phospholipid bilayer, while SEM showed smooth, spherical particles.</p><p><strong>Result: </strong>The Box-Behnken design optimized formulation parameters, achieving high yield (92.64%), small particle size (355 nm), and high entrapment efficiency (93.98%). In vitro release studies displayed a consistent release profile, aligning with Zero-order and Hixson-Crowell models. In vivo evaluation on Wistar rats showed that the phytosomal gel significantly enhanced wound healing, achieving 98.16% wound reduction by day 14, compared to 95.17% for R. rosea extract and 97.13% for standard treatment. Histopathological analysis demonstrated complete tissue regeneration and well-organized collagen fibers in the phytosomal gel group.</p><p><strong>Conclusion: </strong>This research highlights the potential of Rhodiola rosea phytosomal gel as an effective wound healing therapy, with future studies suggested for extended stability tests and human skin permeation studies.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Excision Margins in Skin Melanomas with Breslow Thickness Greater than 2 Mm: A Systematic Review and Meta-Analysis 手术切除乳腺厚度大于2mm的皮肤黑色素瘤:系统回顾和荟萃分析。
IF 2.6 4区 医学
Current pharmaceutical design Pub Date : 2025-03-19 DOI: 10.2174/0113816128341363250225095747
Lucas S Floriano, Rafael V Picon, Camila Dagostim, Marcio F Chedid
{"title":"Surgical Excision Margins in Skin Melanomas with Breslow Thickness Greater than 2 Mm: A Systematic Review and Meta-Analysis","authors":"Lucas S Floriano, Rafael V Picon, Camila Dagostim, Marcio F Chedid","doi":"10.2174/0113816128341363250225095747","DOIUrl":"10.2174/0113816128341363250225095747","url":null,"abstract":"<p><strong>Objective/background: </strong>This systematic review and meta-analysis aimed to evaluate the efficacy of narrow compared to wide surgical excision margins in the treatment of cutaneous malignant melanomas (MM) with Breslow thickness greater than 2 mm. All prior meta-analyses included studies analyzing patients with a variety of Breslow indexes. There is no prior meta-analysis analyzing the survival of the subgroup of MM patients with MMs > 2 mm in Breslow thickness. Hence, the aim of the present meta-analysis and systematic review was to examine the survival of the subgroup of MM patients with MMs > 2mm in Breslow thickness.</p><p><strong>Methods: </strong>We followed the Cochrane Handbook for Systematic Reviews of Interventions and reported our findings in accordance with PRISMA guidelines. We included randomized controlled trials (RCTs) that compared narrow (1-2 cm) versus wide (3-4 cm) surgical excision margins for cutaneous melanomas thicker than 2 mm. Studies on non-cutaneous melanomas, observational studies, and non-randomized trials were excluded. Ten-year mortality rate and overall survival were the primary outcomes. Our searches were conducted in EMBASE and PUBMED databases.</p><p><strong>Results: </strong>Three RCTs were included, with a total of 2,304 randomized patients. This meta-analysis showed no significant difference in 10-year all-cause mortality between narrow (2 cm) and wide (4 cm) margins (risk difference: 3.3%, 95% CI: -1.7% to 8.2%, p=0.202). Similarly, there was no significant difference in overall survival between narrow (1-2 cm) and wide (3-4 cm) margins (hazard ratio: 1.09, 95% CI: 0.974-1.214, p=0.3). Heterogeneity was low and non-significant.</p><p><strong>Conclusions: </strong>This meta-analysis supports the non-inferiority of narrow (1-2 cm) surgical margins compared to wide (3-4 cm) margins for localized cutaneous melanomas with Breslow thickness greater than 2 mm. These findings suggest that narrow margins could be considered in surgical practice, although a 1 cm margin may be inadequate based on the results of individual studies. Further RCTs focusing on patients with localized MM thicker than 2 mm and taking into account modern adjuvant therapies and sentinel lymph node biopsies are recommended to refine surgical guidelines.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comprehensive Review on Novel Therapies for Gastrointestinal Cancers using Translational Platforms. 基于翻译平台的胃肠道癌症新疗法综述
IF 2.6 4区 医学
Current pharmaceutical design Pub Date : 2025-03-19 DOI: 10.2174/0113816128363261250224191453
Trilochan Satapathy, Shiv Kumar Bhardwaj, Arvind Kumar, Kamal Babu Aditya, Princy Kashyap
{"title":"A Comprehensive Review on Novel Therapies for Gastrointestinal Cancers using Translational Platforms.","authors":"Trilochan Satapathy, Shiv Kumar Bhardwaj, Arvind Kumar, Kamal Babu Aditya, Princy Kashyap","doi":"10.2174/0113816128363261250224191453","DOIUrl":"https://doi.org/10.2174/0113816128363261250224191453","url":null,"abstract":"<p><p>Gastrointestinal (GI) cancers, including gastric cancer, are among the most common and deadly cancers worldwide. Patients diagnosed with GI cancer still have a poor prognosis, largely resulting from the late stage of presentation for most of these patients and resistance to conventional therapy. This review covers new therapeutic strategies that apply advances in nanotechnology, immunotherapy, and drug delivery to overcome these challenges. Polymeric and metallic nanoparticles are distinguished for their potential to improve drug stability and solubility, as well as targeting drugs, thus diminishing systemic toxicity. The review centers around the use of immunotherapy in immune checkpoint inhibitors, CAR-T cell therapy, as well as the use of cancer vaccines to re-orient the immune system to be effective against cancer cells. Oncolytic viral therapy and bacteria- based treatments are unique non-conventional approaches that have a potential synergistic impact when used in concomitance with traditional methods. This review presents one of the most promising drug delivery systems: liposomes and micelles that can enhance pharmacokinetics and improve therapeutic results with controlled and site-specific release of anticancer agents. This review critically analyzes the strengths and challenges that include bioavailability, toxicity, and clinical translation, along with strategies to overcome such barriers. The review presents the most salient evidence to date and demonstrates the transformative potential of combining nanotechnology with immunotherapeutic and targeted treatments for managing gastric and other GI cancers. Future research should be focused on optimizing these platforms for clinical applications for the betterment of patient outcomes around the globe.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting the PI3K Pathway: Advancements and Achievements in Breast Cancer Therapy. 靶向PI3K通路:乳腺癌治疗的进展和成就。
IF 2.6 4区 医学
Current pharmaceutical design Pub Date : 2025-03-18 DOI: 10.2174/0113816128357976250122042633
Basavana Gowda Hosur Dinesh, Sunil Kumar Bandral, Nandini Markuli Sadashivappa, Srinivas Ganjipete, Damodar Nayak Ammunje, Selvaraj Kunjiappan, Panneerselvam Theivendren, Judy Jays, Parasuraman Pavadai
{"title":"Targeting the PI3K Pathway: Advancements and Achievements in Breast Cancer Therapy.","authors":"Basavana Gowda Hosur Dinesh, Sunil Kumar Bandral, Nandini Markuli Sadashivappa, Srinivas Ganjipete, Damodar Nayak Ammunje, Selvaraj Kunjiappan, Panneerselvam Theivendren, Judy Jays, Parasuraman Pavadai","doi":"10.2174/0113816128357976250122042633","DOIUrl":"https://doi.org/10.2174/0113816128357976250122042633","url":null,"abstract":"<p><p>Breast cancer is a complex disease caused by the aberrant and unchecked proliferation of breast cells, which leads to the development of tumours. In various types of cancer, the Phosphoinositide 3- kinase/Protein kinase B (PKB, also known as Akt (PI3K/Akt) signalling pathway, is essential for controlling cell survival, metastasis, and metabolism. Currently, marketed PI3K inhibitors for treating breast cancer face several issues, including toxicity, resistance, etc. Significant efforts have been made to develop synthetic and repurposed inhibitor drugs to target PI3K, which are now being tested in clinical trials. Developed synthetic PI3K inhibitors have been reported to have better results in clinical trials in the suppression of tumors. This review article mainly focuses on the PI3K pathway at the cellular and molecular level, the development of PI3K inhibitors, and their clinical trials. Biomarkers, marine drugs, synthetic drugs, and repurposed drugs to treat breast cancer are also discussed, followed by mutational changes in PI3K and the resistance mechanism involved in PI3K inhibitors.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmaceutical Design and Structure-activity Relationships of Psoralen and Derivatives. 补骨脂素及其衍生物的药物设计及构效关系。
IF 2.6 4区 医学
Current pharmaceutical design Pub Date : 2025-03-18 DOI: 10.2174/0113816128365838250128060007
Yingyue Hu, Yuncan Wang, Wenxiu Qin, Shuo Yu, Siyang Dai, Yuehu Pei, Chang Li, Yihui Yang
{"title":"Pharmaceutical Design and Structure-activity Relationships of Psoralen and Derivatives.","authors":"Yingyue Hu, Yuncan Wang, Wenxiu Qin, Shuo Yu, Siyang Dai, Yuehu Pei, Chang Li, Yihui Yang","doi":"10.2174/0113816128365838250128060007","DOIUrl":"https://doi.org/10.2174/0113816128365838250128060007","url":null,"abstract":"<p><p>Psoralen, the simplest linear furanocoumarin, is derived from many medicinal plants, such as Psoralea corylifolia L., Glehnia littoralis Fr. Schmidt ex Miq., and Peucedanum decursivum (Miq.) Maxim. It has been used for treating osteoporosis and some skin disorders, including vitiligo, psoriasis, and atopic eczema. This review focuses on the pharmaceutical design of psoralen and the structure-activity relationships (SARs) of its derivatives. It also includes the biosynthetic pathways, metabolic characteristics, metabolites, and clinical uses of psoralen, as well as its toxicity/side effects and relevant mechanisms. Psoralen, as a promising drug lead compound, is structurally modified to develop numerous derivatives with remarkable biological activities. SARs discussed herein can guide the design and development of novel psoralen-based derivatives for use in pharmaceuticals and widen their therapeutic potencies.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Synthesis of Curcumin Loaded Carbon Dots as a Sustained Drug Delivery for Anticancer Therapy. 绿色合成姜黄素负载碳点作为抗癌药物的持续递送。
IF 2.6 4区 医学
Current pharmaceutical design Pub Date : 2025-03-18 DOI: 10.2174/0113816128353103250116112919
Aniket Saini, Aniket Nandi, Ghanshyam Das Gupta, Ajay Sharma, Kalicharan Sharma
{"title":"Green Synthesis of Curcumin Loaded Carbon Dots as a Sustained Drug Delivery for Anticancer Therapy.","authors":"Aniket Saini, Aniket Nandi, Ghanshyam Das Gupta, Ajay Sharma, Kalicharan Sharma","doi":"10.2174/0113816128353103250116112919","DOIUrl":"https://doi.org/10.2174/0113816128353103250116112919","url":null,"abstract":"<p><strong>Aims: </strong>To enhance curcumin's bioavailability with the help of carbon dot and piperine, due to its promising anticancer activity.</p><p><strong>Background: </strong>Cancer is a disease condition, where some cells grow uncontrollably, and if not controlled, they spread to other parts of the body. Concerning anticancer agents, curcumin has anticancer properties along with anti-inflammatory, antimicrobial, and antioxidant. Here in this study, the pharmacokinetic property was improved with the help of Carbon Dot encapsulation.</p><p><strong>Objective: </strong>To improve the bioavailability of curcumin by improved encapsulation efficiency in carbon dots, to achieve a better cytotoxic effect of curcumin.</p><p><strong>Methods: </strong>Bamboo leaves were used for the preparation of CDs and curcumin was loaded in them and the characterization for particle size, morphology, loading capacity, quantum yield, drug release in vitro studies, and in vitro cell viability activity as anticancer activity was done accordingly.</p><p><strong>Results: </strong>Prepared CDs have a smaller particle size (< 10 nm), good loading capacity, stability, and excellent fluorescence activity. Studies on the release of curcumin have shown that a pH-5.5 solution leads to enhanced curcumin release. The CDs-curcumin shows enhanced toxicity against cancerous cells than the curcumin even at lower concentrations (20, 40, 60, 80,100 μM).</p><p><strong>Conclusion: </strong>Curcumin can be delivered by CDs, which have the advantages of increased bioavailability, small size, high loading capacity, improved photoluminescence, and biocompatibility. These characteristics can result in improved anticancer activities even at low concentrations.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Natural Compounds as Potential COVID-19 Main Protease (Mpro) Inhibitors: A Comprehensive Study and In silico Evidence. 鉴定天然化合物作为潜在的COVID-19主蛋白酶(Mpro)抑制剂:一项综合研究和计算机证据
IF 2.6 4区 医学
Current pharmaceutical design Pub Date : 2025-03-18 DOI: 10.2174/0113816128344055250220100720
Arti Devi, Vagish Dwibedi, Sahil Jain, Gursharan Kaur, Zaved Ahmed Khan, Sudip Kumar Mandal, Aditya Shiven, Kamal Shah, Hitesh Kumar Dewangan, Santosh Kumar Rath
{"title":"Identification of Natural Compounds as Potential COVID-19 Main Protease (Mpro) Inhibitors: A Comprehensive Study and In silico Evidence.","authors":"Arti Devi, Vagish Dwibedi, Sahil Jain, Gursharan Kaur, Zaved Ahmed Khan, Sudip Kumar Mandal, Aditya Shiven, Kamal Shah, Hitesh Kumar Dewangan, Santosh Kumar Rath","doi":"10.2174/0113816128344055250220100720","DOIUrl":"https://doi.org/10.2174/0113816128344055250220100720","url":null,"abstract":"<p><p>SARS-CoV-2, the virus responsible for COVID-19, has resulted in a devastating global impact with millions of lives lost. Remdesivir and 2-DG are among the few drugs authorized for emergency use against COVID-19, but concerns about their efficacy and side effects persist. Vaccines have been developed and approved, yet the emergence of viral mutations has raised questions about their effectiveness against new variants. Natural compounds with antiviral properties have shown promise in combating SARS-CoV-2. The review highlights the potential of medicinal plant compounds, particularly in targeting the virus' main protease, a crucial component for viral replication. Natural, plant-derived compounds represent a promising avenue for COVID-19 therapeutics. Further clinical validation is necessary to ascertain their efficacy and safety in treating COVID-19. This underscores the importance of continued research into alternative treatments for combating this global health crisis. This review examines the potential of natural, plant-derived compounds as safe and cost-effective alternatives for combating COVID-19. It summarizes the pathogenesis of SARS-CoV- 2 and the ongoing drug studies and identifies natural compounds with known antiviral properties. Additionally, it explores the potential of medicinal plant compounds in targeting the SARS-CoV-2 main protease through in silico and molecular docking studies.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Characterization of Zn(1-x-y)MnxCoyO NPs for Liver Cancer Treatment. 用于肝癌治疗的Zn(1-x-y)MnxCoyO NPs的合成与表征
IF 2.6 4区 医学
Current pharmaceutical design Pub Date : 2025-03-17 DOI: 10.2174/0113816128330548250206101727
Nasar Ahmed, Natasha Nazir, Muhammad Asif, M Adnan, M Fakhar-E-Alam, Muhammad Zubair, Khizar Ul Haq, Muhammad Aseer, Muhammad Atif, Safdar Ali
{"title":"Synthesis and Characterization of Zn(1-x-y)MnxCoyO NPs for Liver Cancer Treatment.","authors":"Nasar Ahmed, Natasha Nazir, Muhammad Asif, M Adnan, M Fakhar-E-Alam, Muhammad Zubair, Khizar Ul Haq, Muhammad Aseer, Muhammad Atif, Safdar Ali","doi":"10.2174/0113816128330548250206101727","DOIUrl":"https://doi.org/10.2174/0113816128330548250206101727","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, pure and cobalt manganese-doped ZnO nanoparticles (Zn(1-x-y)MnxCoyO NPs) at varying concentrations were synthesized through sol-gel method, and zinc acetate dihydrate, manganese nitrate, cobalt acetate, and diethyl amine were used as precursors, with samples finally calcined at 700oC.</p><p><strong>Method: </strong>The hexagonal wurtzite structure of pure and co-doped ZnO NPs was confirmed by X-ray diffraction (XRD). The computed grain sizes of pure and co-doped ZnO NPs, according to Scherrer's formula, were 32 nm, 32.5 nm, 36.3 nm, and 36.5 nm, respectively. SEM was used to observe the morphology of nanoparticles. FTIR spectroscopy was used to examine the chemical make-up and vibrational modes of pure and co-doped ZnO NPs. The bandgaps of pure and doped ZnO were examined using UV-Vis spectroscopy.</p><p><strong>Results: </strong>It was found that the optical bandgap of ZnO was lowered by 3.21 eV by manganese and cobalt doping. Elemental composition analysis was performed by using EDX analysis. Finally, anticancer activity of pure and co-doped ZnO NPs was assessed by employing MTT assay, which indicated that Zn0.8 Mn0.1 Co0.1O NPs showed significant anticancer results against liver cancer (HepG-2) cells as compared to ZnO, Zn0.98 Mn0.01Co0.01O and Zn0.90 Mn0.05 Co0.05O NPs. Moreover, Zn0.8 Mn0.1 Co0.1O NPs showed low toxicity and good biocompatibility comparable to doxorubicin (DOX).</p><p><strong>Conclusion: </strong>Comprehensive experimental findings have demonstrated an authentic way of obtaining feasible in vivo liver cancer therapy.</p>","PeriodicalId":10845,"journal":{"name":"Current pharmaceutical design","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信