{"title":"Can Vıtamın D Reduce the Need for SSRI by Modulatıng Serotonın Synthesıs?: A Revıew of Recent Lıterature.","authors":"Zekiye Zeynep Bostan, Melike Şare Bulut, Makbule Gezmen Karadağ","doi":"10.1007/s13668-025-00630-7","DOIUrl":"10.1007/s13668-025-00630-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>This study aims to analyze the effects of vitamin D on serotonin synthesis, release, and function in the brain, and to explore its relationship with various psychiatric disorders.</p><p><strong>Recent findings: </strong>The hormone calcitriol plays a vital role in regulating a multitude of biological processes within the human body. Its deficiency can lead to significant adverse effects on overall health and well-being, including physical and psychological consequences. Evidence indicates that vitamin D may exert influences through receptors in the brain, modulating serotonin production and influencing emotional and cognitive processes. Recent studies propose that elevated serum vitamin D may enhance mood and alleviate depressive states. The impact of vitamin D on cognitive function and behavior remains an area of ongoing investigation. This literature review analyses the available evidence on how vitamin D intake impacts the severity of illness and medication requirements in diverse psychiatric disorders. A review of the literature suggests that there may be a correlation between vitamin D and serotonin, which could potentially contribute to more favorable outcomes in the context of illness. Vitamin D may increase the amount of serotonin in the synaptic gap, which is the intended use of selective serotonin reuptake inhibitors (SSRIs), with its effect on the increase in serotonin release. According to reports, vitamin D supplementation in conjunction with SSRI group medication provides an additive effect for the management of psychiatric disorders.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"39"},"PeriodicalIF":4.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessiree Jie Ning Kwok, Michelle Kaixuan Chen, Chi Wei Ong, Lin Chen
{"title":"Antidiabetic Potential of Bananas (Musa spp.): A Systematic Review of Bioactive Compounds and Antihyperglycemic Activities.","authors":"Jessiree Jie Ning Kwok, Michelle Kaixuan Chen, Chi Wei Ong, Lin Chen","doi":"10.1007/s13668-025-00629-0","DOIUrl":"10.1007/s13668-025-00629-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>Bananas (Musa spp.), a staple fruit crop in Southeast Asia, are widely recognised for their nutritional value and potential medicinal properties, including the management of diabetes. To address the diabetes pandemic, various studies have explored the efficacy of many natural foods in reducing blood glucose, preventing complications that arise from the chronic illness. However, a comprehensive overview of bioactive compounds and their antidiabetic effects across different banana species in recent years is lacking. This review provides a comprehensive overview of bioactive compounds in various parts of the bananas that have demonstrated antihyperglycemic activities. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a thorough literature search using ScienceDirect, Scopus, and PubMed databases, resulting in the inclusion of 27 relevant articles.</p><p><strong>Recent findings: </strong>Emerging evidence suggests that different parts of the banana plant contain various bioactive compounds with antihyperglycemic activities, offering promising benefits for diabetes management. The findings reveal that the antihyperglycemic effects of bananas can be attributed to specific bioactive compounds, such as phenols, saponins, alkaloids, sterols, and flavonoids, through mechanisms like inhibition of α-glucosidase, β-glucosidase, α-amylase and sucrase enzymes, glucose uptake assay, and inhibition of formation of advanced glycation end-products. Liver glycogen content and fasting blood glucose in rat models, along with HbA1c measurements in human subjects, were also assessed to evaluate invivo antidiabetic activity, which has yielded positive outcomes. The results support the potential medicinal and pharmaceutical benefits of bananas in clinical diabetes management and suggest that incorporating banana-derived compounds could enhance the cost-effectiveness of antidiabetic treatments.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"38"},"PeriodicalIF":5.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Impact of Plant-Based Proteins on Muscle Mass and Strength Performance: A Comprehensive Review.","authors":"Miguel López-Moreno, Ariel Kraselnik","doi":"10.1007/s13668-025-00628-1","DOIUrl":"10.1007/s13668-025-00628-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>Plant-based diets, which prioritize plant foods and limit or exclude animal-based products, have gained popularity due to their potential health and environmental benefits. While these diets are recognized as nutritionally adequate for all life stages, plant-based proteins have traditionally been considered less effective for muscle growth and athletic performance compared to animal-based proteins. This study aims to assess the quality of plant-based protein sources and their effects on muscle mass gain and strength performance.</p><p><strong>Recent findings: </strong>Although plant-based proteins may have lower digestibility and amino acid quality, combining protein sources and employing different processing techniques, such as cooking or fermentation, can improve their bioavailability. Animal protein supplementation has been associated with greater gains in lean mass and muscle strength. However, focusing exclusively on isolated protein supplementation fails to reflect the habitual dietary patterns, which typically involve consuming diverse protein sources throughout the day. Consequently, there is a growing interest in examining the broader impact of comprehensive dietary patterns on muscle mass and strength. Recent research suggests that when consumed in adequate amounts and with appropriate combinations, plant-based proteins can effectively support muscle protein synthesis and strength performance when consumed in adequate amounts and with appropriate combinations. When derived from diverse sources and consumed in sufficient quantities, plant-based proteins can effectively support muscle protein synthesis and promote strength development. Further research is needed to assess the impact of plant-based diets on muscle mass and strength in elite athletes and older adults, particularly those at risk of sarcopenia. Long-term studies are essential for a more comprehensive understanding of the sustained effects of plant-based nutrition on these outcomes.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"37"},"PeriodicalIF":4.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabella Mendes, Madalena Geralda Cupertino Ribeiro, Layla Fagundes de Souza, Carla de Oliveira Barbosa Rosa, Helen Hermana Miranda Hermsdorff, Josefina Bressan
{"title":"Effect of Polyphenol Supplementation on Adiposity: A Systematic Review of Randomized Clinical Trials.","authors":"Isabella Mendes, Madalena Geralda Cupertino Ribeiro, Layla Fagundes de Souza, Carla de Oliveira Barbosa Rosa, Helen Hermana Miranda Hermsdorff, Josefina Bressan","doi":"10.1007/s13668-025-00626-3","DOIUrl":"10.1007/s13668-025-00626-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>The obesity is a multifactorial disease, result of high adiposity and excessive body fat, with closed relation to the development of other chronic disease. The growing obesity-related costs has relevant public health impact. In turn, the polyphenol is a dietary bioactive compound with recognized antioxidant propriety and healthy benefits. The polyphenol supplementation can be a promising strategy for obesity treatment, due to its potential antiadipogenic and metabolic control effects, improving quality of life of this population. This systematic review evaluated the effect of polyphenol supplementation on adiposity in overweight adults and elderly people (Systematic Review Registration: CRD42024586193).</p><p><strong>Recent findings: </strong>Current research demonstrates that polyphenol supplementation resulted in a significant decrease in markers of central adiposity (percentage of body fat, fat mass, waist circumference) and visceral adiposity (visceral adipose tissue). The mechanisms may be involved in the activation of lipid turnover pathways, AMPK activation and suppression of transcription factors (SREBPs, PPAR-γ and C/EBP-α) and key enzymes in lipid synthesis in adipose tissue. Furthermore, polyphenol supplementation has also beneficial effects on controlling of blood pressure, blood glucose and lipid profile, contribute to the prevention of other chronic metabolic disorders. Adiposity refers to the distribution of body fat, closely related to cardiometabolic risk, while polyphenols are phytochemicals with potential health-promoting effects. However, the role of these bioactive compounds in controlling adiposity is not well established. This systematic review presents antiadipogenic and metabolic control effects of the dietary polyphenol supplementation. However, there is no consensus on a specific dosage or form of presentation that generates the best results. Further studies are needed to elucidate better the potential effect of these compounds and related-pathway, to perform clinical validation of their use, and to establish the benefits of their long-term use.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"36"},"PeriodicalIF":5.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rana Mahfouz, Yonna Sacre, Lara Hanna-Wakim, Maha Hoteit
{"title":"Progress of Eastern Mediterranean Countries towards Meeting USDA Dietary Guidelines for Pregnant Women: A Focused Review.","authors":"Rana Mahfouz, Yonna Sacre, Lara Hanna-Wakim, Maha Hoteit","doi":"10.1007/s13668-025-00627-2","DOIUrl":"10.1007/s13668-025-00627-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Pregnant women across the globe, in the Eastern Mediterranean Region (EMR), face various dietary obstacles during their pregnancy. In this region, characterized by diverse cultural preferences and traditions, emergencies such as conflicts, natural disasters, epidemics, and displacement continue to exist. This influences food insecurity in the region, particularly among pregnant women. This review aims to enhance maternal and fetal health by analyzing these nutritional challenges and assessing women's nutrient consumption in accordance with the USDA's 2020-2025 Nutritional Guidelines for Pregnant Women, with particular attention to significant nutrient deficiencies. It provides a comprehensive examination of the existing literature and data regarding maternal nutrition in the EMR, highlights deficiencies in data collection and analysis, calls for national surveys, and emphasizes the necessity of raising awareness about the adequate nutrition to improve health outcomes for mothers and their infants in the region. The USDA guidelines were selected for comparisons as they are internationally recognized standards. To enhance the analysis, WHO regional standards were also used, offering context-specific insights that complement the USDA framework.</p><p><strong>Recent findings: </strong>Pregnant women in the EMR commonly experience nutrient inadequacies, particularly in carbohydrates, fruits, and vegetables. A healthy nutritious diet during pregnancy contributes to optimal fetal growth and increases the potential for long-term health for mothers and their offspring. Many antioxidants (vitamin A, C, and E, carotenoids and flavonoids) are derived from the inclusion of vegetables and fruits in pregnant women's diets. Additionally, they also provide folates, potassium and fiber. Starchy carbohydrates and fiber containing whole grain cereals and vegetables are the fundamentals of a healthy diet allowing for good body's functioning and providing energy as a primary source. Whole grain cereal products are particularly rich in minerals, vitamins, and dietary fibers. The study highlights lack of intake in milk and dairy products, sources of iodine, essential for cognitive fetal growth, in addition to an insufficient amount of vitamin D, which is protective against gestational diabetes, as well as vitamin C, essential for immunity and antioxidant properties. The findings emphasize the importance of conducting national surveys among pregnant women in the EMR Region countries to gain a clearer understanding of their food intake and inform the development of targeted interventions. The study focuses on significant nutrient deficiencies and dietary challenges faced by pregnant women in EMR, emphasizing the need for targeted surveys and educational initiatives.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"35"},"PeriodicalIF":4.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characteristic of Essential Oils Extracted from the Industrial-Scale Processing By-Products of Agro-foods.","authors":"Hülya Güҫlü","doi":"10.1007/s13668-025-00624-5","DOIUrl":"10.1007/s13668-025-00624-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>Nowadays, more interest has been focused on the efficient use of agricultural and food processing post-products. The remaining wastes accumulate in large quantities, resulting in a burden on the environment. However, they possess potentially valuable compounds, making them suitable to recover essential oil from solid waste. This review evaluates the production of essential oils from apple, citrus fruits, sour cherry, corn, rice, wheat, and barley processing wastes, highlighting high levels of bioactive compounds such as tocopherols, phytosterols, and unsaturated fatty acids, which contribute to their antioxidant and antimicrobial properties.</p><p><strong>Recent findings: </strong>Agro-food processing wastes are composed of biologically active compounds including essential oil with different functional characteristics such as antibacterial and anti-angiogenic properties. This could be due to the presence of bioactive compounds including phytosterols, tocochromanols, tocopherol, and carotenoids, as well as the natural antioxidants and the higher amount of unsaturated fatty acids. Agro-food processing by-products are a valuable source of essential oil, which is rich in mono-unsaturated and poly-unsaturated fatty acids as well as bioactive compounds. Findings provide a reference for the development of healthy products and open a new horizon for innovative and profitable utilization of the wastes generated from the industrial-scale processing of agro-foods.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"34"},"PeriodicalIF":4.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristina D Thomopoulos-Titomihelakis, Hillary Sachs, Rayna McCann, Qianhui Zhang, Sydney Kurnit, Genesis Codoni De Juan, Amanda Rushing
{"title":"Correction to: Critical Review of Ketogenic Diet Throughout the Cancer Continuum for Neuroglioma: Insights from a Medical Nutrition Therapy (MNT) Perspective.","authors":"Kristina D Thomopoulos-Titomihelakis, Hillary Sachs, Rayna McCann, Qianhui Zhang, Sydney Kurnit, Genesis Codoni De Juan, Amanda Rushing","doi":"10.1007/s13668-025-00625-4","DOIUrl":"10.1007/s13668-025-00625-4","url":null,"abstract":"","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"33"},"PeriodicalIF":4.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rima Obeid, Juergen Geisel, Klaus Pietrzik, Emmanuel Andres
{"title":"A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements.","authors":"Rima Obeid, Juergen Geisel, Klaus Pietrzik, Emmanuel Andres","doi":"10.1007/s13668-025-00622-7","DOIUrl":"10.1007/s13668-025-00622-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>To define an intake threshold of vitamin B12 from food supplements that is sufficient to maintain normal body functions, but it does not cause pharmacological effects.</p><p><strong>Recent findings: </strong>We used studies on the amount of B12 absorbed following oral B12 application and non-comparative case-series studies to synthesize evidence on pharmacological effects of oral B12 (between < 10 µg and 3000 µg) in people with manifested deficiency. There is a dose-dependent intestinal absorption of B12 and in the same time effects on body metabolism and functions. Food supplements providing ≤ 20 µg B12 daily are unlikely to cause pharmacological effects, while 50 µg might correct abnormal biochemical markers in some deficient patients. Foods for special medical purposes for people who cannot absorb B12 may contain 100 µg to 150 µg B12. This dose may ensure 1-4 µg of the vitamin reaching the circulation on a daily basis independent of intrinsic factor. Dosages ≥ 200 µg/d should be considered as drugs that can correct anemia, metabolic markers and clinical symptoms. The content of vitamin B12 in food supplements should not exceed 20 µg. In addition, people with deficiency should receive appropriate medical treatment with high dose B12.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"32"},"PeriodicalIF":4.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luciana Cecilia Muchut, Leandro Fabián Bustos, María Eugenia Hidalgo, Franco Emanuel Vasile
{"title":"Nutritional Prehabilitation: Trends in Supplementation Based on Sustainable Dairy Protein Sources.","authors":"Luciana Cecilia Muchut, Leandro Fabián Bustos, María Eugenia Hidalgo, Franco Emanuel Vasile","doi":"10.1007/s13668-025-00623-6","DOIUrl":"10.1007/s13668-025-00623-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Prehabilitation is an emerging clinical practice that aims to improve the surgical recovery and quality of life of patients undergoing intensive treatments. This review intends to describe the state of the art in prehabilitation, highlighting the role of nutritional strategies and the current trends in supplements.</p><p><strong>Recent findings: </strong>Up-to-date studies have shown the importance of optimizing the nutritional status of patients to cope with the physical and metabolic demands of surgery and intensive treatments. In the context of nutritional prehabilitation, oral nutritional supplementation has emerged as a preferred strategy. The effectiveness of prehabilitation has been demonstrated in various clinical contexts. However, the lack of standardized protocols makes it hard to compare the outcomes. Despite the variability in this type of nutritional intervention found in reports, it has been shown that the most common oral nutritional supplements (ONS) contain dairy proteins. The use of whey proteins represents a promising approach from both a nutritional and a sustainability perspective.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"31"},"PeriodicalIF":4.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gut Microbiome, Diet and Depression: Literature Review of Microbiological, Nutritional and Neuroscientific Aspects.","authors":"Laura Clerici, Davide Bottari, Benedetta Bottari","doi":"10.1007/s13668-025-00619-2","DOIUrl":"10.1007/s13668-025-00619-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review explores the intricate relationships among the gut microbiota, dietary patterns, and mental health, focusing specifically on depression. It synthesizes insights from microbiological, nutritional, and neuroscientific perspectives to understand how the gut-brain axis influences mood and cognitive function.</p><p><strong>Recent findings: </strong>Recent studies underscore the central role of gut microbiota in modulating neurological and psychological health via the gut-brain axis. Key findings highlight the importance of dietary components, including probiotics, prebiotics, and psychobiotics, in restoring microbial balance and enhancing mood regulation. Different dietary patterns exhibit a profound impact on gut microbiota composition, suggesting their potential as complementary strategies for mental health support. Furthermore, mechanisms like tryptophan metabolism, the HPA axis, and microbial metabolites such as SCFAs are implicated in linking diet and microbiota to depression. Clinical trials show promising effects of probiotics in alleviating depressive symptoms. This review illuminates the potential of diet-based interventions targeting the gut microbiota to mitigate depression and improve mental health. While the interplay between microbial diversity, diet, and brain function offers promising therapeutic avenues, further clinical research is needed to validate these findings and establish robust, individualized treatment strategies.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"30"},"PeriodicalIF":4.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}