Current Nutrition Reports最新文献

{"title":"An In-depth Exploration of Non-Dairy Probiotics: Demystifying Regulations, Sources, and Mechanisms.","authors":"Poornima Singh, Surabhi Pandey, Anurag Singh","doi":"10.1007/s13668-026-00741-9","DOIUrl":"10.1007/s13668-026-00741-9","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Consumer demand has shifted from energy-dense foods to balanced nutrition and functional health benefits. Probiotics, live bacteria that promote health beyond a natural diet, are used to improve gut health, boost immunity, and aid in nutrient absorption. RECENT FINDINGS: While dairy products like yogurt and kefir are common probiotic sources, they may cause allergies due to lactose and cholesterol. Non-dairy alternatives, such as fruits, vegetables, grains, and legumes, offer nutrient-rich, affordable options with potential health benefits but face challenges in probiotic delivery due to factors like low pH and off-flavors. Probiotic cultures in non-dairy foods are difficult to deliver due to low pH, antinutritional and phytochemicals, excessive moisture content, and medicinal and off flavor. The increasing consumer demand for a variety of probiotic options has prompted a need for additional research and development in the field of non-dairy probiotics. This review explores non-dairy probiotics, processing issues, and recent advancements. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal Plant Seeds in Nutritional Oncology: An Integrative Review of Emerging Therapeutics for Non-Small Cell Lung Cancer.","authors":"Gajavarthini Senthilkumar, Renuka Saravanan, Sivakumar Ramalingam","doi":"10.1007/s13668-026-00751-7","DOIUrl":"10.1007/s13668-026-00751-7","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Lung cancer, particularly non-small cell lung cancer, remains the leading cause of cancer-related mortality worldwide. Despite advances in therapy, limitations such as late diagnosis, toxicity, and drug resistance necessitate alternative strategies. This review aims to highlight the emerging role of medicinal plant seeds and their phytochemicals as potential anticancer agents against NSCLC. RECENT FINDINGS: Seeds from Nigella sativa, Vitis vinifera, Sesamum indicum, Coix lacryma-jobi, Trigonella foenum-graecum, Artocarpus heterophyllus, Citrullus lanatus, and Linum usitatissimum demonstrate anticancer activity in preclinical lung cancer models. Their bioactive compounds, extracts, oils, and nanoparticle formulations induce apoptosis, arrest the cell cycle, inhibit angiogenesis and metastasis, modulate oxidative stress, and suppress epithelial-mesenchymal transition. These effects are mediated by key pathways including EGFR, PI3K/Akt, NF-κB, Nrf2, and caspase signaling. Compounds such as sesamol, diosgenin, and grape seed procyanidins have shown potential in enhancing chemotherapeutic outcomes and overcoming drug resistance, particularly through nanoformulation-based delivery systems. Medicinal plant seeds exhibit multi-targeted mechanisms and represent promising candidates for lung cancer therapy. Further translational and clinical studies are essential to establish their efficacy and integration into lung cancer management. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D and Health Outcomes: State-of-the-Art Review of Triangulated Evidence and Ongoing Controversies.","authors":"Maria Dalamaga, Rodopi Emfietzoglou, Dimitra Petropoulou, Maria Kypraiou, Dimitris C Kounatidis, Natalia G Vallianou, Spyridon Karras, Faidon Magkos, Irene Karampela","doi":"10.1007/s13668-026-00748-2","DOIUrl":"10.1007/s13668-026-00748-2","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Vitamin D is a pleiotropic hormone with an established role in skeletal integrity and broader actions in immune regulation, inflammation, cellular proliferation, and energy homeostasis. Despite decades of research, its extra-skeletal effects remain controversial, largely due to discordant findings across observational studies, Mendelian randomization studies (MRS), and randomized controlled trials (RCTs). Unlike many prior reviews, this state-of-the-art review synthesizes triangulated evidence across these study designs to clarify outcome-specific causal relationships and ongoing controversies. RECENT FINDINGS: Triangulated evidence provides strong and consistent support for a causal role of vitamin D in skeletal health, particularly in the prevention and treatment of rickets and osteomalacia, and in fracture risk reduction among vitamin D–deficient and older populations. For selected extra-skeletal outcomes, modest and threshold-dependent benefits are observed, including reductions in cancer mortality, protection against autoimmune disorders, most convincingly multiple sclerosis, and decreased risk of acute respiratory infections, including COVID-19, primarily in individuals with low baseline 25(OH)D concentrations. In contrast, associations with cardiovascular disease, metabolic disorders, obesity, and most neuropsychiatric outcomes are not consistently supported by genetic or interventional evidence, suggesting limited or non-causal effects. Across outcomes, evidence indicates a non-linear relationship between vitamin D status and health, with increased risk concentrated at low 25-hydroxyvitamin D concentrations and limited benefit beyond sufficiency. All-cause mortality shows a modest, threshold-dependent association, with supplementation benefits largely confined to deficient or older populations. Key challenges include assay variability, non-linear dose–response relationships, and RCT designs that frequently enroll vitamin D–replete populations, resulting in substantial methodological heterogeneity and limiting causal inference. Overall, the presented triangulated model may reconcile longstanding inconsistencies by reframing vitamin D as a context-dependent determinant of health. These findings argue against indiscriminate population-wide supplementation and support targeted strategies focused on the identification and correction of deficiency. Vitamin D should be regarded neither as a universal panacea nor as a trivial supplement, but as a context-dependent hormone whose clinical value lies in outcome-specific correction of deficiency. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12999768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Health Tools for the Screening and Management of Malnutrition Risk in the Older Adults: A Narrative Review.","authors":"Feliciana Amatrudo, Vincenzo De Luca, Sara Aprano, Davide Mayol, Mariarosaria Negri, Emanuela Giardinelli, Daniela Laudisio, Nicola Tecce, Claudia Pivonello, Guido Iaccarino, Annamaria Colao, Maddalena Illario, Claudia Vetrani","doi":"10.1007/s13668-026-00746-4","DOIUrl":"10.1007/s13668-026-00746-4","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: In this narrative review, we provide an overview of the current understanding of the potential role of technology in supporting older adults and facilitating preventive screening or early intervention strategies to mitigate the risk of malnutrition. RECENT FINDINGS: In the 30 included studies, digital tools (e.g., EHR-embedded screening, dietary apps, photographic monitoring, telemonitoring, and machine-learning based NLP dashboards) increased malnutrition risk detection and improved aspects of nutritional care in diverse settings. Digital tools and applications for the assessment of malnutrition and the monitoring of nutrient intake have proven effective in increasing awareness of malnutrition risk, helping to reduce the workload of healthcare professionals, and decrease the time healthcare professionals spend assessing nutritional status. Importantly, co-design and user-centred interface adaptations consistently improved acceptability and usability among older adults. Indeed, his narrative review demonstrates that older adults’ involvement is an essential prerequisite for the proper functioning and use of experimental tools. To promote successful ageing, digital tools can effectively support older individuals by facilitating preventive screening or early intervention strategies to mitigate the risk of malnutrition. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Nutrition Modulate the Progression of Alzheimer's Disease? A Narrative Review.","authors":"Wojciech Michał Jankowski, Jakub Fichna, Aleksandra Tarasiuk-Zawadzka","doi":"10.1007/s13668-026-00733-9","DOIUrl":"10.1007/s13668-026-00733-9","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration of neurons in the nervous systems, along with the accumulation of abnormal proteins in brain structures. The most common neurodegenerative disease is Alzheimer’s disease (AD), which manifests as memory loss, cognitive deficits, communication difficulties, personality changes and impaired ability to perform daily activities. The purpose of this study is to gather available information on the relationship between dietary habits and the pathogenesis of AD. RECENT FINDINGS: A growing body of scientific literature points to the important influence of diet and its nutrients on the mechanisms of AD development. Polyphenols play a key role in reducing oxidative stress and inflammation in the brain. B vitamins, as well as vitamins A, C, D and E, help protect neurons and improve cognitive function. In addition, omega-3 fatty acids, inhibit the formation of amyloid beta deposits and reduce hyperphosphorylation of tau protein. It is worth noting that the Mediterranean diet has shown beneficial effects on brain health, in contrast to the Western diet, which promotes the development of these conditions. Recent studies also emphasize the role of the gut microbiota and its metabolites, such as short-chain fatty acids, as factors involved in preventing the development of AD. A balanced diet, such as the Mediterranean diet, rich in antioxidants, anti inflammatory components and supportive of a healthy gut microbiome, can slow the progression of AD and serve as a complementary approach to its treatment. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypersensitivity to Intravenous Lipid Emulsions and Food Allergies: a Systematic Review of Case Reports.","authors":"Chanita Unhapipatpong, Narachai Julanon, Mongkhon Sompornrattanaphan, Katherine Schwenger, Ann MacGillivray, Meredith Barwin, Lesley Graham, Paul Lee, Johane P Allard","doi":"10.1007/s13668-026-00737-5","DOIUrl":"10.1007/s13668-026-00737-5","url":null,"abstract":"<p><p>PURPOSE OF THE REVIEW: Intravenous lipid emulsion (ILE) is essential for patients with prolonged intestinal failure but may contain potential allergens. Unnecessary avoidance of ILE in patients with food allergies could limit nutritional options. Therefore, we systematically reviewed the evidence on ILE use in patients with and without food allergies, including those who experienced hypersensitivity reactions. Searches were conducted in Medline, Scopus, Web of Science, Google Scholar, and the Canada Vigilance Adverse Reaction Database through April 30, 2025. RECENT FINDINGS: Twenty-eight individual cases (from 25 reports) met the inclusion criteria, involving 10 pediatric and 18 adult patients. The median time to hypersensitivity reaction was 5 min (IQR 0–45) in children and 60 min (IQR 15–120) in adults. The median cumulative exposure before reaction was 1.5 days (IQR 1–11) in children and 1 day (IQR 1–1) in adults. Anaphylaxis (50.0%) and cutaneous manifestations (42.9%) were the most common reactions. Of the 28 patients, 5 (17.9%) had known food allergies and experienced hypersensitivity to ILE. Among all patients, 4 of 6 (66.7%) who underwent skin testing had negative results; however, 3 of these 4 reacted upon ILE rechallenge. ILE-associated hypersensitivity reactions can occur in both food-allergic and non–food-allergic patients, particularly within the first day of administration. Skin testing for ILE allergy has limited reliability, and diagnostic confirmation is uncommon due to the lack of a standardized allergy evaluation. Individualized risk assessment and selective use of lipid formulations are essential to minimize risk. ILE rechallenge should be performed under the supervision of an immunologist. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-Restricted Eating, Cardiometabolic Health in Obesity and The Optimal Length of the Eating Window.","authors":"Bianca Monteiro Silva, Gabriela Geraldo Benzoni, Marcela Coffacci de Lima Viliod, Caroline Fogagnolo, Gabriela Ferreira Abud, Gabriela Ueta Ortiz, Ivo Vieira de Sousa Neto, Ana Cláudia Rossini-Venturini, Sofia Germano Travieso, Ellen Cristini de Freitas","doi":"10.1007/s13668-026-00742-8","DOIUrl":"10.1007/s13668-026-00742-8","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: This narrative review aims to evaluate how the duration of eating windows influences the cardiometabolic effects of Time-Restricted Eating (TRE) protocols among individuals with obesity. In the context of the global obesity epidemic, TRE has emerged as a promising dietary approach, alternative to conventional energy restriction, capable of improving cardiometabolic health by aligning food intake with circadian rhythms. However, due to the heterogeneity across TRE protocols, the impact of eating windows length on these outcomes remains uncertain. Therefore, this review comprehensively analyzes clinical trials assessing cardiometabolic responses across various durations of eating windows to identify which protocol may provide the greatest benefits. RECENT FINDINGS: Short eating windows (4–6 h), although associated with promising metabolic outcomes, often exhibit poor adherence due to increased hunger, fatigue and social constraints, limiting their long-term viability. Moderate eating windows (8–10 h) appear to offer the optimal balance between metabolic benefits, minimal adverse effects and adherence. Long eating windows (12–14 h), despite higher adherence, provide limited metabolic outcomes and are frequently associated with circadian misalignment, potentially increasing the risk of obesity and related metabolic disorders. All the data mentioned were obtained from clinical trials. TRE has evolved as a promising strategy to enhance cardiometabolic health, especially in individuals with obesity. Eating windows of 8-10h appear to represent the most sustainable TRE protocol, balancing metabolic efficacy with adherence. Nevertheless, further well-designed, long-term randomized controlled trials incorporating chrononutritional assessments are required to establish the optimal eating window for maximizing health outcomes in obesity. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Circadian Composition of Breast Milk: A Natural Starting Point for Chrononutrition.","authors":"Sena Aksu, Sabriye Arslan","doi":"10.1007/s13668-026-00749-1","DOIUrl":"10.1007/s13668-026-00749-1","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Breast milk is a highly bioavailable biological fluid that provides all essential fluids, macro and micronutrients, growth factors, and bioactive substances necessary for optimal growth and development of infants. Chrononutrition is a concept that examines the effects of the timing of food intake on physiological rhythms. This review aims to summarize current evidence on the circadian composition of breast milk and its potential implications for infant chrononutrition and early-life metabolic programming. RECENT FINDINGS: Fluctuations in the composition of breast milk across a 24-hour period, particularly the variations between night and day milk, and infants’ consumption of milk with this changing composition, contribute to breast milk being considered a form of chrononutrition. Thus, infants affected by signals from their mothers during the prenatal period continue to regulate their circadian rhythms by connecting with their mothers after birth. The circadian variation in breast milk is best characterized by higher concentrations of melatonin and tryptophan in night milk and elevated cortisol levels in day milk. Beyond these neuroendocrine factors, the concentrations of macro and micronutrients and immunological components have also been shown to exhibit diurnal fluctuations. These chrononutritional properties of breast milk may contribute to the regulation of infants’ sleep-wake cycles and support growth and development. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fruit- and Vegetable-Based Food Bars for Children with Stunting: a Narrative Review of Formulation and Nutritional Adequacy.","authors":"Lu Ying Khoo, Azrina Azlan","doi":"10.1007/s13668-026-00738-4","DOIUrl":"10.1007/s13668-026-00738-4","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Fruits and vegetables are key sources of dietary fibre, which is essential for children with stunting whose altered gut microbiota requires adequate fibre to support catch-up growth and maintain gastrointestinal health. However, children with stunting often fail to meet recommended intake levels due to limited accessibility, high cost, and perishability. Food bars provide a convenient, shelf-stable alternative for delivering these nutrients, enabling the inclusion of protein- and energy-rich ingredients to address nutritional deficiencies. This review aims to compile and summarise existing fruit- and vegetable-based food bars that meet the energy (~ 367 kcal/100 g) and protein (≥ 8.8 g/100 g) requirements for children with stunting aged 4–6 years, focusing on formulation strategies, ingredient selection, and nutrient composition. RECENT FINDINGS: Are limited, with only two fruit bars and one vegetable bar identified that meet these nutritional requirements, using single-factor or factorial designs. Bars typically contained a lower proportion of fruits and vegetables (17.8–60%) and were complemented with protein- or fat-rich ingredients, such as legumes, nuts, seeds, or milk powder, to ensure adequate nutrition. Converting these ingredients into bar form, along with the addition of energy- and protein-dense components, did not diminish dietary fiber content while providing the required energy and protein for children with stunting. Ingredient interactions substantially influence the nutritional composition of food bars. Even when similar ingredients are used, varying proportions may produce products that fail to meet target energy and protein requirements. This inconsistency reflects a reliance on traditional trial-and-error designs, which are inadequate for developing bars with predefined nutritional specifications for children with stunted growth. Structured, optimization-based formulation approaches are therefore needed to ensure consistent nutrient profiles. Nonetheless, when adequately formulated, fruit- and vegetable-based bars designed to be energy- and protein-dense remain a promising option to improve dietary intake among children with stunting. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Microbiome Modulation: Exploring Lactobacillus spp. as A Targeted Strategy for Type 2 Diabetes Management.","authors":"Ann Sze Cheah, Ji Wei Tan, Faizul Jaafar, Wendy Wai Yeng Yeo","doi":"10.1007/s13668-026-00739-3","DOIUrl":"10.1007/s13668-026-00739-3","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: The International Diabetes Federation projects a prevalence of 783.2 million cases of type 2 diabetes mellitus (T2DM) by 2045. The escalation in healthcare expenditure and adverse effects of current drugs necessitate a clinically effective and low-cost alternative therapeutic option with minimal health complications. Lactobacillus spp., a well-studied gut probiotic has shown promising antidiabetic effects against T2DM in several randomized controlled trials. However, the exact mechanisms of Lactobacillus spp. in regulating the glycaemic profile are not well elucidated, limiting the optimization of probiotic-based interventions. Therefore, this paper aims to explore the various antidiabetic mechanisms of Lactobacillus spp., with a focus on their integration into precision medicine approaches. RECENT FINDINGS: Lactobacillus spp. supplementation alleviates insulin resistance in T2DM by modulating glucose metabolism and transport, exerting anti-inflammatory and anti-oxidative effects as well as restructuring gut microbiota. Lactobacillus spp. also enhance the functional properties of food by increasing the antioxidant capacity and improving glucose metabolism. Despite these promising effects, clinical translation is challenged by strain-specific survivability in the gastrointestinal tract and safety concerns. Thus, leveraging precision medicine via tailoring treatments based on individual microbiome profiles, genetic backgrounds and metabolic phenotype may unravel the full therapeutic potential of targeted Lactobacillus spp. for T2DM treatment. This approach can be reached by integrating multi-omics profiling and artificial intelligence technologies. Lactobacillus spp. may act as adjunctive support in the management T2DM rather than stand-alone therapies in T2DM management, as their efficacy is dependent on appropriate dietary interventions and metabolic context. Altogether, integrating Lactobacillus spp. into personalized treatment frameworks offers a promising avenue for developing more targeted, effective and safe interventions for T2DM. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12960364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}