{"title":"Important Nutritional Concepts and Recommendations at the Level of Medical School Education.","authors":"Heidi Benavides, Rebecca Busch, Camille Liston, Zaid Mahmood, Scout Openshaw, Sonali Palchaudhuri, Akash Pandey, Danielle Wood, Jason Rocha","doi":"10.1007/s13668-025-00648-x","DOIUrl":"https://doi.org/10.1007/s13668-025-00648-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of the review is to share experiential recommendations to improve nutrition education for medical students. The review examines the history and the current state of nutrition education in order to identify opportunities to strengthen medical provider nutrition knowledge. Methods currently in use by medical school educators are highlighted to promote wellness and prevent development of chronic disease. Lastly, strategies and resources are described to integrate fundamental nutrition concepts into medical school education.</p><p><strong>Recent findings: </strong>Several surveys reveal that most U.S. medical students and residents feel underprepared to address patient nutrition and lifestyle concerns. Innovative programs such as culinary medicine, hands-on cooking electives, and modules on motivational interviewing show promise in improving students' competence and confidence. There is a lack of guidance from nutrition experts on how to improve medical school education by incorporating nutrition. A growing number of experts agree that medical school curricula should include more comprehensive nutrition content to prepare future physicians for addressing chronic diseases. Structured learning modules, enrichment electives, real-world community involvement, and interdisciplinary approaches can enhance evidence-based dietary counseling skills in medical trainees.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"59"},"PeriodicalIF":4.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Impact of Cold Plasma and Plasma-Activated Water on Germination of Grains and Legumes for Enhanced Nutritional Value.","authors":"Narmela Asefi, Rakesh K Singh","doi":"10.1007/s13668-025-00643-2","DOIUrl":"https://doi.org/10.1007/s13668-025-00643-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Sprouts are valued for their rich nutritional profile, fresh taste, and ease of production. As consumer demand for healthier foods increases, innovative methods are needed to enhance sprout quality. Cold Plasma (CP) and Plasma-Activated Water (PAW) have emerged as promising, sustainable technologies in agriculture, particularly for improving seed germination and plant growth.</p><p><strong>Recent findings: </strong>CP and PAW influence plant hormonal activity, improve water uptake, and modify seed coats, leading to enhanced sprout quality. These technologies impact bioactive compounds such as proteins, carbohydrates, enzymes, polyphenols, Gamma-Aminobutyric Acid, and antioxidants, which promote seed growth and alter the nutritional and functional properties of sprouts. PAW, with its unique chemical properties, acidifies the environment, modifies redox potential, and produces reactive oxygen and nitrogen species, which are essential for metabolic pathways in seed germination. Researchers are addressing challenges like discoloration, surface etching, and bioactive material degradation to optimize PAW applications in sprout production. CP and PAW offer cost-effective and eco-friendly solutions for improving sprout quality by stimulating seed germination and growth. Their effects on bioactive compounds and metabolic pathways make them valuable tools in modern agriculture. However, optimizing their application is crucial to maximizing benefits while minimizing potential drawbacks. Further research is needed to refine these technologies for commercial sprout production.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"57"},"PeriodicalIF":4.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fiona H McKay, Bolanle Racheal Olajide, Lisa J Melleuish, Penelope Pitt, Eric Hy Lau, Matthew Dunn
{"title":"Food Insecurity Among Post-Secondary Students in High Income Countries: Systematic Review and Meta-Analysis.","authors":"Fiona H McKay, Bolanle Racheal Olajide, Lisa J Melleuish, Penelope Pitt, Eric Hy Lau, Matthew Dunn","doi":"10.1007/s13668-025-00651-2","DOIUrl":"https://doi.org/10.1007/s13668-025-00651-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Food insecurity has recently emerged as a growing problem among students attending post-secondary institutions in high income countries, where it is associated with poorer health outcomes and poorer academic performance. The aim of this systematic literature review and meta-analysis is to synthesize evidence from published studies describing the prevalence of food insecurity among students in post-secondary educational institutions. A broad search was employed to identify any studies related to food security among post-secondary students in high income countries (PROSPERO identifier: CRD42023468944). Four electronic databases were systematically searched: Medline, CINAHL, Global Health, and Embase, in November 2023. Key thematic areas searched were food insecurity and education; no temporal limitations were placed on the search. Only English language peer-reviewed articles were considered. Four authors independently reviewed all articles to identify relevant studies.</p><p><strong>Recent findings: </strong>156 studies are included in this review. Sample sizes ranged from 10 to 122,269 participants (total participants 743,075; 409,047 women) with a median of 4764. Most studies were based in the USA (n = 139, 88%), and most were cross-sectional (n = 131, 84%). All articles were published after 2009, with more than three-quarters (n = 121, 77.5%) published after 2020. One hundred (64%) studies reported the mean age of participants; across these studies the average age was 22.4 years (range 18 to 78 years). Almost all studies employed one form of the USDA household food security survey module. Food insecurity across the whole sample ranged from 11.8 to 98%, the pooled estimate for food insecurity was 42.2%, (95% CI = 38.8-45.8%). Our findings show that a high proportion of students attending post-secondary institutions experience food insecurity, potentially leading to both poorer academic and health outcomes.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"58"},"PeriodicalIF":4.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Baris Afsar, Rengin Elsurer Afsar, Yasar Caliskan, Krista L Lentine
{"title":"The Role of Adiposity and Anthropometrics on Disease Progression in Autosomal Dominant Polycystic Kidney Disease: A Narrative Review.","authors":"Baris Afsar, Rengin Elsurer Afsar, Yasar Caliskan, Krista L Lentine","doi":"10.1007/s13668-025-00650-3","DOIUrl":"https://doi.org/10.1007/s13668-025-00650-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by numerous cysts in kidneys and other organs which enlarge and cause organ dysfunction, with kidney involvement being the most common. Recently, increased body mass index, and adiposity have been associated with disease progression. In this review, we summarized the available literature on anthropometrics (body mass index, waist circumference, weight to hip ratio and visceral adipose tissue and their relationship with ADPKD progression.</p><p><strong>Recent findings: </strong>Although the mechanisms are not clear, various pathological processes and signaling pathways are aberrantly activated with increased adiposity in patients with ADPKD. These alterations may result in glomerular hyperfiltration, chronic inflammation, aberrant signaling, and metabolic alterations which cause disease progression in ADPKD. Although increased adiposity may be associated with ADPKD progression, the best anthropometric parameter related to disease progression is not known. Losing weight in overweight and obese individuals with ADPKD is probably beneficial but the type of diet (daily caloric restriction, intermittent fasting etc.) that is most effective needs to be clarified. Moreover, caution is warranted during weight loss, as caloric restriction may cause malnutrition.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"56"},"PeriodicalIF":4.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcia Ribeiro, Livia Alvarenga, Ludmila F M F Cardozo, Beatriz G Baptista, Danielle Nascimento, Marta Esgalhado, Denise Mafra
{"title":"Urolithin as a Metabolite of Ellagitannins and Ellagic Acid from Fruits and Nuts Produced by the Gut Microbiota: Its Role on Non-Communicable Diseases.","authors":"Marcia Ribeiro, Livia Alvarenga, Ludmila F M F Cardozo, Beatriz G Baptista, Danielle Nascimento, Marta Esgalhado, Denise Mafra","doi":"10.1007/s13668-025-00645-0","DOIUrl":"https://doi.org/10.1007/s13668-025-00645-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>This narrative review investigates how urolithins produced by the gut microbiota can regulate transcription factors (such as NRF2, NF-kB, and PPAR-γ) associated with senescence, inflammation, and imbalanced redox status. It also discusses the potential benefits of urolithins for patients with chronic diseases, including cardiovascular disease, cancer, diabetes, obesity, and chronic kidney disease.</p><p><strong>Recent findings: </strong>Studies have shown that urolithins have many health benefits, including anti-inflammatory, antioxidant, antimicrobial, and anti-atherosclerotic effects. They are also linked to improved mitochondrial function and imbalanced redox associated with activating the Nrf2/ARE pathway. Urolithins are metabolites produced by gut microbiota from ellagic acid and ellagitannins, polyphenols primarily found in nuts and fruits, including pomegranates and berries like raspberries, cloudberries, and blackberries.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"55"},"PeriodicalIF":4.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yash Patel, Osman Mohamed Elfadil, Suhena Patel, Omar M Ghanem, Ryan T Hurt, Manpreet S Mundi
{"title":"Rediscovering Sweetness: The Evolution and Impact of Non-Nutritive and Natural Sweeteners.","authors":"Yash Patel, Osman Mohamed Elfadil, Suhena Patel, Omar M Ghanem, Ryan T Hurt, Manpreet S Mundi","doi":"10.1007/s13668-025-00646-z","DOIUrl":"10.1007/s13668-025-00646-z","url":null,"abstract":"<p><strong>Purpose of the review: </strong>The escalating incidence of obesity and metabolic syndromes has catalyzed a critical evaluation of dietary sugars, leading to an increased interest in non-nutritive and natural sweeteners as viable alternatives. This manuscript reviews the historical developments, safety profiles, and health-related consequences of these sweeteners, tracing the evolution from early discoveries such as saccharin and cyclamate to contemporary compounds like aspartame, sucralose, and plant-derived sweeteners.</p><p><strong>Recent findings: </strong>We explore the physiological mechanisms underpinning sweet taste perception, including the roles of T1R and T2R receptors, and the neurochemical pathways involving dopamine in mediating the rewarding effects of sugar consumption. The review underscores the adverse health impacts associated with excessive intake of added sugars, which correlate positively with conditions such as obesity, type 2 diabetes, and cardiovascular diseases. Attention is given to the contrasting profiles of non-nutritive sweeteners and natural sweetener alternatives, with an emphasis on emerging concerns regarding the safety and long-term ramifications of synthetic sweeteners. The regulatory context surrounding the approval and utilization of sweeteners varies significantly across different jurisdictions, warranting careful consideration. As consumer inclination shifts towards healthier dietary choices, a nuanced understanding of the implications of sweetener selection on public health is imperative.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"54"},"PeriodicalIF":4.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pauline Dacaya, Katerina Sarapis, George Moschonis
{"title":"The Role and Mechanisms of Probiotic Supplementation on Depressive Symptoms: A Narrative Review.","authors":"Pauline Dacaya, Katerina Sarapis, George Moschonis","doi":"10.1007/s13668-025-00644-1","DOIUrl":"10.1007/s13668-025-00644-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>The microbiota-gut-brain-axis (MGBA) plays a role in the aetiology of mental disorders. Depression, a leading cause of disability worldwide, may be improved by probiotics. The aim of this narrative review is to investigate and synthesize the current evidence linking probiotic food supplementation with depressive symptomology.</p><p><strong>Recent findings: </strong>The gut and the brain communicate and interact via the MGBA through inflammation and the immune system, short chain fatty acid production, neuronal innervation and activation as well as endocrine and neurotransmitter modulation. Dysregulation of gut-brain pathways are caused by gut dysbiosis and implicated in the onset, persistence and exacerbation of depression related symptoms. Modulation of the gut microbiota via administration of probiotics has shown to reduce depressive symptom severity with Bifidobacterium and Lactobacillus strains being the most reported. Probiotics may produce greater benefits in mild depression rather than in chronic, treatment resistant depression. Probiotic supplementation is a promising and safe approach for the prevention of severe depressive disorders in high-risk individuals such as people with subthreshold depression. However, the mechanistic pathways of the MGBA require further investigation and additional human clinical trials are necessary to evaluate the role of probiotics on depression.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"53"},"PeriodicalIF":4.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Do the Health Benefits of the Mediterranean Diet Increase with a Higher Proportion of Whole Plant-Based Foods?","authors":"Miguel López-Moreno, Ujué Fresán","doi":"10.1007/s13668-025-00647-y","DOIUrl":"https://doi.org/10.1007/s13668-025-00647-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to explore the potential health effects of increasing the proportion of whole plant-based foods within a Mediterranean diet (MedDiet), summarize the available evidence, and provide recommendations for future research on this topic.</p><p><strong>Recent findings: </strong>Replacing animal-based foods by whole plant-based foods may enhance the health benefits of diets. Beyond evidence on individual food substitutions, an emerging body of literature points out that adopting a plant-forward Mediterranean diet may further amplify the positive health effects of the overall dietary pattern. Additionally, although the MedDiet is recognized as an environmentally sustainable pattern, a fully plant-based version could further reduce its environmental impact and resource use compared to an omnivorous diet. The MedDiet is widely recognized for its health benefits, particularly in the prevention of cardiovascular diseases and other chronic conditions. These benefits are largely attributed to its emphasis on whole, plant-based foods. Although evidence is limited, current findings suggest that reducing the animal-based content of the traditional MedDiet, along with the increase in whole plant-based food, could lead to enhanced health benefits. Furthermore, the reduction in environmental pollution and resources overused could contribute to broader public health and sustainability. Long-term randomized controlled trials are needed to confirm these findings and provide a more comprehensive understanding of the comparative health effects of these dietary patterns.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"52"},"PeriodicalIF":4.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mara E Storto, Suzanne M Bailey-Straebler, Leah C Susser
{"title":"Exploring the Relationship Between Eating Disorders and Reproductive Health, with a Focus on Fertility, Obstetric, and Fetal Outcomes: A Narrative Review.","authors":"Mara E Storto, Suzanne M Bailey-Straebler, Leah C Susser","doi":"10.1007/s13668-025-00641-4","DOIUrl":"https://doi.org/10.1007/s13668-025-00641-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Eating disorders can profoundly impact reproductive health in females, spanning from the onset of puberty through menopause. The impact is due to a variety of factors, including nutritional status, body fat percentage, and hormone regulation. Notably, fertility and pregnancy are particularly vulnerable to undernutrition and disordered eating. This narrative review provides a comprehensive summary and discussion of available literature from the past 5 years exploring the impact of eating disorders on fertility, obstetric outcomes, and fetal outcomes.</p><p><strong>Recent findings: </strong>Current literature demonstrates that EDs can have a negative impact on fertility, obstetric outcomes, and fetal outcomes. Primary research and systematic reviews support associations including increased use of assisted reproductive treatment for infertility, anemia and hyperemesis during pregnancy, and preterm delivery. Associated fetal outcomes include infant low birth weight, small for gestational age, and microcephaly. EDs, when unrecognized and left untreated, can negatively impact fertility, obstetric outcomes, and fetal outcomes. It is important for providers to be aware of these associations and implement screening to identify at-risk patients, as appropriate treatment can improve reproductive outcomes.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"51"},"PeriodicalIF":4.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review of the Clinical and Epidemiologic Evidence Relevant to the Impact of Postdiagnosis Isoflavone Intake on Breast Cancer Outcomes.","authors":"Mark Messina, Sarah Nechuta","doi":"10.1007/s13668-025-00640-5","DOIUrl":"10.1007/s13668-025-00640-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>This narrative review aims to determine the impact of postdiagnosis isoflavone intake, via supplements and foods, on breast cancer outcomes. Foods derived from soybeans are uniquely rich sources of isoflavones, naturally occurring compounds that can bind to estrogen receptors although the extent to which they exert estrogen-like effects in humans is unclear. Isoflavones have been rigorously investigated for a wide range of health benefits including breast cancer prevention. However, their classification as phytoestrogens has led to concern that isoflavones and hence, soy food consumption, could worsen the prognosis of women with breast cancer and interfere with the efficacy of endocrine therapy for this disease.</p><p><strong>Recent findings: </strong>Research in athymic ovariectomized mice shows isoflavones stimulate the growth of existing estrogen-sensitive mammary tumors. However, extensive clinical research indicates that neither soy foods nor isolated isoflavones affect markers of breast cancer risk including mammographic density and breast cell proliferation. No effects are observed even when isoflavone exposure greatly exceeds typical intake in Asian countries. Furthermore, the results from epidemiologic studies indicate postdiagnosis isoflavone intake from soy foods reduces recurrence and possibly mortality from breast cancer. Additionally, the limited observational data do not show that isoflavones interfere with the efficacy of tamoxifen or aromatase inhibitors. Regardless of their treatment status, evidence indicates that women with breast cancer can safely consume soy foods. Limiting intake to no more than two servings of traditional Asian soy foods daily, an amount that provides approximately 50 mg isoflavones, is recommended, not because data indicate exceeding this amount is harmful, but because few population-based studies involved participants consuming more than this intake recommendation.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"50"},"PeriodicalIF":4.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}