Current Nutrition Reports最新文献

{"title":"Evidence-Based Supplementation Strategies for Wrestlers: A Systematic Review.","authors":"Michelle Coutiño Díaz, Arnold Prieto Martínez, Reza Zare, Ali Ali Redha, Scott C Forbes","doi":"10.1007/s13668-025-00672-x","DOIUrl":"https://doi.org/10.1007/s13668-025-00672-x","url":null,"abstract":"<p><strong>Background: </strong>Wrestling is a popular combat sport that requires muscular strength, power, agility, and endurance. Weight classes have motivated wrestlers to compete at a lower weight to optimise power-to-weight ratio and performance. To achieve these characteristics, athletes may use dietary supplements, however, their efficacy in wrestlers has not been systematically evaluated.</p><p><strong>Objective: </strong>The purpose was to systematically review the literature to determine the efficacy of dietary supplements to improve body composition, physiological status, and performance in wrestlers.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, ProQuest Medline, Web of Science, Cochrane Library, and Scopus on the 21st of January 2024 and updated on the 6th of January 2025. Studies were included if the participants were healthy wrestlers ingesting any type of dietary supplement in comparison to a control. Data associated with intervention type and characteristics, target populations, outcomes, and analysis methods were extracted.</p><p><strong>Results: </strong>A total of 24 eligible original articles were included that assessed various supplementation strategies on body composition, exercise performance, and metabolic markers in wrestlers. Individual studies revealed significant effects of sodium citrate, creatine monohydrate, spirulina, green tea and oolong tea extracts, and branched-chain amino acids on body mass or composition. β-Hydroxy-β-methylbutyrate (HMB-FA), creatine monohydrate, and iron supplementation improved recovery and may improve exercise performance. Beet-root juice supplementation enhanced muscular strength and balance. BCAA supplementation produced mixed results on muscle damage biomarkers and performance, while sodium citrate, creatine, and spirulina can act as buffering agents. Thyme tea appears to improve antioxidant capacity.</p><p><strong>Conclusions: </strong>Overall, individual studies show some promise for several dietary supplements to alter body mass and body composition, improve exercise recovery and performance, delay fatigue, and modify serum biomarkers; nevertheless, effect sizes were often small, and results were often mixed.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"86"},"PeriodicalIF":4.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whey Protein Nutrition in Sports: Action Mechanisms and Gaps in Research.","authors":"Dong Pan, Zidong Zhang, Na Liu, Tolulope Joshua Ashaolu","doi":"10.1007/s13668-025-00673-w","DOIUrl":"10.1007/s13668-025-00673-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>Whey protein (WP) is recognized for its rapid digestibility and rich amino acid profile, making it a popular supplement among athletes. Several studies have shown scientific evidence surrounding the physiological effects of WP but important information on its mechanisms of action in exercise performance, recovery, and immune function, optimal dosage and timing, potential side effects/risks, and future directions are necessary.</p><p><strong>Recent findings: </strong>This review articulates WP's composition, types, function, and application, its mechanisms of action in exercise performance, recovery, and immune function, optimal dosage and timing, and potential side effects and risks. Moreover, future directions and gaps in research on WP nutrition in sports are carefully presented. More robust studies are warranted to optimize dosing and timing strategies in specific athletic populations, explore their genetic and metabolic variability, and assess the long-term safety of WP using novel and sustainable technologies. This will enable the scientific community to provide athletes with evidence-based, personalized, and sustainable nutrition strategies, ultimately enhancing performance and recovery.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"84"},"PeriodicalIF":4.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sifting Through the Noise: Identifying Core Fundamentals of Healthy Eating Early in the Life Cycle.","authors":"Diana Schnee, Christina DeTallo, Kadakkal Radhakrishnan, Senthilkumar Sankararaman","doi":"10.1007/s13668-025-00675-8","DOIUrl":"10.1007/s13668-025-00675-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>Optimal nutrition is important across all age groups. However, nutrition provision during early years of life is more crucial and any aberrations in this period could lead to long lasting consequences. The first 1000 days starting from conception to the second birthday is the period of maximum growth velocity and brain growth and suboptimal nutrition in this period should be avoided at all cost.</p><p><strong>Recent findings: </strong>Feeding and nutritional optimization in the early stages of life provides a critical window of opportunity. Implementation of nutritional interventions can be challenging in this age group due to multiple factors such increased nutritional needs, environmental circumstances, and feeding difficulties. Interventions should focus on improving maternal/fetal, infant, child, and adolescent nutrition so that every child can reach her or his full potential of growth and development. Interventions should be simple, sustainable, socio-culturally acceptable and should begin in the fetal period.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"85"},"PeriodicalIF":4.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolite Profiles in Response to Dietary Interventions for Management of Blood Pressure: A Systematic Review.","authors":"María Gómez-Martín, Floor Rikken, Erin D Clarke, Jordan Stanford, Jessica J A Ferguson, Clare E Collins","doi":"10.1007/s13668-025-00676-7","DOIUrl":"10.1007/s13668-025-00676-7","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a major global public health issue. The mechanisms through which diet influences blood pressure (BP) remain to be fully elucidated. Nutritional metabolomics offers an objective method for examining diet-health outcomes, including the contribution of intermediate molecules and metabolic byproducts or metabolites to BP regulation. To date, no review has investigated the relationship between diet, metabolites and BP regulation.</p><p><strong>Objective: </strong>This systematic review aim was to synthesise findings of human dietary intervention studies on BP, including feeding studies providing all foods and meals, as well as those that provided supplements.</p><p><strong>Methods: </strong>Six databases were systematically searched (Scopus, Medline, Embase, CINAHL, PsycINFO, and Cochrane) for intervention studies examining the relationship between dietary metabolites and BP regulation. The Academy of Nutrition and Dietetics Quality Criteria were used to assess the risk of bias.</p><p><strong>Results: </strong>Twelve articles (11 unique studies) met the inclusion criteria, reporting 11 significant associations between metabolites and BP, while one study found no significant associations. More than 100 metabolites were associated with BP, 40 associated with SBP, 29 with DBP, 31 with both, and 2 did not differentiate between SBP or DBP. Only two metabolites, proline-betaine and N-acetylneuraminate, had significant relationships with BP measurement in more than one study.</p><p><strong>Conclusions: </strong>This review identified a shortlist of potential metabolite indicators of response to dietary interventions for BP regulation. Findings highlight nutritional metabolomics as a potential contributor to understanding diet-induced changes in BP and CVD risk reduction. However, variability in reported metabolites and limited replication across studies may affect specificity and limit generalizability. Further research is needed to better understand this relationship.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"82"},"PeriodicalIF":4.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing Sedatic Hunger: Eating To Survive, Not to Savor.","authors":"Sedat Arslan, Hande Öngün Yilmaz, Emre Ciydem","doi":"10.1007/s13668-025-00677-6","DOIUrl":"10.1007/s13668-025-00677-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review introduces Sedatic Hunger as a distinct and underexplored form of hunger. Unlike physiological or hedonic hunger, Sedatic Hunger refers to a neutral, function-oriented motivation to eat-driven by biological need without the pursuit of taste, pleasure, or emotional satisfaction. The purpose of this review is to conceptualize Sedatic Hunger, differentiate it from other hunger types, and highlight its clinical and societal relevance.</p><p><strong>Recent findings: </strong>Emerging clinical observations suggest that individuals with depression, restrictive dietary habits, or those under chronic stress may experience Sedatic Hunger. These individuals consume food purely for energy, with limited sensory or emotional engagement. The article outlines preliminary efforts to develop the Sedatic Hunger Scale (SHS) to assess this construct, aiming to quantify how biological, psychological, and cultural factors intersect in this form of eating behavior. Sedatic Hunger expands our understanding of human motivations for eating by focusing on biologically driven but emotionally neutral food intake. Its recognition may improve approaches in mental health, dietary counseling, and nutrition science. Future research directions include identifying biological markers, evaluating the effects of sensory deprivation, and exploring cross-cultural differences in the manifestation of Sedatic Hunger.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"83"},"PeriodicalIF":4.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-Based Diet and Risk of Iron-deficiency Anemia. A Review of the Current Evidence and Implications for Preventive Strategies.","authors":"Miguel López-Moreno, Adrián Castillo-García, Alberto Roldán-Ruiz, Isabel Viña, Gabriele Bertotti","doi":"10.1007/s13668-025-00671-y","DOIUrl":"10.1007/s13668-025-00671-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review provides a comprehensive overview of iron metabolism, emphasizing the influence of dietary patterns-particularly vegetarian and vegan diets-on iron status and associated health outcomes.</p><p><strong>Recent findings: </strong>Concerns regarding iron deficiency anemia in individuals following plant-based diets necessitate a deeper comprehension of the factors affecting iron bioavailability and absorption. Non-heme iron, which is more abundant in plant-based sources, poses challenges about its lower bioavailability and this could contribute to an increased risk of anemia in these populations. However, recent studies challenge this assumption, revealing a more complex relationship between plant-based nutrition and iron status. Additionally, emerging evidence suggests that the potential association between red meat consumption and cancer may be partially mediated by the high intake of heme iron. This review highlights the complex dynamics of dietary iron in vegetarian and vegan diets, which, despite offering less bioavailable iron, often surpass the intake levels of omnivorous diets. The potential involvement of adaptive physiological mechanisms suggests variability in non-heme iron absorption to meet nutritional requirements. While well-planned plant-based diets can be nutritionally adequate, further research is needed to better understand their long-term effects on iron metabolism.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"81"},"PeriodicalIF":4.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Galangin for the Treatment of Alzheimer's Disease: Journey So Far and Road Ahead.","authors":"Prince Sharma, Tripti Sharma, Bushra Bashir, Nandani Andotra, Ankit Awasthi, Priya Patel, Vetriselvan Subramaniyan, Dinesh Kumar Chellappan, Gaurav Gupta, Sukriti Vishwas, Sachin Kumar Singh","doi":"10.1007/s13668-025-00669-6","DOIUrl":"https://doi.org/10.1007/s13668-025-00669-6","url":null,"abstract":"","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"80"},"PeriodicalIF":4.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chrononutrition and Gut Health: Exploring the Relationship Between Meal Timing and the Gut Microbiome.","authors":"Priya Bajaj, Mahak Sharma","doi":"10.1007/s13668-025-00670-z","DOIUrl":"https://doi.org/10.1007/s13668-025-00670-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review explores the relationship between circadian rhythms and meal timing, or chrononutrition, and how it affects gut health. Since the gut microbiota plays a critical role in immunological response, metabolic control, and digestion, it is critical to comprehend how circadian misalignment impacts gut microbial equilibrium. This review examines research from the last ten years to assess the effects of circadian rhythm disturbances and meal time variations on the composition of the gut microbiota, the integrity of the gut barrier, and metabolic consequences.</p><p><strong>Recent findings: </strong>Using search terms like \"Chrononutrition AND Gut health,\" \"Circadian Rhythm AND Meal timing,\" and similar combinations, 31 peer-reviewed publications from PubMed, Google Scholar, and Scopus were included. There is evidence that circadian misalignment, which can be brought on by shift work, irregular eating habits, or social jet lag, affects lipid metabolism, short-chain fatty acid (SCFA) synthesis, and gut microbial rhythms. According to research, microbial diversity and function are enhanced by early-time-restricted feeding (eTRF), which synchronizes with circadian cycles. Changes in tight junction proteins have been linked to irregular meal timing, which increases intestinal permeability and inflammation. Additionally, new research indicates a bidirectional relationship in which the gut bacteria might affect the central and peripheral circadian clocks. Chrononutrition is a promising non-pharmacological approach to preventing metabolic dysregulation and promoting gut health. Consistently timing meals, especially early-time-restricted feeding, can help maintain microbial balance, improve gut barrier function, and lower the risk of chronic diseases by bringing food intake into alignment with circadian cycles. The need for integrated approaches to food and lifestyle changes in future research and clinical practice is highlighted by the bidirectional relationship between the gut microbiota and circadian systems.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"79"},"PeriodicalIF":4.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review about Metabolic Pathways, Molecular Mechanisms and Clinical Implications of Intermittent Fasting as Autophagy Promotor.","authors":"Álvaro Andrés Vergara Nieto, Andrés Halabi Diaz, Millaray Hernández, Daniel Sagredo","doi":"10.1007/s13668-025-00666-9","DOIUrl":"https://doi.org/10.1007/s13668-025-00666-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>This research aims to elucidate the molecular mechanisms by which intermittent fasting (IF) induces autophagy and to evaluate its therapeutic potential across a range of pathologies. By synthesizing findings from preclinical and clinical studies, the review seeks to clarify the roles of key signaling pathways-such as the AMPK-mTOR axis, sirtuins, and β-hydroxybutyrate-mediated signaling-in orchestrating autophagic processes, thereby enhancing cellular resilience and metabolic homeostasis.</p><p><strong>Recent findings: </strong>Recent evidence demonstrates that IF robustly activates autophagy in metabolically active tissues through conserved molecular pathways. Experimental studies reveal that fasting increases AMPK phosphorylation and inhibits mTOR activity, leading to enhanced expression of autophagy markers like LC3-II, Beclin-1, and ATG proteins. Additionally, IF has been shown to improve insulin sensitivity, reduce hepatic lipid accumulation, and mitigate neurodegenerative processes by promoting the clearance of toxic protein aggregates. Emerging clinical data further support these findings, indicating that tailored fasting protocols can modulate autophagy to yield benefits in metabolic, oncological, and neurodegenerative disorders. The scoped literature underscores IF as a promising non-pharmacological strategy to induce autophagy and improve overall health. While robust preclinical and clinical evidence supports its beneficial effects, challenges remain in standardizing fasting protocols and identifying optimal biomarkers for monitoring autophagic activity. Future research should focus on long-term, well-controlled trials and combined therapeutic approaches to refine IF strategies, ultimately translating these insights into personalized dietary interventions for disease prevention and health optimization.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"78"},"PeriodicalIF":4.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D and Neurodegenerative Diseases Such as Multiple Sclerosis (MS), Parkinson's Disease (PD), Alzheimer's Disease (AD), and Amyotrophic Lateral Sclerosis (ALS): A Review of Current Literature.","authors":"Zehra Savran, Saltuk Bugra Baltaci, Tugce Aladag, Rasim Mogulkoc, Abdulkerim Kasim Baltaci","doi":"10.1007/s13668-025-00663-y","DOIUrl":"10.1007/s13668-025-00663-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review explores the role of Vitamin D3 and its derivatives as inhibitors of pathological metabolic modifications in neurodegenerative diseases. The manuscript investigates how Vitamin D3 impacts neuronal calcium regulation, antioxidative pathways, immunomodulation, and neuroprotection during detoxification, beyond its known functions in intestinal, bone, and kidney calcium and phosphorus absorption, as well as bone mineralization.</p><p><strong>Recent findings: </strong>Recent studies have highlighted the synthesis of the active metabolite 1,25(OH)2D3 (vitamin D) in glial cells via the hydroxylation process of CY-P24A1, an enzyme in the cytochrome P450 system in the brain. The effects of vitamin D occur through the vitamin D receptor (VDR), a nuclear steroid receptor, which has been identified in various brain regions, including the cerebellum, thalamus, hypothalamus, basal ganglia, hippocampus, olfactory system, temporal, and orbital regions. Neurodegeneration is primarily associated with oxidative stress, protein aggregation, neuroinflammation, mitochondrial dysfunction, apoptosis, and autophagy changes, all of which Vitamin D and VDR are believed to influence. Vitamin D and VDR are recognized as both environmental and genetic factors in the etiopathogenesis of neurodegenerative diseases such as Multiple Sclerosis (MS), Parkinson's Disease (PD), Alzheimer's Disease (AD), and Amyotrophic Lateral Sclerosis (ALS). A deficiency in Vitamin D is postulated to have detrimental effects on the brain and other diseases throughout various stages of life. This review consolidates findings from clinical and experimental studies, as well as past publications, focusing on the implications of Vitamin D deficiency in these neurodegenerative conditions. Current articles published in PubMed were extensively considered for this review.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"77"},"PeriodicalIF":4.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}