Association of Vitamins and their Interactions on Depression: A Review.

IF 5.5 3区医学 Q1 NUTRITION & DIETETICS

Current Nutrition Reports Pub Date : 2025-07-26 DOI:10.1007/s13668-025-00686-5

Neil Mistry, Logan T Cowan, Hani M Samawi, Amenah Qotineh, Kelly L Sullivan

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Abstract

Purpose of review: Depression is highly prevalent in the United States. Literature has investigated common demographic risk factors and pharmacological and non-pharmacological treatments. The effects of vitamins and their interactions on depression prevalence and symptoms has gained interest, especially in the context of a large representative sample. The review aims to evaluate the literature concerning individual vitamins and their association with depression.

Recent findings: Several observational studies have been conducted to determine the effects of individual vitamins on depression. These studies have conflicting results regarding the impact and magnitude of vitamin effects, and previous studies evaluating the effect of vitamin interactions on depression have limited generalizability. Despite pharmacologic and biological rationale supporting the potential role of vitamins in combating depression, results of studies evaluating vitamin intake and depression in humans are inconsistent and limited. Further research is needed to assess the link between nutrition and depression in robust populations, particularly in groups at risk for or suffering from depression.

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维生素与抑郁症的关系及其相互作用：综述。

综述目的：抑郁症在美国非常普遍。文献调查了常见的人口危险因素以及药物和非药物治疗。维生素及其相互作用对抑郁症患病率和症状的影响已经引起了人们的兴趣，特别是在一个具有代表性的大样本的背景下。这篇综述的目的是评估有关单个维生素及其与抑郁症的关系的文献。最近的发现：已经进行了几项观察性研究，以确定个别维生素对抑郁症的影响。这些研究在维生素作用的影响和程度方面有相互矛盾的结果，以前评估维生素相互作用对抑郁症影响的研究具有有限的普遍性。尽管药理学和生物学理论支持维生素在对抗抑郁症方面的潜在作用，但评估维生素摄入量和人类抑郁症的研究结果是不一致和有限的。需要进一步的研究来评估健康人群中营养与抑郁症之间的联系，特别是在有抑郁症风险或患有抑郁症的人群中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Nutrition Reports Agricultural and Biological Sciences-Food Science

CiteScore

7.70

自引率

2.00%

发文量

期刊介绍： This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.