Current Nutrition Reports最新文献

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Exploring Paraprobiotics and Postbiotics: A New Frontier in Obesity Treatment via Gut Microbiota Modulation. 探索副益生菌和后益生菌:通过调节肠道微生物群治疗肥胖的新前沿。
IF 8 3区 医学
Current Nutrition Reports Pub Date : 2026-01-04 DOI: 10.1007/s13668-025-00719-z
Seda Gezgin, Mustafa Dikme, Ecem Akan
{"title":"Exploring Paraprobiotics and Postbiotics: A New Frontier in Obesity Treatment via Gut Microbiota Modulation.","authors":"Seda Gezgin, Mustafa Dikme, Ecem Akan","doi":"10.1007/s13668-025-00719-z","DOIUrl":"10.1007/s13668-025-00719-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>Obesity remains a significant public health issue worldwide. This review aims to evaluate the potential of paraprobiotics (non-viable microbial cells) and postbiotics (metabolites and/or structural components derived from non-viable microorganisms) as novel therapeutic strategies for obesity treatment by modulating the gut microbiota. These agents offer a safer profile compared to live probiotics and can be used even in immunocompromised individuals.</p><p><strong>Recent findings: </strong>Paraprobiotics and postbiotics have been shown to exert beneficial effects on obesity by balancing the Firmicutes/Bacteroidetes ratio, enhancing short-chain fatty acid production, strengthening intestinal barrier integrity, and reducing chronic inflammation. Evidence from preclinical models and a limited number of human studies indicates that inactivated forms, particularly those derived from Lactobacillus and Akkermansia species, lead to improvements in metabolic parameters, fat mass, and body weight. Paraprobiotics and postbiotics emerge as promising complementary approaches in the management of obesity. However, translating this potential into clinical practice requires further large-scale randomized controlled human trials to confirm efficacy, establish optimal dosages, and ensure formulation stability.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"129"},"PeriodicalIF":8.0,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioactive Phytoconstituents Targeting Energy Expenditure and Appetite to Combat Obesity: A Comprehensive Review. 针对能量消耗和食欲的生物活性植物成分对抗肥胖:综合综述。
IF 8 3区 医学
Current Nutrition Reports Pub Date : 2026-01-03 DOI: 10.1007/s13668-025-00718-0
Gayatri Thapa, Pervej Alom Barbhuiya, Manash Pratim Pathak
{"title":"Bioactive Phytoconstituents Targeting Energy Expenditure and Appetite to Combat Obesity: A Comprehensive Review.","authors":"Gayatri Thapa, Pervej Alom Barbhuiya, Manash Pratim Pathak","doi":"10.1007/s13668-025-00718-0","DOIUrl":"10.1007/s13668-025-00718-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>Obesity has emerged as a worldwide health issue because of sedentary lifestyles, inadequate nutritional practices, and metabolic dysfunction. Traditional anti-obesity medications, although efficacious, often exhibit considerable adverse effects, resulting in their market removal. Consequently, there is increasing interest in natural phytoconstituents that may regulate obesity by influencing appetite, satiety, and energy expenditure via thermogenesis. This review emphasizes on various bioactive phytoconstituents that ameliorate obesity by modulating energy expenditure and appetite while also putting the focus on various reported mechanisms of the determined effect.</p><p><strong>Recent findings: </strong>Appetite and satiety are regulated by hypothalamic neurons (AgRP/NPY and POMC) and gastrointestinal hormones (ghrelin, CCK, GLP-1, PYY), with phytoconstituents such as celastrol, protopanaxadiol, hydroxycitric acid, naringenin, and β-sitosterol successfully inhibiting appetite via these mechanisms. Furthermore, thermogenic agents like capsaicin, gingerols, curcumin, caffeine, fucoxanthin, and resveratrol increase energy expenditure by stimulating brown adipose tissue (BAT), upregulating uncoupling protein 1 (UCP-1), and facilitating lipolysis. Certain phytoconstituents, such as β-caryophyllene and guggulsterone, demonstrate dual actions by suppressing hunger and enhancing thermogenesis. In comparison to traditional anti-obesity medications (e.g., phentermine, sibutramine, GLP-1 agonists), these natural alternatives have similar effectiveness with less side effects, establishing them as viable therapeutic choices for obesity treatment. This study emphasizes the efficacy of phytoconstituents in obesity management via hunger suppression and thermogenic stimulation. These natural substances provide a safer and more effective method for weight control by focusing on neuroendocrine signaling, mitochondrial uncoupling, and adipokine modulation. Future research must concentrate on clinical validation, increase of bioavailability, and synergistic combinations to maximize anti-obesity benefits.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":"1"},"PeriodicalIF":8.0,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Overview of the Importance of Muscle Health in Oncology: Assessment, Preservation, and Nutritional Recovery Strategies. 概述肿瘤中肌肉健康的重要性:评估、保存和营养恢复策略。
IF 8 3区 医学
Current Nutrition Reports Pub Date : 2025-12-29 DOI: 10.1007/s13668-025-00717-1
Larissa Farinha Maffini, Camilla Horn Soares, Amanda Guterres Beuren, Gabriel Tonin Ferrari, Heloisa Jacques Friedrich, Giovana Breitenbach Camargo, Giovanna Strapasson Faccin, Carolina Pagnoncelli Gabrielli, Giovanna Potrick Stefani, Viviani Ruffo de Oliveira, Thais Steemburgo
{"title":"An Overview of the Importance of Muscle Health in Oncology: Assessment, Preservation, and Nutritional Recovery Strategies.","authors":"Larissa Farinha Maffini, Camilla Horn Soares, Amanda Guterres Beuren, Gabriel Tonin Ferrari, Heloisa Jacques Friedrich, Giovana Breitenbach Camargo, Giovanna Strapasson Faccin, Carolina Pagnoncelli Gabrielli, Giovanna Potrick Stefani, Viviani Ruffo de Oliveira, Thais Steemburgo","doi":"10.1007/s13668-025-00717-1","DOIUrl":"10.1007/s13668-025-00717-1","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Muscle health plays a critical role in the overall prognosis and quality of life of patients with cancer. This review highlights the importance of maintaining skeletal muscle mass and function during cancer treatment and in survivors. It explores the mechanisms by which cancer and its therapies affect muscle and provides evidence-based strategies for assessing, preserving, and restoring muscle health. RECENT FINDINGS: Emerging research confirms that muscle loss is highly prevalent in patients with cancer and is associated with increased treatment toxicity, poorer survival, and reduced physical function. Advances in nutritional assessment tools, such as body composition analysis via imaging techniques (or anthropometric evaluations), allow for the early detection of muscle depletion. Recent studies support tailored nutritional interventions, especially protein optimization, omega-3 fatty acid supplementation, and others as key to preserving lean mass. Multimodal approaches combining nutrition with resistance exercise have shown promising outcomes for muscle recovery post-treatment. Preserving muscle health during cancer care is essential for improving treatment tolerance, recovery, and long-term outcomes. Comprehensive nutritional assessment should be integrated early into the cancer care continuum to improve patient outcomes. Personalized strategies that combine adequate protein intake, anti-inflammatory nutrients, and structured exercise interventions are effective in mitigating muscle loss. Ongoing research supports an interdisciplinary approach involving oncologists, registered dietitians, and physical therapists to optimize muscle preservation and enhance patient resilience throughout the cancer journey. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"130"},"PeriodicalIF":8.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145854938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Maternal Vitamin B12 Status and Supplementation on Child Neurodevelopment and Cognition: A Systematic Review. 母体维生素B12状态和补充对儿童神经发育和认知的影响:系统综述。
IF 8 3区 医学
Current Nutrition Reports Pub Date : 2025-12-20 DOI: 10.1007/s13668-025-00720-6
Dandara Baia Bonifácio, Francielle Barbosa Pena, Kelly Aparecida Dias, Lívia Carvalho Sette Abrantes, Lívya Alves Oliveira, Stephanie Michelin Santana Pereira, Thaís Cupertino Fialho, Valéria Silva de Lana, Susilane Pereira Araújo, Izabela Maria Montezano de Carvalho, Ceres Mattos Della Lucia
{"title":"Effect of Maternal Vitamin B<sub>12</sub> Status and Supplementation on Child Neurodevelopment and Cognition: A Systematic Review.","authors":"Dandara Baia Bonifácio, Francielle Barbosa Pena, Kelly Aparecida Dias, Lívia Carvalho Sette Abrantes, Lívya Alves Oliveira, Stephanie Michelin Santana Pereira, Thaís Cupertino Fialho, Valéria Silva de Lana, Susilane Pereira Araújo, Izabela Maria Montezano de Carvalho, Ceres Mattos Della Lucia","doi":"10.1007/s13668-025-00720-6","DOIUrl":"10.1007/s13668-025-00720-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to systematically evaluate clinical and observational studies that assessed the influence of maternal vitamin B<sub>12</sub> supplementation and status on child neurodevelopment and cognition. Vitamin B<sub>12</sub> plays an essential role in fetal neurodevelopment. However, to date, no study has focused on gathering conclusions about the effect of supplementation and maternal levels of vitamin B<sub>12</sub> on neurodevelopment, focusing on child cognition. Therefore, the databases consulted included PubMed, Scopus, Web of Science, and Embase. The PRISMA guideline was used to conduct and report the review, and the risk of bias was assessed using the Cochrane risk-of-bias tool (version 2) (RoB 2) for randomized controlled trials and Risk of Bias in Non-randomized Studies - of interventions (ROBINS-I). The PROSPERO registration number is CRD42023476614.</p><p><strong>Recent findings: </strong>Eleven studies were reviewed, including four randomized controlled trials and seven observational studies. The results demonstrated that maternal vitamin B<sub>12</sub> supplementation has an impact on the cognitive and language domains in children up to 42 months of age. Observational studies have also reported an association between maternal vitamin B<sub>12</sub> levels and overall neurodevelopment in children under two years of age. This systematic review highlights the importance of assessing maternal vitamin B<sub>12</sub> levels during pregnancy, considering potential adverse effects on child neurodevelopment. Given the limited number of included studies, particularly clinical trials, further research is required to clarify the findings of this review.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"128"},"PeriodicalIF":8.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multidimensionality of Household Food Security: A Systematic Review. 家庭粮食安全的多维度:系统回顾。
IF 8 3区 医学
Current Nutrition Reports Pub Date : 2025-12-17 DOI: 10.1007/s13668-025-00721-5
Komal Sajwan, S P Singh
{"title":"Multidimensionality of Household Food Security: A Systematic Review.","authors":"Komal Sajwan, S P Singh","doi":"10.1007/s13668-025-00721-5","DOIUrl":"10.1007/s13668-025-00721-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>Global, national, household and individual food security assessment varies as the challenges differ at every level. Household level assessment has gained the most attention recently. However, there are no standard measures or dimensions for measuring household food security (HHFS) but there are multidimensional tools that are evolving. This study aims to identify composite indices that have been developed to measure household food security and document the dimensions included within each, as well as the indicators and methodologies used within each index.</p><p><strong>Recent findings: </strong>A systematic literature review was conducted according to PRISMA Statement 2020 reporting guidelines of the 34 studies included in the review, most are from low-income countries, particularly those in Africa and South Asia. Most studies selected a set of indicators under specified dimensions followed by aggregation to construct a composite index. Few studies resorted to aggregation of measures like Food Consumption Score, Coping Strategies Index, etc. Scoring techniques varied across literature with principal component analysis, latent class model and others being used for computation. Lack of a clear theoretical framework in the assessment of HHFS raises concerns about consistency between studies. Similar indicators were chosen under separate dimensions in different studies, such as \"livestock\" being classified under availability, access, and utilization dimensions in different studies. Studying the performance of composite food security index at different time periods can help in understanding the pattern of food security. There is a need for a clear theoretical framework for multidimensional food security indices used at the household level. Consistent methodologies would help in targeting vulnerable populations and allow a more focused approach to address challenging dimensions.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"127"},"PeriodicalIF":8.0,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Orthorexia Nervosa: A Systematic Review of Meta-analytical Findings. 了解神经性厌食症:荟萃分析结果的系统回顾。
IF 5.5 3区 医学
Current Nutrition Reports Pub Date : 2025-12-16 DOI: 10.1007/s13668-025-00714-4
Lorenzo Moccia, Maria Benedetta Anesini, Tommaso Callovini, Delfina Janiri, Caterina Policola, Marco Cintoni, Francesca Focà, Georgios Demetrios Kotzalidis, Fabio Conti, Adolfo Bandettini Di Poggio, Giovanni Camardese, Gabriele Sani
{"title":"Understanding Orthorexia Nervosa: A Systematic Review of Meta-analytical Findings.","authors":"Lorenzo Moccia, Maria Benedetta Anesini, Tommaso Callovini, Delfina Janiri, Caterina Policola, Marco Cintoni, Francesca Focà, Georgios Demetrios Kotzalidis, Fabio Conti, Adolfo Bandettini Di Poggio, Giovanni Camardese, Gabriele Sani","doi":"10.1007/s13668-025-00714-4","DOIUrl":"10.1007/s13668-025-00714-4","url":null,"abstract":"<p><p>Orthorexia Nervosa (ON) is an emerging condition marked by an obsessive focus on healthy eating, often resulting in impairments in well-being, daily functioning, and quality of life. Despite growing awareness, ON is not currently recognized in major psychiatric diagnostic systems, complicating its identification and clinical management.</p><p><strong>Objective: </strong>This umbrella review aims to synthesize evidence from existing meta-analyses on the prevalence and associated factors of ON, while critically assessing the quality of the current literature.</p><p><strong>Methods: </strong>A comprehensive review of five meta-analyses was conducted, focusing on ON prevalence rates, its psychological correlates, and the quality of the included studies. The review also evaluated heterogeneity in findings and the reliability of assessment tools used across studies.</p><p><strong>Results: </strong>Prevalence estimates of ON showed wide variability due to differences in populations and assessment instruments. ON was significantly associated with compulsive exercise, eating disorder symptoms, obsessive-compulsive traits, and perfectionism. Newer diagnostic tools reveal a stronger connection between ON and obsessive-compulsive tendencies, while distinguishing it from traditional eating disorders, due to its focus on food purity rather than weight control. Methodological limitations, such as inconsistent assessment tools and variable study designs, limit the conclusiveness of current evidence, rendering most findings suggestive rather than definitive.</p><p><strong>Discussion: </strong>The review highlights the need for standardized diagnostic criteria, validated screening instruments, and longitudinal studies to establish the clinical relevance of ON. Enhancing understanding of its psychological and behavioral foundations is crucial for improving diagnostic accuracy and developing effective interventions.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"126"},"PeriodicalIF":5.5,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12708686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Exercise or Diet or Combined Interventions on Treatment Efficacy of Chemotherapy for Cancer: A Systematic Review. 运动、饮食或联合干预对癌症化疗疗效的影响:系统综述。
IF 8 3区 医学
Current Nutrition Reports Pub Date : 2025-12-10 DOI: 10.1007/s13668-025-00702-8
Cristina Crespo-Garcia, Francesco Bettariga, Dennis R Taaffe, Carolyn J Peddle-McIntyre, John P Campbell, Emily Jeffery, Anna Maria Markarian, Anita Borsati, Alice Avancini, Sara Pilotto, Daniel A Galvao, Robert U Newton
{"title":"Effects of Exercise or Diet or Combined Interventions on Treatment Efficacy of Chemotherapy for Cancer: A Systematic Review.","authors":"Cristina Crespo-Garcia, Francesco Bettariga, Dennis R Taaffe, Carolyn J Peddle-McIntyre, John P Campbell, Emily Jeffery, Anna Maria Markarian, Anita Borsati, Alice Avancini, Sara Pilotto, Daniel A Galvao, Robert U Newton","doi":"10.1007/s13668-025-00702-8","DOIUrl":"10.1007/s13668-025-00702-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>While exercise and dietary interventions in patients with cancer undergoing chemotherapy have been demonstrated to be safe and feasible and improve patient-reported outcomes, the effects on treatment efficacy have not been widely examined and remain unclear. This review aimed to examine the effects of exercise, dietary, and combined interventions on tumour response and time-to-event outcomes in patients with cancer undergoing chemotherapy.</p><p><strong>Recent findings: </strong>A systematic review of intervention studies was conducted based on PRISMA guidelines Databases searched were PubMed, Medline, CINAHL, Embase, and Web of Science. Methodological quality and risk of bias were assessed using the RoB2 and ROBINS-I tools. A total of 21 studies, involving 1,384 cancer patients, were included. Exercise interventions were studied in 13 studies, nine of which were controlled. Two studies reported improvements in tumour response, although none demonstrated a significant impact on survival outcomes. Dietary interventions were investigated in seven studies, all of which used either ketogenic diets or fasting-mimicking diets; three of these studies were controlled and recruited patients with breast cancer. Among all studies, three showed significant increases in tumour response and survival outcomes. Finally, only one study evaluated the combined effects of exercise and diet, reporting a significant increase in pathological complete response rates in the intervention group. Exercise and dietary interventions, particularly ketogenic and fasting-mimicking diets, may enhance tumour response and survival during chemotherapy in some cases. However, the current evidence is limited and inconsistent. Well-designed randomized controlled trials are needed to better establish the efficacy of these interventions as adjuncts to chemotherapy.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"125"},"PeriodicalIF":8.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Examination of Strategies to Improve Access to Medical Nutrition Therapy among Cancer Patients in the United States: A Narrative Review and a Call to Action. 改善美国癌症患者获得医疗营养治疗的策略研究:叙述回顾和行动呼吁。
IF 8 3区 医学
Current Nutrition Reports Pub Date : 2025-12-06 DOI: 10.1007/s13668-025-00716-2
Bryanna Gloss, Trishnee Bhurosy
{"title":"An Examination of Strategies to Improve Access to Medical Nutrition Therapy among Cancer Patients in the United States: A Narrative Review and a Call to Action.","authors":"Bryanna Gloss, Trishnee Bhurosy","doi":"10.1007/s13668-025-00716-2","DOIUrl":"10.1007/s13668-025-00716-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Our aims were to review literature describing the role and benefits of medical nutrition therapy (MNT) in cancer care, highlight barriers to the integration of MNT into standard clinical practice, and investigate strategies to improve access to MNT in the United States (US).</p><p><strong>Recent findings: </strong>Patients with cancer benefit from receiving MNT, including individualized nutrition counseling, oral nutrition supplements, enteral nutrition, and parenteral nutrition. Recent evidence highlighted the efficacy of MNT in reducing treatment-related toxicity, risk of sarcopenia, gastrointestinal complications, and improving quality of life and overall prognosis. While MNT has been found to be efficacious, its implementation in cancer care is suboptimal due to lack of Medicare coverage for MNT, inadequate nutrition staff, lack of malnutrition screening practices, and low awareness and prioritization of nutrition support among medical professionals. Access to MNT remains limited due to challenges at the patient, healthcare provider, cancer center, community, and policy levels even though MNT is associated with improved outcomes among patients with cancer. Addressing these challenges will require a multi-layered strategy, including educating oncologists and other healthcare providers about nutrition, increasing the number of oncology dietitians, and advocating for legislative changes that pass the MNT Act into action.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"124"},"PeriodicalIF":8.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Mediterranean Diet and Intermittent Fasting in Modulating Inflammation and Clinical Biochemistry Markers in Hereditary Cancer Syndromes: A Review. 地中海饮食和间歇性禁食在遗传性癌症综合征中调节炎症和临床生化标志物的作用:综述
IF 8 3区 医学
Current Nutrition Reports Pub Date : 2025-12-03 DOI: 10.1007/s13668-025-00713-5
Francesco Cacciabaudo, Giulia Accardi, Francesca Carta, Salvatore Tarantino, Giuseppe Annunziata, Tancredi Didier Bazan Russo, Paula Silva, Giuseppina Candore, Antonio Russo, Marcello Ciaccio
{"title":"The Role of Mediterranean Diet and Intermittent Fasting in Modulating Inflammation and Clinical Biochemistry Markers in Hereditary Cancer Syndromes: A Review.","authors":"Francesco Cacciabaudo, Giulia Accardi, Francesca Carta, Salvatore Tarantino, Giuseppe Annunziata, Tancredi Didier Bazan Russo, Paula Silva, Giuseppina Candore, Antonio Russo, Marcello Ciaccio","doi":"10.1007/s13668-025-00713-5","DOIUrl":"10.1007/s13668-025-00713-5","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: This literature review of clinical and preclinical studies aimed to analyse the latest evidence on the Mediterranean diet (MD) and intermittent fasting (IF) to prevent or delay strategies for the onset of cancer in patients with hereditary cancer syndromes, correlating the data about some nutritional, clinical biochemical, and inflammatory biomarkers (e.g. CRP, IL-6, insulin, and IGF-1). Preliminary evidence from the literature suggests that MD and IF can favourably modulate markers of chronic inflammation and metabolism, potentially reducing the risk of cancer. RECENT FINDINGS: Cancer risk increases significantly throughout life in patients with hereditary cancer syndromes such as BRCA1/2. Evidence suggests the role of lifestyle, especially nutrition, in delaying the onset of these diseases. Although existing studies point to promising roles for MD and IF in managing cancer risk, additional research is needed to clarify their long-term effects and define personalised guidelines for individuals with hereditary cancer syndromes. Preliminary data suggest that the MD and IF may help delay cancer onset in hereditary syndromes by modulating inflammation and metabolism. More studies are needed to confirm long-term benefits and guide personalized prevention. </p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"123"},"PeriodicalIF":8.0,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12675562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Processing on Millets: A Pathway To Improved Nutrition and Functionality. 加工对小米的影响:改善营养和功能的途径。
IF 8 3区 医学
Current Nutrition Reports Pub Date : 2025-11-26 DOI: 10.1007/s13668-025-00715-3
Hardeep Singh, Shweta Chaturvedi, Kawaljit Singh Sandhu, Barinderjeet Singh Toor, Vinita Sharma
{"title":"Impact of Processing on Millets: A Pathway To Improved Nutrition and Functionality.","authors":"Hardeep Singh, Shweta Chaturvedi, Kawaljit Singh Sandhu, Barinderjeet Singh Toor, Vinita Sharma","doi":"10.1007/s13668-025-00715-3","DOIUrl":"10.1007/s13668-025-00715-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>Millets are known as Nutri-cereals because they are excellent sources of proteins (7-12%), dietary fiber (15-20%) and have a good amount of essential amino acids, minerals, vitamins, and antioxidants, with the potential to provide several health benefits. However, their global utilization is limited due to lack of awareness, limited consumer knowledge, and the presence of anti-nutrients. Processing techniques can significantly improve their nutritional value, digestibility, and sensory properties.</p><p><strong>Recent findings: </strong>Primary milling operations (cleaning, dehulling, milling), traditional processes (soaking, germination, fermentation, cooking), conventional industrial methods (extrusion, roasting, high-temperature short-time treatment), and novel non-thermal technologies (high-pressure processing, pulsed electric field, cold plasma, ultrasound, irradiation) have demonstrated substantial effects on millet quality. Traditional methods such as germination and fermentation reduce anti-nutrients (tannins and phytic acid are eliminated) while mineral bioavailability and antioxidant levels are increased. Industrial thermal methods, such as extrusion, improve protein digestibility, starch availability, and texture, whereas novel non-thermal technologies contribute to the extension of shelf life and to the enhancement of food safety. Processed millets can be incorporated into diverse food formulations, and combinations of different processing methods may further enhance their role for the fight against food insecurity, malnutrition, and global hunger while supporting sustainable development goals. Continued research and technological advancements are required to maximize the nutritional and economic potential of millet processing.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"122"},"PeriodicalIF":8.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145602889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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