Effectiveness of Grape-Based Interventions on Cognitive and Mental Health: Evidence From Human Trials.

IF 4.6 3区医学 Q1 NUTRITION & DIETETICS

Current Nutrition Reports Pub Date : 2025-01-16 DOI:10.1007/s13668-025-00612-9

Keotshepile Precious Bojang, Manchana Varalakshmi

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Abstract

Purpose of review: This review evaluates current research on grape-based interventions and their impact on cognitive and mental health. It also explores the putative mechanisms by which the grape-derived compounds might modulate cognitive function. The growing prevalence of cognitive decline and mental health disorders necessitates exploring novel dietary approaches. Grapes, rich in polyphenols, have demonstrated potential benefits in preclinical studies. However, translating these findings to humans remains an ongoing endeavor.

Recent findings: Recent clinical trials complement existing observational data, suggesting a positive influence of grape consumption on cognition, particularly in areas of memory, learning, and overall cognitive function and emotional well-being. The potential mechanisms involve the antioxidant and anti-inflammatory properties of grapes, which may mitigate neuroinflammation and protect brain cells from free radical damage. Evidence from existing research suggests that grape based interventions may improve cognitive performance through several neuroprotective mechanisms; however, further investigation is needed to understand the protective effects of grape-based interventions on brain function and mental health. Large-scale trials to assess the long-term effects and safety profile of grape interventions are required. Additionally, extensive epidemiological research is needed to confirm the effect of grape interventions on cognitive health and to determine the best beneficial dosage and duration of supplementations to maximise cognitive benefits.

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基于葡萄的认知和心理健康干预的有效性：来自人体试验的证据。

综述目的：本综述评估了目前关于葡萄干预及其对认知和心理健康影响的研究。它还探讨了葡萄衍生化合物可能调节认知功能的假定机制。认知能力下降和精神健康障碍的日益普遍需要探索新的饮食方法。葡萄富含多酚，在临床前研究中显示出潜在的益处。然而，将这些发现转化为人类仍然是一个持续的努力。最近的发现：最近的临床试验补充了现有的观察数据，表明葡萄消费对认知有积极影响，特别是在记忆、学习、整体认知功能和情绪健康方面。潜在的机制涉及葡萄的抗氧化和抗炎特性，这可能减轻神经炎症，保护脑细胞免受自由基损伤。现有研究证据表明，葡萄干预可能通过几种神经保护机制改善认知能力；然而，需要进一步的研究来了解葡萄干预对脑功能和心理健康的保护作用。需要进行大规模试验来评估葡萄干预措施的长期效果和安全性。此外，需要进行广泛的流行病学研究，以确认葡萄干预对认知健康的影响，并确定最佳有益剂量和补充时间，以最大限度地提高认知益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Nutrition Reports Agricultural and Biological Sciences-Food Science

CiteScore

7.70

自引率

2.00%

发文量

期刊介绍： This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.