{"title":"Nutrition and Huntington's Disease- A Review of Current Practice and Theory.","authors":"Ann Gaba","doi":"10.1007/s13668-025-00610-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Nutition has long been of importance in the care of Huntington's disease (HD). The purpose of this review is to summarize recent research relevant to HD nutrition, and to describe some emerging theoretical approaches to research in this area.</p><p><strong>Recent findings: </strong>Clinical studies have identified swallowing problems and fear of choking as major impediments to maintaining nutritional status with HD. Tube feeding is associated with co-morbidities, and provides limited benefits. Non-human models of HD have been utilized to study diets and supplements. Application of findings from these models to humans has not been shown to be of comparable benefit. While studies of nutritional factors in non-human models of HD have shown some promising results, trials in humans have found little efficacy for diets or supplements. The complexity of human metabolic pathways may require a more sophisticated omics approach to identify and study more beneficial interventions.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"18"},"PeriodicalIF":4.6000,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739192/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Nutrition Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13668-025-00610-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
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Abstract
Purpose of review: Nutition has long been of importance in the care of Huntington's disease (HD). The purpose of this review is to summarize recent research relevant to HD nutrition, and to describe some emerging theoretical approaches to research in this area.
Recent findings: Clinical studies have identified swallowing problems and fear of choking as major impediments to maintaining nutritional status with HD. Tube feeding is associated with co-morbidities, and provides limited benefits. Non-human models of HD have been utilized to study diets and supplements. Application of findings from these models to humans has not been shown to be of comparable benefit. While studies of nutritional factors in non-human models of HD have shown some promising results, trials in humans have found little efficacy for diets or supplements. The complexity of human metabolic pathways may require a more sophisticated omics approach to identify and study more beneficial interventions.
期刊介绍：
This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.
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