Current Nutrition Reports最新文献

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Cholesterol and Immune Microenvironment: Path Towards Tumorigenesis. 胆固醇与免疫微环境:通往肿瘤发生之路。
IF 4.6 3区 医学
Current Nutrition Reports Pub Date : 2024-09-01 Epub Date: 2024-05-02 DOI: 10.1007/s13668-024-00542-y
Eslam E Saad, Rachel Michel, Mostafa A Borahay
{"title":"Cholesterol and Immune Microenvironment: Path Towards Tumorigenesis.","authors":"Eslam E Saad, Rachel Michel, Mostafa A Borahay","doi":"10.1007/s13668-024-00542-y","DOIUrl":"10.1007/s13668-024-00542-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Since obesity is a major risk factor for many different types of cancer, examining one of the most closely associated comorbidities, such as hypercholesterolemia, is crucial to understanding how obesity causes cancer. Hypercholesterolemia is usually associated with many cardiovascular complications such as hypertension, angina, and atherosclerosis. In addition, cholesterol may be a major factor in increasing cancer risk. Cancer patients who received statins, an anti-hypercholesteremic medicine, demonstrated improved prognosis possibly through its effect on tumor proliferation, apoptosis, and oxidative stress. Cholesterol could also aid in tumor progression through reprogramming tumor immunological architecture and mediators. This review focuses on the immunomodulatory role of cholesterol on cellular and molecular levels, which may explain its oncogenic driving activity. We look at how cholesterol modulates tumor immune cells like dendritic cells, T cells, Tregs, and neutrophils. Further, this study sheds light on the modification of the expression pattern of the common cancer-related immune mediators in the tumor immune microenvironment, such as programmed cell death 1 (PD-1), cytotoxic T lymphocyte antigen-4 (CTLA-4), transforming growth factor-beta (TGF-β), interleukin 12 (IL-12), IL-23, and forkhead box protein P3 (FOXP3).</p><p><strong>Recent findings: </strong>We highlight relevant literature demonstrating cholesterol's immunosuppressive role, leading to a worse cancer prognosis. This review invites further research regarding the pathobiological role of cholesterol in many obesity-related cancers such as uterine fibroids, post-menopausal breast, colorectal, endometrial, kidney, esophageal, pancreatic, liver, and gallbladder cancers. This review suggests that targeting cholesterol synthesis may be a fruitful approach to cancer targeting, in addition to traditional chemotherapeutics.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":" ","pages":"557-565"},"PeriodicalIF":4.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing Micronutrient Deficiencies in High-Risk Patients: No Small Feat! 管理高危患者的微量营养素缺乏症:非同小可!
IF 4.6 3区 医学
Current Nutrition Reports Pub Date : 2024-09-01 Epub Date: 2024-07-03 DOI: 10.1007/s13668-024-00552-w
Ethan Steele, David Liu, Endashaw Omer
{"title":"Managing Micronutrient Deficiencies in High-Risk Patients: No Small Feat!","authors":"Ethan Steele, David Liu, Endashaw Omer","doi":"10.1007/s13668-024-00552-w","DOIUrl":"10.1007/s13668-024-00552-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>Micronutrients are vital dietary components for growth and development. Adequate intake of vitamins and minerals through diet is crucial for proper biomolecular and cellular functioning. Many developed countries supplement foods and micronutrient deficiencies are less common. However, many disease states impair micronutrient absorption, metabolism, and excretion. Thus, early recognition of the signs and symptoms of micronutrient deficiencies is critical for providers to improve quality of life and prevent complications in high-risk patients. This article reviews the basic function of micronutrients, recognizes the symptoms of each micronutrient deficiency, provides natural sources of intake, and discusses the diagnosis and supplementation of each micronutrient. High risk patients based on disease state for each micronutrient is discussed. In addition, Bariatric patients are a specific group at high risk of micronutrient deficiency and their management and supplementation for treatment is also covered.</p><p><strong>Recent findings: </strong>Micronutrients play a vital role in antioxidant defense, especially in critically ill patients, due to an increase in oxidative stress. Early intervention with high-dose supplementation with vitamin C, vitamin E, zinc and selenium may have beneficial effects. Micronutrients deficiency remains an issue for patients in the developed world. Providers should recognize patients who are at high risk for micronutrients deficiencies and provide proper screening and prompt supplementation after diagnosis to prevent complications of micronutrient deficiencies.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":" ","pages":"668-678"},"PeriodicalIF":4.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nourishing Physical Productivity and Performance On a Warming Planet - Challenges and Nutritional Strategies to Mitigate Exertional Heat Stress. 在日益变暖的地球上提高体力生产率和工作表现--减轻劳累性热应激的挑战和营养策略。
IF 4.6 3区 医学
Current Nutrition Reports Pub Date : 2024-09-01 Epub Date: 2024-07-12 DOI: 10.1007/s13668-024-00554-8
Alan J McCubbin, Christopher G Irwin, Ricardo J S Costa
{"title":"Nourishing Physical Productivity and Performance On a Warming Planet - Challenges and Nutritional Strategies to Mitigate Exertional Heat Stress.","authors":"Alan J McCubbin, Christopher G Irwin, Ricardo J S Costa","doi":"10.1007/s13668-024-00554-8","DOIUrl":"10.1007/s13668-024-00554-8","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Climate change is predicted to increase the frequency and severity of exposure to hot environments. This can impair health, physical performance, and productivity for active individuals in occupational and athletic settings. This review summarizes current knowledge and recent advancements in nutritional strategies to minimize the impact of exertional-heat stress (EHS). RECENT FINDINGS: Hydration strategies limiting body mass loss to < 3% during EHS are performance-beneficial in weight-supported activities, although evidence regarding smaller fluid deficits (< 2% body mass loss) and weight-dependent activities is less clear due to a lack of well-designed studies with adequate blinding. Sodium replacement requirements during EHS depends on both sweat losses and the extent of fluid replacement, with quantified sodium replacement only necessary once fluid replacement > 60-80% of losses. Ice ingestion lowers core temperature and may improve thermal comfort and performance outcomes when consumed before, but less so during activity. Prevention and management of gastrointestinal disturbances during EHS should focus on high carbohydrate but low FODMAP availability before and during exercise, frequent provision of carbohydrate and/or protein during exercise, adequate hydration, and body temperature regulation. Evidence for these approaches is lacking in occupational settings. Acute kidney injury is a potential concern resulting from inadequate fluid replacement during and post-EHS, and emerging evidence suggests that repeated exposures may increase the risk of developing chronic kidney disease. Nutritional strategies can help regulate hydration, body temperature, and gastrointestinal status during EHS. Doing so minimizes the impact of EHS on health and safety and optimizes productivity and performance outcomes on a warming planet.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":" ","pages":"399-411"},"PeriodicalIF":4.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Updated View of the Effect of Probiotic Supplement on Sports Performance: A Detailed Review. 益生菌补充剂对运动成绩影响的最新观点:详细综述。
IF 4.9 3区 医学
Current Nutrition Reports Pub Date : 2024-06-01 Epub Date: 2024-03-12 DOI: 10.1007/s13668-024-00527-x
Miray Nur Aykut, Esma Nur Erdoğan, Menşure Nur Çelik, Murat Gürbüz
{"title":"An Updated View of the Effect of Probiotic Supplement on Sports Performance: A Detailed Review.","authors":"Miray Nur Aykut, Esma Nur Erdoğan, Menşure Nur Çelik, Murat Gürbüz","doi":"10.1007/s13668-024-00527-x","DOIUrl":"10.1007/s13668-024-00527-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>Modulation of the host microbiota through probiotics has been shown to have beneficial effects on health in the growing body of research. Exercise increases the amount and diversity of beneficial microorganisms in the host microbiome. Although low- and moderate-intensity exercise has been shown to reduce physiological stress and improve immune function, high-intensity prolonged exercise can suppress immune function and reduce microbial diversity due to intestinal hypoperfusion. The effect of probiotic supplementation on sports performance is still being studied; however, questions remain regarding the mechanisms of action, strain used, and dose. In this review, the aim was to investigate the effects of probiotic supplements on exercise performance through modulation of gut microbiota and alleviation of GI symptoms, promotion of the immune system, bioavailability of nutrients, and aerobic metabolism.</p><p><strong>Recent findings: </strong>Probiotic supplementation may improve sports performance by reducing the adverse effects of prolonged high-intensity exercise. Although probiotics have been reported to have positive effects on sports performance, information about the microbiome and nutrition of athletes has not been considered in most current studies. This may have limited the evaluation of the effects of probiotic supplementation on sports performance.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":" ","pages":"251-263"},"PeriodicalIF":4.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11133216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing Intravenous Access for Long-Term Parenteral Nutrition. 优化长期肠外营养的静脉通路。
IF 4.9 3区 医学
Current Nutrition Reports Pub Date : 2024-06-01 Epub Date: 2024-05-02 DOI: 10.1007/s13668-024-00534-y
Ryan T Hurt, Osman Mohamed Elfadil, Jithinraj Edakkanambeth Varayil, Sara L Bonnes, Bradley R Salonen, Manpreet S Mundi
{"title":"Optimizing Intravenous Access for Long-Term Parenteral Nutrition.","authors":"Ryan T Hurt, Osman Mohamed Elfadil, Jithinraj Edakkanambeth Varayil, Sara L Bonnes, Bradley R Salonen, Manpreet S Mundi","doi":"10.1007/s13668-024-00534-y","DOIUrl":"10.1007/s13668-024-00534-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Securing safe and effective intravenous (IV) access is of utmost importance for administering parenteral nutrition (PN). Sustaining this access can indeed pose challenges, especially when dealing with the risk of complications associated with long-term PN. This review emphasizes best practices to optimize intravenous access and reviews the current evidence-based recommendations and consensus guidelines.</p><p><strong>Recent findings: </strong>An individualized approach when selecting central venous catheters (CVC) is recommended, considering the estimated duration of need for IV access and the number of lumens needed. Established and novel approaches to minimize complications, including infection and thrombosis, are recognized. These include placement and positioning of the catheter tip under sonographic guidance and the use of antimicrobial lock therapies. Moreover, when possible, salvaging CVCs can reduce the risk of vascular access loss. CVC selection for patients requiring PN depends on several factors. Carefully reviewing an individual patient's clinical characteristics and discussing options is important. Given the increased infection risk, CVC lumens should be minimized. For long-term PN beyond 6 months, using CVCs with skin barriers and larger diameters should be considered.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":" ","pages":"323-330"},"PeriodicalIF":4.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Overview of the Potential Role of Nutrition in Mental Disorders in the Light of Advances in Nutripsychiatry. 从营养精神病学的进展看营养在精神障碍中的潜在作用》(An Overview of the Potential Role of Nutrition in Mental Disorders in Light of Advances in Nutripsychiatry)。
IF 4.9 3区 医学
Current Nutrition Reports Pub Date : 2024-06-01 Epub Date: 2024-02-08 DOI: 10.1007/s13668-024-00520-4
Nursel Dal, Saniye Bilici
{"title":"An Overview of the Potential Role of Nutrition in Mental Disorders in the Light of Advances in Nutripsychiatry.","authors":"Nursel Dal, Saniye Bilici","doi":"10.1007/s13668-024-00520-4","DOIUrl":"10.1007/s13668-024-00520-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>As research on the potential impact of nutrition on mental disorders, a significant component of global disability continues to grow the concepts of \"nutritional psychiatry, psycho-dietetics/nutripsychiatry\" have taken their place in the literature. This review is a comprehensive examination of the literature on the the potential mechanisms between common mental disorders and nutrition and evaluates the effectiveness of dietary interventions.</p><p><strong>Recent findings: </strong>Inflammation, oxidative stress, intestinal microbiota, mitochondrial dysfunction, and neural plasticity are shown as potential mechanisms in the relationship between mental disorders and nutrition. As a matter of fact, neurotrophic factors, which make important contributions to repair mechanisms throughout life, and neuronal plasticity, which plays a role in mental disorders, are affected by nutritional factors. In metabolism, the antioxidant defense system works with nutritional cofactors and phytochemicals. A balanced, planned diet that provides these components is more likely to provide nutrients that increase resilience against the pathogenesis of mental disorders. Nutrition can be considered a risk factor for mental disorders. Therefore, developing public health strategies focused on improving diet may help reduce the global burden of mental disorders and other related diseases.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":" ","pages":"69-81"},"PeriodicalIF":4.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11133159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Social Media on Diet, Lifestyle, and Performance of Athletes: A Review of Current Evidence. 社交媒体对运动员饮食、生活方式和表现的影响:当前证据综述》。
IF 4.9 3区 医学
Current Nutrition Reports Pub Date : 2024-06-01 Epub Date: 2024-03-09 DOI: 10.1007/s13668-024-00526-y
Santanu Nath, Sangita Bhattacharya, Vani Bhushanam Golla, Rajesh Kumar
{"title":"Effect of Social Media on Diet, Lifestyle, and Performance of Athletes: A Review of Current Evidence.","authors":"Santanu Nath, Sangita Bhattacharya, Vani Bhushanam Golla, Rajesh Kumar","doi":"10.1007/s13668-024-00526-y","DOIUrl":"10.1007/s13668-024-00526-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Social media (SM) plays an important role in providing diet and health advice to athletes, but it also carries with it a risk of credibility in the information sought for and received. The objective of this review is to assess the knowledge gap on how SM influences dietary and lifestyle practices in athletes.</p><p><strong>Recent findings: </strong>For this, relevant literature was searched in three leading databases with appropriate keywords, which were subjected to proper scrutiny that led to inclusion of 22 articles (original research papers, reviews, viewpoints, and commentaries). The current era of digitalization has seen an over-reliance on internet and SM for nutrition and lifestyle advice for an athlete. SM has become a powerful tool in athlete's choice of food, nutrition information, healthy living, and performance, with merits and demerits. Their role in choosing dietary supplements and particular food types (e.g., ketogenic diet), body image, self-esteem and eating disorders, and in lifestyle and performance are discussed. SM should be used with caution and should not be used alone as a source of information for nutrition related pieces of advise by athletes. Any food type and supplements trending in SM should be discussed with a sports nutritionist before consumption. SM influencers having a big follower base may not always be disseminating the right knowledge on food and nutrition, thus caution should be exercised. For optimal benefit to the athlete, SM information should be in alignment with recommendations provided by sports nutrition and coaches.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":" ","pages":"240-250"},"PeriodicalIF":4.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)? 肥胖与肥胖相关的甲状腺功能障碍:极低热量生酮饮食(VLCKD)的潜在作用?
IF 4.9 3区 医学
Current Nutrition Reports Pub Date : 2024-06-01 Epub Date: 2024-03-25 DOI: 10.1007/s13668-024-00528-w
Sebastián Pablo Chapela, Alison Simancas-Racines, Florencia Ceriani, Andrés Luciano Nicolas Martinuzzi, María Paula Russo, Ana Karina Zambrano, Daniel Simancas-Racines, Ludovica Verde, Giovanna Muscogiuri, Christos S Katsanos, Evelyn Frias-Toral, Luigi Barrea
{"title":"Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?","authors":"Sebastián Pablo Chapela, Alison Simancas-Racines, Florencia Ceriani, Andrés Luciano Nicolas Martinuzzi, María Paula Russo, Ana Karina Zambrano, Daniel Simancas-Racines, Ludovica Verde, Giovanna Muscogiuri, Christos S Katsanos, Evelyn Frias-Toral, Luigi Barrea","doi":"10.1007/s13668-024-00528-w","DOIUrl":"10.1007/s13668-024-00528-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to explore in-depth the different aspects of the association between very low-calorie ketogenic diet (VLCKD), obesity and obesity-related thyroid dysfunction.</p><p><strong>Recent findings: </strong>The VLCKD, proposed as a non-pharmacological strategy for the management of certain chronic diseases, is becoming increasingly popular worldwide. Initially used to treat epilepsy, it has been shown to be effective in controlling body weight gain and addressing various pathophysiological conditions. Research has shown that a low-calorie, high-fat diet can affect thyroid hormone levels. Weight loss can also influence thyroid hormone levels. Studies have suggested that long-term use of VLCKD for refractory epilepsy may be related to the development of hypothyroidism, with an effect seen in various populations. In particular, women with obesity following VLCKD tend to have reduced T3 levels. We propose further research to unravel the underlying mechanisms linking VLCKD to obesity and obesity-related thyroid dysfunction.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":" ","pages":"194-213"},"PeriodicalIF":4.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11133069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Overlooked Association Between Nutrition and the Development of Acute Myeloid Leukaemia: A Scoping Review. 被忽视的营养与急性髓性白血病发病之间的关系:范围审查》。
IF 4.6 3区 医学
Current Nutrition Reports Pub Date : 2024-06-01 Epub Date: 2024-03-02 DOI: 10.1007/s13668-024-00522-2
Alex Rezae, Reem Fakak, Kyle G Alexander, Constantina Constantinou
{"title":"The Overlooked Association Between Nutrition and the Development of Acute Myeloid Leukaemia: A Scoping Review.","authors":"Alex Rezae, Reem Fakak, Kyle G Alexander, Constantina Constantinou","doi":"10.1007/s13668-024-00522-2","DOIUrl":"10.1007/s13668-024-00522-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Acute Myeloid Leukaemia (AML) constitutes a mere 1% of global cancer cases. This scoping review aims to investigate the association between nutrition and the development of AML, providing a foundation for future research in this field.</p><p><strong>Recent findings: </strong>A systematic search was conducted across PubMed, EBSCO, Taylor and Francis, Science Direct and Cochrane Library using specific keywords. Inclusion criteria comprised observational studies and clinical trials examining the association between nutrition and the development of AML. Articles selected for analysis were restricted to those published in English between 1990-2023, and available as full text articles. Among the twenty-five articles that were screened, only six met the criteria for data extraction. Four studies did not reveal statistically significant correlations between nutrition and the development of AML, while two studies provided evidence for significant associations. The findings indicated increased AML risk associated with (a) heightened caloric intake, consumption of white potatoes, and red meat (pork and beef) and (b) diminished consumption of vegetables, seafood, nuts, and seeds. The scarcity of comprehensive studies exploring the connection between nutrition and AML, highlights the urgent need for additional research, encompassing pre-clinical studies. This imperative is critical for enhancing our understanding of the molecular mechanisms that underlie the connection between diet and the aetiology of AML. Such knowledge is paramount in advancing effective strategies for both prevention and management of this significant disease.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":" ","pages":"113-125"},"PeriodicalIF":4.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11133215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Interplay Between Dietary Choline and Cardiometabolic Disorders: A Review of Current Evidence. 膳食胆碱与心脏代谢紊乱之间的相互作用:当前证据综述
IF 4.9 3区 医学
Current Nutrition Reports Pub Date : 2024-06-01 Epub Date: 2024-03-01 DOI: 10.1007/s13668-024-00521-3
Natalia G Vallianou, Dimitris Kounatidis, Sotiria Psallida, Fotis Panagopoulos, Theodora Stratigou, Eleni Geladari, Irene Karampela, Dimitrios Tsilingiris, Maria Dalamaga
{"title":"The Interplay Between Dietary Choline and Cardiometabolic Disorders: A Review of Current Evidence.","authors":"Natalia G Vallianou, Dimitris Kounatidis, Sotiria Psallida, Fotis Panagopoulos, Theodora Stratigou, Eleni Geladari, Irene Karampela, Dimitrios Tsilingiris, Maria Dalamaga","doi":"10.1007/s13668-024-00521-3","DOIUrl":"10.1007/s13668-024-00521-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>Choline is an essential nutrient for human health and cellular homeostasis as it is necessary for the synthesis of lipid cell membranes, lipoproteins, and the synthesis of the neurotransmitter acetylcholine. The aim of this review is to analyze the beneficial effects of choline and its significance in cellular metabolism and various inflammatory pathways, such as the inflammasome. We will discuss the significance of dietary choline in cardiometabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD), and chronic kidney disease (CKD) as well as in cognitive function and associated neuropsychiatric disorders.</p><p><strong>Recent findings: </strong>Choline deficiency has been related to the development of NAFLD and cognitive disability in the offspring as well as in adulthood. In sharp contrast, excess dietary intake of choline mediated via the increased production of trimethylamine by the gut microbiota and increased trimethylamine-N-oxide (TMAO) levels has been related to atherosclerosis in most studies. In this context, CVD and CKD through the accumulation of TMAO, p-Cresyl-sulfate (pCS), and indoxyl-sulfate (IS) in serum may be the result of the interplay between excess dietary choline, the increased production of TMAO by the gut microbiota, and the resulting activation of inflammatory responses and fibrosis. A balanced diet, with no excess nor any deficiency in dietary choline, is of outmost importance regarding the prevention of cardiometabolic disorders as well as cognitive function. Large-scale studies with the use of next-generation probiotics, especially Akkermansia muciniphila and Faecalibacterium prausnitzii, should further examine their therapeutic potential in this context.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":" ","pages":"152-165"},"PeriodicalIF":4.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11133147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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