Personalizing Dietary Polyphenols for Health Maintenance and Disease Management: A Nutrigenetic Approach.

IF 5.5 3区医学 Q1 NUTRITION & DIETETICS

Current Nutrition Reports Pub Date : 2025-02-05 DOI:10.1007/s13668-025-00620-9

Omar Ramos-Lopez

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引用次数: 0

Abstract

Purpose of the review: This literature review provides examples of the influence of certain genetic variants on health outcomes after dietary polyphenol consumption or supplementation. Available evidence is organized according to the major classes of polyphenols (flavonoids, phenolic acids, stilbenes, lignans, and tannins) and their derived subgroups.

Recent findings: Nutrigenetic studies have identified mainly single nucleotide polymorphisms located within genes involved in the biotransformation of phenolic acids, stilbenes, lignans and several flavonoid molecules. These genetic variants may affect polyphenol metabolism rates and related predisposition to chronic non-communicable diseases. Moreover, differential cardiometabolic outcomes upon polyphenol supplementation as dietary sources or nutraceuticals have been modulated by specific genotypes. Although current evidence is still limited, growing gene-polyphenol interactions are contributing to systematically elucidate the biological functions of polyphenols; determine individual risk phenotypes to specific diseases or particular responses upon polyphenol exposure; and facilitate the prescription of personalized genotype-based doses of dietary polyphenols to optimize related health benefits. Additionally, the integration of genetics with other omics insights (epigenomics, transcriptomics, metagenomics, and metabolomics) trough biological systems and high-dimensional data analyses and interpretation may provide a more comprehensive understanding of polyphenol metabolism for precision nutrition applications in health and disease.

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个性化膳食多酚对健康维护和疾病管理：营养遗传学方法。

综述目的：本文献综述提供了某些基因变异对饮食多酚摄入或补充后健康结果影响的例子。现有的证据是根据多酚的主要类别（类黄酮、酚酸、二苯乙烯、木脂素和单宁）及其衍生亚群来组织的。最近的发现：营养遗传学研究已经确定了主要的单核苷酸多态性位于基因参与生物转化酚酸，二苯乙烯，木脂素和几种类黄酮分子。这些基因变异可能影响多酚代谢率和慢性非传染性疾病的相关易感性。此外，多酚补充剂作为膳食来源或营养保健品的不同心脏代谢结果受到特定基因型的调节。尽管目前的证据仍然有限，但越来越多的基因-多酚相互作用有助于系统地阐明多酚的生物学功能；确定特定疾病的个体风险表型或多酚暴露后的特定反应；并促进个性化的基于基因型的膳食多酚剂量处方，以优化相关的健康益处。此外，通过生物系统和高维数据分析和解释，将遗传学与其他组学见解（表观基因组学、转录组学、宏基因组学和代谢组学）相结合，可能为多酚代谢在健康和疾病中的精确营养应用提供更全面的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Nutrition Reports Agricultural and Biological Sciences-Food Science

CiteScore

7.70

自引率

2.00%

发文量

期刊介绍： This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.