{"title":"龙眼果副产物对肝脏疾病的营养和治疗潜力：功能性食品的途径。","authors":"Idris Kaida Zubairu, Kanyasiri Rakariyatham, Shitapan Bai-Ngew, Noppol Leksawasdi, Joe M Regenstein, Fei Lao, Hui Hong, Weon-Sun Shin, Khalid J Alzahrani, Yuthana Phimolsiripol","doi":"10.1007/s13668-025-00617-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>The massive processing of longan fruit consequently generates a significant quantity of by-products that are a nuisance to the environment. This review aims to tap these by-products for sustainable applications in treating hepatic diseases.</p><p><strong>Recent findings: </strong>Ethnobotanical investigations show that longan fruit has been utilized in liver functioning for over two millennia and is supported by contemporary scientific findings. Recent studies highlighted that these by-products contain bioactive compounds that decrease oxidative stress and inflammation, key drivers of liver diseases, including liver fibrosis, hepatitis, and non-alcoholic fatty liver disease (NAFLD). These bioactive compounds modulate lipid metabolism, detoxification pathways, and oxidative stress-regulating metabolic pathways of hepatoprotection. In addition, using longan by-products provides a relatively more affordable nutraceutical substitute for synthetic pharmaceuticals. This literature revealed that polyphenolic compounds such as corilagin gallic acid, ellagic acid, and various flavonoids in longan by-products exhibit antioxidant, anti-inflammatory, and immunomodulatory activities that benefit liver health through different pathways including unexplored mechanisms. However, this review recommends exploring the potential functional application of these by-products in food. It emphasizes the need for clinical validation of longan by-product therapies for liver diseases.</p>","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"14 1","pages":"28"},"PeriodicalIF":4.6000,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nutritional and Therapeutic Potential of Longan Fruit By-products for Liver Diseases: Pathway to Functional Foods.\",\"authors\":\"Idris Kaida Zubairu, Kanyasiri Rakariyatham, Shitapan Bai-Ngew, Noppol Leksawasdi, Joe M Regenstein, Fei Lao, Hui Hong, Weon-Sun Shin, Khalid J Alzahrani, Yuthana Phimolsiripol\",\"doi\":\"10.1007/s13668-025-00617-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong>The massive processing of longan fruit consequently generates a significant quantity of by-products that are a nuisance to the environment. This review aims to tap these by-products for sustainable applications in treating hepatic diseases.</p><p><strong>Recent findings: </strong>Ethnobotanical investigations show that longan fruit has been utilized in liver functioning for over two millennia and is supported by contemporary scientific findings. Recent studies highlighted that these by-products contain bioactive compounds that decrease oxidative stress and inflammation, key drivers of liver diseases, including liver fibrosis, hepatitis, and non-alcoholic fatty liver disease (NAFLD). These bioactive compounds modulate lipid metabolism, detoxification pathways, and oxidative stress-regulating metabolic pathways of hepatoprotection. In addition, using longan by-products provides a relatively more affordable nutraceutical substitute for synthetic pharmaceuticals. This literature revealed that polyphenolic compounds such as corilagin gallic acid, ellagic acid, and various flavonoids in longan by-products exhibit antioxidant, anti-inflammatory, and immunomodulatory activities that benefit liver health through different pathways including unexplored mechanisms. However, this review recommends exploring the potential functional application of these by-products in food. It emphasizes the need for clinical validation of longan by-product therapies for liver diseases.</p>\",\"PeriodicalId\":10844,\"journal\":{\"name\":\"Current Nutrition Reports\",\"volume\":\"14 1\",\"pages\":\"28\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-02-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Nutrition Reports\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13668-025-00617-4\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Nutrition Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13668-025-00617-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Nutritional and Therapeutic Potential of Longan Fruit By-products for Liver Diseases: Pathway to Functional Foods.
Purpose of review: The massive processing of longan fruit consequently generates a significant quantity of by-products that are a nuisance to the environment. This review aims to tap these by-products for sustainable applications in treating hepatic diseases.
Recent findings: Ethnobotanical investigations show that longan fruit has been utilized in liver functioning for over two millennia and is supported by contemporary scientific findings. Recent studies highlighted that these by-products contain bioactive compounds that decrease oxidative stress and inflammation, key drivers of liver diseases, including liver fibrosis, hepatitis, and non-alcoholic fatty liver disease (NAFLD). These bioactive compounds modulate lipid metabolism, detoxification pathways, and oxidative stress-regulating metabolic pathways of hepatoprotection. In addition, using longan by-products provides a relatively more affordable nutraceutical substitute for synthetic pharmaceuticals. This literature revealed that polyphenolic compounds such as corilagin gallic acid, ellagic acid, and various flavonoids in longan by-products exhibit antioxidant, anti-inflammatory, and immunomodulatory activities that benefit liver health through different pathways including unexplored mechanisms. However, this review recommends exploring the potential functional application of these by-products in food. It emphasizes the need for clinical validation of longan by-product therapies for liver diseases.
期刊介绍：
This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.
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