Current Nutrition Reports最新文献_第4页

GLP-1 Receptor Agonists for Obesity Management in Older Adults: A Scoping Review on the Risk of Sarcopenia and Sarcopenic Obesity. GLP-1受体激动剂用于老年人肥胖管理：对肌肉减少症和肌肉减少性肥胖风险的范围审查。

IF 8 3区医学

Current Nutrition Reports Pub Date : 2026-06-17 DOI: 10.1007/s13668-026-00777-x

Hilal Simsek, Asli Ucar

{"title":"GLP-1 Receptor Agonists for Obesity Management in Older Adults: A Scoping Review on the Risk of Sarcopenia and Sarcopenic Obesity.","authors":"Hilal Simsek, Asli Ucar","doi":"10.1007/s13668-026-00777-x","DOIUrl":"10.1007/s13668-026-00777-x","url":null,"abstract":"Purpose of review: Obesity pharmacotherapy has become increasingly relevant in older adults due to challenges in lifestyle modification and the burden of non-communicable diseases. Despite the expanding use of anti-obesity medications (AOMs), sarcopenia and sarcopenic obesity (SO) remain major concerns in this population. This review synthesizes current evidence on glucagon-like peptide-1 receptor agonists (GLP-1 RAs), a well-studied AOMs, focusing on their effects on sarcopenia through mechanistic insights and clinical considerations in older adults.Recent findings: GLP-1 RAs effectively induce weight loss; however, concomitant muscle mass loss is common, raising concerns about sarcopenia. Weight cycling introduces uncertainty regarding skeletal muscle health and SO risk. Although data on muscle mass indices and physical performance remain limited and inconsistent, evidence suggests favorable effects on muscle metabolism and composition. Mechanistically, these effects are linked to GLP-1 RA-mediated suppression of inflammatory pathways, modulation of skeletal muscle metabolism, and preservation of mitochondrial function, thereby influencing insulin resistance. The most common adverse events are mild to moderate gastrointestinal symptoms, which may be mitigated through dietary counseling during dose escalation. Integrating GLP-1 RA therapy with tailored resistance exercise and caloric restriction with dietary counseling, including adequate protein intake (1.2-1.6 g/kg/day), may help preserve muscle mass and function in older adults. Implementation of GLP-1 RA-specific medical nutrition therapy protocols, with dietitian involvement to optimize dietary recommendations and manage adverse events, is recommended. Studies addressing skeletal muscle quantity, quality, and functional capacity are needed to clarify the effects of GLP-1 RAs on sarcopenic obesity in older adults.","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13272609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Purpose of Food Processing and Ultra-Processed Food: the Potential, Pitfalls and Path Forward for Public Health. 食品加工和超加工食品的目的：公共卫生的潜力、陷阱和前进道路。

IF 8 3区医学

Current Nutrition Reports Pub Date : 2026-06-06 DOI: 10.1007/s13668-026-00775-z

Samuel J Dicken

{"title":"The Purpose of Food Processing and Ultra-Processed Food: the Potential, Pitfalls and Path Forward for Public Health.","authors":"Samuel J Dicken","doi":"10.1007/s13668-026-00775-z","DOIUrl":"10.1007/s13668-026-00775-z","url":null,"abstract":"Purpose of review: The Nova classification considers the purpose and degree of food processing to capture how recent changes in the food system may link with health. Its value for understanding diet-disease relationships is debated. However, reviews typically focus only on its value, or its limitations. Furthermore, by discussing the degree of processing only and not the purpose, or discussing processing in general, reviews of limitations do not address pitfalls of the Nova classification. This conflict and confusion stalls progress to improve public health. Therefore, this review aims to provide a balanced understanding, interpretation and utilisation of the Nova classification and purpose of food processing, with a critical evaluation of its potential value, of pitfalls largely overlooked to date with recommendations to avoid unintended consequences, and constructive reflections on a path forward.Recent findings: The Nova classification offers a framework linking upstream socioeconomic factors with downstream properties of available food, complementing existing food-based dietary guidance to improve access to healthy diets through food systems transformations. However, its practical application, narrative of intrinsic harm of ultra-processing, usage to guide diets in isolation, and overemphasis on mechanisms with weaker evidence are pitfalls that, whilst avoidable, can have unintended consequences. There is agreement on the need for food systems transformation to ensure access and affordability to healthy diets for all. For public health, the purpose behind food processing provides an understanding of systems drivers of food production and accessibility. This consideration can be reflected in policy to improve access to healthy diets, without necessarily explicit use of the Nova classification.","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits. 健康衰老的靶向补充和营养策略：生理和分子益处综述。

IF 8 3区医学

Current Nutrition Reports Pub Date : 2026-06-03 DOI: 10.1007/s13668-026-00776-y

Jennifer A Kurtz, K Michelle Singleton, Ecaterina Vasenina, Ralf Jäger, Drew Gonzalez, Antonella Schwarz, Jonathan Howard, Jose Antonio

{"title":"Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.","authors":"Jennifer A Kurtz, K Michelle Singleton, Ecaterina Vasenina, Ralf Jäger, Drew Gonzalez, Antonella Schwarz, Jonathan Howard, Jose Antonio","doi":"10.1007/s13668-026-00776-y","DOIUrl":"10.1007/s13668-026-00776-y","url":null,"abstract":"Purpose of review: Aging is marked by progressive physiological decline driven by chronic inflammation, mitochondrial dysfunction, and impaired metabolic and musculoskeletal resilience. As the global population ages, dietary supplements have gained attention as potential tools to support healthy longevity. This review summarizes current evidence on nutritional compounds that target aging-related pathways, focusing on interventions that influence mitochondrial health, cognitive performance, immune function, metabolic regulation, and maintenance of muscle mass in older adults. Thirty-two human studies were identified through PubMed, Scopus, and Web of Science.Recent findings: Evidence indicates that several targeted nutrients, including protein, probiotics, antioxidants, and emerging mitochondrial-support compounds, may contribute to healthy aging. Protein and collagen supplementation, particularly when paired with resistance training, consistently improve muscle mass and physical function. Antioxidants, glycine, N-acetylcysteine, and NAD⁺ precursors show potential benefits for mitochondrial efficiency, cellular stress responses, and cognitive performance; however, findings vary across populations and dosing strategies. Heterogeneity in study designs, supplement formulations, and biomarker endpoints underscores the need for individualized and context-specific application. A personalized, evidence-informed supplementation strategy integrated with exercise and balanced nutrition may help optimize physiological function in aging adults. Future research should refine dosing protocols, evaluate synergistic nutrient combinations, and clarify the roles of antioxidants and mitochondrial-targeted compounds across diverse older populations.","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13233893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Gut Microbiota by DPP-4 Inhibitors in Obesity: Mechanistic Insights and Therapeutic Implications. 通过DPP-4抑制剂靶向肠道微生物群治疗肥胖：机制见解和治疗意义。

IF 8 3区医学

Current Nutrition Reports Pub Date : 2026-05-28 DOI: 10.1007/s13668-026-00773-1

Mansour Alanazi, Hayder M Al-Kuraishy, Ahmed A Mohamed, Shimaa A Abass, Mustafa M Shokr, Mubarak Alruwaili, Gaber El-Saber Batiha

{"title":"Targeting Gut Microbiota by DPP-4 Inhibitors in Obesity: Mechanistic Insights and Therapeutic Implications.","authors":"Mansour Alanazi, Hayder M Al-Kuraishy, Ahmed A Mohamed, Shimaa A Abass, Mustafa M Shokr, Mubarak Alruwaili, Gaber El-Saber Batiha","doi":"10.1007/s13668-026-00773-1","DOIUrl":"10.1007/s13668-026-00773-1","url":null,"abstract":"Purpose of review: Obesity is a complex metabolic disorder driven by factors such as chronic inflammation, insulin resistance, and significant alterations in the gut microbiota. Dipeptidyl peptidase-4 (DPP-4), an enzyme primarily known for inactivating incretin hormones like glucagon-like peptide-1 (GLP-1), is now recognized as a critical link between metabolic dysfunction and gut microbiome dysbiosis. This review aims to examine the mechanistic role of DPP-4 and its inhibitors in obesity, specifically focusing on how they modulate the gut microbiome to influence host energy balance and metabolic health.Recent findings: Recent experimental and clinical evidence indicates that DPP-4 activity contributes to obesity by influencing microbial composition, diversity, and function. Studies demonstrate that DPP-4 inhibitors can reshape the gut microbiota by reducing dysbiosis, decreasing the Firmicutes-to-Bacteroidetes ratio, and enhancing the production of short-chain fatty acids (SCFAs). Furthermore, these inhibitors improve gut barrier integrity and regulate bile acid metabolism, which helps attenuate systemic inflammation and restore insulin sensitivity. While DPP-4 inhibitors are often weight-neutral in clinical settings, they appear to assist in maintaining metabolic stability by enhancing central satiety signaling and reducing neuroinflammation. The gut microbiome acts as a key intermediary in the metabolic regulation managed by DPP-4. By restoring microbial balance and promoting beneficial metabolites, DPP-4 inhibitors offer therapeutic advantages that extend beyond traditional glycemic control to include improved energy equilibrium and reduced adiposity. Targeting the interactions between DPP-4 and the microbiota represents a promising future therapeutic strategy for managing obesity and its associated metabolic complications.","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modernization of Nutritional Assessment in Population Surveys: Integrating Anthropometry, Body Composition, and Biomarkers in the Digital Era. 人口调查中营养评估的现代化：整合数字时代的人体测量、身体成分和生物标志物。

IF 8 3区医学

Current Nutrition Reports Pub Date : 2026-05-26 DOI: 10.1007/s13668-026-00774-0

Tatiana Palotta Minari

{"title":"Modernization of Nutritional Assessment in Population Surveys: Integrating Anthropometry, Body Composition, and Biomarkers in the Digital Era.","authors":"Tatiana Palotta Minari","doi":"10.1007/s13668-026-00774-0","DOIUrl":"10.1007/s13668-026-00774-0","url":null,"abstract":"Purpose of review: This narrative review examines current approaches to nutritional status assessment in population-based surveys, emphasizing the complementary roles of anthropometric measurements, body composition analysis, and biochemical indicators. It aims to critically analyze methodological advances, operational constraints, and emerging strategies to improve the quality and applicability of nutritional surveillance in public health.Recent findings: Anthropometry remains the most widely used method due to its feasibility and scalability, although its diagnostic capacity is limited. Body composition techniques provide more detailed insights into tissue distribution but are constrained by cost and infrastructure requirements. Biochemical indicators offer high sensitivity for detecting metabolic and micronutrient alterations, yet their use in large-scale surveys is restricted by logistical and ethical challenges. The COVID-19 pandemic exposed vulnerabilities in data collection systems and highlighted the need for more resilient surveillance approaches. In parallel, digital technologies have expanded possibilities for data integration and analysis, although their implementation remains uneven across settings. A comprehensive approach to nutritional assessment requires the integration of complementary methods to address the multidimensional nature of malnutrition and chronic disease monitoring. Strengthening population-based surveys depends on balancing methodological rigor with operational feasibility, alongside investments in infrastructure, workforce capacity, and data governance. Advances in digital health may enhance surveillance systems, but their impact will depend on equitable implementation and alignment with public health priorities and equity-oriented strategies.","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13212673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148027886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Edible Insect Species Tenebrio molitor (Mealworm), Acheta domesticus (House Cricket), and Hermetia illucens (Black Soldier Fly) in the Food Industry: Nutritional Value, Safety Profile, and Consumer Acceptance. 食用昆虫粉虫、家蟋蟀和黑虻在食品工业中的应用：营养价值、安全性和消费者接受度

IF 8 3区医学

Current Nutrition Reports Pub Date : 2026-05-22 DOI: 10.1007/s13668-026-00770-4

Simge Cankaya, Hande Mortaş

{"title":"The Use of Edible Insect Species Tenebrio molitor (Mealworm), Acheta domesticus (House Cricket), and Hermetia illucens (Black Soldier Fly) in the Food Industry: Nutritional Value, Safety Profile, and Consumer Acceptance.","authors":"Simge Cankaya, Hande Mortaş","doi":"10.1007/s13668-026-00770-4","DOIUrl":"10.1007/s13668-026-00770-4","url":null,"abstract":"Purpose of review: This review aims to explore the role of edible insects as an alternative protein source in the food industry, focusing on their nutritional value, processing feasibility, food safety, and consumer acceptance. It provides an integrative perspective on how edible insects can contribute to sustainable food systems while addressing challenges related to consumer perception and regulatory frameworks.Recent findings: Recent studies have demonstrated that key edible insect species such as Tenebrio molitor, Acheta domesticus, and Hermetia illucens L. exhibit high protein content, favorable amino acid profiles, optimal omega-3/6 fatty acid ratios, and excellent bioavailability. Processing techniques including drying, extrusion, fermentation, and isolated protein production have been shown to influence both nutritional quality and microbiological safety. Moreover, consumer acceptance studies highlight that attitudes toward insect consumption are shaped by perceived benefits, disgust sensitivity, ethical considerations, and cultural familiarity. Edible insects present a promising alternative protein source with significant nutritional and environmental advantages. However, large-scale industrial adoption requires the combined development of scientific evidence, standardized regulations, and effective consumer education strategies. By integrating nutritional, technological, and psychosocial dimensions, this review provides a comprehensive understanding of the potential of edible insects in advancing sustainable food systems.","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional Perspectives on Parkinson's Disease: The Potential Neuroprotective Role of Coconut Derived Supplements. 帕金森病的营养观点：椰子衍生补充剂的潜在神经保护作用。

IF 8 3区医学

Current Nutrition Reports Pub Date : 2026-05-19 DOI: 10.1007/s13668-026-00772-2

Swetha Subramaniyan, Narayanasamy Marimuthu Prabhu, Karthikeyan Muthusamy

{"title":"Nutritional Perspectives on Parkinson's Disease: The Potential Neuroprotective Role of Coconut Derived Supplements.","authors":"Swetha Subramaniyan, Narayanasamy Marimuthu Prabhu, Karthikeyan Muthusamy","doi":"10.1007/s13668-026-00772-2","DOIUrl":"10.1007/s13668-026-00772-2","url":null,"abstract":"Purpose of review: This review examines the potential role of coconut-derived nutritional supplements in influencing Parkinson's disease risk and progression by modulating oxidative stress and mitochondrial function. Parkinson's disease is a neurodegenerative disease characterized by the death of dopaminergic neurons, mitochondrial damage, and increased oxidative stress. Nutritional approaches have garnered attention as adjunctive therapeutic strategies.Recent findings: The natural products of coconut, including coconut oil, coconut milk, coconut water, and coconut kernel, are rich in fatty acids, antioxidants, vitamins, and other essential minerals, which can have neuroprotective effects. Additionally, evidence suggests an inverse correlation between coconut consumption and the PD prevalence. Consequently, nutrients obtained from coconut products represent promising natural neuroprotective agents for the prevention and management of PD. Further studies ought to focus more on clinical trials to confirm the effectiveness of coconut-based supplements and explain the underlying neuroprotective effects of these supplements in the management of PD.","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147971021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pearl Millet-A Forgotten Ancient Grain with Emerging Immunomodulatory Potential in Sports Nutrition. 珍珠粟——一种被遗忘的古老谷物，在运动营养中具有新兴的免疫调节潜力。

IF 8 3区医学

Current Nutrition Reports Pub Date : 2026-05-16 DOI: 10.1007/s13668-026-00771-3

Alisha Saifi, Kommi Kalpana

{"title":"Pearl Millet-A Forgotten Ancient Grain with Emerging Immunomodulatory Potential in Sports Nutrition.","authors":"Alisha Saifi, Kommi Kalpana","doi":"10.1007/s13668-026-00771-3","DOIUrl":"10.1007/s13668-026-00771-3","url":null,"abstract":"Purpose of review: Athletes are chronically exposed to high physiological stress from intense training, prolonged exercise, and inadequate recovery, whichcan trigger systemic inflammation, oxidative stress, and immune dysregulation. These immune challenges highlight the need for dietary strategies that can modulate inflammatory pathways and support athletic performance and recovery. Pearl millet (Pennisetum glaucum), an underutilised ancient grain, has recently gained attention for its dense nutrient profile and bioactive compounds with potential immunomodulatory effects. Thus, this review aim is to explore the potential of pearl millet in modulating the inflammatory cytokines.Recent findings: Pearl millet is highly nutritious crop packed with fibre, polyphenols, flavonoids, peptides, and essential minerals such as iron, magnesium, and zinc, as well as B-vitamins, which enable it to exhibit antioxidant, anti-inflammatory, and gut-microbiota modulating properties that may contribute to improved immune resilience. Insights from cell-based and whole-organism studies indicates that millet consumption can effect inflammatory inducing cytokines (e.g., TNF-α, IL-6), enhance antioxidant enzyme function, improve metabolic health, and support gut integrity, all of which are directly relevant to athletes' immune function. Emerging research in human populations further suggests that millet-based diets reduce oxidative stress and chronic low-grade inflammation. This review explores current scientific evidence on the immunomodulatory potential of pearl millet, with a focus on its applicability in sports nutrition, and highlights its role as a promising functional grain that can mitigate exercise-induced inflammation and enhance athletic health and performance.","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Sweeteners and Gut Microbiota: Mechanistic Insights and Implications for Metabolic Health. 人工甜味剂和肠道微生物群：代谢健康的机理和意义。

IF 8 3区医学

Current Nutrition Reports Pub Date : 2026-05-16 DOI: 10.1007/s13668-026-00768-y

Rabie Khattab

{"title":"Artificial Sweeteners and Gut Microbiota: Mechanistic Insights and Implications for Metabolic Health.","authors":"Rabie Khattab","doi":"10.1007/s13668-026-00768-y","DOIUrl":"10.1007/s13668-026-00768-y","url":null,"abstract":"Purpose of review: Artificial sweeteners (ASs) are widely used as sugar substitutes to reduce caloric intake. Emerging evidence indicates that these compounds are not metabolically inert and can alter gut microbiota composition and downstream metabolic regulation. This review synthesizes recent mechanistic and clinical evidence on how commonly used ASs-particularly sucralose, saccharin, acesulfame-K, aspartame, and steviol glycosides-modulate intestinal microbiota.Recent findings: Experimental and human studies show that AS exposure is associated with alterations in microbial diversity, short-chain fatty acid (SCFA) production, and gut barrier integrity. These alterations are linked to changes in glucose homeostasis, insulin sensitivity, and energy metabolism. Proposed mechanisms include modulation of nutrient-sensing G-protein-coupled receptors, interference with bile acid metabolism, and receptor-independent activation of intracellular signaling pathways such as PI3K/Akt and mTORC1. Notably, responses in human studies appear highly individualized and dose-dependent, highlighting substantial interindividual variability. This review integrates microbiome, metabolic, and mechanistic perspectives to identify areas of emerging consensus, conflicting results, and critical research gaps in AS-microbiota-metabolism interactions. Current evidence suggests that ASs can modulate host metabolism through both microbiota-dependent and independent mechanisms. These findings have direct implications for clinical dietary guidance and risk stratification, particularly among individuals with obesity, insulin resistance, or other metabolic disorders.","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shining Light on Dysautonomia: The Role of Vitamin D in Cardiac Autonomic Regulation. 照亮自主神经异常：维生素D在心脏自主调节中的作用。

IF 8 3区医学

Current Nutrition Reports Pub Date : 2026-05-14 DOI: 10.1007/s13668-026-00769-x

Huai Heng Loh, Asri Said, Huai Seng Loh, Norlela Sukor

{"title":"Shining Light on Dysautonomia: The Role of Vitamin D in Cardiac Autonomic Regulation.","authors":"Huai Heng Loh, Asri Said, Huai Seng Loh, Norlela Sukor","doi":"10.1007/s13668-026-00769-x","DOIUrl":"10.1007/s13668-026-00769-x","url":null,"abstract":"Purpose of review: Traditionally recognized for its role in calcium homeostasis and bone metabolism, vitamin D is increasingly acknowledged for its broader physiological effects, particularly in cardiovascular health. One area of growing interest is its influence on cardiac autonomic function. Cardiac autonomic dysfunction, characterized by an imbalance between sympathetic and parasympathetic activity, is a well-established predictor of adverse cardiovascular outcomes. This narrative review aims to synthesize the current literature on the association between vitamin D status and cardiac autonomic function.Recent findings: Accumulating observational data indicate that individuals with vitamin D deficiency exhibit poorer cardiac autonomic function, reflected by reduced heart rate variability indices, compared to vitamin D-sufficient individuals. Interventional trials, though limited, suggest that vitamin D supplementation may improve autonomic balance, especially in those with baseline deficiency. The relationship appears to be affected by factors such as glycemic control, disease state, and vitamin D binding protein levels. Vitamin D may modulate autonomic regulation largely via the vitamin D receptor, which activation influences multiple downstream pathways, including central nervous system effects, neurotrophic properties, regulation of the renin-angiotensin-aldosterone system, calcium-parathyroid hormone axis, and immune modulation. However, inconsistencies in study design, population characteristics, and assessment methods limit the strength of current evidence. Further longitudinal and interventional studies are warranted to establish causality and determine whether vitamin D repletion can reduce cardiovascular risk by restoring autonomic balance.","PeriodicalId":10844,"journal":{"name":"Current Nutrition Reports","volume":"15 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0