Current Cardiology Reports最新文献_第2页

The Role of Pericardial Fat in Cardiometabolic Disease: Emerging Evidence and Therapeutic Potential. 心包脂肪在心脏代谢疾病中的作用：新证据和治疗潜力。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-10 DOI: 10.1007/s11886-025-02305-9

Zaid Shahrori, Michel Chedid El Helou, Sherin Sallam, Gianluca Iacobellis, Ian J Neeland

{"title":"The Role of Pericardial Fat in Cardiometabolic Disease: Emerging Evidence and Therapeutic Potential.","authors":"Zaid Shahrori, Michel Chedid El Helou, Sherin Sallam, Gianluca Iacobellis, Ian J Neeland","doi":"10.1007/s11886-025-02305-9","DOIUrl":"https://doi.org/10.1007/s11886-025-02305-9","url":null,"abstract":"Purpose of review: This review explores the unique anatomy and pathophysiology of pericardial fat (including both epicardial adipose tissue [EAT] and paracardial fat), its clinical significance, and its potential role as a therapeutic target. It addresses key questions regarding the contribution of EAT to cardiometabolic conditions such as coronary artery disease, heart failure, atrial fibrillation, and ventricular arrhythmias, and explores interventions that reduce EAT to possibly improve cardiovascular outcomes.Recent findings: Recent studies have established EAT as a metabolically active, pro-inflammatory fat depot directly affecting the myocardium and coronary arteries. Imaging and metabolomic studies have advanced the assessment of EAT burden. Clinical evidence supports lifestyle modification, pharmacologic therapies including GLP-1 RA and SGLT2i, and bariatric surgery to effectively reduce EAT volume. Emerging data link EAT reduction with improved cardiac function and arrhythmia risk, although causality remains unclear. EAT is a modifiable cardiometabolic risk factor associated with adverse outcomes in coronary artery disease, heart failure, atrial fibrillation, and ventricular arrhythmias. Targeting EAT through cardiometabolic risk reduction strategies may improve prognosis. Future research should focus on determining whether reducing EAT directly improves clinical outcomes.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"141"},"PeriodicalIF":3.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiomyopathy in Older Adults. 老年人心肌病。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-09 DOI: 10.1007/s11886-025-02306-8

Deirdre E O'Neill, Daniel E Forman

{"title":"Cardiomyopathy in Older Adults.","authors":"Deirdre E O'Neill, Daniel E Forman","doi":"10.1007/s11886-025-02306-8","DOIUrl":"https://doi.org/10.1007/s11886-025-02306-8","url":null,"abstract":"Purpose of review: Cardiomyopathy is a disorder of the myocardium, in which structural and functional abnormalities of the heart muscle result in mechanical and/or electrical cardiac dysfunction. Aging increases susceptibility to molecular damage and related risks of cardiomyopathy, often in combination with other chronic diseases and geriatric syndromes (e.g., frailty, sarcopenia). With the rapidly growing population of older adults, awareness of the most prevalent cardiomyopathies in this population provides important insight to optimize prevention and treatment.Recent findings: Hypertrophic, restrictive and dilated cardiomyopathies are highly prevalent in older adults. Furthermore, coronary artery disease, hypertension and valve disease increase with aging, and often lead to myocardial abnormalities that have many similar features to cardiomyopathy that are important to clarify. This review provides important age-related perspectives regarding pathophysiology, diagnosis, management and prevention. Aging is associated with inflammation and oxidative stress that can lead to molecular damage and vulnerability to many chronic diseases, including various cardiomyopathies. However, development is not inevitable. Prevention via lifestyle modification is paramount, with novel gerotherapeutic options targeting biologic hallmarks of aging under investigation. This increases the potential to improve the lifespan and healthspan of older adults.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"139"},"PeriodicalIF":3.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcified Nodules: Pathology, Mechanisms, and Clinical Challenges. 钙化结节：病理、机制和临床挑战。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-09 DOI: 10.1007/s11886-025-02292-x

Tomoyo Hamana, Alyssa Grogan, Rika Kawakami, Renu Virmani, Aloke V Finn

{"title":"Calcified Nodules: Pathology, Mechanisms, and Clinical Challenges.","authors":"Tomoyo Hamana, Alyssa Grogan, Rika Kawakami, Renu Virmani, Aloke V Finn","doi":"10.1007/s11886-025-02292-x","DOIUrl":"https://doi.org/10.1007/s11886-025-02292-x","url":null,"abstract":"Purpose of review: Calcified nodules (CNs) account for ~ 5% of acute coronary syndrome cases. Although the progression of calcification generally leads to plaque stability, CNs ─ an advanced form of calcified plaques ─ can trigger coronary thrombosis and sudden cardiac death.Recent findings: CNs are histologically defined as lesions with fibrous cap disruption and luminal thrombus, associated with dense, eruptive calcific nodules protruding into the lumen. They are linked to poor prognosis both post percutaneous coronary intervention and in non-culprit lesions. Interventionalists are exploring various treatment strategies using debulking devices and drug-coated balloons; however, no effective treatment has been established. While histological classifications can be inferred from optical coherence tomography findings, accurately predicting CNs from intravascular imaging remains challenging. This review discusses the pathological features, etiology, clinical outcomes, and current treatment strategies for CNs, offering valuable insights into the correlation and discrepancies between histological findings and optical coherence tomography.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"140"},"PeriodicalIF":3.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SCN5A Cardiomyopathy: from Ion Channel Dysfunction To Clinical Disease. SCN5A心肌病：从离子通道功能障碍到临床疾病

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-09 DOI: 10.1007/s11886-025-02298-5

Astrid B M Heymans, Lorenzo Bianchi, Paul G A Volders, Saskia N van der Crabben, Job A J Verdonschot

{"title":"SCN5A Cardiomyopathy: from Ion Channel Dysfunction To Clinical Disease.","authors":"Astrid B M Heymans, Lorenzo Bianchi, Paul G A Volders, Saskia N van der Crabben, Job A J Verdonschot","doi":"10.1007/s11886-025-02298-5","DOIUrl":"10.1007/s11886-025-02298-5","url":null,"abstract":"Purpose of review: Although SCN5A variants are an established cause of arrhythmia and conduction disease, their association with dilated cardiomyopathy (DCM) is less studied. This review summarizes recent insights into SCN5A-related cardiomyopathy, focusing on genotype-phenotype correlations, overlap with arrhythmia, and implications for management.Recent findings: Both gain- and loss-of-function SCN5A variants are associated with cardiomyopathy, found in 0.5-0.9% of DCM cases. Presentation ranges from isolated DCM to overlap phenotypes, in both pediatric and adult patients. High variability and intrafamilial heterogeneity suggest pleiotropic effects and variable penetrance. High prevalence of arrhythmias and conduction disease suggests the DCM phenotype may be mediated by electrical disturbances. However, functional studies and cases without prior arrhythmia suggest SCN5A variants may directly contribute to structural myocardial changes. SCN5A-related cardiomyopathy is a rare disorder at the intersection of structural and electrical heart disease. Genotype-informed strategies, including arrhythmia management, and early cascade genetic screening are clinically relevant. Further research should address SCN5A-specific risk management in DCM patients.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"138"},"PeriodicalIF":3.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12511166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence-based Management of Heart Failure in the Systemic Right Ventricle. 系统性右心室心力衰竭的循证管理。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-09 DOI: 10.1007/s11886-025-02297-6

Xander Jacquemyn, Jef Van den Eynde, Sruti Rao, Shelby Kutty

{"title":"Evidence-based Management of Heart Failure in the Systemic Right Ventricle.","authors":"Xander Jacquemyn, Jef Van den Eynde, Sruti Rao, Shelby Kutty","doi":"10.1007/s11886-025-02297-6","DOIUrl":"https://doi.org/10.1007/s11886-025-02297-6","url":null,"abstract":"Purpose of review: Explore the clinical progression, diagnostic challenges, and evolving treatments of systemic right ventricular (SRV) failure, highlighting key gaps and advances.Recent findings: Recent evidence highlights the distinct pathophysiology of SRV failure and limited efficacy of conventional heart failure (HF) treatments. Emerging drugs like SGLT2 inhibitors are being studied for modulating ventricular remodeling and fibrosis. Echocardiography, enhanced by speckle-tracking and 3D imaging, is first-line, while cardiac MRI remains the gold standard for volumetric, functional, and tissue characterization. SRV-specific machine learning models improve prognostication and personalized care. Advances in transcatheter tricuspid valve interventions offer less invasive options for high-risk patients. In end-stage SRV failure, ventricular assist devices effectively unload the ventricle, enhance transplant candidacy, may be combined with tricuspid procedures, and are increasingly used as long-term destination therapy. SRV failure is a unique condition requiring personalized, multidisciplinary management, with advances in risk stratification and treatments shaping future care.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"137"},"PeriodicalIF":3.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood Adversity and Cardiovascular Disease; Current Knowledge and Future Directions. 童年逆境与心血管疾病；当前的知识和未来的方向。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-07 DOI: 10.1007/s11886-025-02300-0

Shakira F Suglia

引用次数: 0

Decoding Cardiac Maturation Program: Insights from RNA Splicing Regulation. 解码心脏成熟程序：来自RNA剪接调控的见解。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-09-20 DOI: 10.1007/s11886-025-02271-2

Woan Ting Tay, Yibin Wang

{"title":"Decoding Cardiac Maturation Program: Insights from RNA Splicing Regulation.","authors":"Woan Ting Tay, Yibin Wang","doi":"10.1007/s11886-025-02271-2","DOIUrl":"https://doi.org/10.1007/s11886-025-02271-2","url":null,"abstract":"Purpose of review: Cardiomyocyte postnatal maturation is a critical step of the mammalian heart development continuum, involving a myriad of phenotypic changes at morphological, molecular, and functional levels. While the phenotypic hallmarks of cardiac maturation are well characterized, the molecular mechanisms that govern this maturation process are still poorly defined. This review aims to explore the recent findings on how post-transcriptional regulations orchestrate the fetal-to-adult cardiomyocyte transition and to highlight their clinical implications for cardiac diseases and regeneration medicine.Recent findings: The molecular regulations of cardiac maturation are distinct from the gene regulatory network implicated in embryonic stages of cardiac development. RNA alternative splicing and the resulting isoform switching events are significant part of the post-transcriptional reprogramming during the transitional stage of maturation, driving functional refinement through a network of RNA-binding proteins. Cardiomyocytes undergo significant changes in structure, physiology, metabolic activity, and proliferative capacities during fetal to adult maturation. Recent findings highlight the importance of post-transcriptional regulation in this process, in particular RNA alternative splicing and isoform switch. Understanding the post-transcriptional regulatory mechanisms, including key molecular players that contribute to the fetal-to-adult transition, can provide a new conceptual framework for cardiac development, diseases, and regenerative medicine.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"135"},"PeriodicalIF":3.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Echoes of Inequity: A Critical Examination of the Past, Present, and Future of Cardiac Health Equity. 不公平的回声：心脏健康公平的过去，现在和未来的关键检查。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-09-19 DOI: 10.1007/s11886-025-02275-y

Toluwalase Awoyemi, Cedrick Mutebi, Quentin R Youmans, Ike S Okwuosa, Clyde W Yancy, Kamari Ositelu

{"title":"Echoes of Inequity: A Critical Examination of the Past, Present, and Future of Cardiac Health Equity.","authors":"Toluwalase Awoyemi, Cedrick Mutebi, Quentin R Youmans, Ike S Okwuosa, Clyde W Yancy, Kamari Ositelu","doi":"10.1007/s11886-025-02275-y","DOIUrl":"10.1007/s11886-025-02275-y","url":null,"abstract":"Purpose of review: This review explores the historical, structural, and biological foundations of cardiovascular (CV) health inequities in the U.S. It examines how disparities by ancestry, sex, geography, income, immigration status, and race have emerged, persisted, and, in some cases, worsened while evaluating strategies for advancing equity.Recent findings: Despite progress in prevention and treatment, key disparities remain entrenched. Structural inequities, socioeconomic exclusion, and underrepresentation in research continue to shape outcomes. Social adversity is increasingly understood to exert biological effects through mechanisms such as chronic stress, cardio-kidney-metabolic dysfunction, and epigenetic aging. Novel tools, including place-based deprivation indices, precision risk prediction models, and community-driven interventions offer actionable pathways forward but remain underutilized or unevenly implemented. Cardiac health equity requires more than clinical innovation; it demands structural reform, inclusive science, and equity-centered implementation. Future solutions must embed social context into care, research, and policy to drive durable, population-level impact.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"134"},"PeriodicalIF":3.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To Extract or not To Extract? Navigating Lead Failure in Cardiac Devices. 抽取还是不抽取？心脏装置导航导联失效。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-09-17 DOI: 10.1007/s11886-025-02282-z

Eric W Mills, Dingxin Qin, Theofanie Mela

引用次数: 0

Addressing Diastolic Dysfunction in the Congenital Heart Population. 先天性心脏病患者的舒张功能障碍。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-09-12 DOI: 10.1007/s11886-025-02295-8

Ryan M Edwards, Allison P Levin, Richard A Krasuski

引用次数: 0