Current Cardiology Reports最新文献

Cardiovascular Outcomes of Uric Acid Lowering Medications: A Meta-Analysis. 降尿酸药物的心血管疗效：一项 Meta 分析

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-10-01 DOI: 10.1007/s11886-024-02138-y

Yasser Jamil, Dana Alameddine, Mahmoud El Iskandarani, Ankit Agrawal, Aro D Arockiam, Elio Haroun, Heba Wassif, Patrick Collier, Tom Kai Ming Wang

{"title":"Cardiovascular Outcomes of Uric Acid Lowering Medications: A Meta-Analysis.","authors":"Yasser Jamil, Dana Alameddine, Mahmoud El Iskandarani, Ankit Agrawal, Aro D Arockiam, Elio Haroun, Heba Wassif, Patrick Collier, Tom Kai Ming Wang","doi":"10.1007/s11886-024-02138-y","DOIUrl":"https://doi.org/10.1007/s11886-024-02138-y","url":null,"abstract":"Background: Although hyperuricemia is a recognized risk factor for cardiovascular diseases, mixed results have been reported regarding the associations between uric acid-lowering medications and cardiovascular events. This meta-analysis compared the cardiovascular outcomes of different uric acid-lowering medications and placebo.Methods: Following PRISMA guidelines, we searched OVID Medline, Embase, Web of Science, and Cochrane databases to identify potentially relevant articles until December 2023. Studies must be randomized or observational, report cardiovascular and mortality outcomes, and compare uric acid-lowering medications to placebo or each other. Data was analyzed using Revman (version 5.4) software.Results: A total of 3,393 studies were searched, after which 47 studies were included, totaling 3,803,509 patients (28 studies comparing xanthine oxidase inhibitors (XOI) versus placebo, 17 studies comparing allopurinol and febuxostat, and 2 studies comparing XOI and uricosuric agents). Overall mean age was 57.3 years, and females comprised 20.8% of all studies. There were no significant differences between XOI and placebo for cardiovascular outcomes (mortality, myocardial infarction, major adverse cardiovascular events, heart failure, or arrhythmia). There was significant heterogeneity in all these pooled analyses. Comparing Allopurinol to Febuxostat, there was a lower risk of heart failure in febuxostat than allopurinol in 3 RCTs (OR 0.66, 95% CI 0.50-0.89, p = 0.006). Other cardiovascular outcomes were not different. Lastly, when comparing XOI and uricosuric agents, no significant differences in MI rates were evident.Conclusion: XOI was not associated with reduced cardiovascular events compared to placebo. When comparing XOI agents, Febuxostat might reduce the risk of HF, but future studies are required to confirm the findings from the current study.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Subcutaneous Furosemide in Heart Failure Management: A Systematic Review. 皮下注射呋塞米在心力衰竭治疗中的作用：系统回顾

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-10-01 DOI: 10.1007/s11886-024-02124-4

Wynne Widiarti, Pandit Bagus Tri Saputra, Melissa Valentina Ariyanto, Cornelia Ghea Savitri, Chaq El Chaq Zamzam Multazam, Johanes Nugroho Eko Putranto, Firas Farisi Alkaff

{"title":"The Role of Subcutaneous Furosemide in Heart Failure Management: A Systematic Review.","authors":"Wynne Widiarti, Pandit Bagus Tri Saputra, Melissa Valentina Ariyanto, Cornelia Ghea Savitri, Chaq El Chaq Zamzam Multazam, Johanes Nugroho Eko Putranto, Firas Farisi Alkaff","doi":"10.1007/s11886-024-02124-4","DOIUrl":"https://doi.org/10.1007/s11886-024-02124-4","url":null,"abstract":"Background: Acute decompensated heart failure (ADHF) patients with symptomatic congestion often require in-hospital admission for intravenous (IV) diuretic, impacting both patient well-being and healthcare expenses. Subcutaneous (SC) furosemide has a potential to facilitate outpatient management of ADHF patients. Thus, this study aims to assess the efficacy and safety of SC furosemide utilization, offering a potential alternative to traditional IV administration.Methods: A systematic search was conducted until April 14 2024 across scientific databases. This review included studies comparing SC furosemide with oral and IV formulations in adult HF patients.Results: This study analyzed 687 patients from 20 studies. The results demonstrate that SC furosemide can effectively manage symptomatic congestion in HF patients and results in significant cost reductions, symptom relief, and improved quality of life. Although further investigation into mortality rates is needed, SC furosemide demonstrates efficacy comparable to IV furosemide in diuresis and weight loss, with similar bioavailability and natriuretic effects. Adverse events are generally minor, predominantly related to skin irritation. Innovative strategies, such as developing isotonic alkaline solutions and improved infusion devices, are being explored to address these challenges.Conclusion: SC furosemide offers a promising alternative for managing ADHF, particularly in symptomatic HF patients with volume overload. The integration of SC furosemide into routine clinical practice and future guidelines, could optimize the management of HF, reducing hospital admission and improving patient outcomes.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo and In Vitro Approaches to Modeling Hypoplastic Left Heart Syndrome. 左心发育不全综合征的体内和体外建模方法

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-28 DOI: 10.1007/s11886-024-02122-6

Matthew Alonzo, Javier Contreras, Jakob Bering, Ming-Tao Zhao

引用次数: 0

Echocardiography for Management of Cardiovascular Disease in Pregnancy. 超声心动图治疗妊娠期心血管疾病。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-26 DOI: 10.1007/s11886-024-02126-2

Mary Rodriguez Ziccardi, Joan E Briller

引用次数: 0

The Price We Pay for Progression in Shock Care: Economic Burden, Accessibility, and Adoption of Shock-Teams and Mechanical Circulatory Support Devices. 我们为休克护理的进步付出的代价：休克团队和机械循环支持设备的经济负担、可及性和采用率。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-26 DOI: 10.1007/s11886-024-02108-4

Saraschandra Vallabhajosyula, Shashank S Sinha, Ajar Kochar, Mohit Pahuja, Frank J Amico, Navin K Kapur

{"title":"The Price We Pay for Progression in Shock Care: Economic Burden, Accessibility, and Adoption of Shock-Teams and Mechanical Circulatory Support Devices.","authors":"Saraschandra Vallabhajosyula, Shashank S Sinha, Ajar Kochar, Mohit Pahuja, Frank J Amico, Navin K Kapur","doi":"10.1007/s11886-024-02108-4","DOIUrl":"https://doi.org/10.1007/s11886-024-02108-4","url":null,"abstract":"Purpose of review: Cardiogenic shock (CS) is associated with high in-hospital and long-term mortality and morbidity that results in significant socio-economic impact. Due to the high costs associated with CS care, it is important to define the short- and long-term burden of this disease state on resources and review strategies to mitigate these.Recent findings: In recent times, the focus on CS continues to be on improving short-term outcomes, but there has been increasing emphasis on the long-term morbidity. In this review we discuss the long-term outcomes of CS and the role of hospital-level and system-level disparities in perpetuating this. We discuss mitigation strategies including developing evidence-based protocols and systems of care, improvement in risk stratification and evaluation of futility of care, all of which address the economic burden of CS. CS continues to remain the pre-eminent challenge in acute cardiovascular care, and a combination of multi-pronged strategies are needed to improve outcomes in this population.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovations in Imaging: ¹⁸F-Fluorodeoxyglucose PET/CT for Assessment of Cardiovascular Infection and Inflammation. 成像技术的创新：18F-氟脱氧葡萄糖 PET/CT 用于评估心血管感染和炎症。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-24 DOI: 10.1007/s11886-024-02137-z

Siddharth J Trivedi, Jamieson M Bourque

引用次数: 0

Diagnosing Non-Ischemic Cardiomyopathies on Myocardial Perfusion Imaging with Positron Emission Tomography. 利用正电子发射断层扫描心肌灌注成像诊断非缺血性心肌病。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-21 DOI: 10.1007/s11886-024-02139-x

Roopesh Sai Jakulla, Brett W Sperry

{"title":"Diagnosing Non-Ischemic Cardiomyopathies on Myocardial Perfusion Imaging with Positron Emission Tomography.","authors":"Roopesh Sai Jakulla, Brett W Sperry","doi":"10.1007/s11886-024-02139-x","DOIUrl":"https://doi.org/10.1007/s11886-024-02139-x","url":null,"abstract":"Purpose of review: This article summarizes findings seen in various cardiomyopathies on myocardial perfusion imaging (MPI) with positron emission tomography (PET).Recent findings: MPI is the cornerstone for evaluation of coronary ischemia, and technological advancements have yielded improved imaging quality and reduction in radiation exposure, particularly with PET. Multi-specialty guidelines and appropriate use criteria provide guidance on utilization of PET MPI in various scenarios related to evaluation of chest pain, new onset cardiomyopathy, and other scenarios where coronary ischemia should be assessed. Various non-ischemic cardiomyopathies such as septal and apical hypertrophic cardiomyopathy, amyloidosis, sarcoidosis, takotsubo, and dilated cardiomyopathy have typical imaging findings on PET MPI and can be identified if these patterns are understood. It is essential to recognize specific imaging patterns in non-ischemic cardiomyopathies which may aide in diagnosis. Ultimately, multimodality imaging, including echocardiography and cardiac magnetic resonance, complement PET MPI in diagnosing and guiding treatment options for these conditions.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Statin Therapy on Diabetes Incidence: Implications for Primary Prevention. 他汀类药物治疗对糖尿病发病率的影响：对初级预防的影响

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-20 DOI: 10.1007/s11886-024-02141-3

Rishi Rikhi, Michael D Shapiro

引用次数: 0

Advances in the Multimodality Imaging and Management of Recurrent Pericarditis: A Contemporary Review. 复发性心包炎的多模式成像和管理进展：当代回顾。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-20 DOI: 10.1007/s11886-024-02133-3

Harsha Sanaka, Elio Haroun, Aro Daniela Arockiam, Tiffany Dong, Allan Klein, Tom Kai Ming Wang

引用次数: 0

Computational Medicine: What Electrophysiologists Should Know to Stay Ahead of the Curve. 计算医学：电生理学家保持领先地位须知》。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-20 DOI: 10.1007/s11886-024-02136-0

Matthew J Magoon, Babak Nazer, Nazem Akoum, Patrick M Boyle

{"title":"Computational Medicine: What Electrophysiologists Should Know to Stay Ahead of the Curve.","authors":"Matthew J Magoon, Babak Nazer, Nazem Akoum, Patrick M Boyle","doi":"10.1007/s11886-024-02136-0","DOIUrl":"https://doi.org/10.1007/s11886-024-02136-0","url":null,"abstract":"Purpose of review: Technology drives the field of cardiac electrophysiology. Recent computational advances will bring exciting changes. To stay ahead of the curve, we recommend electrophysiologists develop a robust appreciation for novel computational techniques, including deterministic, statistical, and hybrid models.Recent findings: In clinical applications, deterministic models use biophysically detailed simulations to offer patient-specific insights. Statistical techniques like machine learning and artificial intelligence recognize patterns in data. Emerging clinical tools are exploring avenues to combine all the above methodologies. We review three ways that computational medicine will aid electrophysiologists by: (1) improving personalized risk assessments, (2) weighing treatment options, and (3) guiding ablation procedures. Leveraging clinical data that are often readily available, computational models will offer valuable insights to improve arrhythmia patient care. As emerging tools promote personalized medicine, physicians must continue to critically evaluate technology-driven tools they consider using to ensure their appropriate implementation.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0