Current Cardiology Reports最新文献

Risks and Prognostic Implications of Pericardial Disease and Atrial Fibrillation after Cardiac Surgery. 心脏手术后心包疾病和心房颤动的风险和预后意义。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-23 DOI: 10.1007/s11886-025-02303-x

Lamis El Harake, Mohamed Al-Kazaz, Paul C Cremer

{"title":"Risks and Prognostic Implications of Pericardial Disease and Atrial Fibrillation after Cardiac Surgery.","authors":"Lamis El Harake, Mohamed Al-Kazaz, Paul C Cremer","doi":"10.1007/s11886-025-02303-x","DOIUrl":"https://doi.org/10.1007/s11886-025-02303-x","url":null,"abstract":"Purpose of review: Postoperative atrial fibrillation (POAF) and post pericardiotomy syndrome (PPS) are among the most common complications following cardiac surgery. This review explores their incidence, clinical features, risk factors, and shared inflammatory mechanisms. It also examines prevention and management strategies, with a focus on the relationship between PPS and POAF and remaining gaps in understanding.Recent findings: Pericardial inflammation and innate immune activation are central to the development of both POAF and PPS. Surgical trauma initiates cascades involving cytokines, oxidative stress, and atrial remodeling. PPS has been associated with a higher risk of atrial fibrillation in the early postoperative period. Although current prediction models do not provide optimal discrimination, several preventive strategies, including preoperative medications and surgical options, have been shown to reduce the risk of these complications. However, varying definitions and diagnostic criteria limit comparability across studies, and long-term data are scarce. POAF and PPS are associated with significant morbidity, including longer hospital stays, readmissions, and cardiovascular complications. Identifying high-risk patients is essential to guide early interventions. The overlap in pathophysiology suggests PPS may trigger POAF, but causality remains unconfirmed. Future research should focus on clarifying their relationship, assessing the durability of preventive strategies, and establishing standardized diagnostic criteria to reduce heterogeneity and improve clinical decision-making.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"147"},"PeriodicalIF":3.3,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Positive Affect and Heart Rate Variability: A Systematic Review. 积极情绪与心率变异性之间的关系：一项系统综述。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-23 DOI: 10.1007/s11886-025-02299-4

Martha Schneider, Christian Rominger, Andreas R Schwerdtfeger

{"title":"Associations Between Positive Affect and Heart Rate Variability: A Systematic Review.","authors":"Martha Schneider, Christian Rominger, Andreas R Schwerdtfeger","doi":"10.1007/s11886-025-02299-4","DOIUrl":"https://doi.org/10.1007/s11886-025-02299-4","url":null,"abstract":"Purpose of review: The relationship between positive affect (PA) and heart rate variability (HRV) has attracted considerable interest due to its potential implications for emotion regulation and cardiovascular health. This systematic review synthesizes current literature on the association between PA and HRV, considering resting-state, stress-reactivity and recovery contexts, as well as variations in PA conceptualization.Recent findings: A total of 36 studies (N = 5501) were included, spanning experimental, ambulatory, cross-sectional, and mixed designs. Elevated PA was most often associated with higher vagally mediated HRV, measured as RMSSD or high-frequency (HF) power, but results varied by context. Resting-state and trait-like PA measures showed the most consistent positive associations. In stress-induction paradigms, effects depended on the stress phase and arousal level of PA, with RMSSD emerging as a more consistent index than other HRV metrics. In real-life settings, aggregated activated PA was linked to higher RMSSD, while momentary activated PA was linked to lower RMSSD, suggesting short-term allostatic adjustments. Findings for other HRV metrics, such as LF/HF ratio, LF-HRV, and SDNN, were mixed. Overall, this review highlights the complex interplay between PA and cardiac autonomic regulation and provides directions for future research, which should aim for greater methodological consistency and clarify the temporal dynamics of the PA-HRV relationship.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"148"},"PeriodicalIF":3.3,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal Approach in Staged Chronic Total Occlusion Percutaneous Coronary Intervention. 分阶段慢性全闭塞经皮冠状动脉介入治疗的最佳方法。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-23 DOI: 10.1007/s11886-025-02318-4

Sandeep Jalli, Dimitrios Strepkos, Michaella Alexandrou, Deniz Mutlu, Pedro E P Carvalho, Eleni Kladou, Ozgur S Ser, Jaskanwal Deep Singh Sara, Olga Mastrodemos, Bavana V Rangan, Konstantinos Voudris, M Nicholas Burke, Yader Sandoval, Emmanouil S Brilakis

{"title":"Optimal Approach in Staged Chronic Total Occlusion Percutaneous Coronary Intervention.","authors":"Sandeep Jalli, Dimitrios Strepkos, Michaella Alexandrou, Deniz Mutlu, Pedro E P Carvalho, Eleni Kladou, Ozgur S Ser, Jaskanwal Deep Singh Sara, Olga Mastrodemos, Bavana V Rangan, Konstantinos Voudris, M Nicholas Burke, Yader Sandoval, Emmanouil S Brilakis","doi":"10.1007/s11886-025-02318-4","DOIUrl":"https://doi.org/10.1007/s11886-025-02318-4","url":null,"abstract":"Purpose of review: To discuss the optimal timing of staged chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in patients presenting with acute coronary syndromes (ACS), multiple CTOs and after a CTO modification procedure.Recent findings: In patients with acute coronary syndromes CTO PCI should be performed as part of a complete revascularization strategy within a few weeks or months from the initial presentation. In patients who undergo CTO modification procedures, such as subintimal tracking and re-entry (STAR) earlier re-intervention (within 1-2 months) is better than later re-intervention. Staged intervention is preferred in most patients who need PCI of more than one CTO to minimize the risk of complications. The optimal timing of CTO intervention as part of a complete revascularization strategy remains unknown, as does the optimal timing of repeat intervention after a CTO modification procedure, though earlier is likely better than later in both cases. PCI of more than one CTO in the same patient should also be staged for safety reasons.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"151"},"PeriodicalIF":3.3,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay between Elevated Bile Acids and Reduced Vitamin D Levels in Fontan Circulation: A Double-Edged Sword. 在Fontan循环中胆汁酸升高和维生素D水平降低之间的相互作用：一把双刃剑。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-23 DOI: 10.1007/s11886-025-02304-w

Ashish H Shah, Amir Ravandi, Sanjiv Dhingra, Michel Aliani, Kothandam Sivakumar, Richard A Krasuski, Sivasubramanian Ramakrishnan

{"title":"Interplay between Elevated Bile Acids and Reduced Vitamin D Levels in Fontan Circulation: A Double-Edged Sword.","authors":"Ashish H Shah, Amir Ravandi, Sanjiv Dhingra, Michel Aliani, Kothandam Sivakumar, Richard A Krasuski, Sivasubramanian Ramakrishnan","doi":"10.1007/s11886-025-02304-w","DOIUrl":"https://doi.org/10.1007/s11886-025-02304-w","url":null,"abstract":"Purpose of review: The Fontan procedure, a palliative surgery for single-ventricle congenital heart disease, often leads to multisystem complications. Elevated bile acids and reduced vitamin D3 levels, frequently observed in this population, may share a harmful bidirectional relationship. This review examines their interplay and therapeutic relevance.Recent findings: Fontan-associated liver disease and potential gut dysbiosis contribute to altered bile acid metabolism, with elevated circulating secondary bile acids impairing cardiovascular, hepatic, musculoskeletal, and immune functions. Recent evidence suggests that bile acid accumulation hinders vitamin D absorption and metabolism. In turn, vitamin D deficiency exacerbates systemic inflammation and fibrosis while reducing bile acid detoxification via diminished vitamin D receptor signaling. The dysregulation of bile acid and vitamin D pathways may create a vicious cycle driving Fontan-associated multisystem dysfunction. Interventions targeting this axis-such as vitamin D supplementation and bile acid modulation-may offer novel strategies to mitigate organ injury and improve long-term outcomes in this high-risk population.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"149"},"PeriodicalIF":3.3,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left Atrial Coupling Index for the Prediction of Atrial Fibrillation and Heart Failure: Current Evidence and Clinical Implications. 左房偶联指数预测心房颤动和心力衰竭：目前的证据和临床意义。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-23 DOI: 10.1007/s11886-025-02315-7

Tea Gegenava, Stephan Milhorini Pio, Koen Nieman

引用次数: 0

The Ross Procedure: Historical Context, Modern Outcomes, and the Road Ahead. 罗斯程序：历史背景、现代结果和未来之路。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-23 DOI: 10.1007/s11886-025-02296-7

Christian Eidson, Andrew Well, Joseph Turek, Carlos M Mery, Ziv Beckerman

{"title":"The Ross Procedure: Historical Context, Modern Outcomes, and the Road Ahead.","authors":"Christian Eidson, Andrew Well, Joseph Turek, Carlos M Mery, Ziv Beckerman","doi":"10.1007/s11886-025-02296-7","DOIUrl":"https://doi.org/10.1007/s11886-025-02296-7","url":null,"abstract":"Purpose of review: There remains no single perfect aortic valve replacement option in patients with aortic valve disease. In this manuscript, we will discuss the modern role of the Ross Procedure in children and adults with aortic valve disease.Recent findings: Currently, the Ross procedure is the only established operation that allows replacement of the aortic valve with living, growing tissue. Use of the Ross procedure for aortic valve replacement has waxed and waned in recent decades. However, in recent years, with reports from long-term data series, interest has been redirected at the Ross procedure due to its excellent durability and freedom from long-term valvular morbidity and mortality. In patients requiring aortic valve replacement, the Ross procedure offers excellent short- and long-term outcomes and can be tailored to specific pathologies and the needs of individual patients. In this patient population, it is the only intervention that restores life expectancy to that of the general population. The Ross procedure remains a superb intervention for the treatment of aortic valve disease in children and adults in the modern era and should be heavily considered as an option when aortic valve replacement is required.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"146"},"PeriodicalIF":3.3,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human iPSC-Based in Vitro Cardiovascular Tissue Models for Drug Screening Applications. 基于ipsc的体外心血管组织模型在药物筛选中的应用

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-23 DOI: 10.1007/s11886-025-02284-x

Shivesh Anand, Gaoxian Chen, Astha Khanna, Ngan F Huang

引用次数: 0

Autonomic Imbalance in Cardiomyopathy and Heart Failure: From Neurobiology to Precision Neuromodulation. 心肌病和心力衰竭的自主神经失衡：从神经生物学到精确神经调节。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-21 DOI: 10.1007/s11886-025-02288-7

Aleksandr Talishinsky, Olujimi A Ajijola, Sahib S Khalsa

{"title":"Autonomic Imbalance in Cardiomyopathy and Heart Failure: From Neurobiology to Precision Neuromodulation.","authors":"Aleksandr Talishinsky, Olujimi A Ajijola, Sahib S Khalsa","doi":"10.1007/s11886-025-02288-7","DOIUrl":"10.1007/s11886-025-02288-7","url":null,"abstract":"Purpose of the review: This review provides a framework for understanding autonomic neural regulation of cardiac function and dysfunction, highlighting the anatomical and functional organization of the autonomic nervous system, from intrinsic cardiac neurons to central cortical control centers. We review pathways leading to autonomic dysregulation in heart failure (HF) and cardiomyopathy (CMY), and we discuss the potential for precision neuromodulation informed by biomarkers and neuroimaging.Recent findings: We synthesize emerging insights into the molecular, inflammatory, and psychological mechanisms contributing to autonomic dysregulation in HF, and examine the clinical implications of impaired reflex arcs and persistent neurohormonal activation. Recent advances in neuromodulation, including vagus nerve stimulation, baroreflex activation therapy, spinal cord stimulation, cardiac sympathetic denervation and cortical neuromodulation demonstrate the potential to restore autonomic balance and improve HF outcomes. Autonomic imbalance, characterized by sympathetic overactivation and parasympathetic withdrawal, is a hallmark of HF and CMY, contributing to disease progression and adverse outcomes. While traditional pharmacotherapies target downstream neurohormonal pathways, neuromodulation offers the opportunity to intervene upstream, directly at pathophysiological nexus points. Ultimately, a shift toward personalized, circuit-specific neuromodulation strategies may offer new opportunities for treating autonomic dysregulation in HF and CMY.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"144"},"PeriodicalIF":3.3,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12540530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational Risk Factors for Cardiovascular Disease: A Comprehensive Review. 心血管疾病的职业危险因素：综述

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-20 DOI: 10.1007/s11886-025-02301-z

Seung Yeon Jeon, Chan Young Lee, Yun-Hee Lee, Hyojeong Kim, Jiwon Kim, Soo Kyung Cho, Han Soo Noh, Mo-Yeol Kang

{"title":"Occupational Risk Factors for Cardiovascular Disease: A Comprehensive Review.","authors":"Seung Yeon Jeon, Chan Young Lee, Yun-Hee Lee, Hyojeong Kim, Jiwon Kim, Soo Kyung Cho, Han Soo Noh, Mo-Yeol Kang","doi":"10.1007/s11886-025-02301-z","DOIUrl":"https://doi.org/10.1007/s11886-025-02301-z","url":null,"abstract":"Purpose of review: Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide, with occupational factors emerging as significant yet modifiable risk factors. This comprehensive review evaluates the association between various occupational exposures-including job stress, long working hours, shift work, physical activity at work, and exposure to hazardous substances-and CVD risk. Using the GRADE framework, we assessed the strength of evidence for each risk factor.Recent findings: Job stress, long working hours, night shift work, and carbon monoxide exposure demonstrated moderate evidence linking them to increased CVD risk, while occupational noise, air pollutants, and extreme temperatures had limited evidence. Physical activity at work and exposure to toxic metals showed inconclusive findings due to inconsistencies and indirectness in study populations. This review suggests that evaluating occupational exposures is essential for the early identification and management of individuals at elevated cardiovascular risk, and emphasizes that workplace interventions and health policies should prioritize reducing specific risk factors-such as job stress, long working hours, and hazardous exposures-to prevent CVD at both individual and population levels.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"143"},"PeriodicalIF":3.3,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Emerging Role of Lithotripsy in Structural Heart Interventions. 碎石术在结构性心脏干预中的新作用。

IF 3.3 3区医学

Current Cardiology Reports Pub Date : 2025-10-14 DOI: 10.1007/s11886-025-02285-w

Jonathan X Fang, Leo Kar Lok Lai, Gennaro Giustino, Jaffar M Khan, Pedro Engel Gonzalez, Brian P O'Neill, Tiberio M Frisoli, James C Lee, Ahmad Jabri, Dee Dee Wang, William W O'Neill, Pedro A Villablanca

{"title":"The Emerging Role of Lithotripsy in Structural Heart Interventions.","authors":"Jonathan X Fang, Leo Kar Lok Lai, Gennaro Giustino, Jaffar M Khan, Pedro Engel Gonzalez, Brian P O'Neill, Tiberio M Frisoli, James C Lee, Ahmad Jabri, Dee Dee Wang, William W O'Neill, Pedro A Villablanca","doi":"10.1007/s11886-025-02285-w","DOIUrl":"10.1007/s11886-025-02285-w","url":null,"abstract":"Purpose of review: Lithotripsy, first applied to treating nephrolithiasis, has an evolving role in cardiovascular disease, including intravascular treatment of calcified coronary and peripheral artery disease. Its role is expanding to the management of valvular and structural heart disease. This narrative review provides an overview of the emerging role of lithotripsy in various valvular and structural heart interventions.Recent findings: We have conducted a comprehensive literature review of all publications on lithotripsy in structural heart interventions found in PubMed and Google Scholar. We have also included a series of case examples of lithotripsy in structural heart interventions from a tertiary referral center in the United States (Henry Ford Health, Michigan). Lithotripsy has been used to facilitate large-bore access in both transfemoral and alternative access procedures, to treat valvular stenosis of mitral and aortic valves, manage paravalvular leak closure, aid transcatheter electrosurgery, and manage endovascular, congenital, and structural electrophysiology procedures. While a nationwide registry is available for large-bore access facilitation, the current data on valvular stenosis is limited to a single-center registry. Data on most other applications is restricted to case reports and case series and is subject to publication bias. Only two studies have been published on ex vivo and translational models. Lithotripsy is increasingly used off-label in structural heart interventions, with early clinical successes being reported. Translational research and bench-testing models are necessary to determine the optimal energy transfer conditions for valvular and annular lithotripsy. Multi-center studies and randomized controlled trials are needed to assess the efficacy of these novel procedures.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"142"},"PeriodicalIF":3.3,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0