Current Cardiology Reports最新文献

{"title":"Current Status of Cardiovascular Disease in Asian Americans: One Size Does Not Fit All.","authors":"Pristine Mei, Yamini S Levitzky, Susmita Parashar, Roopa A Rao, Lavanya Kondapalli, D Elizabeth Le","doi":"10.1007/s11886-025-02245-4","DOIUrl":"https://doi.org/10.1007/s11886-025-02245-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>To provide an updated summary of knowledge about cardiovascular disease in Asian Americans living in the United States.</p><p><strong>Recent findings: </strong>Asian Americans living in the United States are a heterogenous and diverse group of individuals with variable coronary artery disease, heart failure, and stroke prevalence and risks and mortality rates. Compared to other Asian American subgroups, East Asians tend to have lower coronary artery disease risks, South Asians have high prevalence of traditional cardiovascular risks, particularly diabetes, and Southeast Asians have high rates of hypertension and age-adjusted stroke mortality death rate. Multiple studies have demonstrated disparities among various Asian Americans subgroups in cardiovascular disease, heart failure, and stroke risk. Valvular heart disease, arrhythmia, pharmacotherapy treatment, and procedural outcome data are limited. It is important to report disaggregated and sex-specific data in future clinical trials not only for racial groups but also for Asian American ethnic subgroups.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"94"},"PeriodicalIF":3.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Care in Women Veterans: An Updated Profile.","authors":"Pristine Mei, Delia Cotiga, Ingy Mahana, Nimra Gilani, Michelle L Dew, Susmita Parashar, D Elizabeth Le","doi":"10.1007/s11886-025-02247-2","DOIUrl":"https://doi.org/10.1007/s11886-025-02247-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>To provide an updated summary of the burden and care of cardiovascular disease in women veterans.</p><p><strong>Recent findings: </strong>Women veterans can develop atherosclerotic cardiovascular disease at a much earlier age of 30 years compared to non-veteran women. Those who experienced chronic stress and environmental exposures were more likely to develop early menopause and premature coronary artery disease. Despite major improvements in therapeutic options for cardiovascular disease, the mortality rate of women veterans continues to rise while that of their counterparts has steadily decreased. Women veterans is the fastest growing group of the veteran population. This is a unique and diverse population with a complex intersection of traditional, sex-specific, and military service-related risks for cardiovascular disease. They have a higher prevalence of both traditional and non-traditional risk factors compared to non-veteran women and are especially impacted by depression, post-traumatic stress syndrome, military sexual trauma, and housing instability.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"93"},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological Aspects of Wearable Health Technologies in Patients with Cardiovascular Disease: A Literature Review and Call to Action.","authors":"Allison E Gaffey, Stephanie A Hooker, Rachel Lampert, Anil K Gehi, Lindsey Rosman","doi":"10.1007/s11886-025-02234-7","DOIUrl":"https://doi.org/10.1007/s11886-025-02234-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review summarizes the psychological effects of consumer wearables in patients with established cardiovascular disease (CVD) and helps to identify remaining challenges that must be resolved to support the appropriate implementation of wearables.</p><p><strong>Recent findings: </strong>Consumer wearables (e.g., smartwatches, portable rhythm devices, rings, fitness bands, skin-surface patches) are increasingly used \"off label\" by patients and healthcare providers for ambulatory CVD monitoring and lifestyle modification. Emerging research suggests that while these technologies can motivate some patients to engage in healthy behaviors, they can also provoke adverse psychological reactions in others. Additionally, there are unintended, downstream consequences for clinicians and healthcare systems. Wearables show great promise for enhancing CVD management by providing patients and clinicians with continuous data on key health metrics that can be used for diagnostic and therapeutic purposes. Yet, the potential risks associated with their use must be acknowledged, rigorously investigated, and appropriately managed. Findings from this review emphasize the need for large, well-designed prospective studies and randomized trials to evaluate a broad range of wearable technologies and their influence on patients' mental health, quality of life, and CVD self-management over longer time periods and in high-risk groups (e.g., women, minorities, and children), and to determine their impact on patient outcomes, provider burden, healthcare utilization and costs. Addressing these challenges is crucial for fully integrating wearable health technologies into clinical practice.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"92"},"PeriodicalIF":3.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilevel Racism and Discrimination and Cardiovascular Disease and Related Biopsychosocial Mechanisms: An Integrated Scoping and Literature Review and Future Research Agenda.","authors":"Danielle L Beatty Moody, Elizabeth J Pantesco, Ayla Novruz, Nedelina Tchangalova, Richard C Sadler, Kellee White Whilby, Jason Ashe, Gilbert C Gee, LaBarron K Hill, Shari R Waldstein","doi":"10.1007/s11886-025-02238-3","DOIUrl":"10.1007/s11886-025-02238-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>In the last two decades, empirical research has significantly advanced our understanding of the link between discrimination and cardiovascular disease (CVD). This integrated scoping and narrative literature review delineates the extant peer-reviewed research on discrimination and clinical and subclinical CVD in samples that include Black adults, using a multilevel conceptualization of race-related discrimination and racism. We also identify potential intermediary mechanisms in the racism-CVD relationship and propose a comprehensive future research agenda.</p><p><strong>Recent findings: </strong>Using the Population, Exposure and Outcome framework and PRISMA guidelines, we identified 37 empirical reports for inclusion drawn from 1900 to 2024. The bulk of the literature has focused on discrimination and racism that occurs at the interpersonal level (28 studies), while a smaller but growing body of work has examined cultural (5 studies) or institutional and structural-level racism and discrimination (4 studies) in relation to CVD risk. The majority of these studies show that greater exposure to discrimination or racism is associated with increased clinical or subclinical CVD risk. Potential pathways include societal, environmental, psychological, and biological factors; however, few studies have conducted formal tests of mediation. The literature suggests robust relations of multilevel racism and discrimination to manifestations of CVD across diverse exposure and outcome measures in Black adults. Our recommendations to eliminate cardiovascular health inequities in Black communities include enhancing academic scholarship training, securing targeted and protected funding, and adopting more robust methodological approaches.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"91"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventional Management of Intracoronary Dissection/Hematoma: A Comprehensive Review.","authors":"Federico Giannino, Gabriele Carciotto, Francesco Pallante, Gabriele Monciino, Matteo Mancuso, Davide Raspanti, Giustina Iuvara, Manuela Ajello, Stefania Lo Giudice, Marcello Marchetta, Samuel La Cola, Maurizio Cusmà Piccione, Vittorio Virga, Antonio Micari, Giampiero Vizzari","doi":"10.1007/s11886-025-02237-4","DOIUrl":"https://doi.org/10.1007/s11886-025-02237-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Intracoronary dissection and hematoma are rare but significant causes of acute coronary syndromes (ACS), often leading to myocardial ischemia and infarction. Given their heterogeneous clinical presentation and the limited evidence on optimal management strategies, this review aims to evaluate current treatment approaches, including conservative, percutaneous, and surgical options, while highlighting emerging innovations and future research directions.</p><p><strong>Recent findings: </strong>Recent studies emphasize the role of advanced intracoronary imaging techniques, such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), in improving diagnostic accuracy and guiding therapeutic decisions. Conservative management is increasingly recognized as a viable option for stable patients, offering favorable long-term outcomes. Percutaneous coronary intervention (PCI) is indicated in cases with ongoing ischemia, hemodynamic instability, or high-risk anatomical features, though it carries risks such as dissection propagation and coronary rupture. Surgical intervention remains essential in cases of failed PCI or left main stem involvement, demonstrating high survival rates despite procedural challenges. Tailored therapeutic strategies, informed by patient-specific factors and intracoronary imaging, are crucial for optimizing outcomes in intracoronary dissection and hematoma. While conservative management is effective in selected cases, PCI and surgical interventions remain vital for high-risk patients. Future research should focus on refining risk stratification tools, improving imaging modalities, and developing standardized treatment algorithms to enhance patient care and clinical outcomes.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"90"},"PeriodicalIF":3.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Cardio-Renal-Metabolic Profile in Dilated Cardiomyopathy.","authors":"Tamim Akbari, Daniel J Hammersley, Clarice Yau-Yee May, Brian P Halliday, Sanjay K Prasad","doi":"10.1007/s11886-025-02241-8","DOIUrl":"10.1007/s11886-025-02241-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>Dilated cardiomyopathy is an important contributor to heart failure burden worldwide. With an aging population and rising multimorbidity, in this review, we describe the prevalence of metabolic syndrome and renal failure in patients with dilated cardiomyopathy and focus on common underlying mechanisms, evaluate outcomes in these patients and highlight newer therapeutic strategies.</p><p><strong>Recent findings: </strong>A significant proportion of patients with dilated cardiomyopathy has concomitant metabolic syndrome and renal disease. This combination of multimorbidity portends worse prognosis and often presents unique challenges in treatment given the complex interplay and shared pathophysiological pathways. Optimization of the cardio-renal-metabolic profile should be a key consideration in the management of patients with dilated cardiomyopathy. Therapeutic strategies targeting common pathophysiological pathways are needed in order to improve overall outcomes.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"89"},"PeriodicalIF":3.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic Risk Scores in Dilated Cardiomyopathy: Towards the Future.","authors":"Daria R Kramarenko, Sean J Jurgens, Yigal M Pinto, Connie R Bezzina, Ahmad S Amin","doi":"10.1007/s11886-025-02239-2","DOIUrl":"https://doi.org/10.1007/s11886-025-02239-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Genome-wide association studies (GWASs) have recently shown that common genetic variations significantly affect the risk of developing dilated cardiomyopathy (DCM). This has enabled the development of polygenic scores (PGSs), which aim to aggregate the impact of multiple common genetic variants across the genome to provide an overall genetic risk score for disease manifestation and disease severity. In this review, we discuss the latest findings pertaining to GWASs and PGSs for DCM and various ways in which PGSs could improve the management of patients with DCM or risk of developing DCM.</p><p><strong>Recent findings: </strong>In 2024 the two largest GWAS meta-analyses for DCM were published. Notably, both studies produced PGSs that were able to discriminate healthy subjects from DCM patients which brings promise for potential clinical application of the scores. Large-scale GWAS have identified common genetic variants associated with DCM, leading to the development of PGS, which show strong associations with disease risk and hold potential for clinical applications. However, before clinical implementation, further research is needed to explore their utility in real-world settings and across diverse populations.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"87"},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility of ¹⁸F-Sodium Fluoride Positron Emission Tomography for Assessing Microcalcification in Coronary Arterial and Thoracic Aortic Atherosclerosis: Is the Signal below the Resolution of PET?","authors":"Ondrej Fanta, Shiv Patil, Thomas Werner, Drew A Torigian, Abass Alavi","doi":"10.1007/s11886-025-02240-9","DOIUrl":"https://doi.org/10.1007/s11886-025-02240-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>The rising prevalence of atherosclerosis has prompted the development of novel diagnostic methods capable of identifying early-stage disease when therapeutic interventions may be most effective. ¹⁸F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) is a molecular imaging technique that can quantify subclinical microcalcification in arterial plaque. The focus of this review article is to discuss the utility of ¹⁸F-NaF PET/CT in assessing atherosclerotic disease of major susceptible blood vessels, particularly the coronary arteries and thoracic aorta.</p><p><strong>Recent findings: </strong>¹⁸F-NaF uptake observed on PET imaging demonstrates promising potential as a marker of atherosclerotic burden in individual coronary arteries, whole heart segmentations, and the thoracic aorta. Global versus focal assessment of ¹⁸F-NaF uptake in small arteries is a significant source of methodological heterogeneity among studies. The accuracy and reproducibility of ¹⁸F-NaF PET/CT may be improved by standardized quantification methods in light of the limited spatial resolution of PET, particularly through the use of techniques to evaluate global atherosclerotic burden.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"88"},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutual Regulation of Cardiovascular and Hematopoietic Development.","authors":"Norika Liu, Haruko Nakano, Atsushi Nakano","doi":"10.1007/s11886-025-02236-5","DOIUrl":"https://doi.org/10.1007/s11886-025-02236-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>The cardiovascular and hematopoietic systems share molecular mechanisms and regulatory interactions across species. Endocardial hematopoiesis, a debated topic in mice, is actually an evolutionarily conserved process from Drosophila. This review explores the origins and significance of endocardial hematopoiesis, highlighting its role in cardiac development and macrophage formation.</p><p><strong>Recent findings: </strong>Despite extensive lineage-tracing and transcriptome studies, it remained unclear until single-cell RNA sequencing (scRNA-seq) identified that endocardial cells possess an intrinsic hematopoietic program independent of known hematopoietic organs. These endocardial-derived macrophages contribute uniquely to cardiac morphogenesis, supporting valve maturation and tissue remodeling. Endocardial hematopoiesis is an evolutionarily conserved phenomenon that is essential for developmental process. The heterogeneity of tissue-resident macrophages and their specialized functions in cardiac development have been further unraveled by single-cell analysis. This review provides an evolutionary perspective on endocardial hematopoiesis and highlights its critical contributions of hematopoietic cells to heart formation and homeostasis.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"86"},"PeriodicalIF":3.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Magnetic Resonance Guidance for the Pathogenetic Definition of Cardiomyopathies.","authors":"Bishow Paudel, Jonathan Pan, Cristiane C Singulane, Shuo Wang, Matthew Thomas, Michael Ayers, Steven Philips, Amit R Patel","doi":"10.1007/s11886-025-02233-8","DOIUrl":"https://doi.org/10.1007/s11886-025-02233-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>Pathogenetics is the study of genetics in disease pathogenesis. Many abnormal gene alleles have been identified in cardiomyopathies, but their clinical utility remains limited. This review aims to examine the integration of cardiac MRI (CMR) with genetic data to enhance early detection, prognostication, and treatment strategies for cardiomyopathies.</p><p><strong>Recent findings: </strong>CMR is the gold standard imaging modality for cardiomyopathy evaluation, capable of detecting subtle structural and functional changes throughout the disease course. When applied to patients with genetic mutations, with or without phenotypic expression, CMR aids in early diagnosis and risk stratification. Cardiomyopathies can be categorized into at least seven clinical groups based on morphology, function, and genetic associations: (1) Dilated cardiomyopathy (DCM), (2) Hypertrophic cardiomyopathy (HCM), (3) Restrictive cardiomyopathy, including transthyretin amyloidosis (ATTR-CM), iron overload, and Anderson-Fabry disease, (4) Arrhythmogenic cardiomyopathy (ACM), (5) Non-dilated left ventricular cardiomyopathy (NDLVC), (6) Peripartum cardiomyopathy, and (7) Muscular dystrophy-related cardiomyopathy. We have described left ventricular noncompaction (LVNC) as a morphological trait rather than a distinct cardiomyopathy. Emerging CMR and genetic data suggest an inflammatory component in DCM and ACM, with potential therapeutic implications for immunotherapy. Advanced CMR techniques, such as quantitative perfusion, can distinguish cardiomyopathies from ischemic heart disease and detect early microvascular dysfunction, particularly in ATTR-CM and HCM. Late gadolinium enhancement (LGE) and parametric mapping (T1 and extracellular volume [ECV]) further enhance early diagnosis, prognostication and treatment response by assessing fibrosis and myocardial composition. The integration of CMR and genetic insights improves our understanding of cardiomyopathy pathogenesis, aiding in early diagnosis and prognostic assessment. Future research should leverage artificial intelligence (AI) to analyze genetic and radiomic CMR features, including perfusion data, to establish a comprehensive pathogenetic framework. This approach could refine disease classification, identify novel therapeutic targets, and advance precision medicine in cardiomyopathy management.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"85"},"PeriodicalIF":3.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}