Cardiac Regeneration and Repair in Zebrafish and Mammalian Models.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Cardiology Reports Pub Date : 2025-06-17 DOI:10.1007/s11886-025-02235-6

Stanislao Igor Travisano, Ching-Ling Lien

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引用次数: 0

Abstract

Aim: In this review, we discuss the regenerative processes in the heart, focusing on non-cardiomyocyte cell populations (fibroblasts, immune cells, and endothelial cells) in zebrafish and mammals. We highlight the role of signaling pathways in heart repair and the potential for therapeutic strategies based on these mechanisms.

Purpose of review: The review examines key molecular and cellular mechanisms in cardiac regeneration, with a focus on fibroblasts, immune modulation, and endothelial function, to identify strategies for enhancing heart repair.

Recent findings: Recent advancements in characterization of different cell types at the single cell level, along with the discovery of regeneration enhancer elements, have opened new avenues for cardiac regeneration. Targeting the epicardium, along with fibroblast activation, immune modulation, and endothelial signaling, may offer therapeutic strategies to enhance heart regeneration by supporting cardiomyocytes in mice and humans. While non-cardiomyocytes in zebrafish contribute to heart regeneration, in mice and humans, these cells often drive fibrosis instead. Understanding these species-specific differences is crucial for optimizing therapeutic approaches to treat cardiac injury and prevent fibrosis.

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斑马鱼和哺乳动物心脏再生和修复模型。

目的：在这篇综述中，我们讨论了心脏的再生过程，重点讨论了斑马鱼和哺乳动物的非心肌细胞群（成纤维细胞、免疫细胞和内皮细胞）。我们强调信号通路在心脏修复中的作用以及基于这些机制的治疗策略的潜力。综述目的：本文综述了心脏再生的关键分子和细胞机制，重点关注成纤维细胞、免疫调节和内皮功能，以确定增强心脏修复的策略。最近的发现：在单细胞水平上不同细胞类型特征的最新进展，以及再生促进因子的发现，为心脏再生开辟了新的途径。靶向心外膜，以及成纤维细胞激活、免疫调节和内皮信号，可能提供通过支持小鼠和人类心肌细胞来增强心脏再生的治疗策略。虽然斑马鱼的非心肌细胞有助于心脏再生，但在小鼠和人类中，这些细胞通常会导致纤维化。了解这些物种特异性差异对于优化治疗心脏损伤和预防纤维化的治疗方法至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.