Current Developments in Nutrition最新文献

{"title":"Abstracts Contents list","authors":"","doi":"10.1016/S2475-2991(24)02339-4","DOIUrl":"https://doi.org/10.1016/S2475-2991(24)02339-4","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 ","pages":"Article 104405"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2475299124023394/pdfft?md5=508948aa0c6f538d8ffbc948f070fb60&pid=1-s2.0-S2475299124023394-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141487440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of d-alanine Intake on Amino Acid Metabolism and Kidney Function in Healthy Adults: A Multicenter, Randomized Pilot Study","authors":"Megumi Oshima ,&nbsp;Tadashi Toyama ,&nbsp;Tatsuhiko Toyama ,&nbsp;Yusuke Nakade ,&nbsp;Toshiaki Tokumaru ,&nbsp;Keisuke Sako ,&nbsp;Sho Kajikawa ,&nbsp;Daiki Hayashi ,&nbsp;Hajime Sanada ,&nbsp;Takahiro Yuasa ,&nbsp;Akihiko Koshino ,&nbsp;Keisuke Horikoshi ,&nbsp;Taichiro Minami ,&nbsp;Shunsuke Tsuge ,&nbsp;Akira Tamai ,&nbsp;Shiori Nakagawa ,&nbsp;Ryo Nishioka ,&nbsp;Takeshi Zoshima ,&nbsp;Kiyoaki Ito ,&nbsp;Shinji Kitajima ,&nbsp;Takashi Wada","doi":"10.1016/j.cdnut.2024.103787","DOIUrl":"10.1016/j.cdnut.2024.103787","url":null,"abstract":"<div><h3>Background</h3><p><span>d</span>-alanine administration prevented kidney damage in a murine acute kidney injury model. Further data are needed on the influence of <span>d</span>-alanine on kidney function in humans.</p></div><div><h3>Objective</h3><p>This study investigated the effects of <span>d</span>-alanine intake on amino acid metabolism and kidney function in healthy volunteers.</p></div><div><h3>Methods</h3><p>This multicenter pilot study randomly assigned individuals from the general Japanese population to receive 3 g or 6 g of <span>d</span>-alanine intake per day for 7 d in a 1:1 ratio. The primary endpoint was the mean change in plasma and urine <span>d</span>-alanine levels from baseline to 7 d after intake. The secondary endpoints were mean changes in kidney function and other clinical factors. Safety was assessed by evaluating adverse events and clinical parameters.</p></div><div><h3>Results</h3><p>We randomly assigned 24 participants to the 3-g (<em>n</em> = 12) and 6-g <span>d</span>-alanine (<em>n</em> = 12) groups. The mean baseline estimated glomerular filtration rate (eGFR) was 73 mL/min/1.73 m². The mean plasma <span>d</span>-alanine concentration increased from baseline by 77.5 ± 34.3 and 192.1 ± 80.9 nmol/mL in the 3-g and 6-g <span>d</span>-alanine groups (both p &lt; 0.0001), respectively, in a dose-dependent manner (between-group difference: 114.6 nmol/mL; 95% CI: 62.1–167.2; <em>P</em> = 0.0002). A similar increase was observed for the urine <span>d</span>-alanine to creatinine ratio. The mean eGFR was elevated by 5.7 ± 8.8 mL/min/1.73 m² in the 6-g <span>d</span>-alanine group (<em>P</em> = 0.045) but did not significantly change in the 3-g <span>d</span>-alanine group. Nonserious adverse events were reported in 11 participants.</p></div><div><h3>Conclusions</h3><p><span>d</span>-alanine intake increased plasma and urine <span>d</span>-alanine levels and was well tolerated in participants with normal kidney function. These results will be useful in future trials investigating the effects of <span>d</span>-alanine intake on kidney disease progression in patients with chronic kidney disease.</p><p>This trial was registered at the UMIN Clinical Trials Registry as UMIN000051466.</p></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 7","pages":"Article 103787"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2475299124017219/pdfft?md5=10de7c5cd41bec56317f9b7ab2f683c7&pid=1-s2.0-S2475299124017219-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141132196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling the Contribution of Multiple Micronutrient Fortification of Salt to Daily Nutrient Intake Among the Ethiopian Population","authors":"Semira Mitiku Saje ,&nbsp;Dawd Gashu ,&nbsp;Edward JM Joy ,&nbsp;Katherine P Adams ,&nbsp;Tibebu Moges ,&nbsp;Masresha Tesemma ,&nbsp;E Louise Ander","doi":"10.1016/j.cdnut.2024.103794","DOIUrl":"10.1016/j.cdnut.2024.103794","url":null,"abstract":"<div><h3>Background</h3><p>Salt is an affordable commodity and has wide coverage regardless of economic and social status and, hence, could be suitable vehicle for multiple micronutrient fortification.</p></div><div><h3>Objectives</h3><p>This study aimed to simulate the contribution folic acid and zinc fortification of iodized salt to nutrient intake among the Ethiopian population.</p></div><div><h3>Methods</h3><p>The 2013 Ethiopian National Food Consumption Survey and various food composition tables were used to estimate baseline individual-level micronutrient intake. Usual intake was estimated using the Simulating Intake of Micronutrients for Policy Learning and Engagement macro tool. Discretionary salt consumption was calculated from total salt intake estimated using urinary sodium excretion. Fortificant addition rates were set to obtain maximum nutrient intake while simultaneously constraining that population with intake above the tolerable upper intake level to &lt;5%. Addis Ababa and Somali (<em>N</em> = 2271), the regions with relatively the lowest and highest micronutrient deficiency prevalence in Ethiopia, were selected.</p></div><div><h3>Result</h3><p>Baseline median intake of Zn was below the estimated average requirement for all demographic groups. Inadequate Zn intake ranged from 73% to 99%, the highest prevalence being observed among women in lower class of wealth quintiles from Somali region. Dietary folate inadequacy was as low as 2% among men in Addis Ababa but almost all (99%) women from Somali region had inadequate folate intake. Calculated discretionary salt intake was 7.5 g/d for adult men and women and 3.4 g/d for children. With addition 0.8 mg Zn and 30 μg of folic acid per gram of salt, multiple salt fortification is estimated to reduce Zn inadequacy by 38 percentage points in urban areas and19 percentage points in rural areas. Modeled reduction in folate inadequacy were 18% in urban areas and 22% in rural areas.</p></div><div><h3>Conclusions</h3><p>Multiple salt fortification could be an effective approach to address micronutrient adequacy in Ethiopia given efficacious, technological, and economical feasibility.</p></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 7","pages":"Article 103794"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2475299124017281/pdfft?md5=69b4d3b4b285f9b930ee3e7b73b5b0e2&pid=1-s2.0-S2475299124017281-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141395967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Fresh Mango Consumption on Fasting Blood Glucose and Body Mass Index in Older Adults With Prediabetes","authors":"Kallie Dawkins ,&nbsp;Saiful Singar ,&nbsp;Pablo Perez ,&nbsp;Sabrina Zheng ,&nbsp;Raedeh Basiri ,&nbsp;Bahram Arjmandi","doi":"10.1016/j.cdnut.2024.102189","DOIUrl":"https://doi.org/10.1016/j.cdnut.2024.102189","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 ","pages":"Article 102189"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2475299124001239/pdfft?md5=7970cf029ef6bf32c7aca227e893e70b&pid=1-s2.0-S2475299124001239-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal Sphingolipid Disruption May Precede Age-Related Lipid Malabsorption","authors":"Sari M Gluck ,&nbsp;Maria Elisa Caetano-Silva ,&nbsp;Akriti Shrestha ,&nbsp;Michael Kiebish ,&nbsp;Jacob M Allen ,&nbsp;Diego Hernandez-Saavedra","doi":"10.1016/j.cdnut.2024.102229","DOIUrl":"https://doi.org/10.1016/j.cdnut.2024.102229","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 ","pages":"Article 102229"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S247529912400163X/pdfft?md5=c790f53a74d6fe28e1717a904565328e&pid=1-s2.0-S247529912400163X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin A Absorption From Bouillon Fortified With Novel and Commercially Available Dry Vitamin A Formulations in Adult Women: Protocol for a Randomized Crossover Study","authors":"Bryan M Gannon ,&nbsp;Sam Brady ,&nbsp;Don Chickering ,&nbsp;Luke Funk ,&nbsp;Chisela Kaliwile ,&nbsp;Justin Chileshe ,&nbsp;Sherry Tanumihardjo","doi":"10.1016/j.cdnut.2024.102247","DOIUrl":"https://doi.org/10.1016/j.cdnut.2024.102247","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 ","pages":"Article 102247"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2475299124001811/pdfft?md5=a51d275ded5fb4fdff6140153e4960e1&pid=1-s2.0-S2475299124001811-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Randomized Multivitamin and Cocoa Extract Supplementation on Serum Carotenoids and Vitamin E in the COSMOS Trial","authors":"Cami N Christopher ,&nbsp;John W Erdman ,&nbsp;Eunjung Kim ,&nbsp;Molly Black ,&nbsp;Pamela M Rist ,&nbsp;JoAnn E Manson ,&nbsp;Howard D Sesso","doi":"10.1016/j.cdnut.2024.102245","DOIUrl":"https://doi.org/10.1016/j.cdnut.2024.102245","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 ","pages":"Article 102245"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2475299124001793/pdfft?md5=eac829d4c841bbb220312606365614db&pid=1-s2.0-S2475299124001793-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141484224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Standardized Boswellia serrata Gum Extract Promotes Chondroprotection and Improves Knee Pain, Function, and Inflammation in Adults With Mild to Moderate Osteoarthritis","authors":"Jennifer L Murphy ,&nbsp;Dawna Salter ,&nbsp;Dinesh Aurora ,&nbsp;Raghu R Somepalli ,&nbsp;Kumar Brijesh","doi":"10.1016/j.cdnut.2024.102213","DOIUrl":"https://doi.org/10.1016/j.cdnut.2024.102213","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 ","pages":"Article 102213"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2475299124001471/pdfft?md5=80953a38be039a35b0612d61e8f2e517&pid=1-s2.0-S2475299124001471-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141484361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Malnutrition Assessment Tools for Identification of Malnutrition in Community-Dwelling Older Adults With Dementia","authors":"Austin M Sullivan ,&nbsp;Heather M Gibbs","doi":"10.1016/j.cdnut.2024.102222","DOIUrl":"https://doi.org/10.1016/j.cdnut.2024.102222","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 ","pages":"Article 102222"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2475299124001562/pdfft?md5=4e64292a7c9840afc684fc1435436645&pid=1-s2.0-S2475299124001562-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the Changes in Cholesterol Ester Lipid Species During Periods of Inactivity in Middle-Aged and Older Adults","authors":"Emily Arentson-Lantz ,&nbsp;Trevor Romsdahl ,&nbsp;Jennifer J Linares ,&nbsp;William Russell ,&nbsp;Doug Paddon-Jones","doi":"10.1016/j.cdnut.2024.102178","DOIUrl":"https://doi.org/10.1016/j.cdnut.2024.102178","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"8 ","pages":"Article 102178"},"PeriodicalIF":3.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2475299124001124/pdfft?md5=94cb348e97b490a2758fe6fe7743a38e&pid=1-s2.0-S2475299124001124-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}