Critical Reviews in Biotechnology最新文献_第4页

Field and laboratory guidelines for reliable bioinformatic and statistical analysis of bacterial shotgun metagenomic data. 细菌霰弹枪宏基因组数据的可靠生物信息学和统计分析的现场和实验室指南。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-09-20 DOI: 10.1080/07388551.2023.2254933

Ostaizka Aizpurua, Robert R Dunn, Lars H Hansen, M T P Gilbert, Antton Alberdi

{"title":"Field and laboratory guidelines for reliable bioinformatic and statistical analysis of bacterial shotgun metagenomic data.","authors":"Ostaizka Aizpurua, Robert R Dunn, Lars H Hansen, M T P Gilbert, Antton Alberdi","doi":"10.1080/07388551.2023.2254933","DOIUrl":"10.1080/07388551.2023.2254933","url":null,"abstract":"Shotgun metagenomics is an increasingly cost-effective approach for profiling environmental and host-associated microbial communities. However, due to the complexity of both microbiomes and the molecular techniques required to analyze them, the reliability and representativeness of the results are contingent upon the field, laboratory, and bioinformatic procedures employed. Here, we consider 15 field and laboratory issues that critically impact downstream bioinformatic and statistical data processing, as well as result interpretation, in bacterial shotgun metagenomic studies. The issues we consider encompass intrinsic properties of samples, study design, and laboratory-processing strategies. We identify the links of field and laboratory steps with downstream analytical procedures, explain the means for detecting potential pitfalls, and propose mitigation measures to overcome or minimize their impact in metagenomic studies. We anticipate that our guidelines will assist data scientists in appropriately processing and interpreting their data, while aiding field and laboratory researchers to implement strategies for improving the quality of the generated results.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1164-1182"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41113414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradable acids for pyrite depression and green flotation separation - an overview. 用于黄铁矿凹陷和绿色浮选分离的可生物降解酸--综述。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-08-20 DOI: 10.1080/07388551.2023.2238885

Ali Asimi Neisiani, Saeed Chehreh Chelgani

{"title":"Biodegradable acids for pyrite depression and green flotation separation - an overview.","authors":"Ali Asimi Neisiani, Saeed Chehreh Chelgani","doi":"10.1080/07388551.2023.2238885","DOIUrl":"10.1080/07388551.2023.2238885","url":null,"abstract":"Exponential increasing demands for base metals have made meaningful processing of their quite low-grade (>1%) resources. Froth flotation is the most important physicochemical pretreatment technique for processing low-grade sulfide ores. In other words, flotation separation can effectively upgrade finely liberated base metal sulfides based on their surface properties. Various sulfide surface characters can be modified by flotation surfactants (collectors, activators, depressants, pH regulators, frothers, etc.). However, these reagents are mostly toxic. Therefore, using biodegradable flotation reagents would be essential for a green transition of ore treatment plants, while flotation circuits deal with massive volumes of water and materials. Pyrite, the most abundant sulfide mineral, is frequently associated with valuable minerals as a troublesome gangue. It causes severe technical and environmental difficulties. Thus, pyrite should be removed early in the beneficiation process to minimize its problematic issues. Recently, conventional inorganic pyrite depressants (such as cyanide, lime, and sulfur-oxy compounds) have been successfully assisted or even replaced with eco-friendly and green reagents (including polysaccharide-based substances and biodegradable acids). Yet, no comprehensive review is specified on the biodegradable acid depression reagents (such as tannic, lactic, humic acids, etc.) for pyrite removal through flotation separation. This study has comprehensively reviewed the previously conducted investigations in this area and provides suggestions for future assessments and developments. This robust review has systematically explored depression performance, various adsorption mechanisms, and aspects of these reagents on pyrite surfaces. Furthermore, factors affecting their efficiency were analyzed, and gaps within each area were highlighted.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1226-1240"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial enhanced oil recovery (MEOR): recent development and future perspectives. 微生物提高采油(MEOR)技术的发展现状与展望

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-12-06 DOI: 10.1080/07388551.2023.2270578

Cong-Yu Ke, Rui Sun, Ming-Xia Wei, Xiu-Ni Yuan, Wu-Juan Sun, Si-Chang Wang, Qun-Zheng Zhang, Xun-Li Zhang

{"title":"Microbial enhanced oil recovery (MEOR): recent development and future perspectives.","authors":"Cong-Yu Ke, Rui Sun, Ming-Xia Wei, Xiu-Ni Yuan, Wu-Juan Sun, Si-Chang Wang, Qun-Zheng Zhang, Xun-Li Zhang","doi":"10.1080/07388551.2023.2270578","DOIUrl":"10.1080/07388551.2023.2270578","url":null,"abstract":"After conventional oil recovery operations, more than half of the crude oil still remains in a form, which is difficult to extract. Therefore, exploring and developing new enhanced oil recovery (EOR) technologies have always been priority research in oilfield development. Microbial enhanced oil recovery (MEOR) is a promising tertiary oil recovery technology that has received widespread attention from the global oil industry in recent years due to its environmental friendliness, simplicity of operation, and cost-effectiveness. This review presents the: principle, characteristics, classification, recent development, and applications of MEOR technology. Based on hundreds of field trials conducted worldwide, the microbial strains, nutrient systems, and actual effects used in these technologies are summarized, with an emphasis on the achievements made in the development and application of MEOR in China in recent years. These technical classifications involve: microbial huff and puff recovery (MHPR), microbial flooding recovery (MFR), microbial selective plugging recovery (MSPR), and microbial wax removal and control (MWRC). Most of them have achieved good results, with a success rate of approximately 80%. These successful cases have accumulated into rich experiential indications for the popularization and application of MEOR technology, but there are still important yet uncertain factors that hinder the industrialization of this technology. Finally, based on the extensive research and development of MEOR by the authors, especially in both laboratory and industrial large scales, the main challenges and future perspectives of the industrial application for MEOR are presented.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1183-1202"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138498014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling of astaxanthin biosynthesis via machine learning, mathematical and metabolic network modeling. 通过机器学习、数学和代谢网络建模建立虾青素生物合成模型。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-08-16 DOI: 10.1080/07388551.2023.2237183

Vinoj Chamilka Liyanaarachchi, Gannoru Kankanamalage Sanuji Hasara Nishshanka, P H Viraj Nimarshana, Jo-Shu Chang, Thilini U Ariyadasa, Dillirani Nagarajan

{"title":"Modeling of astaxanthin biosynthesis via machine learning, mathematical and metabolic network modeling.","authors":"Vinoj Chamilka Liyanaarachchi, Gannoru Kankanamalage Sanuji Hasara Nishshanka, P H Viraj Nimarshana, Jo-Shu Chang, Thilini U Ariyadasa, Dillirani Nagarajan","doi":"10.1080/07388551.2023.2237183","DOIUrl":"10.1080/07388551.2023.2237183","url":null,"abstract":"Natural astaxanthin is synthesized by diverse organisms including: bacteria, fungi, microalgae, and plants involving complex cellular processes, which depend on numerous interrelated parameters. Nonetheless, existing knowledge regarding astaxanthin biosynthesis and the conditions influencing astaxanthin accumulation is fairly limited. Thus, manipulation of the growth conditions to achieve desired biomass and astaxanthin yields can be a complicated process requiring cost-intensive and time-consuming experiment-based research. As a potential solution, modeling and simulation of biological systems have recently emerged, allowing researchers to predict/estimate astaxanthin production dynamics in selected organisms. Moreover, mathematical modeling techniques would enable further optimization of astaxanthin synthesis in a shorter period of time, ultimately contributing to a notable reduction in production costs. Thus, the present review comprehensively discusses existing mathematical modeling techniques which simulate the bioaccumulation of astaxanthin in diverse organisms. Associated challenges, solutions, and future perspectives are critically analyzed and presented.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"996-1017"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10013792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A crosswalk on the genetic and conventional strategies for enhancing astaxanthin production in Haematococcus pluvialis. 关于提高雨生红球藻虾青素产量的遗传和常规策略的人行横道。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-10-01 DOI: 10.1080/07388551.2023.2240009

Adolf Acheampong, Lamei Li, Shereen M Elsherbiny, Yahui Wu, Mohammed Sharif Swallah, Precious Bondzie-Quaye, Qing Huang

{"title":"A crosswalk on the genetic and conventional strategies for enhancing astaxanthin production in Haematococcus pluvialis.","authors":"Adolf Acheampong, Lamei Li, Shereen M Elsherbiny, Yahui Wu, Mohammed Sharif Swallah, Precious Bondzie-Quaye, Qing Huang","doi":"10.1080/07388551.2023.2240009","DOIUrl":"10.1080/07388551.2023.2240009","url":null,"abstract":"Astaxanthin is a naturally occurring xanthophyll with powerful: antioxidant, antitumor, and antibacterial properties that are widely employed in food, feed, medicinal and nutraceutical industries. Currently, chemical synthesis dominates the world's astaxanthin market, but the increasing demand for natural products is shifting the market for natural astaxanthin. Haematococcus pluvialis (H. pluvialis) is the factory source of natural astaxanthin when grown in optimal conditions. Currently, various strategies for the production of astaxanthin have been proposed or are being developed in order to meet its market demand. This up-to-date review scrutinized the current approaches or strategies that aim to increase astaxanthin yield from H. pluvialis. We have emphasized the genetic and environmental parameters that increase astaxanthin yield. We also looked at the transcriptomic dynamics caused by environmental factors (phytohormones induction, light, salt, temperature, and nutrient starvation) on astaxanthin synthesizing genes and other metabolic changes. Genetic engineering and culture optimization (environmental factors) are effective approaches to producing more astaxanthin for commercial purposes. Genetic engineering, in particular, is accurate, specific, potent, and safer than conventional random mutagenesis approaches. New technologies, such as CRISPR-Cas9 coupled with omics and emerging computational tools, may be the principal strategies in the future to attain strains that can produce more astaxanthin. This review provides accessible data on the strategies to increase astaxanthin accumulation natively. Also, this review can be a starting point for new scholars interested in H. pluvialis research.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1018-1039"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41113432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary delivery systems for antimicrobial peptides. 抗微生物肽的肺部输送系统。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-09-20 DOI: 10.1080/07388551.2023.2254932

Lucrezia Caselli, Gisele R Rodrigues, Octavio L Franco, Martin Malmsten

{"title":"Pulmonary delivery systems for antimicrobial peptides.","authors":"Lucrezia Caselli, Gisele R Rodrigues, Octavio L Franco, Martin Malmsten","doi":"10.1080/07388551.2023.2254932","DOIUrl":"10.1080/07388551.2023.2254932","url":null,"abstract":"Bacterial infections of the respiratory tract cause millions of deaths annually. Several diseases exist wherein (1) bacterial infection is the main cause of disease (e.g., tuberculosis and bacterial pneumonia), (2) bacterial infection is a consequence of disease and worsens the disease prognosis (e.g., cystic fibrosis), and (3) bacteria-triggered inflammation propagates the disease (e.g., chronic obstructive pulmonary disease). Current approaches to combat infections generally include long and aggressive antibiotic treatments, which challenge patient compliance, thereby making relapses common and contributing to the development of antibiotic resistance. Consequently, the proportion of infections that cannot be treated with conventional antibiotics is rapidly increasing, and novel therapies are urgently needed. In this context, antimicrobial peptides (AMPs) have received considerable attention as they may exhibit potent antimicrobial effects against antibiotic-resistant bacterial strains but with modest toxicity. In addition, some AMPs suppress inflammation and provide other host defense functions (motivating the alternative term host defense peptides (HDPs)). However, the delivery of AMPs is complicated because they are large, positively charged, and amphiphilic. As a result of this, AMP delivery systems have recently attracted attention. For airway infections, the currently investigated delivery approaches range from aerosols and dry powders to various self-assembly and nanoparticle carrier systems, as well as their combinations. In this paper, we discuss recent developments in the field, ranging from mechanistic mode-of-action studies to the application of these systems for combating bacterial infections in the airways.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"963-980"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41113322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extension characteristics of TdT and its application in biosensors. TdT的延伸特性及其在生物传感器中的应用。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-10-25 DOI: 10.1080/07388551.2023.2270772

He Yang, Longjiao Zhu, Xinxin Wang, Yuhan Song, Yulan Dong, Wentao Xu

引用次数: 0

Hosts engineering and in vitro enzymatic synthesis for the discovery of novel natural products and their derivatives. 用于发现新型天然产品及其衍生物的宿主工程和体外酶合成。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-08-13 DOI: 10.1080/07388551.2023.2236787

Huanyu Zhang, Lanping Guo, Yaowu Su, Rubing Wang, Wenqi Yang, Wenrong Mu, Liangshuang Xuan, Luqi Huang, Juan Wang, Wenyuan Gao

{"title":"Hosts engineering and in vitro enzymatic synthesis for the discovery of novel natural products and their derivatives.","authors":"Huanyu Zhang, Lanping Guo, Yaowu Su, Rubing Wang, Wenqi Yang, Wenrong Mu, Liangshuang Xuan, Luqi Huang, Juan Wang, Wenyuan Gao","doi":"10.1080/07388551.2023.2236787","DOIUrl":"10.1080/07388551.2023.2236787","url":null,"abstract":"Novel natural products (NPs) and their derivatives are important sources for drug discovery, which have been broadly applied in the fields of agriculture, livestock, and medicine, making the synthesis of NPs and their derivatives necessarily important. In recent years, biosynthesis technology has received increasing attention due to its high efficiency in the synthesis of high value-added novel products and its advantages of green, environmental protection, and controllability. In this review, the technological advances of biosynthesis strategies in the discovery of novel NPs and their derivatives are outlined, with an emphasis on two areas of host engineering and in vitro enzymatic synthesis. In terms of hosts engineering, multiple microorganisms, including Streptomyces, Aspergillus, and Penicillium, have been used as the biosynthetic gene clusters (BGCs) provider and host strain for the expression of BGCs to discover new compounds over the past years. In addition, the use of in vitro enzymatic synthesis strategy to generate novel compounds such as triterpenoid saponins and flavonoids is also hereby described.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1121-1139"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9990382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence and opportunities for developing non-transgenic genome edited crops using site-directed nuclease 1 approach. 使用定点核酸酶1方法开发非转基因基因组编辑作物的证据和机会。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-11-01 DOI: 10.1080/07388551.2023.2270581

H M Mamrutha, Wadhwa Zeenat, Deswal Kapil, Nagaveni Budhagatapalli, Divya Tikaniya, Kumar Rakesh, Gopalareddy Krishnappa, Gyanendra Singh, G P Singh

{"title":"Evidence and opportunities for developing non-transgenic genome edited crops using site-directed nuclease 1 approach.","authors":"H M Mamrutha, Wadhwa Zeenat, Deswal Kapil, Nagaveni Budhagatapalli, Divya Tikaniya, Kumar Rakesh, Gopalareddy Krishnappa, Gyanendra Singh, G P Singh","doi":"10.1080/07388551.2023.2270581","DOIUrl":"10.1080/07388551.2023.2270581","url":null,"abstract":"The innovations and progress in genome editing/new breeding technologies have revolutionized research in the field of functional genomics and crop improvement. This revolution has expanded the horizons of agricultural research, presenting fresh possibilities for creating novel plant varieties equipped with desired traits that can effectively combat the challenges posed by climate change. However, the regulation and social acceptance of genome-edited crops still remain as major barriers. Only a few countries considered the site-directed nuclease 1 (SDN1) approach-based genome-edited plants under less or no regulation. Hence, the present review aims to comprise information on the research work conducted using SDN1 in crops by various genome editing tools. It also elucidates the promising candidate genes that can be used for editing and has listed the studies on non-transgenic crops developed through SDN1 either by Agrobacterium-mediated transformation or by ribo nucleoprotein (RNP) complex. The review also hoards the existing regulatory landscape of genome editing and provides an overview of globally commercialized genome-edited crops. These compilations will enable confidence in researchers and policymakers, across the globe, to recognize the full potential of this technology and reconsider the regulatory aspects associated with genome-edited crops. Furthermore, this compilation serves as a valuable resource for researchers embarking on the development of customized non-transgenic crops through the utilization of SDN1.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1140-1150"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arabinose as an overlooked sugar for microbial bioproduction of chemical building blocks. 阿拉伯糖是一种被忽视的糖，用于微生物生物生产化学构建块。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-11-06 DOI: 10.1080/07388551.2023.2270702

Vinod Kumar, Deepti Agrawal, Rajesh Reddy Bommareddy, M Ahsanul Islam, Samuel Jacob, Venkatesh Balan, Vijai Singh, Vijay Kumar Thakur, Naveen Kumar Navani, Nigel S Scrutton

{"title":"Arabinose as an overlooked sugar for microbial bioproduction of chemical building blocks.","authors":"Vinod Kumar, Deepti Agrawal, Rajesh Reddy Bommareddy, M Ahsanul Islam, Samuel Jacob, Venkatesh Balan, Vijai Singh, Vijay Kumar Thakur, Naveen Kumar Navani, Nigel S Scrutton","doi":"10.1080/07388551.2023.2270702","DOIUrl":"10.1080/07388551.2023.2270702","url":null,"abstract":"The circular economy is anticipated to bring a disruptive transformation in manufacturing technologies. Robust and industrial scalable microbial strains that can simultaneously assimilate and valorize multiple carbon substrates are highly desirable, as waste bioresources contain substantial amounts of renewable and fermentable carbon, which is diverse. Lignocellulosic biomass (LCB) is identified as an inexhaustible and alternative resource to reduce global dependence on oil. Glucose, xylose, and arabinose are the major monomeric sugars in LCB. However, primary research has focused on the use of glucose. On the other hand, the valorization of pentose sugars, xylose, and arabinose, has been mainly overlooked, despite possible assimilation by vast microbial communities. The present review highlights the research efforts that have explicitly proven the suitability of arabinose as the starting feedstock for producing various chemical building blocks via biological routes. It begins by analyzing the availability of various arabinose-rich biorenewable sources that can serve as potential feedstocks for biorefineries. The subsequent section outlines the current understanding of arabinose metabolism, biochemical routes prevalent in prokaryotic and eukaryotic systems, and possible products that can be derived from this sugar. Further, currently, exemplar products from arabinose, including arabitol, 2,3-butanediol, 1,2,3-butanetriol, ethanol, lactic acid, and xylitol are discussed, which have been produced by native and non-native microbial strains using metabolic engineering and genome editing tools. The final section deals with the challenges and obstacles associated with arabinose-based production, followed by concluding remarks and prospects.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1103-1120"},"PeriodicalIF":8.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0