Critical Reviews in Biotechnology最新文献_第4页

Dancing to the tune of the light regime: from perception to secondary metabolite biosynthesis in plants. 随着光的调子起舞：从感知到植物次生代谢物的生物合成。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-06-01 Epub Date: 2026-03-02 DOI: 10.1080/07388551.2026.2619534

Ashwani Punia, Satyakam, Vishal Saini, Monika Chouhan, Niranjan Chakraborty, Rajiv Kumar

{"title":"Dancing to the tune of the light regime: from perception to secondary metabolite biosynthesis in plants.","authors":"Ashwani Punia, Satyakam, Vishal Saini, Monika Chouhan, Niranjan Chakraborty, Rajiv Kumar","doi":"10.1080/07388551.2026.2619534","DOIUrl":"10.1080/07388551.2026.2619534","url":null,"abstract":"The orchestra of ambient light intensity and wavelengths are pivotal in regulating the biosynthesis of secondary metabolites. Hence, the implications of light on plants' secondary metabolites are an active area of research, and new information is slowly being accrued. Plants have inbuilt light-sensitive molecules, such as: phytochromes, cryptochromes, phototropins, UVR8, and zeitlupe family proteins. In particular, blue light absorbed by cryptochrome has positive effects on antioxidants and other bioactive compounds. However, far-red light perceived by phytochrome reduces anthocyanin biosynthesis in plants, whereas mixed light in varying proportions is more beneficial for secondary metabolite synthesis. This article reviews the current information on plants' perception of light, their downstream signaling, and the role of different light regimes on secondary metabolite biosynthesis and accumulation. It also examines the epigenetic regulation of secondary metabolite biosynthesis under various light regimes. Additionally the review examines the economic and medicinal aspects of manipulating/controlling/optimizing secondary metabolite synthesis by light modulation. Consequently, this review is expected to benefit any researchers involved in fundamental and applied research.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"541-561"},"PeriodicalIF":8.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and progress toward real-time detection of airborne viral pathogens. 空气传播病毒病原体实时检测的挑战和进展。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-06-01 Epub Date: 2026-03-05 DOI: 10.1080/07388551.2026.2628597

Michael Caffrey, Igor Paprotny, Rebecca Smith

引用次数: 0

Multifaceted roles of carboxyl compounds in antibiofilm potency and resistance modulation in Acinetobacter baumannii. 羧基化合物在鲍曼不动杆菌抗菌膜效力和耐药性调节中的多方面作用。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-06-01 Epub Date: 2026-03-02 DOI: 10.1080/07388551.2026.2628602

Bharath Reddy Boya, Jennessa Jacob, Olajide Sunday Faleye, Vinothkannan Ravichandran, Durga Mohan, Liangbin Hu, Jintae Lee, Satish Kumar Rajasekharan

{"title":"Multifaceted roles of carboxyl compounds in antibiofilm potency and resistance modulation in Acinetobacter baumannii.","authors":"Bharath Reddy Boya, Jennessa Jacob, Olajide Sunday Faleye, Vinothkannan Ravichandran, Durga Mohan, Liangbin Hu, Jintae Lee, Satish Kumar Rajasekharan","doi":"10.1080/07388551.2026.2628602","DOIUrl":"10.1080/07388551.2026.2628602","url":null,"abstract":"The escalating threat of multidrug-resistant (MDR) Acinetobacter baumannii is primarily driven by its robust biofilm-forming capacity and complex antimicrobial resistance mechanisms. This review comprehensively explores the pivotal role of the carboxyl functional group in modulating biofilm-associated virulence, quorum sensing (QS), and resistance pathways in A. baumannii. We emphasize the critical regulatory functions of the BfmRS two-component system and the AbaI/R QS system in biofilm formation, antibiotic resistance, and immune evasion. A diverse range of carboxyl-functionalized compounds, including: fatty acids, terpenoids, benzoic acids, and cinnamic acids, are highlighted for their broad-spectrum antibiofilm, anti-resistance, and antimicrobial activities, achieved through mechanisms, such as: quorum quenching, efflux pump inhibition, membrane destabilization, and metal ion chelation. These compounds enhance antimicrobial efficacy and show promise as adjuvants that potentiate existing antibiotics while minimizing resistance development. Furthermore, the review discusses the carboxyl motif's role in targeting bacterial persisters, a major challenge in chronic infections, and the evolutionary constraints imposed by carboxyl-bearing compounds on resistance evolution. Despite challenges related to membrane permeability and metabolic liabilities, innovative drug design approaches and advanced delivery systems offer promising solutions. This review underscores the versatile potential of carboxyl scaffolds as multi-target therapeutic agents against MDR A. baumannii and other high-risk pathogens, advocating their integration into future antimicrobial and repurposing strategies.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"673-693"},"PeriodicalIF":8.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in hierarchically porous metal-organic frameworks mediated enzyme immobilization: progress and perspective. 分层多孔金属有机框架介导的酶固定化的最新进展：进展和前景。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-06-01 Epub Date: 2026-03-22 DOI: 10.1080/07388551.2026.2621102

Prasanna J Patil, Muhammad Usman, Xiaoxiao Dong, Haroon Shah, Nagesh Manurkar, Chengnan Zhang, Akhtiar Ali, Xiuting Li

{"title":"Recent advances in hierarchically porous metal-organic frameworks mediated enzyme immobilization: progress and perspective.","authors":"Prasanna J Patil, Muhammad Usman, Xiaoxiao Dong, Haroon Shah, Nagesh Manurkar, Chengnan Zhang, Akhtiar Ali, Xiuting Li","doi":"10.1080/07388551.2026.2621102","DOIUrl":"10.1080/07388551.2026.2621102","url":null,"abstract":"Enzymes are essential catalysts in numerous biological processes due to their efficiency, specificity, and selectivity. To enhance their stability and reusability, enzyme immobilization onto solid supports is crucial. Hierarchically porous metal-organic frameworks (HP-MOFs), with tunable meso- and macropores, have emerged as a promising solution for enzyme encapsulation, significantly improving catalytic performance. This review examines the development of various metal-based HP-MOFs, such as: iron, copper, zirconium, zinc, aluminum, and chromium, specifically designed for enzyme immobilization. The focus is on novel synthesis strategies, including functional group incorporation and hierarchical pore design, which optimize enzyme performance. Key advancements in immobilization techniques, such as: adsorption, covalent binding, in situ encapsulation, and post-synthetic infiltration, are also discussed. The review addresses the often-overlooked issue of HP-MOF toxicity, presenting both challenges and benefits. It also emphasizes the regulatory implications of HP-MOF applications, particularly in the food, pharmaceutical, and biomedical sectors, offering insights into how these materials can be safely integrated into these industries. Data from various studies demonstrate significant improvements in enzyme activity retention, stability, and efficiency in biocatalytic applications. Additionally, diverse applications in biocatalysis, biodiesel production, biosensing, and disease diagnosis are explored. A key feature of this review is the focus on advancing HP-MOF-enzyme composites toward higher technology readiness levels (TRLs), a topic not comprehensively covered in the literature. This review provides valuable insights for researchers aiming to optimize HP-MOFs for enzyme encapsulation and industrial biotechnological applications.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"582-632"},"PeriodicalIF":8.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy and stress tolerance in plants: the central role of ATG18-a review. 植物自噬和胁迫耐受：atg18的核心作用综述。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-06-01 Epub Date: 2026-02-15 DOI: 10.1080/07388551.2026.2621917

Sishan Wei, Zexun Chen, Chenkai Xu, Xin Qian, Qiong Tang

引用次数: 0

The development of active membranes: use of immobilized enzymes as fouling-reducing and self-cleaning agents. 活性膜的发展：利用固定化酶作为除污剂和自洁剂。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-06-01 Epub Date: 2026-03-22 DOI: 10.1080/07388551.2026.2639607

Jéssica Mulinari, Carolina Elisa Demaman Oro, Alessandra Cristina de Meneses, Guilherme Zin, Luciane Maria Colla, Marco Di Luccio, Rogério Marcos Dallago

{"title":"The development of active membranes: use of immobilized enzymes as fouling-reducing and self-cleaning agents.","authors":"Jéssica Mulinari, Carolina Elisa Demaman Oro, Alessandra Cristina de Meneses, Guilherme Zin, Luciane Maria Colla, Marco Di Luccio, Rogério Marcos Dallago","doi":"10.1080/07388551.2026.2639607","DOIUrl":"10.1080/07388551.2026.2639607","url":null,"abstract":"Integrating of immobilized enzymes into membrane technology represents a significant advancement in the field of membrane science, particularly in addressing issues of fouling and self-cleaning. This review explores the development, techniques, and applications of enzymatic membranes, focusing on their fouling-degrading and self-cleaning properties. Enzymatic membranes combine catalytic and separation functions, offering environmentally friendly solutions with high selectivity and mild operating conditions. The review traces the historical development from early attempts in the 1970s using proteases in polymeric membranes to recent advancements involving a variety of enzymes and support materials. Various immobilization techniques, such as covalent bonding and physical adsorption, are discussed in relation to their impact on membrane performance. Applications span multiple industries, including food, biofuels, and wastewater treatment. Despite significant progress, the field continues to evolve with emerging technologies and novel enzyme immobilization strategies, presenting ongoing opportunities for research and industrial application.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"633-654"},"PeriodicalIF":8.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol dehydrogenases catalyzed asymmetric reductions of "difficult-to-reduce" ketones and the involved mechanism of stereoselective recognition and regulation. 醇脱氢酶催化“难还原”酮的不对称还原及其立体选择识别和调控机制。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-06-01 Epub Date: 2026-03-22 DOI: 10.1080/07388551.2026.2638569

Xin Su, Jie Gu, Yan Xu, Yao Nie

引用次数: 0

Microbial lipids for a sustainable future: the growing potential of synthetic microbial engineering for consumer oils. 可持续未来的微生物脂质：合成微生物工程用于食用油的日益增长的潜力。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-05-01 Epub Date: 2026-02-15 DOI: 10.1080/07388551.2026.2615047

Thomas R V Collier, Patrick A da Roza, Hugh D Goold, Surinder Singh, Ian T Paulsen, Roy S K Walker, Isak S Pretorius

引用次数: 0

Advances in primary cell isolation, sorting, and preservation from livestock for cultured meat applications. 畜禽培养肉原代细胞分离、分选和保存的研究进展。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-05-01 Epub Date: 2026-02-17 DOI: 10.1080/07388551.2026.2618192

Sanghun Park, Gyutae Park, Sehyuk Oh, Sol-Hee Lee, Jungseok Choi

{"title":"Advances in primary cell isolation, sorting, and preservation from livestock for cultured meat applications.","authors":"Sanghun Park, Gyutae Park, Sehyuk Oh, Sol-Hee Lee, Jungseok Choi","doi":"10.1080/07388551.2026.2618192","DOIUrl":"10.1080/07388551.2026.2618192","url":null,"abstract":"Cultured meat production relies on the efficient: isolation, purification, expansion, and preservation of livestock-derived primary cells with robust proliferation and differentiation potential. Satellite cells and fibro-adipogenic progenitors from muscle and adipose tissues are key cellular sources for the in vitro reconstruction of meat-like structures. This review critically examines current methodologies used for primary cell processing in cultured meat scalable bioprocessing research. Tissue dissociation strategies are classified as enzymatic, non-enzymatic, and hybrid protocols and compared in terms of yield, scalability, and preservation of cell functionality. Cell purification techniques include: density gradient centrifugation, pre-plating, fluorescence-activated cell sorting (FACS), and magnetic-activated cell sorting (MACS), each offering different levels of specificity, throughput, and compatibility with food-grade applications. Long-term storage via cryopreservation is essential for establishing reliable cell banks. However, challenges remain in minimizing cryoinjury, selecting optimal cryoprotective agents, and maintaining post-thaw viability. Emerging alternatives, such as temperature-responsive cell sheet technology and biochemical protection strategies, are highlighted for their potential to improve cell recovery and functionality. Unlike existing reviews that often focus on isolated aspects, this article integrates dissociation, purification, and preservation into one framework. It highlights how optimized protocols can overcome current bottlenecks in cell processing. This review emphasizes the importance of standardized and food-safe platforms. Such advances will support commercialization and sustainable delivery of cultured meat products.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"522-540"},"PeriodicalIF":8.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scope for vitamin B deficiency redressal through microbial vitamins with reference to India and South Africa. 通过微生物维生素治疗维生素B缺乏症的范围参照印度和南非。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-05-01 Epub Date: 2026-02-19 DOI: 10.1080/07388551.2026.2616412

Priyadarshini Pratikshya Nayak, Tinashe Andrew Gona, Sinesipho Galada, Ngwekazi Nwabisa Mehlomakulu, Gargi Dey, Elna Maria Buys, Sandeep Kumar Panda

{"title":"Scope for vitamin B deficiency redressal through microbial vitamins with reference to India and South Africa.","authors":"Priyadarshini Pratikshya Nayak, Tinashe Andrew Gona, Sinesipho Galada, Ngwekazi Nwabisa Mehlomakulu, Gargi Dey, Elna Maria Buys, Sandeep Kumar Panda","doi":"10.1080/07388551.2026.2616412","DOIUrl":"10.1080/07388551.2026.2616412","url":null,"abstract":"B vitamins are the most widely used supplements for women and children to maintain good health conditions. Vitamin B deficiency is prevalent in many countries including India and South Africa. Synthetic vitamins (such as folic acid) are administered orally to vulnerable groups to address the vitamin B deficiency. B vitamin-fortified foods have also been adopted as the mandate of the governments of India and South Africa. However, the policies have not been able to bring any sustainable solutions to vitamin B deficiency. This article describes the natural production of B vitamins by cultured microorganisms. Furthermore, this article describes the scope of microbial B vitamin availability in India and South Africa through dietary interventions (foods obtained from microbial processing/fermented food products). The article also elucidates the different fermented foods of India and South Africa and the increment of different B vitamins, namely riboflavin (vitamin B2), folate (vitamin B9), and cyanocobalamin (vitamin B12) during the fermentation. The technoeconomical feasibility and commercial aspects have been discussed in the article.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"380-398"},"PeriodicalIF":8.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0