Noor Ul Huda, Noor Hassan, Hazrat Ali, Yingqian Kang
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Regulation and molecular biology of prodigiosin by Serratia marcescens.
Prodigiosin is an alkaloid, cell-associated, red pigment extensively produced as a secondary metabolite by Gram negative bacterium, Serratia marcescens. The red pigment holds immense recognition for multifunctional tri-pyrrole structure and as a promising candidate for wide array of industrial applications. The biosynthesis and regulation of prodigiosin in S. marcescens is a complex process, manifesting biological information at multiple cellular levels as genomics, transcriptomics and proteomics. The current review delves into molecular biology of S. marcescens highlighting it as a prolific producer of prodigiosin. This review also highlights crucial aspects of regulatory mechanisms for prodigiosin production in S. marcescens, along with recent advancements in strain improvement and heterologous production of pigment in industrially compliant host. In addition, this review integrates current knowledge on molecular biology and regulation of prodigiosin, addressing the approaches employed for high level of prodigiosin production, potential applications, challenges and future perspective for harnessing industrial potential of prodigiosin in future.
期刊介绍：
Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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