Regulation and molecular biology of prodigiosin by Serratia marcescens.

IF 7.7 2区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Critical Reviews in Biotechnology Pub Date : 2025-07-20 DOI:10.1080/07388551.2025.2529588

Noor Ul Huda, Noor Hassan, Hazrat Ali, Yingqian Kang

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引用次数: 0

Abstract

Prodigiosin is an alkaloid, cell-associated, red pigment extensively produced as a secondary metabolite by Gram negative bacterium, Serratia marcescens. The red pigment holds immense recognition for multifunctional tri-pyrrole structure and as a promising candidate for wide array of industrial applications. The biosynthesis and regulation of prodigiosin in S. marcescens is a complex process, manifesting biological information at multiple cellular levels as genomics, transcriptomics and proteomics. The current review delves into molecular biology of S. marcescens highlighting it as a prolific producer of prodigiosin. This review also highlights crucial aspects of regulatory mechanisms for prodigiosin production in S. marcescens, along with recent advancements in strain improvement and heterologous production of pigment in industrially compliant host. In addition, this review integrates current knowledge on molecular biology and regulation of prodigiosin, addressing the approaches employed for high level of prodigiosin production, potential applications, challenges and future perspective for harnessing industrial potential of prodigiosin in future.

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粘质沙雷菌对芥子红素的调控及分子生物学研究。

Prodigiosin是一种生物碱，与细胞相关的红色色素，作为革兰氏阴性菌粘质沙雷氏菌的次级代谢物广泛产生。红色颜料具有巨大的认可，多功能三吡咯结构和作为一个有前途的候选人，广泛的工业应用。粘质松子子红素的生物合成和调控是一个复杂的过程，在基因组学、转录组学和蛋白质组学等多个细胞水平上表现出生物信息。目前的综述深入研究了S. marcescens的分子生物学，突出了它作为一种多产的生产者。这篇综述还强调了粘质葡萄球菌产生芥子红素的调控机制的关键方面，以及在菌株改良和工业适应宿主中异源生产色素方面的最新进展。此外，本文还综述了目前国内外关于芥子红素的分子生物学和调控方面的研究进展，阐述了芥子红素高水平生产的途径、应用前景、面临的挑战以及今后利用芥子红素产业潜力的展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物

CiteScore

20.80

自引率

1.10%

发文量

审稿时长

4.8 months

期刊介绍： Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.