Coronary artery disease最新文献

{"title":"Optical frequency domain imaging versus intravascular ultrasound for percutaneous coronary intervention: a meta-analysis and trial sequential analysis of randomized controlled trials.","authors":"Hosam I Taha, Mohamed S Elgendy, Abdalhakim Shubietah, Ahmed Mazen Amin, Mohamed R Ezz, Abdelrahman M Ghazal, Mohamed Anas ElShanat, Hazem Zayan, Khalid Tolba, Mohamed Abuelazm, Islam Y Elgendy","doi":"10.1097/MCA.0000000000001535","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001535","url":null,"abstract":"<p><p>Intravascular ultrasound (IVUS) or optical frequency domain imaging (OFDI) for guiding percutaneous coronary interventions (PCI) reduces the risk of adverse events compared with angiographic guidance. However, only a few trials compared both modalities. This study aims to assess and compare OFDI- vs. IVUS-guided PCI. We conducted a meta-analysis of randomized controlled trials (RCTs) retrieved from PubMed, Scopus, WOS, Embase, and Cochrane Library till September 2024. The primary outcome was major adverse cardiac events (MACE). Risk ratios (RR) were applied for dichotomous outcomes and mean differences (MD) for continuous outcomes, both with 95% confidence intervals (CI). PROSPERO ID: CRD42024595477. Four RCTs with 1135 patients were included. There was no significant difference between the two modalities in terms of MACE [RR: 0.99; 95% CI: (0.53, 1.86); P = 0.98], all-cause mortality [RR: 0.72; 95% CI: (0.15, 3.56); P = 0.69], cardiac mortality [RR: 1.00; 95% CI: (0.18, 5.68); P = 1.00] and myocardial infarction [RR: 1.21; 95% CI: (0.35, 4.18); P = 0.76]. Additionally, there was no significant difference in PCI success [RR: 1.00; 95% CI: (0.99, 1.02); P = 0.64]. However, OFDI was associated with a significant increase in contrast volume [MD: 19.81 ml; 95% CI: (2.53, 37.09); P = 0.02] and reduction in fluoroscopy time [MD: -7.05 min; 95% CI: (-9.32, -4.79); P < 0.01]. This meta-analysis of RCTs suggests that OFDI is comparable to IVUS in efficacy and safety for guiding PCI, with no significant differences in clinical outcomes. These findings support the use of either modality for PCI guidance. However, additional large-scale, multicenter RCTs to recommended to validate these findings and enhance their generalizability.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary sodium-potassium ratio as a genetic predictor of myocardial infarction.","authors":"Ziyang Wu, Dong Wang, Chengchun Tang","doi":"10.1097/MCA.0000000000001532","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001532","url":null,"abstract":"<p><strong>Background: </strong>The relationship between the urinary sodium-potassium ratio (USPR) and risk factors for heart disease has been observed over time. We evaluated the relationship between USPR and myocardial infarction (MI).</p><p><strong>Methods: </strong>Causal relationships were estimated based on USPR and MI data from genome-wide association studies. The main analysis method for bidirectional two-sample Mendelian randomization was inverse-variance weighting (IVW), with four other supplementary methods used.</p><p><strong>Results: </strong>The IVW method indicated a positive correlation between USPR levels and MI (IVW, odds ratio = 1.504, 95% confidence interval: 1.108-2.041, P = 0.009). In contrast, the inverse analysis provided evidence suggesting that MI affected USPR (P > 0.05). The Cochran Q test showed heterogeneity, while the intercept test revealed no horizontal pleiotropy, and the leave-one-out analysis demonstrated that the analyses were reliable.</p><p><strong>Conclusions: </strong>This study provides evidence for the causal effect of the USPR on MI; however, this was not the case in the opposite situation. It is plausible that the USPR serves as a promoting factor for MI.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting postoperative atrial fibrillation after cardiac surgery using the Naples prognostic score.","authors":"Dogac Oksen, Baris Guven, Ayca Donmez, Mehmet Ali Yesiltas, Ahmet Ozan Koyuncu, Seran Gulbudak, Veysel Oktay","doi":"10.1097/MCA.0000000000001438","DOIUrl":"10.1097/MCA.0000000000001438","url":null,"abstract":"<p><strong>Introduction: </strong>The Naples prognostic score (NPS) is a novel indicator of nutritional and inflammatory statuses in cancer patients. Development of atrial fibrillation after cardiac surgery (POAF) is a common complication that increases the incidence of adverse events. Numerous studies have investigated predictors of POAF. Yet, this study is the first to evaluate the prognostic value of NPS in predicting the development of POAF.</p><p><strong>Materials and methods: </strong>The population of this retrospective single-center case-control study consisted of all consecutive patients who underwent cardiac surgery between January 2021 and December 2023. The patients included in the study sample were divided into two groups according to whether they had POAF (group POAF) or remained in sinus rhythm (group RSR). Univariate and multivariate analyses were conducted to identify the variables that significantly predicted the development of POAF.</p><p><strong>Results: </strong>This study consisted of 860 patients with a mean age of 61.77 ± 9.13 years and 77.5% ( n  = 667) were male. The incidence of POAF in the sample was 24.8% ( n  = 214). NPS was significantly higher in group POAF than in group RSR (2.18 ± 0.99 vs. 1.96 ± 1.02, P  = 0.008). Multivariate analysis revealed age [odds ratio (OR): 1.242, 95% confidence interval (CI): 1.020-1.304, P  < 0.001] and high NPS (OR: 1.698, 95% CI: 1.121-1.930, P  < 0.010) as independent predictors of POAF.</p><p><strong>Conclusion: </strong>High NPS values, along with advanced age, were found to be strongly associated with an increased risk of developing POAF. Therefore, it is concluded that NPS is a significant and independent predictor of POAF in patients undergoing cardiac surgery.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"225-231"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of new postoperative atrial fibrillation after cardiac surgery.","authors":"Mesut Engin, İsmail Sivri","doi":"10.1097/MCA.0000000000001472","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001472","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":"36 3","pages":"263"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Culprit vessel revascularization prior to complete angiography as a strategy to minimize delays in primary percutaneous coronary intervention for patients with ST-elevation myocardial infarction: a systematic review and meta-analysis.","authors":"Elísio Bulhões, Vanio L J Antunes, Maria L R Defante, Roberto Mazetto, Anselmo C Garcia, Thiago C C Garcia, Camila Guida","doi":"10.1097/MCA.0000000000001450","DOIUrl":"10.1097/MCA.0000000000001450","url":null,"abstract":"<p><p>The rapid restoration of blood flow in patients with acute myocardial infarction with ST elevation through percutaneous coronary intervention (PCI) is crucial for the survival of this population. Attempts to decrease the time from diagnosis of ST-segment elevation myocardial infarction (STEMI) to arrival at the catheterization laboratory have been extensively investigated. However, strategies during the procedure aiming to reduce the time to reperfusion are lacking. We conducted a meta-analysis to evaluate culprit vessel revascularization prior to complete angiography as a strategy to minimize delays in primary PCI for patients with STEMI. We searched PubMed, Embase, and Cochrane Central. Outcomes: vascular access-to-balloon, door-to-balloon, and first medical contact-to-balloon times; death, reinfarction in 30 days, Bleeding Academic Research Consortium ≥3 type, coronary artery bypass grafting referral, and left ventricular ejection fraction %. Statistical analysis was performed using the R program (version 4.3.2). Heterogeneity was assessed with I2 statistics. We included 2050 patients from six studies, of which two were randomized controlled trials and four were observational studies. Culprit vessel revascularization prior to complete angiography was associated with a statistically significant decrease of times: vascular access-to-balloon time (mean difference -6.79 min; 95% CI: -8.00 to -5.58; P  < 0.01; I2  = 82%) and door-to-balloon time (mean difference -9.02 min; 95% CI: -12.83 to -5.22; P  < 0.01; I2  = 93%). In this meta-analysis, performing PCI on the culprit lesion prior to complete coronary angiography led to significantly shorter reperfusion times, with no discernible differences in complication rates.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"232-239"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomalous left main coronary artery originating from right coronary artery.","authors":"Xingzhou Zhao, Zhanwen Xu","doi":"10.1097/MCA.0000000000001404","DOIUrl":"10.1097/MCA.0000000000001404","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"266"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zero-contrast intravascular ultrasound-guided percutaneous coronary intervention in a patient with high-risk iodinated contrast allergy: navigating in the dark through a brighter inner light.","authors":"Giuseppe Colletti, Asad Shabbir, Alexandre Natalis, Claudiu Ungureanu","doi":"10.1097/MCA.0000000000001444","DOIUrl":"10.1097/MCA.0000000000001444","url":null,"abstract":"","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"269-270"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair cortisol concentration, a stress biomarker, is gradually increasing before an acute myocardial infarction.","authors":"Nikolaos Kosmas, Panagiotis Simitsis, Evangelos Alevyzakis, Emmanouil Rizos, Dimitrios Zapantiotis, Loukianos Stylianos Rallidis","doi":"10.1097/MCA.0000000000001468","DOIUrl":"10.1097/MCA.0000000000001468","url":null,"abstract":"<p><strong>Background: </strong>Chronic stress is believed to play a role in the pathophysiology of acute myocardial infarction (AMI). Cortisol is a biomarker associated with stress. We sought to assess stress contribution to AMI using hair cortisol concentration (HCCs) as a surrogate biomarker.</p><p><strong>Methods: </strong>HCC was measured in hair segments, corresponding to distinctive periods before hair sampling, in 102 male AMI patients and 50 healthy male controls. Standard baseline variables were collected for both groups, whereas for AMI patients, laboratory and psychological tests were also carried out. Linear mixed models were applied to assess the effect of group and baseline variables on the trend of cortisol before hair sampling.</p><p><strong>Results: </strong>HCC was significantly higher in AMI patients the last 30 days before hair sampling with an overall higher rate of increase (time-group interaction P  < 0.001). AMI patients with BMI ≥25 kg/m 2 had a slower rate of increase compared with those with BMI <25 kg/m 2 (adjusted P  = 0.008). Among AMI patients, there was no difference in the rate of cortisol increase between STEMI and NSTEMI patients (time-group interaction P  = 0.841). Lower BMI conferred higher rates of cortisol increase irrespectively of AMI type.</p><p><strong>Conclusion: </strong>HCC, a biomarker of stress, showed an increasing trend over a period of 2 months before the occurrence of AMI suggesting a potential role of stress, through cortisol secretion, in the pathophysiology of AMI.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"218-224"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive correlation between n- 6 : n- 3 PUFA ratio intake with serum oxHDL/HDL-c ratio in patients with coronary artery disease.","authors":"Sissi Godinez-Mora, Wendy Campos-Perez, Mariana Perez-Robles, Cesar Robles-Jimarez, Alejandra Muñoz-Hernandez, Joel Torres-Vanegas, Erika Martinez-Lopez","doi":"10.1097/MCA.0000000000001437","DOIUrl":"10.1097/MCA.0000000000001437","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery disease (CAD) is one of the most prevalent cardiovascular diseases where serum lipoprotein oxidation plays a significant role. Polyunsaturated fatty acids (PUFA) n -6 :  n -3 unbalance ratio consumption, affects lipoprotein oxidation, and inflammation processes. This study aimed to analyze the relationship between n -6 :  n -3 PUFA ratio intake with oxidized lipoproteins in individuals with CAD.</p><p><strong>Methods: </strong>A cross-sectional study was performed including 105 subjects (51 diagnosed with CAD and 54 non-CAD) from western Mexico. Dietary information was collected using a habitual day food record. Serum oxidized low-density lipoprotein (oxLDL) and oxidized high-density lipoprotein (oxHDL) concentrations were quantified by enzyme linked immunosorbent assay.</p><p><strong>Results: </strong>CAD subjects had higher oxHDL/HDL cholesterol (HDL-c) ratio [0.102 (0.092-0.112) vs. 0.080 (0.070-0.090), P  = 0.004] and oxLDL/LDL cholesterol (LDL-c) ratio [129.2 (108-150.4) vs. 59.7 (39.3-80), P  < 0.001] compared to non-CAD subjects. Risk factors associated with CAD were a high n -6 :  n -3 PUFA ratio (odds ratio, OR = 2.3, P  = 0.046), hypoalphalipoproteinemia in men (OR = 3.2, P  = 0.014), moderate/high tobacco index (OR = 6.33, P  = 0.003), elevated waist circumference in women (OR = 7, P  = 0.004), hypertension (OR = 21.14, P  < 0.001), and type 2 diabetes (OR: 25, P  < 0.001). The oxHDL/HDL-c ratio was positively associated with the n -6 :  n -3 PUFA ratio [ r2  = 28.3, B  = 0.002 (0.001-0.003), P  < 0.001] in CAD patients.</p><p><strong>Conclusions: </strong>This study showed that a higher n -6 :  n -3 PUFA ratio intake correlates with higher serum oxHDL/HDL-c in CAD patients.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"190-199"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled low-density lipoprotein cholesterol attenuates cardiovascular risk mediated by elevated lipoprotein(a) after percutaneous coronary intervention.","authors":"Ahmed K Mahmoud, Kamal Awad, Juan M Farina, Mohammed Tiseer Abbas, Nima Baba Ali, Hesham M Abdalla, Amro Badr, Muhammad A Elahi, Milagros Pereyra, Isabel G Scalia, Niloofar Javadi, Nadera N Bismee, Said Alsidawi, Steven J Lester, Chadi Ayoub, Reza Arsanjani","doi":"10.1097/MCA.0000000000001460","DOIUrl":"10.1097/MCA.0000000000001460","url":null,"abstract":"<p><strong>Background: </strong>Lipoprotein(a) [Lp(a)] is an independent, causal risk factor for cardiovascular disease. However, it is still unclear whether controlling low-density lipoprotein cholesterol (LDL-C) to optimal levels can attenuate cardiovascular risk mediated by elevated Lp(a), especially in the setting of secondary prevention.</p><p><strong>Methods: </strong>Adult patients with a baseline Lp(a) measurement who underwent percutaneous coronary intervention (PCI) and reached their LDL-C target levels (<70 mg/dl) at Mayo Clinic sites between 2006 and 2017 were included. Primary outcomes included major adverse cardiovascular events (MACE) and all-cause mortality. Kaplan-Meier curves were created to compare the survival probabilities among patients with Lp(a) ≥ 50 mg/dl compared with Lp(a) < 50 mg/dl. Multivariable Cox regression analyses were performed to quantify the association of elevated Lp(a) with our relevant outcomes and to control for possible confounders.</p><p><strong>Results: </strong>In total, 878 patients (median age: 68 years, and 74% males) who underwent PCI were included for analysis. Of them, 29.7% had elevated Lp(a) ≥ 50 mg/dl. Kaplan-Meier curves did not reveal any significant difference in survival probabilities for elevated Lp(a) for any outcome including MACE ( P  = 0.91), all-cause mortality ( P  = 0.26), or the separate MACE components. Similarly, the multivariable analysis showed no significant association for MACE (hazard ratio: 1.07, 95% confidence interval: 0.84-1.37) or all-cause mortality (hazard ratio: 0.98, 95% confidence interval: 0.74-1.30).</p><p><strong>Conclusion: </strong>In patients who underwent PCI and have their LDL-C controlled below 70 mg/dl, no significant association was found between elevated Lp(a) ≥ 50 mg/dl and risk for MACE or all-cause mortality.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":"183-189"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}