Coronary artery disease最新文献

Association between pulse wave velocity and coronary atherosclerosis. 脉搏波速度与冠状动脉粥样硬化的关系。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-24 DOI: 10.1097/MCA.0000000000001548

Anshul Saxena, Muni Rubens, Shozab S Ali, Javier Jimenez, Juan Ruiz-Pelaez, Lara Arias, Raul Herrera, Theodore Feldman, Ricardo C Cury, Harneet K Walia, Sadeer Al-Kindi, Khurram Nasir, Jonathan A Fialkow, Sandra Chaparro

{"title":"Association between pulse wave velocity and coronary atherosclerosis.","authors":"Anshul Saxena, Muni Rubens, Shozab S Ali, Javier Jimenez, Juan Ruiz-Pelaez, Lara Arias, Raul Herrera, Theodore Feldman, Ricardo C Cury, Harneet K Walia, Sadeer Al-Kindi, Khurram Nasir, Jonathan A Fialkow, Sandra Chaparro","doi":"10.1097/MCA.0000000000001548","DOIUrl":"10.1097/MCA.0000000000001548","url":null,"abstract":"Background: Pulse wave velocity (PWV) is considered a more direct and accurate measure of arterial stiffness. This study explored the relationship between PWV and the presence and severity of coronary artery calcification (CAC) and coronary artery plaque (CAP).Methods: The current study was a cross-sectional analysis of data from the Miami Heart Study (MiHeart). The primary outcome variable of this study was the CAC score. The secondary outcome was the presence of CAC and CAP. Multivariable logistic regression and Bayesian linear regression were used to find the association between PWV CAC and CAP.Results: A total of 2359 participants were included in the study. The mean age (SD) of the sample was 53.4 (6.8) years and 50.4% were men. Multivariable logistic regression analysis showed that the odds of having CAC greater than 0 was significantly higher with increasing PWV [odds ratio (OR): 1.09, 95% confidence interval (CI): 1.01-1.18]. Similarly, multivariable logistic regression analysis also showed that the odds for CAP were significantly higher with increasing PWV (OR: 1.14, 95% CI: 1.06-1.23). The results of Bayesian linear regression analysis showed that there was a significant association between PWV and log CAC score.Conclusion: In a large sample of participants from the community and without a history of known cardiovascular disorder, we found that an increase in PWV was associated with the presence of CAC and CAP. In addition, we also found that PWV was associated with severity of CAC as well. Our findings show that PWV could be an important marker of subclinical coronary atherosclerosis in the general population.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of drug-eluting stent combined with drug-coated balloon in the treatment of complex coronary artery lesions. 药物洗脱支架联合药物包被球囊治疗复杂冠状动脉病变的安全性和有效性。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-18 DOI: 10.1097/MCA.0000000000001543

Xiaotao Li, Yuhong Yang, Ran Zhang, Dawei Yang, Xiaojie Chen, Jia Wang, Chenhao Zhang

{"title":"Safety and efficacy of drug-eluting stent combined with drug-coated balloon in the treatment of complex coronary artery lesions.","authors":"Xiaotao Li, Yuhong Yang, Ran Zhang, Dawei Yang, Xiaojie Chen, Jia Wang, Chenhao Zhang","doi":"10.1097/MCA.0000000000001543","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001543","url":null,"abstract":"Objective: The aim of this study was to explore the safety and efficacy of drug-eluting stents (DES) combined with drug-coated balloons (DCB) in the treatment of complex coronary artery lesions.Methods: In total, 305 patients with complex coronary artery lesions who underwent percutaneous coronary intervention were retrospectively included in this study. The patients were divided into the DES combined with the DCB treatment group (hybrid group) and the DES-only treatment group (DES group), and the target lesion revascularization (TLR) and major adverse cardiovascular events (MACE) were compared between the two groups during 2-year follow-up.Results: There were no significant differences between the two groups in baseline clinical characteristics (P > 0.05). In the treated lesions of reference vessel diameters (RVD) ≥3 mm, there were no significant differences in coronary angiography and interventional characteristics between the two groups. In the treated lesion of RVD <3 mm, hybrid group had higher proportion of lesion preparation (P < 0.001) and a higher rate of residual stenosis after stent implantation (P < 0.001). During the 2-year follow-up, the clinical outcomes between the two groups showed no significant differences. After propensity score matching, there were still no significant differences between the two groups in the cumulative survival rates without TLR (95.8% vs. 94.2%; log-rank P = 0.560) or MACE (89.4% vs. 87.8%; log-rank P = 0.578) at 2-year follow-up.Conclusion: During the 2-year follow-up, DES combined with DCB treatment showed similar efficacy and safety compared with DES-only treatment in complex coronary artery lesions.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons learned from the first-in-man study of a novel everolimus-coated balloon for coronary in-stent restenosis. 新型依维莫司涂层球囊治疗冠状动脉支架内再狭窄的首次人体研究的经验教训。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001541

Rupak Desai, Nihar K Jena

引用次数: 0

Scoring-balloon fenestration for abrupt closure caused by spiral coronary artery dissection and hematoma immediately after intravascular lithotripsy. 记分球囊开窗治疗血管内碎石术后螺旋状冠状动脉剥离和血肿引起的突然关闭。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001542

Akira Shinoda, Kazuhiro Dan

引用次数: 0

Association between visceral fat metabolism score and atherosclerotic cardiovascular disease: evidence from NHANES 2005 to 2016. 内脏脂肪代谢评分与动脉粥样硬化性心血管疾病的相关性：来自NHANES 2005 - 2016的证据

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001545

Songjie Wu, Sirui Jiang, Yefeng Yao, Mengying Li

{"title":"Association between visceral fat metabolism score and atherosclerotic cardiovascular disease: evidence from NHANES 2005 to 2016.","authors":"Songjie Wu, Sirui Jiang, Yefeng Yao, Mengying Li","doi":"10.1097/MCA.0000000000001545","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001545","url":null,"abstract":"Background: Obesity and metabolic disorders are key contributors to the development of atherosclerotic cardiovascular disease (ASCVD). This study sought to investigate the relationship between the newly introduced Metabolic Score for Visceral Fat (METS-VF) and ASCVD, utilizing data from the National Health and Nutrition Examination Survey (NHANES).Methods: Data from NHANES 2005-2016 were analyzed. Adults with complete METS-VF and ASCVD data were included. Weighted multivariate logistic regression models assessed associations between METS-VF and ASCVD. Smoothed curve fitting and subgroup analyses further explored the relationship. Receiver operating characteristic curves were used to compare the predictive performance of METS-VF with other indicators of visceral fat.Results: A total of 9979 participants were included, among whom 807 had ASCVD. In the fully adjusted model, each 1-unit increase in METS-VF was associated with a 43% higher ASCVD risk (OR = 1.43, 95% CI: 1.11-1.85). Compared with Q1, the ORs for Q2, Q3, and Q4 were 1.71, 1.72, and 2.10, respectively (P for trend <0.05). The curve fitting showed a linear positive association. Subgroup analyses indicated significant associations in men, non-Hispanic Whites and Blacks, and participants without hypertension, who smoked, drank alcohol, or physically inactive. METS-VF showed better predictive ability (AUC = 0.734) than LAP, VAI, WC, and WHtR.Conclusions: METS-VF is a reliable, noninvasive, and cost-effective predictor of visceral obesity that demonstrates a linear positive correlation with ASCVD, supporting its use as an accurate measure of ASCVD risk.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated left main coronary artery disease in two young HIV-positive men without traditional risk factors. 孤立的左主干冠状动脉疾病的两个年轻的hiv阳性男子没有传统的危险因素。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001547

Didar Mirzamidinov, Kurtulus Karauzum, Hacer Dogan, Kaan Hanci, Irem Yilmaz, Goksel Kahraman, Tayfun Sahin

引用次数: 0

Bilirubin may mediate the anti-inflammatory effects of aerobic exercise habits: implications for the antiatherosclerotic effects of aerobic exercise. 胆红素可能介导有氧运动习惯的抗炎作用：有氧运动的抗动脉粥样硬化作用的含义。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001546

Shigemasa Tani, Yasuyuki Suzuki, Tsukasa Yagi, Atsuhiko Takahashi

{"title":"Bilirubin may mediate the anti-inflammatory effects of aerobic exercise habits: implications for the antiatherosclerotic effects of aerobic exercise.","authors":"Shigemasa Tani, Yasuyuki Suzuki, Tsukasa Yagi, Atsuhiko Takahashi","doi":"10.1097/MCA.0000000000001546","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001546","url":null,"abstract":"Background: Moderately elevated serum bilirubin levels and aerobic exercise effectively reduce the risk of coronary artery disease (CAD). However, the relationships among aerobic exercise, total serum bilirubin (TSB), and inflammation remain unclear. We investigated the associations among aerobic exercise, TSB, and inflammatory response, with TSB as a mediator of this association.Methods: This cross-sectional study included 8290 participants registered at the Health Planning Center of Nihon University Hospital in 2019. We defined aerobic exercise as 30 min of sweating at least twice a week for over a year.Results: In this cohort (average age, 46.7±13.0 years; 59% men), participants who undertook habitual aerobic exercise (n=2131) had significantly higher TSB levels [0.78 (0.91/0.99) mg/dl vs. 0.74 (0.58/0.95) mg/dl, P<0.0001] than those who did not (n=6159). Multivariable logistic regression analysis demonstrated that aerobic exercise independently predicted higher TSB levels (>50th percentile set as the dependent variable). Participants with habitual aerobic exercise had significantly lower inflammatory blood cell components, including leukocyte, neutrophil, and platelet counts, than those who did not (all P<0.0001). The levels of these inflammatory markers significantly decreased with increasing TSB levels. Mediation analysis indicated that higher TSB levels partially mediated the association between aerobic exercise and lower counts of inflammatory markers.Conclusion: Habitual aerobic exercise was associated with lower levels of inflammatory markers and higher TSB levels, which mediated the anti-inflammatory effects of aerobic exercise. These associations potentially elucidate the preventive effects of aerobic exercise on CAD risk.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epicardial adipose tissue volume, compositional plaque progression, and vulnerability in nonobstructive coronary artery disease. 非阻塞性冠状动脉疾病的心外膜脂肪组织体积、组成斑块进展和易感性

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001539

Ingela Khan, Caroline A B Hondros, Silja Hanseth, Eva R Pedersen, Siren Hovland, Terje H Larsen, Mai Tone Lønnebakken

{"title":"Epicardial adipose tissue volume, compositional plaque progression, and vulnerability in nonobstructive coronary artery disease.","authors":"Ingela Khan, Caroline A B Hondros, Silja Hanseth, Eva R Pedersen, Siren Hovland, Terje H Larsen, Mai Tone Lønnebakken","doi":"10.1097/MCA.0000000000001539","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001539","url":null,"abstract":"Background: Inflammation is a driver of atherosclerosis and plaque vulnerability. Epicardial adipose tissue (EAT) accumulation is associated with inflammation. The aim of this study was, therefore, to explore the association between EAT volume, compositional plaque progression, and vulnerability in nonobstructive coronary artery disease (CAD).Methods: We identified 31 individuals [median age 58 (52, 68) years, 42% women] from the Norwegian Registry of Invasive Cardiology with nonobstructive CAD undergoing clinically indicated serial cardiac computed tomography (CT) and coronary CT angiography (CCTA). EAT volume was measured at baseline by a semiautomatic analysis software. Patients were grouped according to lower or higher than median baseline EAT (b-EAT) volume. Plaque progression was quantified by CCTA as annual change in total and compositional plaque volume. Hypodense plaques were adjudicated as vulnerable plaques.Results: Patients with high b-EAT volume had numerically lower calcium score, coronary artery segment involvement score, total coronary plaque burden, and increased prevalence of vulnerable plaques compared with patients with low EAT volume at baseline and follow-up, even if it did not reach statistical significance. Compared with patients with low b-EAT volume, patients with high b-EAT volume tended to have an annual regression in total plaque volume, while the proportion of vulnerable hypodense plaque volume increased.Conclusion: In nonobstructive CAD, patients with high b-EAT volume tended to have a regression of total plaque volume, but a transformation into a vulnerable plaque phenotype during follow-up. Whether lifestyle changes may improve prognosis in nonobstructive CAD needs to be confirmed in larger trials.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uric acid-to-albumin ratio × monocyte-to-lymphocyte ratio is a novel biomarker for predicting all-cause mortality and cardiovascular mortality in patients with ST-segment elevation myocardial infarction. 尿酸/白蛋白比值×单核细胞/淋巴细胞比值是预测st段抬高型心肌梗死患者全因死亡率和心血管死亡率的一种新的生物标志物。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001544

Hong Wei, Yanji Zhou, Yu Wang, Dan Xu, Yunhong Yang, Tao Shi, Sirui Yang, Xinuo Ma, Lixing Chen

{"title":"Uric acid-to-albumin ratio × monocyte-to-lymphocyte ratio is a novel biomarker for predicting all-cause mortality and cardiovascular mortality in patients with ST-segment elevation myocardial infarction.","authors":"Hong Wei, Yanji Zhou, Yu Wang, Dan Xu, Yunhong Yang, Tao Shi, Sirui Yang, Xinuo Ma, Lixing Chen","doi":"10.1097/MCA.0000000000001544","DOIUrl":"https://doi.org/10.1097/MCA.0000000000001544","url":null,"abstract":"Background: Uric acid-to-albumin ratio (UAR) and monocyte-to-lymphocyte ratio (MLR) predict adverse outcomes in cardiovascular disease (CVD). We aim to explore the predictive value of UAR combined with MLR for all-cause and cardiovascular mortality in patients with ST-segment elevation myocardial infarction (STEMI).Methods: This retrospective cohort study included 1045 patients with STEMI who had undergone emergency percutaneous coronary intervention (PCI) (2018-2023). Uric acid-to-albumin ratio × monocyte-to-lymphocyte ratio (UAML) was defined as the product of UAR and MLR. Mortality prediction was evaluated via Kaplan-Meier, Cox regression, and time-dependent receiver operating characteristic (ROC) analyses.Results: Stratifying 1045 patients with STEMI by median UAML (3.35) revealed significantly higher cumulative all-cause mortality (log-rank χ2 =41.114, P < 0.001) and cardiovascular mortality (χ2 = 32.153, P < 0.001) in the high-UAML (≥3.35) vs. low-UAML (<3.35) group. Multivariate Cox analysis confirmed UAML as an independent predictor of all-cause mortality [hazard ratio (HR) = 2.217, 95% confidence interval (CI): 1.399-3.514; P < 0.001] and cardiovascular mortality (HR = 2.160, 95% CI: 1.267-3.618; P = 0.005). Time-dependent ROC demonstrated superior predictive discrimination for UAML over individual components in both all-cause mortality [area under the ROC curve (AUC) = 0.704 vs. UAR = 0.686/MLR = 0.627] and cardiovascular mortality (AUC = 0.700 vs. 0.690/0.615).Conclusion: UAML may serve as a strong prognostic factor for all-cause and cardiovascular mortality in patients with STEMI who undergo emergency PCI, and UAML has a stronger predictive value than UAR or MLR.","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual anomalous origins of the left anterior descending and left circumflex from the right coronary sinus with interarterial and retroaortic course. 左前降支和左旋支起源于右冠状动脉窦并伴有动脉间和主动脉后的双重异常起源。

IF 1.5 4区医学

Coronary artery disease Pub Date : 2025-06-17 DOI: 10.1097/MCA.0000000000001538

Kurtulus Karauzum, Didar Mirzamidinov, Ozgur Cakir, Irem Yilmaz, Tayfun Sahin

引用次数: 0